Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

Radiotherapy and Oncology

Volumn 92, Issue 3, 2009, Pages 423-428

  Dubois, Ludwig ^a   Lieuwes, Natasja G ^a   Maresca, Alfonso ^b   Thiry, Anne ^a,c   Supuran, Claudiu T ^b   Scozzafava, Andrea ^b   Wouters, Bradly G ^a,d,e   Lambin, Philippe ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF NAMUR   (Belgium)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

Carbonic anhydrase IX (CA IX); Fluorescent imaging; Sulfonamide; Tumour hypoxia

Indexed keywords

CARBOGEN; CARBONATE DEHYDRATASE IX; FLUORESCENT DYE; NICOTINAMIDE; OXYGEN; SULFONAMIDE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; COLORECTAL TUMOR; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HYPOXIA; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; TUMOR XENOGRAFT;

ANIMALS; ANTIGENS, NEOPLASM; BINDING SITES; CARBONIC ANHYDRASES; CELL HYPOXIA; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OXYGEN; OXYGEN CONSUMPTION; PROBABILITY; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC; SULFONAMIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 69949128698     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2009.06.019     Document Type: Article

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