Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion

British Journal of Cancer

Volumn 82, Issue 11, 2000, Pages 1808-1813

  Zavada J ^a   Zavadova Z ^a   Pastorek, J ^b   Biesova Z ^b   Jezek J ^c   Velek, J ^c  

^a INSTITUTE OF MATHEMATICS   (Czech Republic)

^b INSTITUTE OF VIROLOGY   (Slovakia)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Carbonic anhydrase; Cell adhesion molecules; Drug design; Phage display; Tumour immunology

Indexed keywords

CARBONATE DEHYDRATASE; CELL SURFACE PROTEIN; EPITOPE; HEPTAPEPTIDE; MONOCLONAL ANTIBODY; OLIGOPEPTIDE; PROTEOGLYCAN;

ARTICLE; CANCER; CELL ADHESION; DRUG DESIGN; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0034024783     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1111     Document Type: Article

References (19)

1. DeCamp D, Ogden R, Kuntz I and Craik CS (1996) Site-directed drug design. In: Protein Engineering, Principles and Practice, Cleland JL and Craik CS (eds), pp. 467-505. Wiley-Liss: New York
2. Falkbring SO, Göthe PO and Nyman PO (1972) Affinity chromatography of carbonic anhydrase. FEBS Lett 24: 229-235
3. Liao SY, Brewer C, Závada J, Pastorek J, Pastorekova S, Manetta A, Berman ML, DiSaia PJ and Stanbridge EJ (1994) Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. Am J Pathol 145: 598-609
4. Liao SY, Aurelio ON, Jan K, Závada J and Stanbridge EJ (1997) Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res 57: 2827-2831
5. Merrifield B (1995) Solid-phase peptide synthesis. In: Peptides: Synthesis, Structures and Applications, Gutte B (ed). pp. 93-169. Academic Press: San Diego
6. Oosterwijk E, Ruiter DJ, Hocdemacker PJ, Pauwels EKJ, Jonas U, Zwartendijk J and Warnaar SO (1986) Monoclonal antibody G250 recognizes determinant present in renal cell carcinoma and absent from normal kidney. Int J Cancer 38: 489-494
7. Opavsky R, Pastorekova S, Zelnik V, Gibadulinova A, Stanbridge EJ, Závada J, Kettmann R and Pastorek J (1996) Human MN/CA9 gene, a novel member of the carbonic anhydras family: structure and exon to protein domain relationship Genomics 33: 480-487
8. Pastorek J, Pastorekova S, Callebaut I, Mornon JP, Zelnik V, Opavrsky R, Zatovicova M, Liao S, Portetelle D, Stanbridge EJ, Zavada J, Burny A and Kettmann R (1994) Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and putative helix-loop DNA binding segment. Oncogene 9: 2877-2888
9. Pastorekova S, Zavadova Z, Kostal M, Babusikova O and Zavada J (1992) A novel quasi-viral agent, MaTu, is a two-component system. Virology 187: 620-626
10. Piersbacher MD and Ruoslahti E (1984) Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc Natl Acad Sci USA 81: 5985-5988
11. Saarnio J, Parkkila S, Parkkila AK, Haukipuro K, Pastorekova S, Pastorek J, Kairatuoma MI and Karttunen TJ (1998a) Immunohistochemical study of colorectal tumors expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 153: 279-285
12. Saarnio J, Parkkila S, Parkkila AK, Waheed A, Casey MC, Zhou XY, Pastorekova S, Pastorek J, Karttunen T, Haukipuro K, Kairaluoma MI and Sly WS (1998b) Immunochemisiry of carbonic anhydrase isozyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferate capacity. J Histochem Cytochem 46: 497-504
13. Steffens MG, Boerman OC, Oosterwijk-Wakka JC, Oosterhof GON, Witjes JA, Koenders EB, Oyen WJ, Buijs WC, Debruyne FMJ, Corstens FHM and Oostenvijk E (1997) Targeting of renal cell carcinoma with Iodine-131-labeled chimeric monoclonal antibody G250. J Clin Oncol 15: 1529-1539
14. Turner JR, Odze RD, Crum CP and Resnick MB (1997) MN antigen expression in normal, preneoplastic, and neoplastic esophagus: a clinicopathological study of a new cancer-associated biomarker. Hum Pathol 28: 740-744
15. Uemura H, Kitagawa H, Hirao Y, Okajima E, Debruyne FMJ and Oosterwijk E (1997) Expression of tumor-associated antigen MN/G250 in urologic carcinoma, potential therapeutic target. J Urol 157: 377
16. Vermylen P, Roufosse C, Burny A, Verhest A, Bosschaerts T, Pastorekova S, Ninane V and Sculier J-P (1999) Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lung carcinoma. Eur Respir J 14: 806-811
17. Winter J (1996) Bacteriophage display libraries. In: Protein Engineering, Principles and Practice, Cleland JL and Craik CS (eds). pp. 349-369. Wiley-Liss: New York
18. Závada J, Zavadova Z, Pastorekova S, Ciampor F, Pastorek J and Zelnik V (1993) Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int J Cancer 54: 268-274
19. Závada J, Zavadova Z, Machon O, Kutinova L, Nemeckova S, Opavsky R and Pastorek J (1997) Transient transformation of mammalian cells by MN protein, a tumor-associated cell adhesion molecule with carbonic anhydrase activity. Int J Oncol 10: 857-863