-
1
-
-
0035936886
-
HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1 alpha degradation
-
Berra, E., Richard, D. E., Gothie, E. and Pouyssegur, J. (2001). HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1 alpha degradation. FEBS Lett. 491, 85-90.
-
(2001)
FEBS Lett.
, vol.491
, pp. 85-90
-
-
Berra, E.1
Richard, D.E.2
Gothie, E.3
Pouyssegur, J.4
-
2
-
-
0036434346
-
Two-photon absorption and emission spectra of fluorochromes relevant for cell imaging
-
Bestvater, F., Spiess, E., Stobrawa, G., Hacker, M., Feurer, T., Porwol, T., Berchner-Pfannschmidt, U., Wotzlaw, C. and Acker, H. (2002). Two-photon absorption and emission spectra of fluorochromes relevant for cell imaging. J. Microsc. 208, 108-115.
-
(2002)
J. Microsc.
, vol.208
, pp. 108-115
-
-
Bestvater, F.1
Spiess, E.2
Stobrawa, G.3
Hacker, M.4
Feurer, T.5
Porwol, T.6
Berchner-Pfannschmidt, U.7
Wotzlaw, C.8
Acker, H.9
-
3
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick, R. K. and McKnight, S. L. (2001). A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
4
-
-
0034682783
-
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J. and Maxwell, P. H. (2000). Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275, 25733-25741.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
5
-
-
0033592926
-
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa
-
Darby, C., Cosma, C. L., Thomas, J. H. and Manoil, C. (1999). Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 96, 15202-15207.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 15202-15207
-
-
Darby, C.1
Cosma, C.L.2
Thomas, J.H.3
Manoil, C.4
-
6
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
-
Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L. and Fujii-Kuriyama, Y. (1999). Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 18, 1905-1914.
-
(1999)
EMBO J.
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
Sogawa, K.6
Poellinger, L.7
Fujii-Kuriyama, Y.8
-
7
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A. et al. (2001). C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.R.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
8
-
-
0036314978
-
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
-
Groulx, I. and Lee, S. (2002). Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 22, 5319-5336.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5319-5336
-
-
Groulx, I.1
Lee, S.2
-
9
-
-
18544386401
-
Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to Factor Inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y. M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M. et al. (2002) Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to Factor Inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 26351-26355.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
-
10
-
-
0035651033
-
Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1 alpha activation cascade: Implications for HIF-1alpha gene therapy
-
Hofer, T., Desbaillets, I., Hopfl, G., Gassmann, M. and Wenger, R. H. (2001). Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1 alpha activation cascade: implications for HIF-1alpha gene therapy. FASEB J. 15, 2715-2717.
-
(2001)
FASEB J.
, vol.15
, pp. 2715-2717
-
-
Hofer, T.1
Desbaillets, I.2
Hopfl, G.3
Gassmann, M.4
Wenger, R.H.5
-
11
-
-
18444368709
-
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
-
Hon, W. C., Wilson, M. I., Harlos, K., Claridge, T. D., Schofield, C. J., Pugh, C. W., Maxwell, P. H., Ratcliffe, P. J., Stuart, D. I. and Jones, E. Y. (2002). Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature 417, 975-978.
-
(2002)
Nature
, vol.417
, pp. 975-978
-
-
Hon, W.C.1
Wilson, M.I.2
Harlos, K.3
Claridge, T.D.4
Schofield, C.J.5
Pugh, C.W.6
Maxwell, P.H.7
Ratcliffe, P.J.8
Stuart, D.I.9
Jones, E.Y.10
-
12
-
-
0037131159
-
Sequence determinants in hypoxia inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
-
Huang, J., Zhao, Q., Mooney, S. M. and Lee, F. S. (2002). Sequence determinants in hypoxia inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J. Biol. Chem. 277, 39792-39800.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
14
-
-
0037119415
-
Hsp90 regulates a VHL-independent HIF-1α degradative pathway
-
Isaacs, J. S., Jung, Y. J., Mimnaugh, E. G., Martinez, A., Cuttitta, F. and Neckers, L. M. (2002). Hsp90 regulates a VHL-independent HIF-1α degradative pathway. J. Biol. Chem. 277, 29936-29944.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
15
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292, 464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin W.G., Jr.10
-
16
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292, 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
17
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
-
Kallio, P. J., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H. and Poellinger, L. (1998). Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J. 17, 6573-6586.
-
(1998)
EMBO J.
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
18
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J. and Whitelaw, M. L. (2002a) Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science 295, 858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
19
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L. and Bruick, R. K. (2002b). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471.
-
(2002)
Genes Dev.
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
20
-
-
0035895928
-
SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons
-
Lipscomb, E. A., Sarmiere, P. D. and Freeman, R. S. (2001). SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. J. Biol. Chem. 276, 5085-5092.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5085-5092
-
-
Lipscomb, E.A.1
Sarmiere, P.D.2
Freeman, R.S.3
-
21
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon, P. C., Hirota, K. and Semenza, G. L. (2001). FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686.
-
(2001)
Genes Dev.
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
22
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
-
Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J. (2001). Independent function of two destruction domains in hypoxia-inducible factor-α. chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206.
-
(2001)
EMBO J.
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
23
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R. and Ratcliffe, P. J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
24
-
-
0037035851
-
Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling
-
Min, J. H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G., Jr and Pavletich, N. P. (2002). Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling. Science 296, 1886-1889.
-
(2002)
Science
, vol.296
, pp. 1886-1889
-
-
Min, J.H.1
Yang, H.2
Ivan, M.3
Gertler, F.4
Kaelin W.G., Jr.5
Pavletich, N.P.6
-
25
-
-
0036391915
-
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
-
Oehme, F., Ellinghaus, P., Kolkhof, P., Smith, T. J., Ramakrishnan, S., Hütter, J., Schramm, M. and Flamme, I. (2002) Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Biochem. Biophys. Res. Commun. 296, 343-349.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.296
, pp. 343-349
-
-
Oehme, F.1
Ellinghaus, P.2
Kolkhof, P.3
Smith, T.J.4
Ramakrishnan, S.5
Hütter, J.6
Schramm, M.7
Flamme, I.8
-
26
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
-
Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V. and Kaelin, W. G. (2000). Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2, 423-427.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
27
-
-
0033593219
-
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1alpha
-
O'Rourke, J. F., Tian, Y. M., Ratcliffe, P. J. and Pugh, C. W. (1999) Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J. Biol. Chem. 274, 2060-2071.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2060-2071
-
-
O'Rourke, J.F.1
Tian, Y.M.2
Ratcliffe, P.J.3
Pugh, C.W.4
-
28
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
-
Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J. M. and Ratcliffe, P. J. (1997). Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J. Biol. Chem. 272, 11205-11214.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
30
-
-
0037064141
-
Functional analysis of hypoxia-inducible factor-1-mediated transactivation - Identification of amino acid residues critical for transcriptional activation and/or interaction with CBP
-
Ruas, J. L., Poellinger, L. and Pereira, T. (2002). Functional analysis of hypoxia-inducible factor-1-mediated transactivation - identification of amino acid residues critical for transcriptional activation and/or interaction with CBP. J. Biol. Chem. 277, 38723-38730.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38723-38730
-
-
Ruas, J.L.1
Poellinger, L.2
Pereira, T.3
-
31
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda, S. and Caro, J. (1997). Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272, 22642-22647.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
32
-
-
0036232662
-
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP
-
Sang, N., Fang, J., Srinivas, V., Leshchinsky, I. and Caro, J. (2002). Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Mol. Cell. Biol. 22, 2984-2992.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2984-2992
-
-
Sang, N.1
Fang, J.2
Srinivas, V.3
Leshchinsky, I.4
Caro, J.5
-
34
-
-
0033529656
-
Perspectives on oxygen sensing
-
Semenza, G. L. (1999). Perspectives on oxygen sensing. Cell 98, 281-284.
-
(1999)
Cell
, vol.98
, pp. 281-284
-
-
Semenza, G.L.1
-
35
-
-
0037165244
-
Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)
-
Seth, P., Krop, I., Porter, D. and Polyak, K. (2002). Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression). Oncogene 21, 836-843.
-
(2002)
Oncogene
, vol.21
, pp. 836-843
-
-
Seth, P.1
Krop, I.2
Porter, D.3
Polyak, K.4
-
36
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto, K., Makino, Y., Pereira, T. and Poellinger, L. (2000). Mechanism of regulation of the hypoxia-inducible factor-1α. by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19, 4298-4309.
-
(2000)
EMBO J.
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
37
-
-
0035812318
-
Characterization and comparative analysis of the EGLN gene family
-
Taylor, M. S. (2001). Characterization and comparative analysis of the EGLN gene family. Gene 275, 125-132.
-
(2001)
Gene
, vol.275
, pp. 125-132
-
-
Taylor, M.S.1
-
38
-
-
0020808726
-
EGG-laying defective mutants of the nematode Caenorhabditis elegans
-
Trent, C., Tsung, N. and Horvitz, H. R. (1983). EGG-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
-
(1983)
Genetics
, vol.104
, pp. 619-647
-
-
Trent, C.1
Tsung, N.2
Horvitz, H.R.3
-
40
-
-
0034107952
-
Mammalian oxygen sensing, signalling and gene regulation
-
Wenger, R. H. (2000). Mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 203, 1253-1263.
-
(2000)
J. Exp. Biol.
, vol.203
, pp. 1253-1263
-
-
Wenger, R.H.1
-
41
-
-
0036320934
-
2-regulated gene expression
-
2-regulated gene expression. FASEB J. 16, 1151-1162.
-
(2002)
FASEB J.
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
42
-
-
0035859692
-
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu, F., White, S. B., Zhao, Q. and Lee, F. S. (2001). HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 98, 9630-9635.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
|