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Volumn 26, Issue 2, 2007, Pages 299-310

Regulation of tumor pH and the role of carbonic anhydrase 9

Author keywords

Fluorescence; Hypoxia; Imaging; Intracellular and extracellular pH; Nuclear magnetic resonance

Indexed keywords

BICARBONATE; CARBON DIOXIDE; CARBONATE DEHYDRATASE IX; HYDROGEN; HYPOXIA INDUCIBLE FACTOR 1; LACTIC ACID;

EID: 34447547148     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-007-9064-0     Document Type: Review
Times cited : (458)

References (103)
  • 3
    • 0027479225 scopus 로고
    • Induction of protein phosphorylation, protein synthesis, immediate-early-gene expression and cellular proliferation by intracellular pH modulation. Implications for the role of hydrogen ions in signal transduction
    • Isfort, R. J., Cody, D. B., Asquith, T. N., Ridder, G. M., Stuard, S. B., & LeBoeuf, R. A. (1993). Induction of protein phosphorylation, protein synthesis, immediate-early-gene expression and cellular proliferation by intracellular pH modulation. Implications for the role of hydrogen ions in signal transduction. European Journal of Biochemistry, 213, 349-357.
    • (1993) European Journal of Biochemistry , vol.213 , pp. 349-357
    • Isfort, R.J.1    Cody, D.B.2    Asquith, T.N.3    Ridder, G.M.4    Stuard, S.B.5    Leboeuf, R.A.6
  • 4
    • 0026623304 scopus 로고
    • Clastogenicity of low pH to various cultured mammalian cells
    • Morita, T., Nagaki, T., Fukuda, I., & Okumura, K. (1992). Clastogenicity of low pH to various cultured mammalian cells. Mutation Research, 268, 297-305.
    • (1992) Mutation Research , vol.268 , pp. 297-305
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 5
    • 0029845577 scopus 로고    scopus 로고
    • Signal transduction pathways in apoptosis
    • McConkey, D. J., & Orrenius, S. (1996). Signal transduction pathways in apoptosis. Stem Cells, 14, 619-631.
    • (1996) Stem Cells , vol.14 , pp. 619-631
    • McConkey, D.J.1    Orrenius, S.2
  • 7
    • 0024311944 scopus 로고
    • Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts
    • Kallinowski, F., Schlenger, K. H., Runkel, S., Kloes, M., Stohrer, M., Okunieff, P., et al. (1989). Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Research, 49, 3759-3764.
    • (1989) Cancer Research , vol.49 , pp. 3759-3764
    • Kallinowski, F.1    Schlenger, K.H.2    Runkel, S.3    Kloes, M.4    Stohrer, M.5    Okunieff, P.6
  • 8
  • 10
    • 0028465482 scopus 로고
    • 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate
    • Gillies, R. J., Liu, Z., & Bhujwalla, Z. (1994). 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. American Journal of Physiology, 267, C195-C203.
    • (1994) American Journal of Physiology , vol.267
    • Gillies, R.J.1    Liu, Z.2    Bhujwalla, Z.3
  • 11
    • 0028432597 scopus 로고
    • Imidazol-1-ylalkanoic acids as extrinsic 1H NMR probes for the determination of intracellular pH, extracellular pH and cell volume
    • Gil, S., Zaderenzo, P., Cruz, F., Cerdan, S., & Ballesteros, P. (1994). Imidazol-1-ylalkanoic acids as extrinsic 1H NMR probes for the determination of intracellular pH, extracellular pH and cell volume. Bioorganic & Medicinal Chemistry, 2, 305-314.
    • (1994) Bioorganic & Medicinal Chemistry , vol.2 , pp. 305-314
    • Gil, S.1    Zaderenzo, P.2    Cruz, F.3    Cerdan, S.4    Ballesteros, P.5
  • 13
    • 34547129682 scopus 로고    scopus 로고
    • Extracellular-facing carbonic anhydrase IX helps to dissipate pH non-uniformity and coordinates pH regulation across large clusters of cells
    • Washington D.C.
    • Swietach, P., Wigfield, S., Harris, A., & Vaughan-Jones, R. (2007). Extracellular-facing carbonic anhydrase IX helps to dissipate pH non-uniformity and coordinates pH regulation across large clusters of cells. In Experimental Biology Annual Meeting, Washington D.C.
    • (2007) In Experimental Biology Annual Meeting
    • Swietach, P.1    Wigfield, S.2    Harris, A.3    Vaughan-Jones, R.4
  • 16
    • 33748324485 scopus 로고    scopus 로고
    • Oxygen and glucose consumption in gastrointestinal adenocarcinomas: Correlation with markers of hypoxia, acidity and anaerobic glycolysis
    • Koukourakis, M. I., Pitiakoudis, M., Giatromanolaki, A., Tsarouha, A., Polychronidis, A., Sivridis, E., et al. (2006). Oxygen and glucose consumption in gastrointestinal adenocarcinomas: Correlation with markers of hypoxia, acidity and anaerobic glycolysis. Cancer Science, 97, 1056-1060.
    • (2006) Cancer Science , vol.97 , pp. 1056-1060
    • Koukourakis, M.I.1    Pitiakoudis, M.2    Giatromanolaki, A.3    Tsarouha, A.4    Polychronidis, A.5    Sivridis, E.6
  • 17
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis
    • Gatenby, R. A., & Gillies, R. J. (2004). Why do cancers have high aerobic glycolysis? Nature Reviews Cancer, 4, 891-899.
    • (2004) Nature Reviews Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 19
    • 0025771024 scopus 로고
    • Glucose starvation and acidosis: Effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells
    • Schlappack, O. K., Zimmermann, A., & Hill, R. P. (1991). Glucose starvation and acidosis: Effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. British Journal of Cancer, 64, 663-670.
    • (1991) British Journal of Cancer , vol.64 , pp. 663-670
    • Schlappack, O.K.1    Zimmermann, A.2    Hill, R.P.3
  • 20
    • 0026667311 scopus 로고
    • Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines
    • Kato, Y., Nakayama, Y., Umeda, M., & Miyazaki, K. (1992). Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. Journal of Biological Chemistry, 267, 11424-11430.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 11424-11430
    • Kato, Y.1    Nakayama, Y.2    Umeda, M.3    Miyazaki, K.4
  • 21
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • Gatenby, R. A., & Gawlinski, E. T. (1996). A reaction-diffusion model of cancer invasion. Cancer Research, 56, 5745-5753.
    • (1996) Cancer Research , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 22
    • 0032788570 scopus 로고    scopus 로고
    • Acidic environment causes apoptosis by increasing caspase activity
    • Park, H. J., Lyons, J. C., Ohtsubo, T., & Song, C. W. (1999). Acidic environment causes apoptosis by increasing caspase activity. British Journal of Cancer, 80, 1892-1897.
    • (1999) British Journal of Cancer , vol.80 , pp. 1892-1897
    • Park, H.J.1    Lyons, J.C.2    Ohtsubo, T.3    Song, C.W.4
  • 23
    • 0022559201 scopus 로고
    • Effects of growth factors on intracellular pH regulation
    • Moolenaar, W. H. (1986). Effects of growth factors on intracellular pH regulation. Annual Review of Physiology, 48, 363-376.
    • (1986) Annual Review of Physiology , vol.48 , pp. 363-376
    • Moolenaar, W.H.1
  • 24
    • 0033609365 scopus 로고    scopus 로고
    • An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis
    • Williams, A. C., Collard, T. J., & Paraskeva, C. (1999). An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene, 18, 3199-3204.
    • (1999) Oncogene , vol.18 , pp. 3199-3204
    • Williams, A.C.1    Collard, T.J.2    Paraskeva, C.3
  • 26
    • 0032080644 scopus 로고    scopus 로고
    • Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells
    • Lee, A. H., & Tannock, I. F. (1998). Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Research, 58, 1901-1908.
    • (1998) Cancer Research , vol.58 , pp. 1901-1908
    • Lee, A.H.1    Tannock, I.F.2
  • 29
    • 0033746761 scopus 로고    scopus 로고
    • Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
    • Reshkin, S. J., Bellizzi, A., Caldeira, S., Albarani, V., Malanchi, I., Poignee, M., et al. (2000). Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB Journal, 14, 2185-2197.
    • (2000) FASEB Journal , vol.14 , pp. 2185-2197
    • Reshkin, S.J.1    Bellizzi, A.2    Caldeira, S.3    Albarani, V.4    Malanchi, I.5    Poignee, M.6
  • 30
    • 33745955010 scopus 로고    scopus 로고
    • Positron emission tomography as an imaging biomarker
    • Weber, W. A. (2006). Positron emission tomography as an imaging biomarker. Journal of Clinical Oncology, 24, 3282-3292.
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 3282-3292
    • Weber, W.A.1
  • 31
    • 0036717382 scopus 로고    scopus 로고
    • Molecular imaging of cancer with positron emission tomography. Nature Reviews
    • Gambhir, S. S. (2002). Molecular imaging of cancer with positron emission tomography. Nature Reviews. Cancer, 2, 683-693.
    • (2002) Cancer , vol.2 , pp. 683-693
    • Gambhir, S.S.1
  • 32
  • 33
    • 84911539247 scopus 로고
    • The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue
    • Krogh, A. (1919). The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. Journal of Physiology, 52, 409-415.
    • (1919) Journal of Physiology , vol.52 , pp. 409-415
    • Krogh, A.1
  • 35
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel, M., & Vaupel, P. (2001). Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. Journal of the National Cancer Institute, 93, 266-276.
    • (2001) Journal of the National Cancer Institute , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 36
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G. L., & Wang, G. L. (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molecular and Cellular Biology, 12, 5447-5454.
    • (1992) Molecular and Cellular Biology , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 37
    • 0031969042 scopus 로고    scopus 로고
    • Hypoxia and the regulation of gene expression
    • Gleadle, J. M., & Ratcliffe, P. J. (1998). Hypoxia and the regulation of gene expression. Molecular Medicine Today, 4, 122-129.
    • (1998) Molecular Medicine Today , vol.4 , pp. 122-129
    • Gleadle, J.M.1    Ratcliffe, P.J.2
  • 38
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. (2003). Targeting HIF-1 for cancer therapy. Nature Reviews Cancer, 3, 721-732.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 39
    • 0037155247 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
    • Minchenko, A., Leshchinsky, I., Opentanova, I., Sang, N., Srinivas, V., Armstead, V., et al. (2002). Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. Journal of Biological Chemistry, 277, 6183-6187.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 6183-6187
    • Minchenko, A.1    Leshchinsky, I.2    Opentanova, I.3    Sang, N.4    Srinivas, V.5    Armstead, V.6
  • 40
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G. L., Roth, P. H., Fang, H. M., & Wang, G. L. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. Journal of Biological Chemistry, 269, 23757-23763.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 41
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G. L., Jiang, B. H., Leung, S. W., Passantino, R., Concordet, J. P., Maire, P., et al. (1996). Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. Journal of Biological Chemistry, 271, 32529-32537.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6
  • 42
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J. W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3, 177-185.
    • (2006) Cell Metabolism , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 43
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006). HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metabolism, 3, 187-197.
    • (2006) Cell Metabolism , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 44
    • 4444292601 scopus 로고    scopus 로고
    • Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: A marker of tumour acute hypoxia
    • Baudelet, C., Ansiaux, R., Jordan, B. F., Havaux, X., Macq, B., & Gallez, B. (2004). Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: A marker of tumour acute hypoxia? Physics in Medicine & Biology, 49, 3389-3411.
    • (2004) Physics in Medicine & Biology , vol.49 , pp. 3389-3411
    • Baudelet, C.1    Ansiaux, R.2    Jordan, B.F.3    Havaux, X.4    MacQ, B.5    Gallez, B.6
  • 45
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: There is more to growth than just surviving
    • Plas, D. R., & Thompson, C. B. (2005). Akt-dependent transformation: There is more to growth than just surviving. Oncogene, 24, 7435-7442.
    • (2005) Oncogene , vol.24 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 46
    • 0024576266 scopus 로고
    • Growth-related changes of oxygen consumption rates of tumor cells grown in vitro and in vivo
    • Kallinowski, F., Tyler, G., Mueller-Klieser, W., & Vaupel, P. (1989). Growth-related changes of oxygen consumption rates of tumor cells grown in vitro and in vivo. Journal of Cellular Physiology, 138, 183-191.
    • (1989) Journal of Cellular Physiology , vol.138 , pp. 183-191
    • Kallinowski, F.1    Tyler, G.2    Mueller-Klieser, W.3    Vaupel, P.4
  • 47
    • 0021111735 scopus 로고
    • Protons and anaerobiosis
    • Hochachka, P. W., &. Mommsen, T. P. (1983). Protons and anaerobiosis. Science, 219, 1391-1397.
    • (1983) Science , vol.219 , pp. 1391-1397
    • Hochachka, P.W.1    Mommsen, T.P.2
  • 48
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel, P., Kallinowski, F., & Okunieff, P. (1989). Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Research, 49, 6449-6465.
    • (1989) Cancer Research , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 49
    • 0018605908 scopus 로고
    • Effects of hyperglycemia and hyperthermia on the pH, glycolysis, and respiration of the Yoshida sarcoma in vivo
    • Dickson, J. A., & Calderwood, S. K. (1979). Effects of hyperglycemia and hyperthermia on the pH, glycolysis, and respiration of the Yoshida sarcoma in vivo. Journal of the National Cancer Institute, 63, 1371-1381.
    • (1979) Journal of the National Cancer Institute , vol.63 , pp. 1371-1381
    • Dickson, J.A.1    Calderwood, S.K.2
  • 50
    • 0024403112 scopus 로고
    • Effect of intraperitoneal versus intravenous glucose administration on laser Doppler flow in murine FSaII tumors and normal skin
    • Kalmus, J., Okunieff, P., & Vaupel, P. (1989). Effect of intraperitoneal versus intravenous glucose administration on laser Doppler flow in murine FSaII tumors and normal skin. Cancer Research, 49, 6313-6317.
    • (1989) Cancer Research , vol.49 , pp. 6313-6317
    • Kalmus, J.1    Okunieff, P.2    Vaupel, P.3
  • 51
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap, A. P., & Meredith, D. (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Archiv: European Journal of Physiology, 447, 619-628.
    • (2004) Pflugers Archiv: European Journal of Physiology , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 52
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Pt 2
    • Halestrap, A. P., & Price, N. T. (1999). The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation. Biochemical Journal, 343(Pt 2), 281-299.
    • (1999) Biochemical Journal , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 53
    • 25144464638 scopus 로고    scopus 로고
    • Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer
    • Ord, J. J., Streeter, E. H., Roberts, I. S., Cranston, D., & Harris, A. L. (2005). Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer. British Journal of Cancer, 93, 346-354.
    • (2005) British Journal of Cancer , vol.93 , pp. 346-354
    • Ord, J.J.1    Streeter, E.H.2    Roberts, I.S.3    Cranston, D.4    Harris, A.L.5
  • 54
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006). The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. Journal of Biological Chemistry, 281, 9030-9037.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 56
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • Yamagata, M., Hasuda, K., Stamato, T., & Tannock, I. F. (1998). The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase. British Journal of Cancer, 77, 1726-1731.
    • (1998) British Journal of Cancer , vol.77 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4
  • 58
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • Helmlinger, G., Sckell, A., Dellian, M., Forbes, N. S., & Jain, R. K. (2002). Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clinical Cancer Research, 8, 1284-1291.
    • (2002) Clinical Cancer Research , vol.8 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 59
    • 0025924223 scopus 로고
    • [3H]acetazolamide binding to carbonic anhydrase in normal and transformed cells
    • Meyerson, L. R., & Nesta, D. (1991). [3H]acetazolamide binding to carbonic anhydrase in normal and transformed cells. Biochemical Pharmacology, 41, 995-1000.
    • (1991) Biochemical Pharmacology , vol.41 , pp. 995-1000
    • Meyerson, L.R.1    Nesta, D.2
  • 61
    • 33750514380 scopus 로고    scopus 로고
    • The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates
    • Esbaugh, A. J., & Tufts, B. L. (2006). The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates. Respiration Physiology. Neurobiology, 154, 185-198.
    • (2006) Respiration Physiology. Neurobiology , vol.154 , pp. 185-198
    • Esbaugh, A.J.1    Tufts, B.L.2
  • 62
    • 0035930581 scopus 로고    scopus 로고
    • A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers
    • Sterling, D., Reithmeier, R. A., & Casey, J. R. (2001). A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. Journal of Biological Chemistry, 276, 47886-47894.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 47886-47894
    • Sterling, D.1    Reithmeier, R.A.2    Casey, J.R.3
  • 65
    • 0029975564 scopus 로고    scopus 로고
    • Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
    • Opavsky, R., Pastorekova, S., Zelnik, V., Gibadulinova, A., Stanbridge, E. J., Zavada, J., et al. (1996). Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics, 33, 480-487.
    • (1996) Genomics , vol.33 , pp. 480-487
    • Opavsky, R.1    Pastorekova, S.2    Zelnik, V.3    Gibadulinova, A.4    Stanbridge, E.J.5    Zavada, J.6
  • 66
    • 0028111173 scopus 로고
    • Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment
    • Pastorek, J., Pastorekova, S., Callebaut, I., Mornon, J. P., Zelnik, V., Opavsky, R., et al. (1994). Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment. Oncogene, 9, 2877-2888.
    • (1994) Oncogene , vol.9 , pp. 2877-2888
    • Pastorek, J.1    Pastorekova, S.2    Callebaut, I.3    Mornon, J.P.4    Zelnik, V.5    Opavsky, R.6
  • 69
    • 27944500753 scopus 로고    scopus 로고
    • Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
    • Zatovicova, M., Sedlakova, O., Svastova, E., Ohradanova, A., Ciampor, F., Arribas, J., et al. (2005). Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17. British Journal of Cancer, 93, 1267-1276.
    • (2005) British Journal of Cancer , vol.93 , pp. 1267-1276
    • Zatovicova, M.1    Sedlakova, O.2    Svastova, E.3    Ohradanova, A.4    Ciampor, F.5    Arribas, J.6
  • 70
    • 0031040821 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
    • Pastorekova, S., Parkkila, S., Parkkila, A. K., Opavsky, R., Zelnik, V., Saarnio, J., et al. (1997). Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology, 112, 398-408.
    • (1997) Gastroenterology , vol.112 , pp. 398-408
    • Pastorekova, S.1    Parkkila, S.2    Parkkila, A.K.3    Opavsky, R.4    Zelnik, V.5    Saarnio, J.6
  • 73
    • 33644638219 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas
    • Driessen, A., Landuyt, W., Pastorekova, S., Moons, J., Goethals, L., Haustermans, K., et al. (2006). Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas. Annals of Surgery, 243, 334-340.
    • (2006) Annals of Surgery , vol.243 , pp. 334-340
    • Driessen, A.1    Landuyt, W.2    Pastorekova, S.3    Moons, J.4    Goethals, L.5    Haustermans, K.6
  • 74
    • 0035881075 scopus 로고    scopus 로고
    • Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase ix, in invasive breast carcinoma
    • Chia, S. K., Wykoff, C. C., Watson, P. H., Han, C., Leek, R. D., Pastorek, J., et al. (2001). Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase ix, in invasive breast carcinoma. Journal of Clinical Oncology, 19, 3660-3668.
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 3660-3668
    • Chia, S.K.1    Wykoff, C.C.2    Watson, P.H.3    Han, C.4    Leek, R.D.5    Pastorek, J.6
  • 75
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
    • Beasley, N. J., Wykoff, C. C., Watson, P. H., Leek, R., Turley, H., Gatter, K., et al. (2001). Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. Cancer Research, 61, 5262-5267.
    • (2001) Cancer Research , vol.61 , pp. 5262-5267
    • Beasley, N.J.1    Wykoff, C.C.2    Watson, P.H.3    Leek, R.4    Turley, H.5    Gatter, K.6
  • 76
    • 0035181306 scopus 로고    scopus 로고
    • Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy
    • Koukourakis, M. I., Giatromanolaki, A., Sivridis, E., Simopoulos, K., Pastorek, J., Wykoff, C. C., et al. (2001). Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy. Clinical Cancer Research, 7, 3399-3403.
    • (2001) Clinical Cancer Research , vol.7 , pp. 3399-3403
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Simopoulos, K.4    Pastorek, J.5    Wykoff, C.C.6
  • 79
    • 33751111993 scopus 로고    scopus 로고
    • Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer
    • Generali, D., Fox, S. B., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., et al. (2006). Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer. Endocrine-related Cancer, 13, 921-930.
    • (2006) Endocrine-related Cancer , vol.13 , pp. 921-930
    • Generali, D.1    Fox, S.B.2    Berruti, A.3    Brizzi, M.P.4    Campo, L.5    Bonardi, S.6
  • 80
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster, J. A., Harris, A. L., Davidson, S. E., Logue, J. P., Hunter, R. D., Wycoff, C. C., et al. (2001). Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Research, 61, 6394-6399.
    • (2001) Cancer Research , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6
  • 81
  • 82
    • 31544445490 scopus 로고    scopus 로고
    • Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: A metabolic survival role for tumor-associated stroma
    • Koukourakis, M. I., Giatromanolaki, A., Harris, A. L., & Sivridis, E. (2006). Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: A metabolic survival role for tumor-associated stroma. Cancer Research, 66, 632-637.
    • (2006) Cancer Research , vol.66 , pp. 632-637
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Harris, A.L.3    Sivridis, E.4
  • 83
    • 4344699403 scopus 로고    scopus 로고
    • Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion
    • Robertson, N., Potter, C., & Harris, A. L. (2004). Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Research, 64, 6160-6165.
    • (2004) Cancer Research , vol.64 , pp. 6160-6165
    • Robertson, N.1    Potter, C.2    Harris, A.L.3
  • 84
    • 0036069159 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2
    • Bartosova, M., Parkkila, S., Pohlodek, K., Karttunen, T. J., Galbavy, S., Mucha, V., et al. (2002). Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2. Journal of Pathology, 197, 314-321.
    • (2002) Journal of Pathology , vol.197 , pp. 314-321
    • Bartosova, M.1    Parkkila, S.2    Pohlodek, K.3    Karttunen, T.J.4    Galbavy, S.5    Mucha, V.6
  • 85
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki, A., Koukourakis, M. I., Sivridis, E., Pastorek, J., Wykoff, C. C., Gatter, K. C., et al. (2001). Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Research, 61, 7992-7998.
    • (2001) Cancer Research , vol.61 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Pastorek, J.4    Wykoff, C.C.5    Gatter, K.C.6
  • 86
    • 8844249356 scopus 로고    scopus 로고
    • Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
    • Svastova, E., Hulikova, A., Rafajova, M., Zat'ovicova, M., Gibadulinova, A., Casini, A., et al. (2004). Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Letters, 577, 439-445.
    • (2004) FEBS Letters , vol.577 , pp. 439-445
    • Svastova, E.1    Hulikova, A.2    Rafajova, M.3    Zat'Ovicova, M.4    Gibadulinova, A.5    Casini, A.6
  • 87
    • 0034039938 scopus 로고    scopus 로고
    • The distribution and physiological significance of carbonic anhydrase in vertebrate gas exchange organs
    • Henry, R. P., & Swenson, E. R. (2000). The distribution and physiological significance of carbonic anhydrase in vertebrate gas exchange organs. Respiration Physiology, 121, 1-12.
    • (2000) Respiration Physiology , vol.121 , pp. 1-12
    • Henry, R.P.1    Swenson, E.R.2
  • 88
    • 0032101914 scopus 로고    scopus 로고
    • Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte
    • Pt 2
    • Leem, C. H., Vaughan-Jones, R. D. (1998). Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte. Journal of Physiology, 509(Pt 2), 471-485.
    • (1998) Journal of Physiology , vol.509 , pp. 471-485
    • Leem, C.H.1    Vaughan-Jones, R.D.2
  • 90
    • 0033119723 scopus 로고    scopus 로고
    • A novel role for carbonic anhydrase: Cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes
    • Pt 1
    • Stewart, A. K., Boyd, C. A., & Vaughan-Jones, R. D. (1999). A novel role for carbonic anhydrase: Cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes. Journal of Physiology, 516(Pt 1), 209-217.
    • (1999) Journal of Physiology , vol.516 , pp. 209-217
    • Stewart, A.K.1    Boyd, C.A.2    Vaughan-Jones, R.D.3
  • 91
    • 0037095882 scopus 로고    scopus 로고
    • Facilitation of intracellular H(+) ion mobility by CO(2)/HCO(3)(-) in rabbit ventricular myocytes is regulated by carbonic anhydrase
    • Spitzer, K. W., Skolnick, R. L., Peercy, B. E., Keener, J. P., Vaughan-Jones, R. D. (2002). Facilitation of intracellular H(+) ion mobility by CO(2)/HCO(3)(-) in rabbit ventricular myocytes is regulated by carbonic anhydrase. Journal of Physiology, 541, 159-167.
    • (2002) Journal of Physiology , vol.541 , pp. 159-167
    • Spitzer, K.W.1    Skolnick, R.L.2    Peercy, B.E.3    Keener, J.P.4    Vaughan-Jones, R.D.5
  • 92
    • 0025319198 scopus 로고
    • Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle
    • Irving, M., Maylie, J., Sizto, N. L., & Chandler, W. K. (1990). Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle. Biophysical Journal, 57, 717-721.
    • (1990) Biophysical Journal , vol.57 , pp. 717-721
    • Irving, M.1    Maylie, J.2    Sizto, N.L.3    Chandler, W.K.4
  • 93
    • 0034100924 scopus 로고    scopus 로고
    • Carbon dioxide transport and carbonic anhydrase in blood and muscle
    • Geers, C., & Gros, G. (2000). Carbon dioxide transport and carbonic anhydrase in blood and muscle. Physiological Reviews, 80, 681-715.
    • (2000) Physiological Reviews , vol.80 , pp. 681-715
    • Geers, C.1    Gros, G.2
  • 94
  • 96
    • 33745852743 scopus 로고    scopus 로고
    • Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes
    • Lu, J., Daly, C. M., Parker, M. D., Gill, H. S., Piermarini, P. M., Pelletier, M. F., et al. (2006). Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes. Journal of Biological Chemistry, 281, 19241-19250.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 19241-19250
    • Lu, J.1    Daly, C.M.2    Parker, M.D.3    Gill, H.S.4    Piermarini, P.M.5    Pelletier, M.F.6
  • 97
    • 13444272912 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma
    • Koukourakis, M. I., Giatromanolaki, A., Sivridis, E., Gatter, K. C., Harris, A. L. (2005). Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma. Neoplasia, 7, 1-6.
    • (2005) Neoplasia , vol.7 , pp. 1-6
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Gatter, K.C.4    Harris, A.L.5
  • 98
    • 29644442625 scopus 로고    scopus 로고
    • Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    • Lu, H., Dalgard, C. L., Mohyeldin, A., McFate, T., Tait, A. S., & Verma, A. (2005). Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. Journal of Biological Chemistry, 280, 41928-41939.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 41928-41939
    • Lu, H.1    Dalgard, C.L.2    Mohyeldin, A.3    McFate, T.4    Tait, A.S.5    Verma, A.6
  • 99
    • 0027367258 scopus 로고
    • A carbonic anhydrase inhibitor as a potential modulator of cancer therapies
    • Teicher, B. A., Liu, S. D., Liu, J. T., Holden, S. A., & Herman, T. S. (1993). A carbonic anhydrase inhibitor as a potential modulator of cancer therapies. Anticancer Research, 13, 1549-1556.
    • (1993) Anticancer Research , vol.13 , pp. 1549-1556
    • Teicher, B.A.1    Liu, S.D.2    Liu, J.T.3    Holden, S.A.4    Herman, T.S.5
  • 102
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin, V. R., St-Pierre, J., & Leder, P. (2006). Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell, 9, 425-434.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3


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