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Volumn 14, Issue 4, 2014, Pages 233-247

Roles of F-box proteins in cancer

Author keywords

[No Author keywords available]

Indexed keywords

ATROGIN 1; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN 1; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN 2; F BOX AND LEUCINE RICH REPEAT PROTEIN 10; F BOX AND LEUCINE RICH REPEAT PROTEIN 2; F BOX AND LEUCINE RICH REPEAT PROTEIN 20; F BOX AND LEUCINE RICH REPEAT PROTEIN 21; F BOX AND LEUCINE RICH REPEAT PROTEIN 3; F BOX AND LEUCINE RICH REPEAT PROTEIN 5; F BOX AND WD REPEAT DOMAIN CONTAINING 7 PROTEIN; F BOX AND WD REPEAT DOMAIN CONTAINING 8 PROTEIN; F BOX ONLY PROTEIN 1; F BOX ONLY PROTEIN 10; F BOX ONLY PROTEIN 11; F BOX ONLY PROTEIN 15; F BOX ONLY PROTEIN 18; F BOX ONLY PROTEIN 2; F BOX ONLY PROTEIN 31; F BOX ONLY PROTEIN 4; F BOX ONLY PROTEIN 45; F BOX ONLY PROTEIN 5; F BOX ONLY PROTEIN 7; F BOX ONLY PROTEIN 9; F BOX PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG;

EID: 84897085768     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3700     Document Type: Review
Times cited : (419)

References (198)
  • 1
    • 44949231368 scopus 로고    scopus 로고
    • Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling
    • Li, W. et al. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE 3, e1487 (2008).
    • (2008) PLoS ONE , vol.3
    • Li, W.1
  • 3
    • 11244351579 scopus 로고    scopus 로고
    • Function and regulation of cullin-RING ubiquitin ligases
    • Petroski, M. D. & Deshaies, R. J. Function and regulation of cullin-RING ubiquitin ligases. Nature Rev. Mol. Cell Biol. 6, 9-20 (2005)
    • (2005) Nature Rev. Mol. Cell Biol. , vol.6 , pp. 9-20
    • Petroski, M.D.1    Deshaies, R.J.2
  • 4
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: Tipping the scales of cancer
    • Frescas, D. & Pagano, M. Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer. Nature Rev. Cancer 8, 438-449 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 438-449
    • Frescas, D.1    Pagano, M.2
  • 5
    • 0030602813 scopus 로고    scopus 로고
    • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    • Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274 (1996).
    • (1996) Cell , vol.86 , pp. 263-274
    • Bai, C.1
  • 6
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama, K. I. & Nakayama, K. Ubiquitin ligases: cell-cycle control and cancer. Nature Rev. Cancer 6, 369-381 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 7
    • 1842428734 scopus 로고    scopus 로고
    • M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
    • Watanabe, N. et al. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP. Proc. Natl Acad. Sci. USA 101, 4419-4424 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4419-4424
    • Watanabe, N.1
  • 8
    • 33747589184 scopus 로고    scopus 로고
    • The anaphase promoting complex/cyclosome: A machine designed to destroy
    • Peters, J. M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nature Rev. Mol. Cell Biol. 7, 644-656 (2006).
    • (2006) Nature Rev. Mol. Cell Biol. , vol.7 , pp. 644-656
    • Peters, J.M.1
  • 9
    • 0036713310 scopus 로고    scopus 로고
    • The anaphase-promoting complex: It's not just for mitosis any more
    • Harper, J. W., Burton, J. L. & Solomon, M. J. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179-2206 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2179-2206
    • Harper, J.W.1    Burton, J.L.2    Solomon, M.J.3
  • 10
    • 77954240714 scopus 로고    scopus 로고
    • SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
    • D'Angiolella, V. et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466, 138-142 (2010).
    • (2010) Nature , vol.466 , pp. 138-142
    • D'Angiolella, V.1
  • 11
    • 84855447125 scopus 로고    scopus 로고
    • FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
    • Duan, S. et al. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature 481, 90-93 (2012).
    • (2012) Nature , vol.481 , pp. 90-93
    • Duan, S.1
  • 12
    • 79960618956 scopus 로고    scopus 로고
    • FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children
    • Rye, M. S. et al. FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children. Genes Immun. 12, 352-359 (2011).
    • (2011) Genes Immun. , vol.12 , pp. 352-359
    • Rye, M.S.1
  • 13
    • 66649117243 scopus 로고    scopus 로고
    • F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
    • Santra, M. K., Wajapeyee, N. & Green, M. R. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459, 722-725 (2009).
    • (2009) Nature , vol.459 , pp. 722-725
    • Santra, M.K.1    Wajapeyee, N.2    Green, M.R.3
  • 14
    • 84878260314 scopus 로고    scopus 로고
    • Mechanisms and function of substrate recruitment by F-box proteins
    • Skaar, J. R., Pagan, J. K. & Pagano, M. Mechanisms and function of substrate recruitment by F-box proteins. Nature Rev. Mol. Cell Biol. 14, 369-381 (2013).
    • (2013) Nature Rev. Mol. Cell Biol. , vol.14 , pp. 369-381
    • Skaar, J.R.1    Pagan, J.K.2    Pagano, M.3
  • 15
    • 0035969559 scopus 로고    scopus 로고
    • Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
    • Nash, P. et al. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414, 514-521 (2001).
    • (2001) Nature , vol.414 , pp. 514-521
    • Nash, P.1
  • 16
    • 0037462424 scopus 로고    scopus 로고
    • Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
    • Orlicky, S., Tang, X., Willems, A., Tyers, M. & Sicheri, F. Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell 112, 243-256 (2003).
    • (2003) Cell , vol.112 , pp. 243-256
    • Orlicky, S.1    Tang, X.2    Willems, A.3    Tyers, M.4    Sicheri, F.5
  • 17
    • 0242321836 scopus 로고    scopus 로고
    • Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains
    • Yoshida, Y. et al. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J. Biol. Chem. 278, 43877-43884 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 43877-43884
    • Yoshida, Y.1
  • 18
    • 18444413218 scopus 로고    scopus 로고
    • E3 ubiquitin ligase that recognizes sugar chains
    • Yoshida, Y. et al. E3 ubiquitin ligase that recognizes sugar chains. Nature 418, 438-442 (2002).
    • (2002) Nature , vol.418 , pp. 438-442
    • Yoshida, Y.1
  • 19
    • 84861544402 scopus 로고    scopus 로고
    • Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair
    • D'Angiolella, V. et al. Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell 149, 1023-1034 (2012).
    • (2012) Cell , vol.149 , pp. 1023-1034
    • D'Angiolella, V.1
  • 20
    • 84877577024 scopus 로고    scopus 로고
    • FBXL2-And PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade
    • Kuchay, S. et al. FBXL2-And PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nature Cell Biol. 15, 472-480 (2013).
    • (2013) Nature Cell Biol. , vol.15 , pp. 472-480
    • Kuchay, S.1
  • 21
    • 84875806981 scopus 로고    scopus 로고
    • CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration
    • Abbas, T. et al. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Mol. Cell 49, 1147-1158 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 1147-1158
    • Abbas, T.1
  • 22
    • 84875804530 scopus 로고    scopus 로고
    • Fbxo11 ubiquitin ligase
    • Fbxo11 ubiquitin ligase. Mol. Cell 49, 1159-1166 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 1159-1166
    • Rossi, M.1
  • 23
    • 84870308969 scopus 로고    scopus 로고
    • EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
    • Lee, J. M. et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol. Cell 48, 572-586 (2012).
    • (2012) Mol. Cell , vol.48 , pp. 572-586
    • Lee, J.M.1
  • 24
    • 17044370346 scopus 로고    scopus 로고
    • Regulation of the cell cycle by SCF-type ubiquitin ligases
    • Nakayama, K. I. & Nakayama, K. Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin. Cell Dev. Biol. 16, 323-333 (2005).
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 323-333
    • Nakayama, K.I.1    Nakayama, K.2
  • 26
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker, M. & Clurman, B. E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nature Rev. Cancer 8, 83-93 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 27
    • 1542364470 scopus 로고    scopus 로고
    • Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
    • Tsunematsu, R. et al. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J. Biol. Chem. 279, 9417-9423 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 9417-9423
    • Tsunematsu, R.1
  • 28
    • 1542409037 scopus 로고    scopus 로고
    • Defective cardiovascular development and elevated cyclin e and Notch proteins in mice lacking the Fbw7 F-box protein
    • Tetzlaff, M. T. et al. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl Acad. Sci. USA 101, 3338-3345 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3338-3345
    • Tetzlaff, M.T.1
  • 29
    • 35148842479 scopus 로고    scopus 로고
    • FBXW7/hCDC4 is a general tumor suppressor in human cancer
    • Akhoondi, S. et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res. 67, 9006-9012 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 9006-9012
    • Akhoondi, S.1
  • 30
    • 36549071481 scopus 로고    scopus 로고
    • Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
    • Onoyama, I. et al. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J. Exp. Med. 204, 2875-2888 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2875-2888
    • Onoyama, I.1
  • 31
    • 42149132696 scopus 로고    scopus 로고
    • Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    • Matsuoka, S. et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 22, 986-991 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 986-991
    • Matsuoka, S.1
  • 32
    • 45149123052 scopus 로고    scopus 로고
    • Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
    • Thompson, B. J. et al. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J. Exp. Med. 205, 1395-1408 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1395-1408
    • Thompson, B.J.1
  • 33
    • 34250863886 scopus 로고    scopus 로고
    • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
    • Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007).
    • (2007) Nature , vol.447 , pp. 966-971
    • Maser, R.S.1
  • 34
    • 84879364450 scopus 로고    scopus 로고
    • The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
    • King, B. et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153, 1552-1566 (2013).
    • (2013) Cell , vol.153 , pp. 1552-1566
    • King, B.1
  • 35
    • 77956165036 scopus 로고    scopus 로고
    • F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor
    • Sancho, R. et al. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139, 929-941 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 929-941
    • Sancho, R.1
  • 36
    • 84897959817 scopus 로고    scopus 로고
    • Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines
    • Davis, H., Lewis, A., Behrens, A. & Tomlinson, I. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut http://dx.doi.org/10.1136/gutjnl-2013-304719 (2013)
    • (2013) Gut
    • Davis, H.1    Lewis, A.2    Behrens, A.3    Tomlinson, I.4
  • 37
    • 34047255191 scopus 로고    scopus 로고
    • Fbw7/hCDC4 dimerization regulates its substrate interactions
    • Welcker, M. & Clurman, B. E. Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div. 2, 7 (2007).
    • (2007) Cell Div. , vol.2 , pp. 7
    • Welcker, M.1    Clurman, B.E.2
  • 38
    • 34250017680 scopus 로고    scopus 로고
    • Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
    • Tang, X. et al. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell 129, 1165-1176 (2007).
    • (2007) Cell , vol.129 , pp. 1165-1176
    • Tang, X.1
  • 39
    • 78650928027 scopus 로고    scopus 로고
    • Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
    • Onoyama, I. et al. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J. Clin. Invest. 121, 342-354 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 342-354
    • Onoyama, I.1
  • 40
    • 10644269326 scopus 로고    scopus 로고
    • Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
    • Mao, J. H. et al. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432, 775-779 (2004).
    • (2004) Nature , vol.432 , pp. 775-779
    • Mao, J.H.1
  • 41
    • 78649494384 scopus 로고    scopus 로고
    • Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
    • Akhoondi, S. et al. Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res. 12, R105 (2010).
    • (2010) Breast Cancer Res. , vol.12
    • Akhoondi, S.1
  • 42
    • 79952766066 scopus 로고    scopus 로고
    • Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress
    • Matsumoto, A. et al. Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci. 102, 749-755 (2011).
    • (2011) Cancer Sci. , vol.102 , pp. 749-755
    • Matsumoto, A.1
  • 43
    • 65949107856 scopus 로고    scopus 로고
    • P53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases
    • Yokobori, T. et al. p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res. 69, 3788-3794 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3788-3794
    • Yokobori, T.1
  • 44
    • 32544446008 scopus 로고    scopus 로고
    • CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer
    • Koh, M. S., Ittmann, M., Kadmon, D., Thompson, T. C. & Leach, F. S. CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer. Cancer Biol. Ther. 5, 78-83 (2006).
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 78-83
    • Koh, M.S.1    Ittmann, M.2    Kadmon, D.3    Thompson, T.C.4    Leach, F.S.5
  • 45
    • 84859947197 scopus 로고    scopus 로고
    • Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • Mann, K. M. et al. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc. Natl Acad. Sci. USA 109, 5934-5941 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5934-5941
    • Mann, K.M.1
  • 46
    • 33750394887 scopus 로고    scopus 로고
    • A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse
    • Hardisty-Hughes, R. E. et al. A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse. Hum. Mol. Genet. 15, 3273-3279 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 3273-3279
    • Hardisty-Hughes, R.E.1
  • 47
    • 33747024045 scopus 로고    scopus 로고
    • Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development
    • Tsunematsu, R. et al. Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol. Cell. Biol. 26, 6157-6169 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 6157-6169
    • Tsunematsu, R.1
  • 48
    • 37849020693 scopus 로고    scopus 로고
    • Disruption of the Fbxw8 gene results in pre-And postnatal growth retardation in mice
    • Tsutsumi, T., Kuwabara, H., Arai, T., Xiao, Y. & Decaprio, J. A. Disruption of the Fbxw8 gene results in pre-And postnatal growth retardation in mice. Mol. Cell. Biol. 28, 743-751 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 743-751
    • Tsutsumi, T.1    Kuwabara, H.2    Arai, T.3    Xiao, Y.4    Decaprio, J.A.5
  • 49
    • 84871703377 scopus 로고    scopus 로고
    • MTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
    • Kim, S. J. et al. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol. Cell 48, 875-887 (2012).
    • (2012) Mol. Cell , vol.48 , pp. 875-887
    • Kim, S.J.1
  • 50
    • 34047189884 scopus 로고    scopus 로고
    • A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
    • Okabe, H. et al. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1, e128 (2006).
    • (2006) PLoS ONE , vol.1
    • Okabe, H.1
  • 51
    • 85027958158 scopus 로고    scopus 로고
    • Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells
    • Lin, P. et al. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol. Biol. Rep. 38, 1741-1747 (2011).
    • (2011) Mol. Biol. Rep. , vol.38 , pp. 1741-1747
    • Lin, P.1
  • 52
    • 34249097203 scopus 로고    scopus 로고
    • Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
    • Siepka, S. M. et al. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129, 1011-1023 (2007).
    • (2007) Cell , vol.129 , pp. 1011-1023
    • Siepka, S.M.1
  • 53
    • 34248525919 scopus 로고    scopus 로고
    • The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
    • Godinho, S. I. et al. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316, 897-900 (2007).
    • (2007) Science , vol.316 , pp. 897-900
    • Godinho, S.I.1
  • 54
    • 34248566788 scopus 로고    scopus 로고
    • SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
    • Busino, L. et al. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316, 900-904 (2007).
    • (2007) Science , vol.316 , pp. 900-904
    • Busino, L.1
  • 55
    • 84874768419 scopus 로고    scopus 로고
    • Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
    • Yoo, S. H. et al. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell 152, 1091-1105 (2013).
    • (2013) Cell , vol.152 , pp. 1091-1105
    • Yoo, S.H.1
  • 56
    • 84875899177 scopus 로고    scopus 로고
    • FBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket
    • FBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature 496, 64-68 (2013).
    • (2013) Nature , vol.496 , pp. 64-68
    • Xing, W.1
  • 57
    • 84887609711 scopus 로고    scopus 로고
    • Circadian molecular clocks and cancer
    • Kelleher, F. C., Rao, A. & Maguire, A. Circadian molecular clocks and cancer. Cancer Lett. 342, 9-18 (2014).
    • (2014) Cancer Lett. , vol.342 , pp. 9-18
    • Kelleher, F.C.1    Rao, A.2    Maguire, A.3
  • 58
    • 84870790528 scopus 로고    scopus 로고
    • Circadian clock disruptions and the risk of cancer
    • Lahti, T., Merikanto, I. & Partonen, T. Circadian clock disruptions and the risk of cancer. Ann. Med. 44, 847-853 (2012).
    • (2012) Ann. Med. , vol.44 , pp. 847-853
    • Lahti, T.1    Merikanto, I.2    Partonen, T.3
  • 59
    • 1542344329 scopus 로고    scopus 로고
    • Cyclin F disruption compromises placental development and affects normal cell cycle execution
    • Tetzlaff, M. T. et al. Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol. Cell. Biol. 24, 2487-2498 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2487-2498
    • Tetzlaff, M.T.1
  • 60
    • 84875606355 scopus 로고    scopus 로고
    • Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis
    • Fu, J. et al. Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis. Cancer Sci. 104, 508-515 (2013).
    • (2013) Cancer Sci. , vol.104 , pp. 508-515
    • Fu, J.1
  • 61
    • 83255192193 scopus 로고    scopus 로고
    • The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
    • Vaites, L. P. et al. The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol. Cell. Biol. 31, 4513-4523 (2011).
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 4513-4523
    • Vaites, L.P.1
  • 62
    • 84856781262 scopus 로고    scopus 로고
    • Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation
    • Kanie, T. et al. Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol. Cell. Biol. 32, 590-605 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 590-605
    • Kanie, T.1
  • 63
    • 33750460897 scopus 로고    scopus 로고
    • FBX4-αB crystallin complex
    • FBX4-αB crystallin complex. Mol. Cell 24, 355-366 (2006).
    • (2006) Mol. Cell , vol.24 , pp. 355-366
    • Lin, D.I.1
  • 64
    • 45849131324 scopus 로고    scopus 로고
    • Fbx4 ligase and contribute to cyclin D1 overexpression in human cancer
    • Fbx4 ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14, 68-78 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 68-78
    • Barbash, O.1
  • 65
    • 84874641177 scopus 로고    scopus 로고
    • Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
    • Chiorazzi, M. et al. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proc. Natl Acad. Sci. USA 110, 3943-3948 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 3943-3948
    • Chiorazzi, M.1
  • 66
    • 34547537530 scopus 로고    scopus 로고
    • Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk
    • Samuelson, D. J. et al. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc. Natl Acad. Sci. USA 104, 6299-6304 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6299-6304
    • Samuelson, D.J.1
  • 67
    • 84855289407 scopus 로고    scopus 로고
    • An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a
    • Smits, B. M. et al. An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a. Nucleic Acids Res. 40, 132-147 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 132-147
    • Smits, B.M.1
  • 68
    • 84895783151 scopus 로고    scopus 로고
    • Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF)
    • Xu, X. et al. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol. Carcinog. http://dx.doi. org/10.1002/mc.21977 (2012).
    • (2012) Mol. Carcinog
    • Xu, X.1
  • 69
    • 84875892495 scopus 로고    scopus 로고
    • FBH1 protects melanocytes from transformation and is deregulated in melanomas
    • Jeong, Y. T., Cermak, L., Guijarro, M. V., Hernando, E. & Pagano, M. FBH1 protects melanocytes from transformation and is deregulated in melanomas. Cell Cycle 12, 1128-1132 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 1128-1132
    • Jeong, Y.T.1    Cermak, L.2    Guijarro, M.V.3    Hernando, E.4    Pagano, M.5
  • 70
    • 29244485581 scopus 로고    scopus 로고
    • FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex
    • Kumar, R. et al. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res. 65, 11304-11313 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 11304-11313
    • Kumar, R.1
  • 71
    • 77956307171 scopus 로고    scopus 로고
    • FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma
    • Huang, H. L., Zheng, W. L., Zhao, R., Zhang, B. & Ma, W. L. FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma. Oncol. Rep. 24, 715-720 (2010).
    • (2010) Oncol. Rep. , vol.24 , pp. 715-720
    • Huang, H.L.1    Zheng, W.L.2    Zhao, R.3    Zhang, B.4    Ma, W.L.5
  • 72
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano, A. C., Eytan, E., Hershko, A. & Pagano, M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nature Cell Biol. 1, 193-199 (1999).
    • (1999) Nature Cell Biol. , vol.1 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 73
    • 0033174070 scopus 로고    scopus 로고
    • P45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
    • Sutterluty, H. et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nature Cell Biol. 1, 207-214 (1999).
    • (1999) Nature Cell Biol. , vol.1 , pp. 207-214
    • Sutterluty, H.1
  • 75
    • 0032530151 scopus 로고    scopus 로고
    • Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
    • Yu, Z. K., Gervais, J. L. & Zhang, H. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc. Natl Acad. Sci. USA 95, 11324-11329 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 11324-11329
    • Yu, Z.K.1    Gervais, J.L.2    Zhang, H.3
  • 76
    • 0037379776 scopus 로고    scopus 로고
    • Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate
    • Shim, E. H. et al. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Cancer Res. 63, 1583-1588 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1583-1588
    • Shim, E.H.1
  • 77
    • 0035956971 scopus 로고    scopus 로고
    • Role of the F-box protein Skp2 in lymphomagenesis
    • Latres, E. et al. Role of the F-box protein Skp2 in lymphomagenesis. Proc. Natl Acad. Sci. USA 98, 2515-2520 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2515-2520
    • Latres, E.1
  • 78
    • 35648940733 scopus 로고    scopus 로고
    • Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor
    • Umanskaya, K. et al. Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor. Mol. Cell. Biol. 27, 7615-7622 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7615-7622
    • Umanskaya, K.1
  • 79
    • 77949741498 scopus 로고    scopus 로고
    • Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    • Lin, H. K. et al. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 464, 374-379 (2010).
    • (2010) Nature , vol.464 , pp. 374-379
    • Lin, H.K.1
  • 80
    • 84861552793 scopus 로고    scopus 로고
    • The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
    • Chan, C. H. et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell 149, 1098-1111 (2012).
    • (2012) Cell , vol.149 , pp. 1098-1111
    • Chan, C.H.1
  • 81
    • 84887560579 scopus 로고    scopus 로고
    • Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors
    • Zhao, H. et al. Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors. Cancer Cell 24, 645-659 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 645-659
    • Zhao, H.1
  • 82
    • 73349139851 scopus 로고    scopus 로고
    • +/- mice
    • +/- mice. Nature Genet. 42, 83-88 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 83-88
    • Wang, H.1
  • 83
    • 84876525804 scopus 로고    scopus 로고
    • Kip1 accumulation
    • Kip1 accumulation. Am. J. Pathol. 182, 1854-1864 (2013).
    • (2013) Am. J. Pathol. , vol.182 , pp. 1854-1864
    • Sistrunk, C.1
  • 84
    • 77950916977 scopus 로고    scopus 로고
    • Prognostic significance of S-phase kinase-Associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: Effects of rituximab
    • Seki, R. et al. Prognostic significance of S-phase kinase-Associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab. Ann. Oncol. 21, 833-841 (2010).
    • (2010) Ann. Oncol. , vol.21 , pp. 833-841
    • Seki, R.1
  • 85
    • 80053906629 scopus 로고    scopus 로고
    • Skp2: A novel potential therapeutic target for prostate cancer
    • Wang, Z. et al. Skp2: a novel potential therapeutic target for prostate cancer. Biochim. Biophys. Acta 1825, 11-17 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1825 , pp. 11-17
    • Wang, Z.1
  • 86
    • 21644448195 scopus 로고    scopus 로고
    • Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors
    • Li, J. Q. et al. Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int. J. Oncol. 25, 87-95 (2004).
    • (2004) Int. J. Oncol. , vol.25 , pp. 87-95
    • Li, J.Q.1
  • 87
    • 78651432897 scopus 로고    scopus 로고
    • Clinical relevance of SKP2 alterations in metastatic melanoma
    • Rose, A. E. et al. Clinical relevance of SKP2 alterations in metastatic melanoma. Pigment Cell. Melanoma Res. 24, 197-206 (2011).
    • (2011) Pigment Cell. Melanoma Res. , vol.24 , pp. 197-206
    • Rose, A.E.1
  • 88
    • 57649109825 scopus 로고    scopus 로고
    • Effect of S-phase kinase-Associated protein 2 expression on distant metastasis and survival in nasopharyngeal carcinoma patients
    • Fang, F. M. et al. Effect of S-phase kinase-Associated protein 2 expression on distant metastasis and survival in nasopharyngeal carcinoma patients. Int. J. Radiat. Oncol. Biol. Phys. 73, 202-207 (2009).
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.73 , pp. 202-207
    • Fang, F.M.1
  • 89
    • 78650846477 scopus 로고    scopus 로고
    • SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis
    • Schuler, S. et al. SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis. Int. J. Oncol. 38, 219-225 (2011).
    • (2011) Int. J. Oncol. , vol.38 , pp. 219-225
    • Schuler, S.1
  • 90
    • 19444367346 scopus 로고    scopus 로고
    • Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer
    • Radke, S., Pirkmaier, A. & Germain, D. Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer. Oncogene 24, 3448-3458 (2005).
    • (2005) Oncogene , vol.24 , pp. 3448-3458
    • Radke, S.1    Pirkmaier, A.2    Germain, D.3
  • 91
    • 23844500471 scopus 로고    scopus 로고
    • Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy
    • Zheng, W. Q., Zheng, J. M., Ma, R., Meng, F. F. & Ni, C. R. Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy. Steroids 70, 770-774 (2005).
    • (2005) Steroids , vol.70 , pp. 770-774
    • Zheng, W.Q.1    Zheng, J.M.2    Ma, R.3    Meng, F.F.4    Ni, C.R.5
  • 92
    • 75049085839 scopus 로고    scopus 로고
    • The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma
    • Lu, M. et al. The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma. Pathol. Oncol. Res. 15, 679-687 (2009).
    • (2009) Pathol. Oncol. Res. , vol.15 , pp. 679-687
    • Lu, M.1
  • 93
    • 30444455166 scopus 로고    scopus 로고
    • Relation of overexpression of S phase kinase-Associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma
    • Ma, X. M., Liu, Y., Guo, J. W., Liu, J. H. & Zuo, L. F. Relation of overexpression of S phase kinase-Associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma. World J. Gastroenterol. 11, 6716-6721 (2005).
    • (2005) World J. Gastroenterol. , vol.11 , pp. 6716-6721
    • Ma, X.M.1    Liu, Y.2    Guo, J.W.3    Liu, J.H.4    Zuo, L.F.5
  • 94
    • 33745850483 scopus 로고    scopus 로고
    • Mouse emi1 has an essential function in mitotic progression during early embryogenesis
    • Lee, H. et al. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol. Cell. Biol. 26, 5373-5381 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 5373-5381
    • Lee, H.1
  • 95
    • 33746225420 scopus 로고    scopus 로고
    • Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
    • Lehman, N. L., Verschuren, E. W., Hsu, J. Y., Cherry, A. M. & Jackson, P. K. Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. Cell Cycle 5, 1569-1573 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 1569-1573
    • Lehman, N.L.1    Verschuren, E.W.2    Hsu, J.Y.3    Cherry, A.M.4    Jackson, P.K.5
  • 96
    • 34250883376 scopus 로고    scopus 로고
    • Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    • Lehman, N. L. et al. Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am. J. Pathol. 170, 1793-1805 (2007).
    • (2007) Am. J. Pathol. , vol.170 , pp. 1793-1805
    • Lehman, N.L.1
  • 97
    • 41149135779 scopus 로고    scopus 로고
    • Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
    • Gutgemann, I., Lehman, N. L., Jackson, P. K. & Longacre, T. A. Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod. Pathol. 21, 445-454 (2008).
    • (2008) Mod. Pathol. , vol.21 , pp. 445-454
    • Gutgemann, I.1    Lehman, N.L.2    Jackson, P.K.3    Longacre, T.A.4
  • 98
    • 84871659005 scopus 로고    scopus 로고
    • Clear cell carcinomas of the ovary: A multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3
    • Min, K. W. et al. Clear cell carcinomas of the ovary: a multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3. Int. J. Gynecol. Pathol. 32, 3-14 (2013).
    • (2013) Int. J. Gynecol. Pathol. , vol.32 , pp. 3-14
    • Min, K.W.1
  • 99
    • 84873704427 scopus 로고    scopus 로고
    • Kip1
    • Kip1. Hum. Pathol. 44, 365-373 (2013).
    • (2013) Hum. Pathol. , vol.44 , pp. 365-373
    • Zhao, Y.1
  • 101
    • 78649655199 scopus 로고    scopus 로고
    • Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells
    • Chen, J. Y., Wang, M. C. & Hung, W. C. Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J. Cell. Physiol. 226, 407-413 (2011).
    • (2011) J. Cell. Physiol. , vol.226 , pp. 407-413
    • Chen, J.Y.1    Wang, M.C.2    Hung, W.C.3
  • 102
    • 84871714173 scopus 로고    scopus 로고
    • SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
    • Fernandez-Saiz, V. et al. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nature Cell Biol. 15, 72-81 (2013).
    • (2013) Nature Cell Biol. , vol.15 , pp. 72-81
    • Fernandez-Saiz, V.1
  • 103
    • 33746473618 scopus 로고    scopus 로고
    • Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy
    • Suzuki, T. et al. Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy. Neurosci. Lett. 405, 126-131 (2006).
    • (2006) Neurosci. Lett. , vol.405 , pp. 126-131
    • Suzuki, T.1
  • 104
    • 1942502180 scopus 로고    scopus 로고
    • The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer
    • Fuchs, S. Y., Spiegelman, V. S. & Kumar, K. G. The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028-2036 (2004).
    • (2004) Oncogene , vol.23 , pp. 2028-2036
    • Fuchs, S.Y.1    Spiegelman, V.S.2    Kumar, K.G.3
  • 105
    • 0041305974 scopus 로고    scopus 로고
    • Impaired degradation of inhibitory subunit of NF-κ B (I κ B) and β-catenin as a result of targeted disruption of the β-TrCP1 gene
    • Nakayama, K. et al. Impaired degradation of inhibitory subunit of NF-κ B (I κ B) and β-catenin as a result of targeted disruption of the β-TrCP1 gene. Proc. Natl Acad. Sci. USA 100, 8752-8757 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8752-8757
    • Nakayama, K.1
  • 106
    • 0038243172 scopus 로고    scopus 로고
    • Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo
    • Guardavaccaro, D. et al. Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo. Dev. Cell 4, 799-812 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 799-812
    • Guardavaccaro, D.1
  • 107
    • 4444346332 scopus 로고    scopus 로고
    • Role of F-box protein βtrcp1 in mammary gland development and tumorigenesis
    • Kudo, Y. et al. Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis. Mol. Cell. Biol. 24, 8184-8194 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8184-8194
    • Kudo, Y.1
  • 109
    • 3543078617 scopus 로고    scopus 로고
    • Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin, and NF-κB in colorectal cancer
    • Ougolkov, A. et al. Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin, and NF-κB in colorectal cancer. J. Natl Cancer Institute 96, 1161-1170 (2004).
    • (2004) J. Natl Cancer Institute , vol.96 , pp. 1161-1170
    • Ougolkov, A.1
  • 110
    • 13944252061 scopus 로고    scopus 로고
    • Increased expression of the E3-ubiquitin ligase receptor subunit βtRCP1 relates to constitutive nuclear factor-κB activation and chemoresistance in pancreatic carcinoma cells
    • Muerkoster, S. et al. Increased expression of the E3-ubiquitin ligase receptor subunit βTRCP1 relates to constitutive nuclear factor-κB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res. 65, 1316-1324 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 1316-1324
    • Muerkoster, S.1
  • 111
    • 20444466479 scopus 로고    scopus 로고
    • Elevated expression of Wnt antagonists is a common event in hepatoblastomas
    • Koch, A. et al. Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin. Cancer Res. 11, 4295-4304 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4295-4304
    • Koch, A.1
  • 112
    • 33846837673 scopus 로고    scopus 로고
    • Somatic mutations of the β-TrCP gene in gastric cancer
    • Kim, C. J. et al. Somatic mutations of the β-TrCP gene in gastric cancer. APMIS 115, 127-133 (2007).
    • (2007) APMIS , vol.115 , pp. 127-133
    • Kim, C.J.1
  • 113
    • 0035344148 scopus 로고    scopus 로고
    • Expression profiles of βtRCP1 and βtRCP2, and mutation analysis of βtRCP2 in gastric cancer
    • Saitoh, T. & Katoh, M. Expression profiles of βTRCP1 and βTRCP2, and mutation analysis of βTRCP2 in gastric cancer. Int. J. Oncol. 18, 959-964 (2001).
    • (2001) Int. J. Oncol. , vol.18 , pp. 959-964
    • Saitoh, T.1    Katoh, M.2
  • 114
    • 84875799835 scopus 로고    scopus 로고
    • Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation
    • Wu, X., Johansen, J. V. & Helin, K. Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol. Cell 49, 1134-1146 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 1134-1146
    • Wu, X.1    Johansen, J.V.2    Helin, K.3
  • 115
    • 84873343056 scopus 로고    scopus 로고
    • KDM2B promotes pancreatic cancer via Polycomb-dependent and-independent transcriptional programs
    • Tzatsos, A. et al. KDM2B promotes pancreatic cancer via Polycomb-dependent and-independent transcriptional programs. J. Clin. Invest. 123, 727-739 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 727-739
    • Tzatsos, A.1
  • 116
    • 79951855952 scopus 로고    scopus 로고
    • Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly
    • Fukuda, T., Tokunaga, A., Sakamoto, R. & Yoshida, N. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol. Cell. Neurosci. 46, 614-624 (2011).
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 614-624
    • Fukuda, T.1    Tokunaga, A.2    Sakamoto, R.3    Yoshida, N.4
  • 117
    • 55549147132 scopus 로고    scopus 로고
    • The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)
    • He, J., Kallin, E. M., Tsukada, Y. & Zhang, Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nature Struct. Mol. Biol. 15, 1169-1175 (2008).
    • (2008) Nature Struct. Mol. Biol. , vol.15 , pp. 1169-1175
    • He, J.1    Kallin, E.M.2    Tsukada, Y.3    Zhang, Y.4
  • 118
    • 36049022778 scopus 로고    scopus 로고
    • JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
    • Frescas, D., Guardavaccaro, D., Bassermann, F., Koyama-Nasu, R. & Pagano, M. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 450, 309-313 (2007).
    • (2007) Nature , vol.450 , pp. 309-313
    • Frescas, D.1    Guardavaccaro, D.2    Bassermann, F.3    Koyama-Nasu, R.4    Pagano, M.5
  • 121
    • 84866322433 scopus 로고    scopus 로고
    • Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation
    • Kanei-Ishii, C., Nomura, T., Egoh, A. & Ishii, S. Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation. Biochem. Biophys. Res. Commun. 426, 59-64 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.426 , pp. 59-64
    • Kanei-Ishii, C.1    Nomura, T.2    Egoh, A.3    Ishii, S.4
  • 122
    • 84885706043 scopus 로고    scopus 로고
    • CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-Activating protein tumor suppressor promotes non-small cell lung cancer cell growth
    • Kim, T. Y. et al. CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-Activating protein tumor suppressor promotes non-small cell lung cancer cell growth. Proc. Natl Acad. Sci. USA 110, 16868-16873 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16868-16873
    • Kim, T.Y.1
  • 123
    • 41649117158 scopus 로고    scopus 로고
    • WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase
    • Hu, J. et al. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev. 22, 866-871 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 866-871
    • Hu, J.1
  • 124
    • 41549153923 scopus 로고    scopus 로고
    • Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary
    • De La Chesnaye, E. et al. Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary. Biol. Reprod. 78, 714-725 (2008).
    • (2008) Biol. Reprod. , vol.78 , pp. 714-725
    • De La Chesnaye, E.1
  • 125
    • 84874774494 scopus 로고    scopus 로고
    • Fbxw15 mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation
    • Fbxw15 mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. J. Biol. Chem. 288, 6306-6316 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 6306-6316
    • Zou, C.1
  • 126
    • 84859294951 scopus 로고    scopus 로고
    • F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation
    • Chen, B. B. et al. F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Blood 119, 3132-3141 (2012).
    • (2012) Blood , vol.119 , pp. 3132-3141
    • Chen, B.B.1
  • 127
    • 84861340823 scopus 로고    scopus 로고
    • F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest
    • Chen, B. B., Glasser, J. R., Coon, T. A. & Mallampalli, R. K. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. Oncogene 31, 2566-2579 (2012).
    • (2012) Oncogene , vol.31 , pp. 2566-2579
    • Chen, B.B.1    Glasser, J.R.2    Coon, T.A.3    Mallampalli, R.K.4
  • 128
    • 84882581249 scopus 로고    scopus 로고
    • Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis
    • Chen, B. B., Glasser, J. R., Coon, T. A. & Mallampalli, R. K. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 4, e759 (2013).
    • (2013) Cell Death Dis. , vol.4
    • Chen, B.B.1    Glasser, J.R.2    Coon, T.A.3    Mallampalli, R.K.4
  • 129
    • 34249706792 scopus 로고    scopus 로고
    • FBXL5 interacts with p150Glued and regulates its ubiquitination
    • Zhang, N. et al. FBXL5 interacts with p150Glued and regulates its ubiquitination. Biochem. Biophys. Res. Commun. 359, 34-39 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.359 , pp. 34-39
    • Zhang, N.1
  • 130
    • 84872081370 scopus 로고    scopus 로고
    • F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
    • Ruiz, J. C., Walker, S. D., Anderson, S. A., Eisenstein, R. S. & Bruick, R. K. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. J. Biol. Chem. 288, 552-560 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 552-560
    • Ruiz, J.C.1    Walker, S.D.2    Anderson, S.A.3    Eisenstein, R.S.4    Bruick, R.K.5
  • 131
    • 80052698326 scopus 로고    scopus 로고
    • The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo
    • Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell. Metab. 14, 339-351 (2011).
    • (2011) Cell. Metab. , vol.14 , pp. 339-351
    • Moroishi, T.1    Nishiyama, M.2    Takeda, Y.3    Iwai, K.4    Nakayama, K.I.5
  • 132
    • 84868122688 scopus 로고    scopus 로고
    • Role of FBXL20 in human colorectal adenocarcinoma
    • Zhu, J., Li, K., Dong, L. & Chen, Y. Role of FBXL20 in human colorectal adenocarcinoma. Oncol. Rep. 28, 2290-2298 (2012).
    • (2012) Oncol. Rep. , vol.28 , pp. 2290-2298
    • Zhu, J.1    Li, K.2    Dong, L.3    Chen, Y.4
  • 133
    • 84864115547 scopus 로고    scopus 로고
    • MiR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia
    • Eisfeld, A. K. et al. miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia. Blood 120, 249-258 (2012).
    • (2012) Blood , vol.120 , pp. 249-258
    • Eisfeld, A.K.1
  • 134
    • 84874772651 scopus 로고    scopus 로고
    • FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
    • Hirano, A. et al. FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell 152, 1106-1118 (2013)
    • (2013) Cell , vol.152 , pp. 1106-1118
    • Hirano, A.1
  • 135
    • 79960343321 scopus 로고    scopus 로고
    • Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells
    • Meziane el, K., Randle, S. J., Nelson, D. E., Lomonosov, M. & Laman, H. Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. J. Cell Sci. 124, 2175-2186 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 2175-2186
    • Meziane El, K.1    Randle, S.J.2    Nelson, D.E.3    Lomonosov, M.4    Laman, H.5
  • 136
    • 3543047297 scopus 로고    scopus 로고
    • Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region
    • Hsu, J. M., Lee, Y. C., Yu, C. T. & Huang, C. Y. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J. Biol. Chem. 279, 32592-32602 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 32592-32602
    • Hsu, J.M.1    Lee, Y.C.2    Yu, C.T.3    Huang, C.Y.4
  • 137
    • 33644897044 scopus 로고    scopus 로고
    • The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination
    • Chang, Y. F., Cheng, C. M., Chang, L. K., Jong, Y. J. & Yuo, C. Y. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem. Biophys. Res. Commun. 342, 1022-1026 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 1022-1026
    • Chang, Y.F.1    Cheng, C.M.2    Chang, L.K.3    Jong, Y.J.4    Yuo, C.Y.5
  • 138
    • 27144506205 scopus 로고    scopus 로고
    • Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6
    • Laman, H. et al. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. EMBO J. 24, 3104-3116 (2005).
    • (2005) EMBO J. , vol.24 , pp. 3104-3116
    • Laman, H.1
  • 139
    • 79959260925 scopus 로고    scopus 로고
    • Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis
    • Lomonosov, M. et al. Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis. PLoS ONE 6, e21165 (2011).
    • (2011) PLoS ONE , vol.6
    • Lomonosov, M.1
  • 140
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita, K., Ichisaka, T. & Yamanaka, S. Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317 (2007).
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 141
    • 84867878045 scopus 로고    scopus 로고
    • Cancer stem cell definitions and terminology: The devil is in the details
    • Valent, P. et al. Cancer stem cell definitions and terminology: the devil is in the details. Nature Rev. Cancer 12, 767-775 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 767-775
    • Valent, P.1
  • 142
    • 0037383685 scopus 로고    scopus 로고
    • Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
    • Tokuzawa, Y. et al. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23, 2699-2708 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2699-2708
    • Tokuzawa, Y.1
  • 143
    • 84880026012 scopus 로고    scopus 로고
    • FBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
    • FBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer. EMBO Mol. Med. 5, 999-1018 (2013).
    • (2013) EMBO Mol. Med. , vol.5 , pp. 999-1018
    • Cepeda, D.1
  • 144
    • 0035941020 scopus 로고    scopus 로고
    • Identification of ubiquitin ligases required for skeletal muscle atrophy
    • Bodine, S. C. et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294, 1704-1708 (2001).
    • (2001) Science , vol.294 , pp. 1704-1708
    • Bodine, S.C.1
  • 145
    • 36049026136 scopus 로고    scopus 로고
    • Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    • Li, H. H. et al. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J. Clin. Invest. 117, 3211-3223 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3211-3223
    • Li, H.H.1
  • 146
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J. et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21, 1050-1063 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1050-1063
    • Tan, J.1
  • 147
    • 77649092118 scopus 로고    scopus 로고
    • Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer
    • Chou, J. L. et al. Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. Lab. Invest. 90, 414-425 (2010).
    • (2010) Lab. Invest. , vol.90 , pp. 414-425
    • Chou, J.L.1
  • 148
    • 79955666401 scopus 로고    scopus 로고
    • Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX
    • Song, M. H., Ha, J. C., Lee, S. M., Park, Y. M. & Lee, S. Y. Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX. Biochem. Biophys. Res. Commun. 408, 195-201 (2011).
    • (2011) Biochem. Biophys. Res. Commun. , vol.408 , pp. 195-201
    • Song, M.H.1    Ha, J.C.2    Lee, S.M.3    Park, Y.M.4    Lee, S.Y.5
  • 149
    • 84870337676 scopus 로고    scopus 로고
    • The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation
    • Lu, Y. et al. The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J. Biol. Chem. 287, 41014-41022 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 41014-41022
    • Lu, Y.1
  • 150
    • 69849083542 scopus 로고    scopus 로고
    • The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
    • Peschiaroli, A., Scialpi, F., Bernassola, F., Pagano, M. & Melino, G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 28, 3157-3166 (2009).
    • (2009) Oncogene , vol.28 , pp. 3157-3166
    • Peschiaroli, A.1    Scialpi, F.2    Bernassola, F.3    Pagano, M.4    Melino, G.5
  • 151
    • 67650088235 scopus 로고    scopus 로고
    • Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development
    • Saiga, T. et al. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol. Cell. Biol. 29, 3529-3543 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3529-3543
    • Saiga, T.1
  • 152
    • 84881192827 scopus 로고    scopus 로고
    • Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
    • Chan, C. H. et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154, 556-568 (2013).
    • (2013) Cell , vol.154 , pp. 556-568
    • Chan, C.H.1
  • 153
    • 47149092405 scopus 로고    scopus 로고
    • Skp2 results in p27-And Skp2-mediated cell-cycle arrest and activation of autophagy
    • Skp2 results in p27-And Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 111, 4690-4699 (2008).
    • (2008) Blood , vol.111 , pp. 4690-4699
    • Chen, Q.1
  • 154
    • 84871569969 scopus 로고    scopus 로고
    • Specific small molecule inhibitors of Skp2-mediated p27 degradation
    • Wu, L. et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem. Biol. 19, 1515-1524 (2012).
    • (2012) Chem. Biol. , vol.19 , pp. 1515-1524
    • Wu, L.1
  • 155
    • 84886546357 scopus 로고    scopus 로고
    • Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: Therapeutic potential for endometrial cancer
    • Pavlides, S. C. et al. Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer. Endocrinology 154, 4030-4045 (2013).
    • (2013) Endocrinology , vol.154 , pp. 4030-4045
    • Pavlides, S.C.1
  • 156
    • 79952261405 scopus 로고    scopus 로고
    • FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
    • FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471, 104-109 (2011).
    • (2011) Nature , vol.471 , pp. 104-109
    • Inuzuka, H.1
  • 157
    • 79952271269 scopus 로고    scopus 로고
    • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    • Wertz, I. E. et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471, 110-114 (2011)
    • (2011) Nature , vol.471 , pp. 110-114
    • Wertz, I.E.1
  • 158
    • 84863000735 scopus 로고    scopus 로고
    • Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase
    • Min, S. H. et al. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol. Cell 46, 771-783 (2012).
    • (2012) Mol. Cell , vol.46 , pp. 771-783
    • Min, S.H.1
  • 159
    • 84860740820 scopus 로고    scopus 로고
    • Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1
    • Wu, J. et al. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol. Cell 46, 351-361 (2012).
    • (2012) Mol. Cell , vol.46 , pp. 351-361
    • Wu, J.1
  • 160
    • 33748279259 scopus 로고    scopus 로고
    • Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
    • Miller, J. J. et al. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 20, 2410-2420 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 2410-2420
    • Miller, J.J.1
  • 161
    • 84897049814 scopus 로고    scopus 로고
    • Beyond ubiquitination: The atypical functions of Fbxo7 and other F-box proteins
    • Nelson, D. E., Randle, S. J. & Laman, H. Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biol. 3, 130131 (2013).
    • (2013) Open Biol. , vol.3 , pp. 130131
    • Nelson, D.E.1    Randle, S.J.2    Laman, H.3
  • 162
    • 84876434253 scopus 로고    scopus 로고
    • Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
    • Reavie, L. et al. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell 23, 362-375 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 362-375
    • Reavie, L.1
  • 163
    • 84876422526 scopus 로고    scopus 로고
    • Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence
    • Takeishi, S. et al. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 23, 347-361 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 347-361
    • Takeishi, S.1
  • 164
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal, N. et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333, 1154-1157 (2011).
    • (2011) Science , vol.333 , pp. 1154-1157
    • Agrawal, N.1
  • 165
    • 84870532434 scopus 로고    scopus 로고
    • Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
    • Le Gallo, M. et al. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nature Genet. 44, 1310-1315 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 1310-1315
    • Le Gallo, M.1
  • 166
    • 27144498420 scopus 로고    scopus 로고
    • Identification of mutations in CUL7 in 3-M syndrome
    • Huber, C. et al. Identification of mutations in CUL7 in 3-M syndrome. Nature Genet. 37, 1119-1124 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 1119-1124
    • Huber, C.1
  • 167
    • 0034022728 scopus 로고    scopus 로고
    • Five human genes encoding F-box proteins: Chromosome mapping and analysis in human tumors
    • Chiaur, D. S. et al. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. Cytogenet. Cell Genet. 88, 255-258 (2000).
    • (2000) Cytogenet. Cell Genet. , vol.88 , pp. 255-258
    • Chiaur, D.S.1
  • 168
    • 77952581198 scopus 로고    scopus 로고
    • Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress
    • Laulier, C., Cheng, A., Huang, N. & Stark, J. M. Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress. DNA Repair (Amst.) 9, 708-717 (2010).
    • (2010) DNA Repair (Amst.) , vol.9 , pp. 708-717
    • Laulier, C.1    Cheng, A.2    Huang, N.3    Stark, J.M.4
  • 169
    • 0036733716 scopus 로고    scopus 로고
    • Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
    • Signoretti, S. et al. Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J. Clin. Invest. 110, 633-641 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 633-641
    • Signoretti, S.1
  • 170
    • 0035942224 scopus 로고    scopus 로고
    • Skp2 is oncogenic and overexpressed in human cancers
    • Gstaiger, M. et al. Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl Acad. Sci. USA 98, 5043-5048 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5043-5048
    • Gstaiger, M.1
  • 171
    • 3042692332 scopus 로고    scopus 로고
    • Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes
    • Yokoi, S. et al. Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes. Am. J. Pathol. 165, 175-180 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 175-180
    • Yokoi, S.1
  • 172
    • 77649153374 scopus 로고    scopus 로고
    • Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion
    • Kanarek, N. et al. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion. Genes Dev. 24, 470-477 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 470-477
    • Kanarek, N.1
  • 173
    • 72949115258 scopus 로고    scopus 로고
    • An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (βTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese
    • Chen, S. et al. An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (βTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese. Biochem. Biophys. Res. Commun. 391, 552-556 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 552-556
    • Chen, S.1
  • 174
    • 33751223831 scopus 로고    scopus 로고
    • Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma
    • Scott, D. K. et al. Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma. Cell Cycle 5, 2381-2389 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 2381-2389
    • Scott, D.K.1
  • 175
    • 84863229317 scopus 로고    scopus 로고
    • FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis
    • Watanabe, T., Hikichi, Y., Willuweit, A., Shintani, Y. & Horiguchi, T. FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. J. Neurosci. 32, 3352-3365 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 3352-3365
    • Watanabe, T.1    Hikichi, Y.2    Willuweit, A.3    Shintani, Y.4    Horiguchi, T.5
  • 176
    • 34347373487 scopus 로고    scopus 로고
    • Global gene expression profiling in human lung cells exposed to cobalt
    • Malard, V. et al. Global gene expression profiling in human lung cells exposed to cobalt. BMC Genomics 8, 147 (2007).
    • (2007) BMC Genomics , vol.8 , pp. 147
    • Malard, V.1
  • 177
    • 84872159985 scopus 로고    scopus 로고
    • SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses
    • Takagi, H., Setou, M., Ito, S. & Yao, I. SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses. Neural Plast. 2012, 352829 (2012).
    • (2012) Neural Plast. , vol.2012 , pp. 352829
    • Takagi, H.1    Setou, M.2    Ito, S.3    Yao, I.4
  • 178
    • 34248359919 scopus 로고    scopus 로고
    • Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit
    • Nelson, R. F. et al. Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit. J. Neurosci. 27, 5163-5171 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 5163-5171
    • Nelson, R.F.1
  • 179
    • 79951698621 scopus 로고    scopus 로고
    • FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
    • Babaei-Jadidi, R. et al. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J. Exp. Med. 208, 295-312 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 295-312
    • Babaei-Jadidi, R.1
  • 180
    • 79955845570 scopus 로고    scopus 로고
    • FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development
    • Davis, H. et al. FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 224, 180-189 (2011).
    • (2011) J. Pathol. , vol.224 , pp. 180-189
    • Davis, H.1
  • 181
    • 80052645934 scopus 로고    scopus 로고
    • The F-box protein Fbw7 is required for cerebellar development
    • Jandke, A. et al. The F-box protein Fbw7 is required for cerebellar development. Dev. Biol. 358, 201-212 (2011).
    • (2011) Dev. Biol. , vol.358 , pp. 201-212
    • Jandke, A.1
  • 182
    • 84864000763 scopus 로고    scopus 로고
    • Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer
    • Grim, J. E. et al. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol. Cell. Biol. 32, 2160-2167 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 2160-2167
    • Grim, J.E.1
  • 183
    • 79953899846 scopus 로고    scopus 로고
    • Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells
    • Matsumoto, A. et al. Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J. Biol. Chem. 286, 13754-13764 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 13754-13764
    • Matsumoto, A.1
  • 184
    • 78049231370 scopus 로고    scopus 로고
    • Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
    • Hoeck, J. D. et al. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nature Neurosci. 13, 1365-1372 (2010).
    • (2010) Nature Neurosci. , vol.13 , pp. 1365-1372
    • Hoeck, J.D.1
  • 185
    • 84879384549 scopus 로고    scopus 로고
    • Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions
    • Sancho, R. et al. Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol. 11, e1001586 (2013).
    • (2013) PLoS Biol. , vol.11
    • Sancho, R.1
  • 186
    • 84862523798 scopus 로고    scopus 로고
    • Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development
    • Kwon, Y. W. et al. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol. Cancer Res. 10, 834-844 (2012).
    • (2012) Mol. Cancer Res. , vol.10 , pp. 834-844
    • Kwon, Y.W.1
  • 187
    • 0034595292 scopus 로고    scopus 로고
    • Targeted disruption of Skp2 results in accumulation of cyclin e and p27(Kip1), polyploidy and centrosome overduplication
    • Nakayama, K. et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081 (2000).
    • (2000) EMBO J. , vol.19 , pp. 2069-2081
    • Nakayama, K.1
  • 188
    • 34948821871 scopus 로고    scopus 로고
    • Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
    • Zhong, L., Georgia, S., Tschen, S. I., Nakayama, K. & Bhushan, A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells. J. Clin. Invest. 117, 2869-2876 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2869-2876
    • Zhong, L.1    Georgia, S.2    Tschen, S.I.3    Nakayama, K.4    Bhushan, A.5
  • 189
    • 33847250516 scopus 로고    scopus 로고
    • Skp2 controls adipocyte proliferation during the development of obesity
    • Sakai, T. et al. Skp2 controls adipocyte proliferation during the development of obesity. J. Biol. Chem. 282, 2038-2046 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 2038-2046
    • Sakai, T.1
  • 190
    • 34248341002 scopus 로고    scopus 로고
    • Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice
    • Fotovati, A., Nakayama, K. & Nakayama, K. I. Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice. Cell Div. 1, 4 (2006).
    • (2006) Cell Div. , vol.1 , pp. 4
    • Fotovati, A.1    Nakayama, K.2    Nakayama, K.I.3
  • 191
    • 0036172085 scopus 로고    scopus 로고
    • Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice
    • Minamishima, Y. A. & Nakayama, K. Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res. 62, 995-999 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 995-999
    • Minamishima, Y.A.1    Nakayama, K.2
  • 192
    • 52649104330 scopus 로고    scopus 로고
    • Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease
    • Agarwal, A. et al. Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease. Blood 112, 1960-1970 (2008).
    • (2008) Blood , vol.112 , pp. 1960-1970
    • Agarwal, A.1
  • 193
    • 84862070506 scopus 로고    scopus 로고
    • Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies
    • Kratzat, S. et al. Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies. PLoS ONE 7, e37433 (2012).
    • (2012) PLoS ONE , vol.7
    • Kratzat, S.1
  • 194
    • 7544220618 scopus 로고    scopus 로고
    • Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
    • Kossatz, U. et al. Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev. 18, 2602-2607 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2602-2607
    • Kossatz, U.1
  • 195
    • 79959440818 scopus 로고    scopus 로고
    • Skp2 is necessary for Myc-induced keratinocyte proliferation but
    • Sistrunk, C., Macias, E., Nakayama, K., Kim, Y. & Rodriguez-Puebla, M. L. Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium. Am. J. Pathol. 178, 2470-2477 (2011).
    • (2011) Am. J. Pathol. , vol.178 , pp. 2470-2477
    • Sistrunk, C.1    Macias, E.2    Nakayama, K.3    Kim, Y.4    Rodriguez-Puebla, M.L.5
  • 196
  • 197
    • 81555196348 scopus 로고    scopus 로고
    • The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
    • Wang, J. et al. The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal. Blood 118, 5429-5438 (2011).
    • (2011) Blood , vol.118 , pp. 5429-5438
    • Wang, J.1
  • 198
    • 70349336998 scopus 로고    scopus 로고
    • Abnormal retinal development in the Btrc null mouse
    • Baguma-Nibasheka, M. & Kablar, B. Abnormal retinal development in the Btrc null mouse. Dev. Dyn. 238, 2680-2687 (2009).
    • (2009) Dev. Dyn. , vol.238 , pp. 2680-2687
    • Baguma-Nibasheka, M.1    Kablar, B.2


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