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Volumn 2, Issue 1, 2002, Pages 38-47

Hypoxia - A key regulatory factor in tumour growth

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; CALPHOSTIN C; DIPHENYLIODONIUM SALT; ERYTHROPOIETIN; GEFITINIB; HERBIMYCIN; HYPOXIA INDUCIBLE FACTOR 1; MANNOHEPTULOSE; RAPAMYCIN; THROMBOSPONDIN; TRASTUZUMAB; WORTMANNIN; ARNT PROTEIN, HUMAN; ARNT PROTEIN, MOUSE; AROMATIC HYDROCARBON RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA BINDING PROTEIN; ENDOTHELIAL CELL GROWTH FACTOR; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOKINE; NUCLEAR PROTEIN; ONCOPROTEIN; OXYGEN; PRODRUG; PROTEIN TYROSINE KINASE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

EID: 0036359548     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc704     Document Type: Review
Times cited : (4569)

References (117)
  • 1
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson, R. & Gray, L. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Canc. 9, 539-549 (1955).
    • (1955) Br. J. Canc. , vol.9 , pp. 539-549
    • Thomlinson, R.1    Gray, L.2
  • 2
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown, J. M. & Giaccia, A. J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 58, 1408-1416 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 3
    • 0035061344 scopus 로고    scopus 로고
    • Oxygen sensing during intermittent hypoxia: Cellular and molecular mechanisms
    • Prabhakar N. R. Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J. Appl. Physiol. 90, 1986-1994 (2001).
    • (2001) J. Appl. Physiol. , vol.90 , pp. 1986-1994
    • Prabhakar, N.R.1
  • 4
    • 0030926491 scopus 로고    scopus 로고
    • Cells at intermediate oxygen levels can be more important than the hypoxic fraction in determining tumor response to fractionated radiotherapy
    • Wouters, B. G. & Brown, J. M. Cells at intermediate oxygen levels can be more important than the hypoxic fraction in determining tumor response to fractionated radiotherapy. Radiat. Res 147, 541-550 (1997).
    • (1997) Radiat. Res , vol.147 , pp. 541-550
    • Wouters, B.G.1    Brown, J.M.2
  • 5
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel, M. & Vaupel, P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl Cancer Inst. 93, 266-276 (2001).
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 6
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancers with low apoptotic index are highly aggressive
    • Hockel, M., Schlenger, K., Hockel, S. & Vaupel, P. Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res. 59, 4525-4528 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 4525-4528
    • Hockel, M.1    Schlenger, K.2    Hockel, S.3    Vaupel, P.4
  • 7
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang, C. V. & Semenza, G. L. Oncogenic alterations of metabolism. Trends Biochem. Sci. 24, 68-72 (1999).
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 9
    • 0033986948 scopus 로고    scopus 로고
    • Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor-1α
    • Carrero, P. et al. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor-1α. Mol. Cell Biol. 20, 402-415 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 402-415
    • Carrero, P.1
  • 10
    • 0034681378 scopus 로고    scopus 로고
    • A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF)-1α and the HIF-like factor
    • Lando, D., Pongratz, I., Poellingers, L. & Whitelaw, M. L. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF)-1α and the HIF-like factor. J. Biol. Chem. 275, 4618-4627 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 4618-4627
    • Lando, D.1    Pongratz, I.2    Poellingers, L.3    Whitelaw, M.L.4
  • 11
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman, M. E. et al. Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein J. Biol. Chem. 275, 25733-25741 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 25733-25741
    • Cockman, M.E.1
  • 12
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
    • Ohh, M. et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nature Cell Biol. 2, 423-427 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1
  • 13
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF-1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • Kamura, T. et al. Activation of HIF-1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl Acad. Sci. USA 97, 10430-10435 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10430-10435
    • Kamura, T.1
  • 14
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto, K., Makino, Y., Pereira, T. & Poellinger, L. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19, 4298-4309 (2000). References 11-14 report that VHL protein modifies HIF-1α by ubiquitylation.
    • (2000) EMBO J. , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 15
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275 (1999). The first to show that mutations in VHL caused upregulation of HIF-1α, coupling a tumour-suppressor pathway to HIF-1 signalling.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1
  • 16
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-elongin-C-elongin-B complex: Implications for VHL tumor suppressor function
    • Stebbins, C. E., Kaelin, W. G. Jr & Pavletich, N. P. Structure of the VHL-elongin-C-elongin-B complex: implications for VHL tumor suppressor function. Science 284, 455-461 (1999).
    • (1999) Science , vol.284 , pp. 455-461
    • Stebbins, C.E.1    Kaelin W.G., Jr.2    Pavletich, N.P.3
  • 17
    • 0035917808 scopus 로고    scopus 로고
    • 2-regulated prolyl hydroxylation
    • 2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 18
    • 0035917313 scopus 로고    scopus 로고
    • 2 sensing
    • 2 sensing. Science 292, 464-468 (2001). References 17 and 18 were the first descriptions of an enzyme that covalently modifies HIF-1α in an oxygen-dependent manner.
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1
  • 19
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
    • Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W. & Ratcliffe, P. J. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206 (2001).
    • (2001) EMBO J. , vol.20 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3    Pugh, C.W.4    Ratcliffe, P.J.5
  • 21
    • 0035933716 scopus 로고    scopus 로고
    • Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway
    • Srinivas, V. et al. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J. Biol. Chem. 276, 21995-21998 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 21995-21998
    • Srinivas, V.1
  • 22
    • 0035880239 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
    • Vaux, E. C., Metzen, E., Yeates, K. M. & Ratcliffe, P. J. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98, 296-302 (2001).
    • (2001) Blood , vol.98 , pp. 296-302
    • Vaux, E.C.1    Metzen, E.2    Yeates, K.M.3    Ratcliffe, P.J.4
  • 23
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein, A. C. et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54 (2001).
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1
  • 24
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick, R. K. & McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340 (2001). References 23 and 24 describe the characterization of three enzymes that act as oxygen sensors, using HIF-1α as a substrate and requiring oxygen.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 25
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1α is required for solid tumor formation and embryonic vascularization
    • Ryan, H. E., Lo, J. & Johnson, R. S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005-3015 (1998). This study, along with references 28 and 44, shows that HIF-1α has a significant role in tumour growth in vivo.
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 26
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W. & McKnight, S. L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12, 3320-3324 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 27
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor-2α plays an important role in vascular remodeling
    • Peng, J., Zhang, L., Drysdale, L. & Fong, G. H. The transcription factor EPAS-1/hypoxia-inducible factor-2α plays an important role in vascular remodeling. Proc. Natl Acad. Sci. USA 97, 8386-8391 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 28
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • Maxwell, P. H. et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94, 8104-8109 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1
  • 29
    • 0033870281 scopus 로고    scopus 로고
    • Expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks, K. L. et al. Expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411-421 (2000). The authors used a monoclonal antibody against HIF-1α to examine its expression and distribution in a variety of solid tumours. They observed nuclear localization of HIF-1α and -2α in subsets of the tumour cells, and reported that HIF-2α was also strongly expressed by subsets of tumour-associated macrophages.
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1
  • 30
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor-1α in common human cancers and their metastases
    • Zhong, H. et al. Overexpression of hypoxia-inducible factor-1α in common human cancers and their metastases Cancer Res. 59, 5830-5835 (1999). HIF-1α expression was analysed by immunohistochemistry in 179 tumour specimens, and found to be overexpressed in a variety of tumour types. HIF-1α expression was also correlated with aberrant p53 accumulation and cell proliferation. These results provided the first clinical data indicating that HIF-1α was important for human cancer progression.
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1
  • 31
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson, D. A., Ryan, H. E., Snow, J. W., Johnson, R. & Arbeit, J. M. Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 60, 6189-6195 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6189-6195
    • Elson, D.A.1    Ryan, H.E.2    Snow, J.W.3    Johnson, R.4    Arbeit, J.M.5
  • 32
    • 0034676331 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg, M. et al. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19, 5435-5443 (2000).
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1
  • 33
    • 0034614637 scopus 로고    scopus 로고
    • A The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. A The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.2
  • 34
    • 0033970086 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
    • Denko, N. et al. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin. Cancer Res. 6, 480-487 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 480-487
    • Denko, N.1
  • 35
    • 0034652779 scopus 로고    scopus 로고
    • Candidate genes for the hypoxic tumor phenotype
    • Koong, A. C. et al. Candidate genes for the hypoxic tumor phenotype. Cancer Res. 60, 883-887 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 883-887
    • Koong, A.C.1
  • 36
    • 0034649507 scopus 로고    scopus 로고
    • Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
    • Wykoff, C. C., Pugh, C. W., Maxwell, P. H., Harris, A. L. & Ratcliffe, P. J. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 19, 6297-6305 (2000).
    • (2000) Oncogene , vol.19 , pp. 6297-6305
    • Wykoff, C.C.1    Pugh, C.W.2    Maxwell, P.H.3    Harris, A.L.4    Ratcliffe, P.J.5
  • 37
    • 0035812284 scopus 로고    scopus 로고
    • Transcriptional response to hypoxia in human tumors
    • Lal, A. et al. Transcriptional response to hypoxia in human tumors. J. Natl Cancer Inst. 93, 1337-1343 (2001). References 35-37 described a large number of hypoxia-regulated genes, among which there are many proangiogenic pathways.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1337-1343
    • Lal, A.1
  • 38
    • 0034668187 scopus 로고    scopus 로고
    • Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
    • Berra, E. et al. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem. Pharmacol. 60, 1171-1178 (2000).
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1171-1178
    • Berra, E.1
  • 39
    • 0033584965 scopus 로고    scopus 로고
    • EPAS1 trans-activation during hypoxia requires p42/p44 MAPK
    • Conrad, P. W., Beitner-Johnson, D. & Millhorn, D. E. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 274, 33709-33713 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 33709-33713
    • Conrad, P.W.1    Beitner-Johnson, D.2    Millhorn, D.E.3
  • 40
    • 0035866784 scopus 로고    scopus 로고
    • Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway that results in glycogen synthase kinase-3 inactivation
    • Chen, E. Y., Mazure, N. M., Cooper, J. A. & Giaccia, A. J. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res. 61, 2429-2433 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 2429-2433
    • Chen, E.Y.1    Mazure, N.M.2    Cooper, J.A.3    Giaccia, A.J.4
  • 41
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel, W. et al. Loss of PTEN facilitates HIF-1-mediated gene expression Genes Dev. 14, 391-396 (2000). One of several papers showing that the PI3K pathway regulates HIF through a hypoxia-independent pathway.
    • (2000) Genes Dev. , vol.14 , pp. 391-396
    • Zundel, W.1
  • 42
    • 0033870727 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
    • Ryan, H. E. et al. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res. 60, 4010-4015 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4010-4015
    • Ryan, H.E.1
  • 43
    • 0030683603 scopus 로고    scopus 로고
    • The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy
    • Mazurek, S., Boschek, C. B. & Eigenbrodt, E. The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy. J. Bioenerg. Biomembr. 29, 315-330 (1997).
    • (1997) J. Bioenerg. Biomembr. , vol.29 , pp. 315-330
    • Mazurek, S.1    Boschek, C.B.2    Eigenbrodt, E.3
  • 44
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet, P. et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485-490 (1998).
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1
  • 45
    • 0035069527 scopus 로고    scopus 로고
    • Heterogeneous vascular dependence of tumor cell populations
    • Yu, J. L. et al. Heterogeneous vascular dependence of tumor cell populations. Am. J. Pathol. 158, 1325-1334 (2001).
    • (2001) Am. J. Pathol. , vol.158 , pp. 1325-1334
    • Yu, J.L.1
  • 46
    • 0034529914 scopus 로고    scopus 로고
    • Suppression of tumor growth through disruption of hypoxia-inducible transcription
    • Kung, A. L., Wang, S., Klco, J. M., Kaelin, W. G. & Livingston, D. M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Med. 6, 1335-1340 (2000). Revealed that blockade of HIF-1 signalling by a peptide can completely inhibit tumour growth in vivo.
    • (2000) Nature Med. , vol.6 , pp. 1335-1340
    • Kung, A.L.1    Wang, S.2    Klco, J.M.3    Kaelin, W.G.4    Livingston, D.M.5
  • 48
    • 0035027828 scopus 로고    scopus 로고
    • Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
    • Seagroves, T. N. et al. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells Mol. Cell Biol. 21, 3436-3444 (2001).
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3436-3444
    • Seagroves, T.N.1
  • 49
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of GLUT1 mRNA by hypoxia-inducible factor-1: Interaction between H-ras and hypoxia
    • Chen, C. H., Pore, N., Behrooz, A., Ismail, B.-F. & Maity, A. Regulation of GLUT1 mRNA by hypoxia-inducible factor-1: interaction between H-ras and hypoxia. J. Biol. Chem. 276, 9519-9525 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 9519-9525
    • Chen, C.H.1    Pore, N.2    Behrooz, A.3    Ismail, B.-F.4    Maity, A.5
  • 50
    • 0033526838 scopus 로고    scopus 로고
    • Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells
    • Seimiya, H. et al. Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells. Biochem. Biophys. Res. Commun. 260, 365-370 (1999)
    • (1999) Biochem. Biophys. Res. Commun. , vol.260 , pp. 365-370
    • Seimiya, H.1
  • 51
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle, A., Toledo, F., Stern, S., Bieth, A. & Debatisse, M. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol. Cell 2, 259-265 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 52
    • 0034662615 scopus 로고    scopus 로고
    • Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
    • Yuan, J., Narayanan, L., Rockwell, S. & Glazer, P. M. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 60, 4372-4376 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4372-4376
    • Yuan, J.1    Narayanan, L.2    Rockwell, S.3    Glazer, P.M.4
  • 53
    • 0035048449 scopus 로고    scopus 로고
    • Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
    • Kim, M. S. et al. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nature Med. 7, 437-443 (2001).
    • (2001) Nature Med. , vol.7 , pp. 437-443
    • Kim, M.S.1
  • 54
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick, R. K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl Acad. Sci. USA 97, 9082-9087 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 55
    • 0033942613 scopus 로고    scopus 로고
    • BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
    • Vande Verde, C. et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol. Cell Biol. 20, 5454-5468 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 5454-5468
    • Vande Verde, C.1
  • 56
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter, H. M., Ratcliffe, P. J., Watson, P., Greenberg, A. H. & Harris, A. L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61, 6669-6673 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3    Greenberg, A.H.4    Harris, A.L.5
  • 57
    • 0035855668 scopus 로고    scopus 로고
    • Dephosphorylated hypoxia-inducible factor-1α as a mediator of p53-dependent apoptosis during hypoxia
    • Suzuki, H., Tomida, A. & Tsuruo, T. Dephosphorylated hypoxia-inducible factor-1α as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 20, 5779-5788 (2001).
    • (2001) Oncogene , vol.20 , pp. 5779-5788
    • Suzuki, H.1    Tomida, A.2    Tsuruo, T.3
  • 58
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
    • Graeber, T. G. et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 379, 88-91 (1996). Shows that hypoxia selects for a more aggressive tumour phenotype in vivo.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1
  • 59
    • 0035140981 scopus 로고    scopus 로고
    • Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
    • Koumenis, C. et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol. Cell Biol. 21, 1297-1310 (2001).
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1297-1310
    • Koumenis, C.1
  • 60
    • 0033515883 scopus 로고    scopus 로고
    • Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
    • Soengas, M. S. et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284, 156-159 (1999). Defines the key pathways of hypoxia-induced apoptosis.
    • (1999) Science , vol.284 , pp. 156-159
    • Soengas, M.S.1
  • 61
    • 0032568448 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor-1α
    • An, W. G. et al. Stabilization of wild-type p53 by hypoxia-inducible factor-1α. Nature 392, 405-408 (1998).
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1
  • 62
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor-1α
    • Ravi, R. et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor-1α. Genes Dev. 14, 34-44 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 34-44
    • Ravi, R.1
  • 63
    • 0035378480 scopus 로고    scopus 로고
    • Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia, HIF-1-independent mechanisms
    • Dong, Z. et al. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia, HIF-1-independent mechanisms J. Biol. Chem. 276, 18702-18709 (2001). Reports non-HIF-1 pathways that are important for cell survival that is regulated by hypoxia.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18702-18709
    • Dong, Z.1
  • 64
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov, S. V. et al. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl Acad. Sci. USA 95, 12596-2601 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12596-12601
    • Ivanov, S.V.1
  • 65
    • 0034671307 scopus 로고    scopus 로고
    • Hypoxia-inducible expression of tumor-associated carbonic anhydrases
    • Wykoff, C. C. et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases Cancer Res. 60, 7075-7083 (2000). Shows that acid pH in tumours might be determined by novel hypoxia-regulated pathways.
    • (2000) Cancer Res. , vol.60 , pp. 7075-7083
    • Wykoff, C.C.1
  • 66
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster, J. A. et al. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61, 6394-6399 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1
  • 67
    • 0035881075 scopus 로고    scopus 로고
    • Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma
    • Chia, S. K. et al. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J. Clin. Oncol. 19, 3660-3668 (2001)
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3660-3668
    • Chia, S.K.1
  • 68
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • Yamagata, M., Hasuda, K., Stamato, T. & Tannock, I. F. The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. Br. J. Cancer 77, 1726-1731 (1998).
    • (1998) Br. J. Cancer , vol.77 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4
  • 69
    • 0035896558 scopus 로고    scopus 로고
    • Hypoxia inhibits G1/S transition through regulation of p 27 expression
    • Gardner, L. B. et al. Hypoxia inhibits G1/S transition through regulation of p27 expression. J. Biol. Chem. 276, 7919-7926 (2001)
    • (2001) J. Biol. Chem. , vol.276 , pp. 7919-7926
    • Gardner, L.B.1
  • 70
    • 0035145591 scopus 로고    scopus 로고
    • p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
    • Green, S. L., Freiberg, R. A. & Giaccia, A. J. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol. Cell Biol. 21, 1196-1206 (2001).
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1196-1206
    • Green, S.L.1    Freiberg, R.A.2    Giaccia, A.J.3
  • 71
    • 0034114771 scopus 로고    scopus 로고
    • A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas
    • Raleigh, J. A. et al. A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas. Clin. Cancer Res. 6, 855-862 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 855-862
    • Raleigh, J.A.1
  • 72
    • 0034710890 scopus 로고    scopus 로고
    • Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia
    • Taylor, C. T., Furuta, G. T., Synnestvedt, K. & Colgan, S. P. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc. Natl Acad. Sci. USA 97, 12091-12096 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12091-12096
    • Taylor, C.T.1    Furuta, G.T.2    Synnestvedt, K.3    Colgan, S.P.4
  • 73
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
    • Schmedtje, J. F. Jr, Ji, Y. S., Liu, W. L., DuBois, R. N. & Runge, M. S. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 272, 601-608 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 601-608
    • Schmedtje J.F., Jr.1    Ji, Y.S.2    Liu, W.L.3    DuBois, R.N.4    Runge, M.S.5
  • 74
    • 0033591346 scopus 로고    scopus 로고
    • Hypoxia-associated induction of early growth response-1 gene expression
    • Yan, S. F. et al. Hypoxia-associated induction of early growth response-1 gene expression. J. Biol. Chem. 274, 15030-15040 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 15030-15040
    • Yan, S.F.1
  • 75
    • 0033635663 scopus 로고    scopus 로고
    • A pathway leading to hypoxia-induced vascular fibrin deposition
    • Yan, S. F., Pinsky, D. J. & Stern, D. M. A pathway leading to hypoxia-induced vascular fibrin deposition. Semin Thromb. Hemost. 26, 479-483 (2000).
    • (2000) Semin Thromb. Hemost. , vol.26 , pp. 479-483
    • Yan, S.F.1    Pinsky, D.J.2    Stern, D.M.3
  • 76
    • 0033559578 scopus 로고    scopus 로고
    • Activatin of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1
    • Murphy, B. J. et al. Activatin of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res 59, 1315-1322 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 1315-1322
    • Murphy, B.J.1
  • 77
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nature Med. 7, 575-583 (2001).
    • (2001) Nature Med. , vol.7 , pp. 575-583
    • Carmeliet, P.1
  • 78
    • 0034989312 scopus 로고    scopus 로고
    • The impact of hemoglobin levels on treatment outcomes in patients with cancer
    • Littlewood, T. J. The impact of hemoglobin levels on treatment outcomes in patients with cancer. Semin. Oncol. 28, 49-53 (2001).
    • (2001) Semin. Oncol. , vol.28 , pp. 49-53
    • Littlewood, T.J.1
  • 79
    • 0035367087 scopus 로고    scopus 로고
    • Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: Results of a randomized, double-blind, placebo-controlled trial
    • Littlewood, T. J., Bajetta, E., Nortier J. W., Vercammen. E. & Rapoport, B. Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial. J. Clin. Oncol. 19, 2865-2874 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2865-2874
    • Littlewood, T.J.1    Bajetta, E.2    Nortier, J.W.3    Vercammen, E.4    Rapoport, B.5
  • 80
    • 0034194225 scopus 로고    scopus 로고
    • ARCON: Accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC)
    • Bernier, J. et al. ARCON: accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC). Radiother. Oncol. 55, 111-119 (2000).
    • (2000) Radiother. Oncol. , vol.55 , pp. 111-119
    • Bernier, J.1
  • 81
    • 0035266246 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras
    • Cohen, J.-E. et al. The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras. Cancer Res. 61, 2289-2293 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 2289-2293
    • Cohen, J.-E.1
  • 82
    • 0035010504 scopus 로고    scopus 로고
    • Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
    • Wardman, P. Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Curr. Med. Chem. 8, 739-761 (2001).
    • (2001) Curr. Med. Chem. , vol.8 , pp. 739-761
    • Wardman, P.1
  • 83
    • 0034104328 scopus 로고    scopus 로고
    • Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors
    • von Pawel, J. et al. Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors. J. Clin. Oncol. 18, 1351-1359 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1351-1359
    • Von Pawel, J.1
  • 85
    • 0035003528 scopus 로고    scopus 로고
    • Gene transfer of antisense hypoxia inducible factor-1 a enhances the therapeutic efficacy of cancer immunotherapy
    • Sun, X. et al. Gene transfer of antisense hypoxia inducible factor-1 a enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther 8, 638-645 (2001). Describes how the synergy between anti-HIF-1 therapy and immunotherapy might be an important model for future clinical trials.
    • (2001) Gene Ther. , vol.8 , pp. 638-645
    • Sun, X.1
  • 86
    • 0032900610 scopus 로고    scopus 로고
    • Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
    • Bhattacharya, S. et al. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13, 64-75 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 64-75
    • Bhattacharya, S.1
  • 87
    • 0028844810 scopus 로고
    • Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia Implications for the mechanism of oxygen sensing
    • Gleadle, J. M., Ebert, B. L. & Ratcliffe, P. J. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia Implications for the mechanism of oxygen sensing. Eur. J. Biochem. 234, 92-99 (1995).
    • (1995) Eur. J. Biochem. , vol.234 , pp. 92-99
    • Gleadle, J.M.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 88
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • Dachs, G. U. et al. Targeting gene expression to hypoxic tumor cells. Nature Med. 3, 515-520 (1997). Shows that the HIF-1 pathway can be manipulated to activate therapeutic genes at specific oxygen tensions in vivo.
    • (1997) Nature Med. , vol.3 , pp. 515-520
    • Dachs, G.U.1
  • 89
    • 0030865697 scopus 로고    scopus 로고
    • Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment
    • Lemmon, M. J. et al. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther 4, 791-796 (1997).
    • (1997) Gene Ther. , vol.4 , pp. 791-796
    • Lemmon, M.J.1
  • 91
    • 0033998433 scopus 로고    scopus 로고
    • The macrophage: A novel system to deliver gene therapy to pathological hypoxia
    • Griffiths, L. et al. The macrophage: a novel system to deliver gene therapy to pathological hypoxia. Gene Ther. 7, 255-262 (2000).
    • (2000) Gene Ther. , vol.7 , pp. 255-262
    • Griffiths, L.1
  • 92
    • 0034213449 scopus 로고    scopus 로고
    • Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells
    • Koshikawa, N., Takenaga, K., Tagawa, M. & Sakiyama, S. Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells. Cancer. Res. 60, 2936-2941 (2000).
    • (2000) Cancer. Res. , vol.60 , pp. 2936-2941
    • Koshikawa, N.1    Takenaga, K.2    Tagawa, M.3    Sakiyama, S.4
  • 93
    • 0035955745 scopus 로고    scopus 로고
    • The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression
    • Pioli, P. A. & Rigby W. F. The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression J. Biol. Chem. 274, 40346-40352 (2001). Discusses the role of RNA stabilization in hypoxia gene regulation, particularly the direct role of VHL.
    • (2001) J. Biol. Chem. , vol.274 , pp. 40346-40352
    • Pioli, P.A.1    Rigby, W.F.2
  • 94
    • 0032085240 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
    • Ohh, M. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol. Cell 7, 959-968 (1998).
    • (1998) Mol. Cell , vol.7 , pp. 959-968
    • Ohh, M.1
  • 95
    • 0033600881 scopus 로고    scopus 로고
    • Direct interaction of the β-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
    • Okuda, H. et al. Direct interaction of the β-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes. Biochem. Biophys. Res. Commun. 263, 491-497 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 491-497
    • Okuda, H.1
  • 96
    • 0032727343 scopus 로고    scopus 로고
    • The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
    • Kamura, T., Conrad, M. N., Yan, Q., Conaway, R. C. & Conaway J. W. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 Genes Dev. 13, 2928-2933 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2928-2933
    • Kamura, T.1    Conrad, M.N.2    Yan, Q.3    Conaway, R.C.4    Conaway, J.W.5
  • 97
    • 0035918213 scopus 로고    scopus 로고
    • Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300/CBP
    • Yamashita, K., Discher D. J., Hu, J., Bishopric, N. H. & Webster, K. A. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300/CBP. J. Biol. Chem. 276, 12645-12653 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 12645-12653
    • Yamashita, K.1    Discher, D.J.2    Hu, J.3    Bishopric, N.H.4    Webster, K.A.5
  • 99
    • 0032510778 scopus 로고    scopus 로고
    • The basic helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
    • Hogenesch, J. B., Gu, Y. Z., Jain, S. & Bradfield, C. A. The basic helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl Acad. Sci. USA 95, 5474-5479 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5474-5479
    • Hogenesch, J.B.1    Gu, Y.Z.2    Jain, S.3    Bradfield, C.A.4
  • 100
    • 0033585496 scopus 로고    scopus 로고
    • αHIF: A natural antisense transcript overexpressed in human renal cancer and dunng hypoxia
    • Thrash-Bingham, C. A. & Tartof, K. D. αHIF: a natural antisense transcript overexpressed in human renal cancer and dunng hypoxia. J. Natl Cancer Inst. 91, 143-151 (1999).
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 143-151
    • Thrash-Bingham, C.A.1    Tartof, K.D.2
  • 101
    • 0032513043 scopus 로고    scopus 로고
    • Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
    • Levy, N. S., Chung, S., Furneaux, H. & Levy, A. P. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J. Biol. Chem. 273, 6417-6423 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 6417-6423
    • Levy, N.S.1    Chung, S.2    Furneaux, H.3    Levy, A.P.4
  • 102
    • 0030961524 scopus 로고    scopus 로고
    • Sequencing of the human vascular endothelial growth factor (VEGF) 3′ untranslated region (UTR): Conservation of five hypoxia-inducible RNA-protein binding sites
    • Levy, N. S., Goldberg, M. A. & Levy, A. P. Sequencing of the human vascular endothelial growth factor (VEGF) 3′ untranslated region (UTR): conservation of five hypoxia-inducible RNA-protein binding sites. Biochim. Biophys. Acta 1352, 167-173 (1997).
    • (1997) Biochim. Biophys. Acta , vol.1352 , pp. 167-173
    • Levy, N.S.1    Goldberg, M.A.2    Levy, A.P.3
  • 103
    • 0031888729 scopus 로고    scopus 로고
    • Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
    • Palmer, L. A., Semenza, G. L., Stoler, M. H. & Johns, R. A. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am. J. Physiol. 274, L212-L219 (1998).
    • (1998) Am. J. Physiol. , vol.274
    • Palmer, L.A.1    Semenza, G.L.2    Stoler, M.H.3    Johns, R.A.4
  • 104
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
    • Zelzer, E. et al. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT EMBO J. 17, 5085-5094 (1998).
    • (1998) EMBO J. , vol.17 , pp. 5085-5094
    • Zelzer, E.1
  • 105
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor-1α in vascular smooth muscle cells
    • Richard, D. E., Berra, E. & Pouyssegur, J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor-1α in vascular smooth muscle cells. J. Biol. Chem. 275, 26765-26771 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 106
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor-1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C. & Semenza, G. L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor-1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell. Biol. 21, 3995-4004 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 107
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor-1α
    • Sodhi, A. et al. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor-1α. Cancer Res. 60, 4873-4880 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4873-4880
    • Sodhi, A.1
  • 108
    • 0035877728 scopus 로고    scopus 로고
    • Rac1 activity is required for the activation of hypoxia-inducible factor-1
    • Hirota, K. & Semenza, G. L. Rac1 activity is required for the activation of hypoxia-inducible factor-1. J. Biol. Chem. 276, 21166-21172 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 21166-21172
    • Hirota, K.1    Semenza, G.L.2
  • 109
    • 0030659531 scopus 로고    scopus 로고
    • v-SRC induces expression of hypoxia-inducible factor-1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang, B. H., Agani, F., Passaniti, A. & Semenza, G. L. v-SRC induces expression of hypoxia-inducible factor-1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 57, 5328-5335 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 110
    • 0035971220 scopus 로고    scopus 로고
    • Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor-1 by low oxygen tension
    • Aragones, J. et al. Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor-1 by low oxygen tension. J. Biol. Chem. 276, 10548-10555 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 10548-10555
    • Aragones, J.1
  • 111
    • 0034673319 scopus 로고    scopus 로고
    • Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesis
    • Lee, S. W. et al. Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesis. Biochem. Biophys. Res. Commun, 268, 456-461 (2000).
    • (2000) Biochem. Biophys. Res. Commun , vol.268 , pp. 456-461
    • Lee, S.W.1
  • 112
    • 0028785860 scopus 로고
    • Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor-1
    • Wang, G. L., Jiang, B. H. & Semenza, G. L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor-1. Biochem. Biophys. Res. Commun. 216, 669-675 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 669-675
    • Wang, G.L.1    Jiang, B.H.2    Semenza, G.L.3
  • 113
    • 0034671256 scopus 로고    scopus 로고
    • Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines
    • Blancher, C., Moore, J. W., Talks, K. L., Houlbrook, S. & Harris, A. L. Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Cancer Res. 60, 7106-7113 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 7106-7113
    • Blancher, C.1    Moore, J.W.2    Talks, K.L.3    Houlbrook, S.4    Harris, A.L.5
  • 114
    • 0035037527 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the transactivation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α
    • Hur, E., Chang, K. Y., Lee, E., Lee, S. K. & Park, H. Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the transactivation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α. Mol. Pharmacol. 59, 1216-1224 (2001).
    • (2001) Mol. Pharmacol. , vol.59 , pp. 1216-1224
    • Hur, E.1    Chang, K.Y.2    Lee, E.3    Lee, S.K.4    Park, H.5
  • 115
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor-1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H. et al. Modulation of hypoxia-inducible factor-1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60, 1541-1545 (2000). Reports that oncogenic signalling pathways regulate HIF-1α, independently of hypoxia. Inhibitors of these pathways also block hypoxia-induced HIF-1 signalling.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1
  • 116
    • 0028978268 scopus 로고
    • High Km glucose-phosphorylating (glucokinase) activities in a range of tumour cell lines and inhibition of rates of tumour growth by the specific enzyme inhibitor mannoheptulose
    • Board, M., Colquhoun, A. & Newsholme, E. A. High Km glucose-phosphorylating (glucokinase) activities in a range of tumour cell lines and inhibition of rates of tumour growth by the specific enzyme inhibitor mannoheptulose. Cancer Res. 55, 3278-3285 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 3278-3285
    • Board, M.1    Colquhoun, A.2    Newsholme, E.A.3
  • 117
    • 0031918244 scopus 로고    scopus 로고
    • Regulation of proliferation-survival decisions during tumor cell hypoxia
    • Schmaltz, C., Hardenbergh, P. H., Wells, A. & Fisher, D. E. Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol. Cell. Biol. 18, 2845-2854 (1998). Shows that cell death in hypoxia might be mediated by low pH rather than low oxygen.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2845-2854
    • Schmaltz, C.1    Hardenbergh, P.H.2    Wells, A.3    Fisher, D.E.4


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