-
1
-
-
44949231368
-
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling
-
Li, W. et al. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE 3, e1487 (2008).
-
(2008)
PLoS ONE
, vol.3
-
-
Li, W.1
-
3
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
Petroski, M. D. & Deshaies, R. J. Function and regulation of cullin-RING ubiquitin ligases. Nature Rev. Mol. Cell Biol. 6, 9-20 (2005)
-
(2005)
Nature Rev. Mol. Cell Biol.
, vol.6
, pp. 9-20
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
4
-
-
44349122993
-
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: Tipping the scales of cancer
-
Frescas, D. & Pagano, M. Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer. Nature Rev. Cancer 8, 438-449 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 438-449
-
-
Frescas, D.1
Pagano, M.2
-
5
-
-
0030602813
-
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
-
Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274 (1996).
-
(1996)
Cell
, vol.86
, pp. 263-274
-
-
Bai, C.1
-
6
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
Nakayama, K. I. & Nakayama, K. Ubiquitin ligases: cell-cycle control and cancer. Nature Rev. Cancer 6, 369-381 (2006).
-
(2006)
Nature Rev. Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
7
-
-
1842428734
-
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
-
Watanabe, N. et al. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP. Proc. Natl Acad. Sci. USA 101, 4419-4424 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4419-4424
-
-
Watanabe, N.1
-
8
-
-
33747589184
-
The anaphase promoting complex/cyclosome: A machine designed to destroy
-
Peters, J. M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nature Rev. Mol. Cell Biol. 7, 644-656 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol.
, vol.7
, pp. 644-656
-
-
Peters, J.M.1
-
9
-
-
0036713310
-
The anaphase-promoting complex: It's not just for mitosis any more
-
Harper, J. W., Burton, J. L. & Solomon, M. J. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179-2206 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 2179-2206
-
-
Harper, J.W.1
Burton, J.L.2
Solomon, M.J.3
-
10
-
-
77954240714
-
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
-
D'Angiolella, V. et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466, 138-142 (2010).
-
(2010)
Nature
, vol.466
, pp. 138-142
-
-
D'Angiolella, V.1
-
11
-
-
84855447125
-
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
-
Duan, S. et al. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature 481, 90-93 (2012).
-
(2012)
Nature
, vol.481
, pp. 90-93
-
-
Duan, S.1
-
12
-
-
79960618956
-
FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children
-
Rye, M. S. et al. FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children. Genes Immun. 12, 352-359 (2011).
-
(2011)
Genes Immun.
, vol.12
, pp. 352-359
-
-
Rye, M.S.1
-
13
-
-
66649117243
-
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
-
Santra, M. K., Wajapeyee, N. & Green, M. R. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459, 722-725 (2009).
-
(2009)
Nature
, vol.459
, pp. 722-725
-
-
Santra, M.K.1
Wajapeyee, N.2
Green, M.R.3
-
14
-
-
84878260314
-
Mechanisms and function of substrate recruitment by F-box proteins
-
Skaar, J. R., Pagan, J. K. & Pagano, M. Mechanisms and function of substrate recruitment by F-box proteins. Nature Rev. Mol. Cell Biol. 14, 369-381 (2013).
-
(2013)
Nature Rev. Mol. Cell Biol.
, vol.14
, pp. 369-381
-
-
Skaar, J.R.1
Pagan, J.K.2
Pagano, M.3
-
15
-
-
0035969559
-
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
-
Nash, P. et al. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414, 514-521 (2001).
-
(2001)
Nature
, vol.414
, pp. 514-521
-
-
Nash, P.1
-
16
-
-
0037462424
-
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
-
Orlicky, S., Tang, X., Willems, A., Tyers, M. & Sicheri, F. Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell 112, 243-256 (2003).
-
(2003)
Cell
, vol.112
, pp. 243-256
-
-
Orlicky, S.1
Tang, X.2
Willems, A.3
Tyers, M.4
Sicheri, F.5
-
17
-
-
0242321836
-
Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains
-
Yoshida, Y. et al. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J. Biol. Chem. 278, 43877-43884 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43877-43884
-
-
Yoshida, Y.1
-
18
-
-
18444413218
-
E3 ubiquitin ligase that recognizes sugar chains
-
Yoshida, Y. et al. E3 ubiquitin ligase that recognizes sugar chains. Nature 418, 438-442 (2002).
-
(2002)
Nature
, vol.418
, pp. 438-442
-
-
Yoshida, Y.1
-
19
-
-
84861544402
-
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair
-
D'Angiolella, V. et al. Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell 149, 1023-1034 (2012).
-
(2012)
Cell
, vol.149
, pp. 1023-1034
-
-
D'Angiolella, V.1
-
20
-
-
84877577024
-
FBXL2-And PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade
-
Kuchay, S. et al. FBXL2-And PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nature Cell Biol. 15, 472-480 (2013).
-
(2013)
Nature Cell Biol.
, vol.15
, pp. 472-480
-
-
Kuchay, S.1
-
21
-
-
84875806981
-
CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration
-
Abbas, T. et al. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Mol. Cell 49, 1147-1158 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 1147-1158
-
-
Abbas, T.1
-
22
-
-
84875804530
-
Fbxo11 ubiquitin ligase
-
Fbxo11 ubiquitin ligase. Mol. Cell 49, 1159-1166 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 1159-1166
-
-
Rossi, M.1
-
23
-
-
84870308969
-
EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
-
Lee, J. M. et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol. Cell 48, 572-586 (2012).
-
(2012)
Mol. Cell
, vol.48
, pp. 572-586
-
-
Lee, J.M.1
-
24
-
-
17044370346
-
Regulation of the cell cycle by SCF-type ubiquitin ligases
-
Nakayama, K. I. & Nakayama, K. Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin. Cell Dev. Biol. 16, 323-333 (2005).
-
(2005)
Semin. Cell Dev. Biol.
, vol.16
, pp. 323-333
-
-
Nakayama, K.I.1
Nakayama, K.2
-
26
-
-
38549086019
-
FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
-
Welcker, M. & Clurman, B. E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nature Rev. Cancer 8, 83-93 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
27
-
-
1542364470
-
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
-
Tsunematsu, R. et al. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J. Biol. Chem. 279, 9417-9423 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9417-9423
-
-
Tsunematsu, R.1
-
28
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin e and Notch proteins in mice lacking the Fbw7 F-box protein
-
Tetzlaff, M. T. et al. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl Acad. Sci. USA 101, 3338-3345 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
-
29
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
Akhoondi, S. et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res. 67, 9006-9012 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 9006-9012
-
-
Akhoondi, S.1
-
30
-
-
36549071481
-
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
-
Onoyama, I. et al. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J. Exp. Med. 204, 2875-2888 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2875-2888
-
-
Onoyama, I.1
-
31
-
-
42149132696
-
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
-
Matsuoka, S. et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 22, 986-991 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 986-991
-
-
Matsuoka, S.1
-
32
-
-
45149123052
-
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
-
Thompson, B. J. et al. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J. Exp. Med. 205, 1395-1408 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1395-1408
-
-
Thompson, B.J.1
-
33
-
-
34250863886
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
-
Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007).
-
(2007)
Nature
, vol.447
, pp. 966-971
-
-
Maser, R.S.1
-
34
-
-
84879364450
-
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
-
King, B. et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153, 1552-1566 (2013).
-
(2013)
Cell
, vol.153
, pp. 1552-1566
-
-
King, B.1
-
35
-
-
77956165036
-
F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor
-
Sancho, R. et al. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139, 929-941 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 929-941
-
-
Sancho, R.1
-
36
-
-
84897959817
-
Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines
-
Davis, H., Lewis, A., Behrens, A. & Tomlinson, I. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut http://dx.doi.org/10.1136/gutjnl-2013-304719 (2013)
-
(2013)
Gut
-
-
Davis, H.1
Lewis, A.2
Behrens, A.3
Tomlinson, I.4
-
37
-
-
34047255191
-
Fbw7/hCDC4 dimerization regulates its substrate interactions
-
Welcker, M. & Clurman, B. E. Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div. 2, 7 (2007).
-
(2007)
Cell Div.
, vol.2
, pp. 7
-
-
Welcker, M.1
Clurman, B.E.2
-
38
-
-
34250017680
-
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
-
Tang, X. et al. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell 129, 1165-1176 (2007).
-
(2007)
Cell
, vol.129
, pp. 1165-1176
-
-
Tang, X.1
-
39
-
-
78650928027
-
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
-
Onoyama, I. et al. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J. Clin. Invest. 121, 342-354 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 342-354
-
-
Onoyama, I.1
-
40
-
-
10644269326
-
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
-
Mao, J. H. et al. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432, 775-779 (2004).
-
(2004)
Nature
, vol.432
, pp. 775-779
-
-
Mao, J.H.1
-
41
-
-
78649494384
-
Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
-
Akhoondi, S. et al. Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res. 12, R105 (2010).
-
(2010)
Breast Cancer Res.
, vol.12
-
-
Akhoondi, S.1
-
42
-
-
79952766066
-
Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress
-
Matsumoto, A. et al. Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci. 102, 749-755 (2011).
-
(2011)
Cancer Sci.
, vol.102
, pp. 749-755
-
-
Matsumoto, A.1
-
43
-
-
65949107856
-
P53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases
-
Yokobori, T. et al. p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res. 69, 3788-3794 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 3788-3794
-
-
Yokobori, T.1
-
44
-
-
32544446008
-
CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer
-
Koh, M. S., Ittmann, M., Kadmon, D., Thompson, T. C. & Leach, F. S. CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer. Cancer Biol. Ther. 5, 78-83 (2006).
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 78-83
-
-
Koh, M.S.1
Ittmann, M.2
Kadmon, D.3
Thompson, T.C.4
Leach, F.S.5
-
45
-
-
84859947197
-
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
-
Mann, K. M. et al. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc. Natl Acad. Sci. USA 109, 5934-5941 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 5934-5941
-
-
Mann, K.M.1
-
46
-
-
33750394887
-
A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse
-
Hardisty-Hughes, R. E. et al. A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse. Hum. Mol. Genet. 15, 3273-3279 (2006).
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 3273-3279
-
-
Hardisty-Hughes, R.E.1
-
47
-
-
33747024045
-
Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development
-
Tsunematsu, R. et al. Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol. Cell. Biol. 26, 6157-6169 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 6157-6169
-
-
Tsunematsu, R.1
-
48
-
-
37849020693
-
Disruption of the Fbxw8 gene results in pre-And postnatal growth retardation in mice
-
Tsutsumi, T., Kuwabara, H., Arai, T., Xiao, Y. & Decaprio, J. A. Disruption of the Fbxw8 gene results in pre-And postnatal growth retardation in mice. Mol. Cell. Biol. 28, 743-751 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 743-751
-
-
Tsutsumi, T.1
Kuwabara, H.2
Arai, T.3
Xiao, Y.4
Decaprio, J.A.5
-
49
-
-
84871703377
-
MTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
-
Kim, S. J. et al. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol. Cell 48, 875-887 (2012).
-
(2012)
Mol. Cell
, vol.48
, pp. 875-887
-
-
Kim, S.J.1
-
50
-
-
34047189884
-
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
-
Okabe, H. et al. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1, e128 (2006).
-
(2006)
PLoS ONE
, vol.1
-
-
Okabe, H.1
-
51
-
-
85027958158
-
Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells
-
Lin, P. et al. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol. Biol. Rep. 38, 1741-1747 (2011).
-
(2011)
Mol. Biol. Rep.
, vol.38
, pp. 1741-1747
-
-
Lin, P.1
-
52
-
-
34249097203
-
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
-
Siepka, S. M. et al. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129, 1011-1023 (2007).
-
(2007)
Cell
, vol.129
, pp. 1011-1023
-
-
Siepka, S.M.1
-
53
-
-
34248525919
-
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
-
Godinho, S. I. et al. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316, 897-900 (2007).
-
(2007)
Science
, vol.316
, pp. 897-900
-
-
Godinho, S.I.1
-
54
-
-
34248566788
-
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
-
Busino, L. et al. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316, 900-904 (2007).
-
(2007)
Science
, vol.316
, pp. 900-904
-
-
Busino, L.1
-
55
-
-
84874768419
-
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
-
Yoo, S. H. et al. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell 152, 1091-1105 (2013).
-
(2013)
Cell
, vol.152
, pp. 1091-1105
-
-
Yoo, S.H.1
-
56
-
-
84875899177
-
FBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket
-
FBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature 496, 64-68 (2013).
-
(2013)
Nature
, vol.496
, pp. 64-68
-
-
Xing, W.1
-
57
-
-
84887609711
-
Circadian molecular clocks and cancer
-
Kelleher, F. C., Rao, A. & Maguire, A. Circadian molecular clocks and cancer. Cancer Lett. 342, 9-18 (2014).
-
(2014)
Cancer Lett.
, vol.342
, pp. 9-18
-
-
Kelleher, F.C.1
Rao, A.2
Maguire, A.3
-
58
-
-
84870790528
-
Circadian clock disruptions and the risk of cancer
-
Lahti, T., Merikanto, I. & Partonen, T. Circadian clock disruptions and the risk of cancer. Ann. Med. 44, 847-853 (2012).
-
(2012)
Ann. Med.
, vol.44
, pp. 847-853
-
-
Lahti, T.1
Merikanto, I.2
Partonen, T.3
-
59
-
-
1542344329
-
Cyclin F disruption compromises placental development and affects normal cell cycle execution
-
Tetzlaff, M. T. et al. Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol. Cell. Biol. 24, 2487-2498 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2487-2498
-
-
Tetzlaff, M.T.1
-
60
-
-
84875606355
-
Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis
-
Fu, J. et al. Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis. Cancer Sci. 104, 508-515 (2013).
-
(2013)
Cancer Sci.
, vol.104
, pp. 508-515
-
-
Fu, J.1
-
61
-
-
83255192193
-
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
-
Vaites, L. P. et al. The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol. Cell. Biol. 31, 4513-4523 (2011).
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 4513-4523
-
-
Vaites, L.P.1
-
62
-
-
84856781262
-
Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation
-
Kanie, T. et al. Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol. Cell. Biol. 32, 590-605 (2012).
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 590-605
-
-
Kanie, T.1
-
63
-
-
33750460897
-
FBX4-αB crystallin complex
-
FBX4-αB crystallin complex. Mol. Cell 24, 355-366 (2006).
-
(2006)
Mol. Cell
, vol.24
, pp. 355-366
-
-
Lin, D.I.1
-
64
-
-
45849131324
-
Fbx4 ligase and contribute to cyclin D1 overexpression in human cancer
-
Fbx4 ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14, 68-78 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 68-78
-
-
Barbash, O.1
-
65
-
-
84874641177
-
Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
-
Chiorazzi, M. et al. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proc. Natl Acad. Sci. USA 110, 3943-3948 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 3943-3948
-
-
Chiorazzi, M.1
-
66
-
-
34547537530
-
Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk
-
Samuelson, D. J. et al. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc. Natl Acad. Sci. USA 104, 6299-6304 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 6299-6304
-
-
Samuelson, D.J.1
-
67
-
-
84855289407
-
An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a
-
Smits, B. M. et al. An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a. Nucleic Acids Res. 40, 132-147 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 132-147
-
-
Smits, B.M.1
-
68
-
-
84895783151
-
Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF)
-
Xu, X. et al. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol. Carcinog. http://dx.doi. org/10.1002/mc.21977 (2012).
-
(2012)
Mol. Carcinog
-
-
Xu, X.1
-
69
-
-
84875892495
-
FBH1 protects melanocytes from transformation and is deregulated in melanomas
-
Jeong, Y. T., Cermak, L., Guijarro, M. V., Hernando, E. & Pagano, M. FBH1 protects melanocytes from transformation and is deregulated in melanomas. Cell Cycle 12, 1128-1132 (2013).
-
(2013)
Cell Cycle
, vol.12
, pp. 1128-1132
-
-
Jeong, Y.T.1
Cermak, L.2
Guijarro, M.V.3
Hernando, E.4
Pagano, M.5
-
70
-
-
29244485581
-
FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex
-
Kumar, R. et al. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res. 65, 11304-11313 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 11304-11313
-
-
Kumar, R.1
-
71
-
-
77956307171
-
FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma
-
Huang, H. L., Zheng, W. L., Zhao, R., Zhang, B. & Ma, W. L. FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma. Oncol. Rep. 24, 715-720 (2010).
-
(2010)
Oncol. Rep.
, vol.24
, pp. 715-720
-
-
Huang, H.L.1
Zheng, W.L.2
Zhao, R.3
Zhang, B.4
Ma, W.L.5
-
72
-
-
0033176887
-
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
-
Carrano, A. C., Eytan, E., Hershko, A. & Pagano, M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nature Cell Biol. 1, 193-199 (1999).
-
(1999)
Nature Cell Biol.
, vol.1
, pp. 193-199
-
-
Carrano, A.C.1
Eytan, E.2
Hershko, A.3
Pagano, M.4
-
73
-
-
0033174070
-
P45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
-
Sutterluty, H. et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nature Cell Biol. 1, 207-214 (1999).
-
(1999)
Nature Cell Biol.
, vol.1
, pp. 207-214
-
-
Sutterluty, H.1
-
75
-
-
0032530151
-
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
-
Yu, Z. K., Gervais, J. L. & Zhang, H. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc. Natl Acad. Sci. USA 95, 11324-11329 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 11324-11329
-
-
Yu, Z.K.1
Gervais, J.L.2
Zhang, H.3
-
76
-
-
0037379776
-
Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate
-
Shim, E. H. et al. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Cancer Res. 63, 1583-1588 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1583-1588
-
-
Shim, E.H.1
-
77
-
-
0035956971
-
Role of the F-box protein Skp2 in lymphomagenesis
-
Latres, E. et al. Role of the F-box protein Skp2 in lymphomagenesis. Proc. Natl Acad. Sci. USA 98, 2515-2520 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 2515-2520
-
-
Latres, E.1
-
78
-
-
35648940733
-
Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor
-
Umanskaya, K. et al. Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor. Mol. Cell. Biol. 27, 7615-7622 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 7615-7622
-
-
Umanskaya, K.1
-
79
-
-
77949741498
-
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
-
Lin, H. K. et al. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 464, 374-379 (2010).
-
(2010)
Nature
, vol.464
, pp. 374-379
-
-
Lin, H.K.1
-
80
-
-
84861552793
-
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
-
Chan, C. H. et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell 149, 1098-1111 (2012).
-
(2012)
Cell
, vol.149
, pp. 1098-1111
-
-
Chan, C.H.1
-
81
-
-
84887560579
-
Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors
-
Zhao, H. et al. Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors. Cancer Cell 24, 645-659 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 645-659
-
-
Zhao, H.1
-
82
-
-
73349139851
-
+/- mice
-
+/- mice. Nature Genet. 42, 83-88 (2010).
-
(2010)
Nature Genet.
, vol.42
, pp. 83-88
-
-
Wang, H.1
-
83
-
-
84876525804
-
Kip1 accumulation
-
Kip1 accumulation. Am. J. Pathol. 182, 1854-1864 (2013).
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 1854-1864
-
-
Sistrunk, C.1
-
84
-
-
77950916977
-
Prognostic significance of S-phase kinase-Associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: Effects of rituximab
-
Seki, R. et al. Prognostic significance of S-phase kinase-Associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab. Ann. Oncol. 21, 833-841 (2010).
-
(2010)
Ann. Oncol.
, vol.21
, pp. 833-841
-
-
Seki, R.1
-
85
-
-
80053906629
-
Skp2: A novel potential therapeutic target for prostate cancer
-
Wang, Z. et al. Skp2: a novel potential therapeutic target for prostate cancer. Biochim. Biophys. Acta 1825, 11-17 (2012).
-
(2012)
Biochim. Biophys. Acta
, vol.1825
, pp. 11-17
-
-
Wang, Z.1
-
86
-
-
21644448195
-
Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors
-
Li, J. Q. et al. Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int. J. Oncol. 25, 87-95 (2004).
-
(2004)
Int. J. Oncol.
, vol.25
, pp. 87-95
-
-
Li, J.Q.1
-
87
-
-
78651432897
-
Clinical relevance of SKP2 alterations in metastatic melanoma
-
Rose, A. E. et al. Clinical relevance of SKP2 alterations in metastatic melanoma. Pigment Cell. Melanoma Res. 24, 197-206 (2011).
-
(2011)
Pigment Cell. Melanoma Res.
, vol.24
, pp. 197-206
-
-
Rose, A.E.1
-
88
-
-
57649109825
-
Effect of S-phase kinase-Associated protein 2 expression on distant metastasis and survival in nasopharyngeal carcinoma patients
-
Fang, F. M. et al. Effect of S-phase kinase-Associated protein 2 expression on distant metastasis and survival in nasopharyngeal carcinoma patients. Int. J. Radiat. Oncol. Biol. Phys. 73, 202-207 (2009).
-
(2009)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.73
, pp. 202-207
-
-
Fang, F.M.1
-
89
-
-
78650846477
-
SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis
-
Schuler, S. et al. SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis. Int. J. Oncol. 38, 219-225 (2011).
-
(2011)
Int. J. Oncol.
, vol.38
, pp. 219-225
-
-
Schuler, S.1
-
90
-
-
19444367346
-
Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer
-
Radke, S., Pirkmaier, A. & Germain, D. Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer. Oncogene 24, 3448-3458 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 3448-3458
-
-
Radke, S.1
Pirkmaier, A.2
Germain, D.3
-
91
-
-
23844500471
-
Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy
-
Zheng, W. Q., Zheng, J. M., Ma, R., Meng, F. F. & Ni, C. R. Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy. Steroids 70, 770-774 (2005).
-
(2005)
Steroids
, vol.70
, pp. 770-774
-
-
Zheng, W.Q.1
Zheng, J.M.2
Ma, R.3
Meng, F.F.4
Ni, C.R.5
-
92
-
-
75049085839
-
The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma
-
Lu, M. et al. The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma. Pathol. Oncol. Res. 15, 679-687 (2009).
-
(2009)
Pathol. Oncol. Res.
, vol.15
, pp. 679-687
-
-
Lu, M.1
-
93
-
-
30444455166
-
Relation of overexpression of S phase kinase-Associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma
-
Ma, X. M., Liu, Y., Guo, J. W., Liu, J. H. & Zuo, L. F. Relation of overexpression of S phase kinase-Associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma. World J. Gastroenterol. 11, 6716-6721 (2005).
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 6716-6721
-
-
Ma, X.M.1
Liu, Y.2
Guo, J.W.3
Liu, J.H.4
Zuo, L.F.5
-
94
-
-
33745850483
-
Mouse emi1 has an essential function in mitotic progression during early embryogenesis
-
Lee, H. et al. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol. Cell. Biol. 26, 5373-5381 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5373-5381
-
-
Lee, H.1
-
95
-
-
33746225420
-
Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
-
Lehman, N. L., Verschuren, E. W., Hsu, J. Y., Cherry, A. M. & Jackson, P. K. Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. Cell Cycle 5, 1569-1573 (2006).
-
(2006)
Cell Cycle
, vol.5
, pp. 1569-1573
-
-
Lehman, N.L.1
Verschuren, E.W.2
Hsu, J.Y.3
Cherry, A.M.4
Jackson, P.K.5
-
96
-
-
34250883376
-
Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
-
Lehman, N. L. et al. Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am. J. Pathol. 170, 1793-1805 (2007).
-
(2007)
Am. J. Pathol.
, vol.170
, pp. 1793-1805
-
-
Lehman, N.L.1
-
97
-
-
41149135779
-
Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
-
Gutgemann, I., Lehman, N. L., Jackson, P. K. & Longacre, T. A. Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod. Pathol. 21, 445-454 (2008).
-
(2008)
Mod. Pathol.
, vol.21
, pp. 445-454
-
-
Gutgemann, I.1
Lehman, N.L.2
Jackson, P.K.3
Longacre, T.A.4
-
98
-
-
84871659005
-
Clear cell carcinomas of the ovary: A multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3
-
Min, K. W. et al. Clear cell carcinomas of the ovary: a multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3. Int. J. Gynecol. Pathol. 32, 3-14 (2013).
-
(2013)
Int. J. Gynecol. Pathol.
, vol.32
, pp. 3-14
-
-
Min, K.W.1
-
99
-
-
84873704427
-
Kip1
-
Kip1. Hum. Pathol. 44, 365-373 (2013).
-
(2013)
Hum. Pathol.
, vol.44
, pp. 365-373
-
-
Zhao, Y.1
-
101
-
-
78649655199
-
Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells
-
Chen, J. Y., Wang, M. C. & Hung, W. C. Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J. Cell. Physiol. 226, 407-413 (2011).
-
(2011)
J. Cell. Physiol.
, vol.226
, pp. 407-413
-
-
Chen, J.Y.1
Wang, M.C.2
Hung, W.C.3
-
102
-
-
84871714173
-
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
-
Fernandez-Saiz, V. et al. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nature Cell Biol. 15, 72-81 (2013).
-
(2013)
Nature Cell Biol.
, vol.15
, pp. 72-81
-
-
Fernandez-Saiz, V.1
-
103
-
-
33746473618
-
Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy
-
Suzuki, T. et al. Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy. Neurosci. Lett. 405, 126-131 (2006).
-
(2006)
Neurosci. Lett.
, vol.405
, pp. 126-131
-
-
Suzuki, T.1
-
104
-
-
1942502180
-
The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer
-
Fuchs, S. Y., Spiegelman, V. S. & Kumar, K. G. The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028-2036 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 2028-2036
-
-
Fuchs, S.Y.1
Spiegelman, V.S.2
Kumar, K.G.3
-
105
-
-
0041305974
-
Impaired degradation of inhibitory subunit of NF-κ B (I κ B) and β-catenin as a result of targeted disruption of the β-TrCP1 gene
-
Nakayama, K. et al. Impaired degradation of inhibitory subunit of NF-κ B (I κ B) and β-catenin as a result of targeted disruption of the β-TrCP1 gene. Proc. Natl Acad. Sci. USA 100, 8752-8757 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 8752-8757
-
-
Nakayama, K.1
-
106
-
-
0038243172
-
Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo
-
Guardavaccaro, D. et al. Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo. Dev. Cell 4, 799-812 (2003).
-
(2003)
Dev. Cell
, vol.4
, pp. 799-812
-
-
Guardavaccaro, D.1
-
107
-
-
4444346332
-
Role of F-box protein βtrcp1 in mammary gland development and tumorigenesis
-
Kudo, Y. et al. Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis. Mol. Cell. Biol. 24, 8184-8194 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8184-8194
-
-
Kudo, Y.1
-
108
-
-
79952634896
-
Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin
-
Bhatia, N., Demmer, T. A., Sharma, A. K., Elcheva, I. & Spiegelman, V. S. Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin. Arch. Biochem. Biophys. 508, 178-184 (2011).
-
(2011)
Arch. Biochem. Biophys.
, vol.508
, pp. 178-184
-
-
Bhatia, N.1
Demmer, T.A.2
Sharma, A.K.3
Elcheva, I.4
Spiegelman, V.S.5
-
109
-
-
3543078617
-
Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin, and NF-κB in colorectal cancer
-
Ougolkov, A. et al. Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin, and NF-κB in colorectal cancer. J. Natl Cancer Institute 96, 1161-1170 (2004).
-
(2004)
J. Natl Cancer Institute
, vol.96
, pp. 1161-1170
-
-
Ougolkov, A.1
-
110
-
-
13944252061
-
Increased expression of the E3-ubiquitin ligase receptor subunit βtRCP1 relates to constitutive nuclear factor-κB activation and chemoresistance in pancreatic carcinoma cells
-
Muerkoster, S. et al. Increased expression of the E3-ubiquitin ligase receptor subunit βTRCP1 relates to constitutive nuclear factor-κB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res. 65, 1316-1324 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 1316-1324
-
-
Muerkoster, S.1
-
111
-
-
20444466479
-
Elevated expression of Wnt antagonists is a common event in hepatoblastomas
-
Koch, A. et al. Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin. Cancer Res. 11, 4295-4304 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 4295-4304
-
-
Koch, A.1
-
112
-
-
33846837673
-
Somatic mutations of the β-TrCP gene in gastric cancer
-
Kim, C. J. et al. Somatic mutations of the β-TrCP gene in gastric cancer. APMIS 115, 127-133 (2007).
-
(2007)
APMIS
, vol.115
, pp. 127-133
-
-
Kim, C.J.1
-
113
-
-
0035344148
-
Expression profiles of βtRCP1 and βtRCP2, and mutation analysis of βtRCP2 in gastric cancer
-
Saitoh, T. & Katoh, M. Expression profiles of βTRCP1 and βTRCP2, and mutation analysis of βTRCP2 in gastric cancer. Int. J. Oncol. 18, 959-964 (2001).
-
(2001)
Int. J. Oncol.
, vol.18
, pp. 959-964
-
-
Saitoh, T.1
Katoh, M.2
-
114
-
-
84875799835
-
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation
-
Wu, X., Johansen, J. V. & Helin, K. Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol. Cell 49, 1134-1146 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 1134-1146
-
-
Wu, X.1
Johansen, J.V.2
Helin, K.3
-
115
-
-
84873343056
-
KDM2B promotes pancreatic cancer via Polycomb-dependent and-independent transcriptional programs
-
Tzatsos, A. et al. KDM2B promotes pancreatic cancer via Polycomb-dependent and-independent transcriptional programs. J. Clin. Invest. 123, 727-739 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 727-739
-
-
Tzatsos, A.1
-
116
-
-
79951855952
-
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly
-
Fukuda, T., Tokunaga, A., Sakamoto, R. & Yoshida, N. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol. Cell. Neurosci. 46, 614-624 (2011).
-
(2011)
Mol. Cell. Neurosci.
, vol.46
, pp. 614-624
-
-
Fukuda, T.1
Tokunaga, A.2
Sakamoto, R.3
Yoshida, N.4
-
117
-
-
55549147132
-
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)
-
He, J., Kallin, E. M., Tsukada, Y. & Zhang, Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nature Struct. Mol. Biol. 15, 1169-1175 (2008).
-
(2008)
Nature Struct. Mol. Biol.
, vol.15
, pp. 1169-1175
-
-
He, J.1
Kallin, E.M.2
Tsukada, Y.3
Zhang, Y.4
-
118
-
-
36049022778
-
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
-
Frescas, D., Guardavaccaro, D., Bassermann, F., Koyama-Nasu, R. & Pagano, M. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 450, 309-313 (2007).
-
(2007)
Nature
, vol.450
, pp. 309-313
-
-
Frescas, D.1
Guardavaccaro, D.2
Bassermann, F.3
Koyama-Nasu, R.4
Pagano, M.5
-
119
-
-
84877064688
-
Fbxw4, interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers
-
Fbxw4, interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS ONE 8, e63610 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Lockwood, W.W.1
Chandel, S.K.2
Stewart, G.L.3
Erdjument-Bromage, H.4
Beverly, L.J.5
-
120
-
-
62049085542
-
An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1β signaling pathway
-
Minoda, Y., Sakurai, H., Kobayashi, T., Yoshimura, A. & Takaesu, G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1β signaling pathway. Biochem. Biophys. Res. Commun. 381, 412-417 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.381
, pp. 412-417
-
-
Minoda, Y.1
Sakurai, H.2
Kobayashi, T.3
Yoshimura, A.4
Takaesu, G.5
-
121
-
-
84866322433
-
Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation
-
Kanei-Ishii, C., Nomura, T., Egoh, A. & Ishii, S. Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation. Biochem. Biophys. Res. Commun. 426, 59-64 (2012).
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.426
, pp. 59-64
-
-
Kanei-Ishii, C.1
Nomura, T.2
Egoh, A.3
Ishii, S.4
-
122
-
-
84885706043
-
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-Activating protein tumor suppressor promotes non-small cell lung cancer cell growth
-
Kim, T. Y. et al. CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-Activating protein tumor suppressor promotes non-small cell lung cancer cell growth. Proc. Natl Acad. Sci. USA 110, 16868-16873 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 16868-16873
-
-
Kim, T.Y.1
-
123
-
-
41649117158
-
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase
-
Hu, J. et al. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev. 22, 866-871 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 866-871
-
-
Hu, J.1
-
124
-
-
41549153923
-
Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary
-
De La Chesnaye, E. et al. Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary. Biol. Reprod. 78, 714-725 (2008).
-
(2008)
Biol. Reprod.
, vol.78
, pp. 714-725
-
-
De La Chesnaye, E.1
-
125
-
-
84874774494
-
Fbxw15 mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation
-
Fbxw15 mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. J. Biol. Chem. 288, 6306-6316 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 6306-6316
-
-
Zou, C.1
-
126
-
-
84859294951
-
F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation
-
Chen, B. B. et al. F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Blood 119, 3132-3141 (2012).
-
(2012)
Blood
, vol.119
, pp. 3132-3141
-
-
Chen, B.B.1
-
127
-
-
84861340823
-
F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest
-
Chen, B. B., Glasser, J. R., Coon, T. A. & Mallampalli, R. K. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. Oncogene 31, 2566-2579 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 2566-2579
-
-
Chen, B.B.1
Glasser, J.R.2
Coon, T.A.3
Mallampalli, R.K.4
-
128
-
-
84882581249
-
Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis
-
Chen, B. B., Glasser, J. R., Coon, T. A. & Mallampalli, R. K. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 4, e759 (2013).
-
(2013)
Cell Death Dis.
, vol.4
-
-
Chen, B.B.1
Glasser, J.R.2
Coon, T.A.3
Mallampalli, R.K.4
-
129
-
-
34249706792
-
FBXL5 interacts with p150Glued and regulates its ubiquitination
-
Zhang, N. et al. FBXL5 interacts with p150Glued and regulates its ubiquitination. Biochem. Biophys. Res. Commun. 359, 34-39 (2007).
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.359
, pp. 34-39
-
-
Zhang, N.1
-
130
-
-
84872081370
-
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
-
Ruiz, J. C., Walker, S. D., Anderson, S. A., Eisenstein, R. S. & Bruick, R. K. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. J. Biol. Chem. 288, 552-560 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 552-560
-
-
Ruiz, J.C.1
Walker, S.D.2
Anderson, S.A.3
Eisenstein, R.S.4
Bruick, R.K.5
-
131
-
-
80052698326
-
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo
-
Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell. Metab. 14, 339-351 (2011).
-
(2011)
Cell. Metab.
, vol.14
, pp. 339-351
-
-
Moroishi, T.1
Nishiyama, M.2
Takeda, Y.3
Iwai, K.4
Nakayama, K.I.5
-
132
-
-
84868122688
-
Role of FBXL20 in human colorectal adenocarcinoma
-
Zhu, J., Li, K., Dong, L. & Chen, Y. Role of FBXL20 in human colorectal adenocarcinoma. Oncol. Rep. 28, 2290-2298 (2012).
-
(2012)
Oncol. Rep.
, vol.28
, pp. 2290-2298
-
-
Zhu, J.1
Li, K.2
Dong, L.3
Chen, Y.4
-
133
-
-
84864115547
-
MiR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia
-
Eisfeld, A. K. et al. miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia. Blood 120, 249-258 (2012).
-
(2012)
Blood
, vol.120
, pp. 249-258
-
-
Eisfeld, A.K.1
-
134
-
-
84874772651
-
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
-
Hirano, A. et al. FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell 152, 1106-1118 (2013)
-
(2013)
Cell
, vol.152
, pp. 1106-1118
-
-
Hirano, A.1
-
135
-
-
79960343321
-
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells
-
Meziane el, K., Randle, S. J., Nelson, D. E., Lomonosov, M. & Laman, H. Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. J. Cell Sci. 124, 2175-2186 (2011).
-
(2011)
J. Cell Sci.
, vol.124
, pp. 2175-2186
-
-
Meziane El, K.1
Randle, S.J.2
Nelson, D.E.3
Lomonosov, M.4
Laman, H.5
-
136
-
-
3543047297
-
Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region
-
Hsu, J. M., Lee, Y. C., Yu, C. T. & Huang, C. Y. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J. Biol. Chem. 279, 32592-32602 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 32592-32602
-
-
Hsu, J.M.1
Lee, Y.C.2
Yu, C.T.3
Huang, C.Y.4
-
137
-
-
33644897044
-
The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination
-
Chang, Y. F., Cheng, C. M., Chang, L. K., Jong, Y. J. & Yuo, C. Y. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem. Biophys. Res. Commun. 342, 1022-1026 (2006).
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.342
, pp. 1022-1026
-
-
Chang, Y.F.1
Cheng, C.M.2
Chang, L.K.3
Jong, Y.J.4
Yuo, C.Y.5
-
138
-
-
27144506205
-
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6
-
Laman, H. et al. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. EMBO J. 24, 3104-3116 (2005).
-
(2005)
EMBO J.
, vol.24
, pp. 3104-3116
-
-
Laman, H.1
-
139
-
-
79959260925
-
Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis
-
Lomonosov, M. et al. Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis. PLoS ONE 6, e21165 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Lomonosov, M.1
-
140
-
-
34249880066
-
Generation of germline-competent induced pluripotent stem cells
-
Okita, K., Ichisaka, T. & Yamanaka, S. Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317 (2007).
-
(2007)
Nature
, vol.448
, pp. 313-317
-
-
Okita, K.1
Ichisaka, T.2
Yamanaka, S.3
-
141
-
-
84867878045
-
Cancer stem cell definitions and terminology: The devil is in the details
-
Valent, P. et al. Cancer stem cell definitions and terminology: the devil is in the details. Nature Rev. Cancer 12, 767-775 (2012).
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 767-775
-
-
Valent, P.1
-
142
-
-
0037383685
-
Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
-
Tokuzawa, Y. et al. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23, 2699-2708 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2699-2708
-
-
Tokuzawa, Y.1
-
143
-
-
84880026012
-
FBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
-
FBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer. EMBO Mol. Med. 5, 999-1018 (2013).
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 999-1018
-
-
Cepeda, D.1
-
144
-
-
0035941020
-
Identification of ubiquitin ligases required for skeletal muscle atrophy
-
Bodine, S. C. et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294, 1704-1708 (2001).
-
(2001)
Science
, vol.294
, pp. 1704-1708
-
-
Bodine, S.C.1
-
145
-
-
36049026136
-
Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
-
Li, H. H. et al. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J. Clin. Invest. 117, 3211-3223 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3211-3223
-
-
Li, H.H.1
-
146
-
-
34247625135
-
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
-
Tan, J. et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21, 1050-1063 (2007).
-
(2007)
Genes Dev.
, vol.21
, pp. 1050-1063
-
-
Tan, J.1
-
147
-
-
77649092118
-
Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer
-
Chou, J. L. et al. Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. Lab. Invest. 90, 414-425 (2010).
-
(2010)
Lab. Invest.
, vol.90
, pp. 414-425
-
-
Chou, J.L.1
-
148
-
-
79955666401
-
Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX
-
Song, M. H., Ha, J. C., Lee, S. M., Park, Y. M. & Lee, S. Y. Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX. Biochem. Biophys. Res. Commun. 408, 195-201 (2011).
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.408
, pp. 195-201
-
-
Song, M.H.1
Ha, J.C.2
Lee, S.M.3
Park, Y.M.4
Lee, S.Y.5
-
149
-
-
84870337676
-
The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation
-
Lu, Y. et al. The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J. Biol. Chem. 287, 41014-41022 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 41014-41022
-
-
Lu, Y.1
-
150
-
-
69849083542
-
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
-
Peschiaroli, A., Scialpi, F., Bernassola, F., Pagano, M. & Melino, G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 28, 3157-3166 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 3157-3166
-
-
Peschiaroli, A.1
Scialpi, F.2
Bernassola, F.3
Pagano, M.4
Melino, G.5
-
151
-
-
67650088235
-
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development
-
Saiga, T. et al. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol. Cell. Biol. 29, 3529-3543 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3529-3543
-
-
Saiga, T.1
-
152
-
-
84881192827
-
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
-
Chan, C. H. et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154, 556-568 (2013).
-
(2013)
Cell
, vol.154
, pp. 556-568
-
-
Chan, C.H.1
-
153
-
-
47149092405
-
Skp2 results in p27-And Skp2-mediated cell-cycle arrest and activation of autophagy
-
Skp2 results in p27-And Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 111, 4690-4699 (2008).
-
(2008)
Blood
, vol.111
, pp. 4690-4699
-
-
Chen, Q.1
-
154
-
-
84871569969
-
Specific small molecule inhibitors of Skp2-mediated p27 degradation
-
Wu, L. et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem. Biol. 19, 1515-1524 (2012).
-
(2012)
Chem. Biol.
, vol.19
, pp. 1515-1524
-
-
Wu, L.1
-
155
-
-
84886546357
-
Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: Therapeutic potential for endometrial cancer
-
Pavlides, S. C. et al. Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer. Endocrinology 154, 4030-4045 (2013).
-
(2013)
Endocrinology
, vol.154
, pp. 4030-4045
-
-
Pavlides, S.C.1
-
156
-
-
79952261405
-
FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471, 104-109 (2011).
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
-
157
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz, I. E. et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471, 110-114 (2011)
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
-
158
-
-
84863000735
-
Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase
-
Min, S. H. et al. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol. Cell 46, 771-783 (2012).
-
(2012)
Mol. Cell
, vol.46
, pp. 771-783
-
-
Min, S.H.1
-
159
-
-
84860740820
-
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1
-
Wu, J. et al. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol. Cell 46, 351-361 (2012).
-
(2012)
Mol. Cell
, vol.46
, pp. 351-361
-
-
Wu, J.1
-
160
-
-
33748279259
-
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
-
Miller, J. J. et al. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 20, 2410-2420 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 2410-2420
-
-
Miller, J.J.1
-
161
-
-
84897049814
-
Beyond ubiquitination: The atypical functions of Fbxo7 and other F-box proteins
-
Nelson, D. E., Randle, S. J. & Laman, H. Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biol. 3, 130131 (2013).
-
(2013)
Open Biol.
, vol.3
, pp. 130131
-
-
Nelson, D.E.1
Randle, S.J.2
Laman, H.3
-
162
-
-
84876434253
-
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
-
Reavie, L. et al. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell 23, 362-375 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 362-375
-
-
Reavie, L.1
-
163
-
-
84876422526
-
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence
-
Takeishi, S. et al. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 23, 347-361 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 347-361
-
-
Takeishi, S.1
-
164
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal, N. et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333, 1154-1157 (2011).
-
(2011)
Science
, vol.333
, pp. 1154-1157
-
-
Agrawal, N.1
-
165
-
-
84870532434
-
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
-
Le Gallo, M. et al. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nature Genet. 44, 1310-1315 (2012).
-
(2012)
Nature Genet.
, vol.44
, pp. 1310-1315
-
-
Le Gallo, M.1
-
166
-
-
27144498420
-
Identification of mutations in CUL7 in 3-M syndrome
-
Huber, C. et al. Identification of mutations in CUL7 in 3-M syndrome. Nature Genet. 37, 1119-1124 (2005).
-
(2005)
Nature Genet.
, vol.37
, pp. 1119-1124
-
-
Huber, C.1
-
167
-
-
0034022728
-
Five human genes encoding F-box proteins: Chromosome mapping and analysis in human tumors
-
Chiaur, D. S. et al. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. Cytogenet. Cell Genet. 88, 255-258 (2000).
-
(2000)
Cytogenet. Cell Genet.
, vol.88
, pp. 255-258
-
-
Chiaur, D.S.1
-
168
-
-
77952581198
-
Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress
-
Laulier, C., Cheng, A., Huang, N. & Stark, J. M. Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress. DNA Repair (Amst.) 9, 708-717 (2010).
-
(2010)
DNA Repair (Amst.)
, vol.9
, pp. 708-717
-
-
Laulier, C.1
Cheng, A.2
Huang, N.3
Stark, J.M.4
-
169
-
-
0036733716
-
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
-
Signoretti, S. et al. Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J. Clin. Invest. 110, 633-641 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 633-641
-
-
Signoretti, S.1
-
170
-
-
0035942224
-
Skp2 is oncogenic and overexpressed in human cancers
-
Gstaiger, M. et al. Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl Acad. Sci. USA 98, 5043-5048 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5043-5048
-
-
Gstaiger, M.1
-
171
-
-
3042692332
-
Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes
-
Yokoi, S. et al. Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes. Am. J. Pathol. 165, 175-180 (2004).
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 175-180
-
-
Yokoi, S.1
-
172
-
-
77649153374
-
Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion
-
Kanarek, N. et al. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion. Genes Dev. 24, 470-477 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 470-477
-
-
Kanarek, N.1
-
173
-
-
72949115258
-
An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (βTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese
-
Chen, S. et al. An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (βTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese. Biochem. Biophys. Res. Commun. 391, 552-556 (2010).
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.391
, pp. 552-556
-
-
Chen, S.1
-
174
-
-
33751223831
-
Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma
-
Scott, D. K. et al. Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma. Cell Cycle 5, 2381-2389 (2006).
-
(2006)
Cell Cycle
, vol.5
, pp. 2381-2389
-
-
Scott, D.K.1
-
175
-
-
84863229317
-
FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis
-
Watanabe, T., Hikichi, Y., Willuweit, A., Shintani, Y. & Horiguchi, T. FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. J. Neurosci. 32, 3352-3365 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 3352-3365
-
-
Watanabe, T.1
Hikichi, Y.2
Willuweit, A.3
Shintani, Y.4
Horiguchi, T.5
-
176
-
-
34347373487
-
Global gene expression profiling in human lung cells exposed to cobalt
-
Malard, V. et al. Global gene expression profiling in human lung cells exposed to cobalt. BMC Genomics 8, 147 (2007).
-
(2007)
BMC Genomics
, vol.8
, pp. 147
-
-
Malard, V.1
-
177
-
-
84872159985
-
SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses
-
Takagi, H., Setou, M., Ito, S. & Yao, I. SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses. Neural Plast. 2012, 352829 (2012).
-
(2012)
Neural Plast.
, vol.2012
, pp. 352829
-
-
Takagi, H.1
Setou, M.2
Ito, S.3
Yao, I.4
-
178
-
-
34248359919
-
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit
-
Nelson, R. F. et al. Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit. J. Neurosci. 27, 5163-5171 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 5163-5171
-
-
Nelson, R.F.1
-
179
-
-
79951698621
-
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
-
Babaei-Jadidi, R. et al. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J. Exp. Med. 208, 295-312 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 295-312
-
-
Babaei-Jadidi, R.1
-
180
-
-
79955845570
-
FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development
-
Davis, H. et al. FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 224, 180-189 (2011).
-
(2011)
J. Pathol.
, vol.224
, pp. 180-189
-
-
Davis, H.1
-
181
-
-
80052645934
-
The F-box protein Fbw7 is required for cerebellar development
-
Jandke, A. et al. The F-box protein Fbw7 is required for cerebellar development. Dev. Biol. 358, 201-212 (2011).
-
(2011)
Dev. Biol.
, vol.358
, pp. 201-212
-
-
Jandke, A.1
-
182
-
-
84864000763
-
Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer
-
Grim, J. E. et al. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol. Cell. Biol. 32, 2160-2167 (2012).
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 2160-2167
-
-
Grim, J.E.1
-
183
-
-
79953899846
-
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells
-
Matsumoto, A. et al. Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J. Biol. Chem. 286, 13754-13764 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 13754-13764
-
-
Matsumoto, A.1
-
184
-
-
78049231370
-
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
-
Hoeck, J. D. et al. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nature Neurosci. 13, 1365-1372 (2010).
-
(2010)
Nature Neurosci.
, vol.13
, pp. 1365-1372
-
-
Hoeck, J.D.1
-
185
-
-
84879384549
-
Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions
-
Sancho, R. et al. Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol. 11, e1001586 (2013).
-
(2013)
PLoS Biol.
, vol.11
-
-
Sancho, R.1
-
186
-
-
84862523798
-
Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development
-
Kwon, Y. W. et al. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol. Cancer Res. 10, 834-844 (2012).
-
(2012)
Mol. Cancer Res.
, vol.10
, pp. 834-844
-
-
Kwon, Y.W.1
-
187
-
-
0034595292
-
Targeted disruption of Skp2 results in accumulation of cyclin e and p27(Kip1), polyploidy and centrosome overduplication
-
Nakayama, K. et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 2069-2081
-
-
Nakayama, K.1
-
188
-
-
34948821871
-
Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
-
Zhong, L., Georgia, S., Tschen, S. I., Nakayama, K. & Bhushan, A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells. J. Clin. Invest. 117, 2869-2876 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2869-2876
-
-
Zhong, L.1
Georgia, S.2
Tschen, S.I.3
Nakayama, K.4
Bhushan, A.5
-
189
-
-
33847250516
-
Skp2 controls adipocyte proliferation during the development of obesity
-
Sakai, T. et al. Skp2 controls adipocyte proliferation during the development of obesity. J. Biol. Chem. 282, 2038-2046 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2038-2046
-
-
Sakai, T.1
-
190
-
-
34248341002
-
Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice
-
Fotovati, A., Nakayama, K. & Nakayama, K. I. Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice. Cell Div. 1, 4 (2006).
-
(2006)
Cell Div.
, vol.1
, pp. 4
-
-
Fotovati, A.1
Nakayama, K.2
Nakayama, K.I.3
-
191
-
-
0036172085
-
Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice
-
Minamishima, Y. A. & Nakayama, K. Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res. 62, 995-999 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 995-999
-
-
Minamishima, Y.A.1
Nakayama, K.2
-
192
-
-
52649104330
-
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease
-
Agarwal, A. et al. Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease. Blood 112, 1960-1970 (2008).
-
(2008)
Blood
, vol.112
, pp. 1960-1970
-
-
Agarwal, A.1
-
193
-
-
84862070506
-
Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies
-
Kratzat, S. et al. Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies. PLoS ONE 7, e37433 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Kratzat, S.1
-
194
-
-
7544220618
-
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
-
Kossatz, U. et al. Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev. 18, 2602-2607 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 2602-2607
-
-
Kossatz, U.1
-
195
-
-
79959440818
-
Skp2 is necessary for Myc-induced keratinocyte proliferation but
-
Sistrunk, C., Macias, E., Nakayama, K., Kim, Y. & Rodriguez-Puebla, M. L. Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium. Am. J. Pathol. 178, 2470-2477 (2011).
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 2470-2477
-
-
Sistrunk, C.1
Macias, E.2
Nakayama, K.3
Kim, Y.4
Rodriguez-Puebla, M.L.5
-
197
-
-
81555196348
-
The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
-
Wang, J. et al. The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal. Blood 118, 5429-5438 (2011).
-
(2011)
Blood
, vol.118
, pp. 5429-5438
-
-
Wang, J.1
-
198
-
-
70349336998
-
Abnormal retinal development in the Btrc null mouse
-
Baguma-Nibasheka, M. & Kablar, B. Abnormal retinal development in the Btrc null mouse. Dev. Dyn. 238, 2680-2687 (2009).
-
(2009)
Dev. Dyn.
, vol.238
, pp. 2680-2687
-
-
Baguma-Nibasheka, M.1
Kablar, B.2
|