Fbxw7-dependent degradation of notch is required for control of "Stemness" and neuronal-glial differentiation in neural stem cells

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 13754-13764

  Matsumoto, Akinobu ^a,b   Onoyama, Ichiro ^a,b   Sunabori, Takehiko ^c   Kageyama, Ryoichiro ^b,d   Okano, Hideyuki ^c   Nakayama, Keiichi I ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DEVELOPMENT; IN-VITRO; IN-VIVO; KEY REGULATORS; MUTANT MICE; NEURAL PROGENITOR CELLS; NEURAL STEM CELL; NOTCH SIGNALING PATHWAYS; PHARMACOLOGICAL INHIBITORS; PROTEIN SUBUNITS; TARGET GENES; UBIQUITIN LIGASES; UP-REGULATION;

BRAIN; DEGRADATION; GENES; MAINTENANCE; SIGNALING;

STEM CELLS;

F BOX PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN; CELL COUNT; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CRE GENE; FBXW7 GENE; GENE; GENE TARGETING; GLIA CELL; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NERVOUS SYSTEM DEVELOPMENT; NESTIN GENE; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; BRAIN; CELL DIFFERENTIATION; F-BOX PROTEINS; MICE; MICE, KNOCKOUT; NEUROGLIA; NEURONS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; SKP CULLIN F-BOX PROTEIN LIGASES; STEM CELLS; UBIQUITIN-PROTEIN LIGASES;

MUS;

EID: 79953899846     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.194936     Document Type: Article

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