SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

Science

Volumn 316, Issue 5826, 2007, Pages 900-904

  Busino, Luca ^a   Bassermann, Florian ^a   Maiolica, Alessio ^b   Lee, Choogon ^c   Nolan, Patrick M ^d   Godinho, Sofia I H ^d   Draetta, Giulio F ^e   Pagano, Michele ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME; CRYPTOCHROME 1; CRYPTOCHROME 2; F BOX PROTEIN; PER1 PROTEIN; PER2 PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; FBXL3 PROTEIN, HUMAN; FBXL3 PROTEIN, MOUSE; FLAVOPROTEIN; NUCLEAR PROTEIN; PER1 PROTEIN, MOUSE; PER2 PROTEIN, MOUSE; PROTEIN BMAL1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; UBIQUITIN;

BIODEGRADATION; CIRCADIAN RHYTHM; GENE EXPRESSION; INHIBITOR; PROTEIN; TUMOR;

ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME REGULATION; HUMAN; HUMAN CELL; OSCILLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ANIMAL; CELL CULTURE; CELL STRAIN 3T3; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; MOUSE; PROMOTER REGION; RNA INTERFERENCE;

MAMMALIA;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CELLS, CULTURED; CIRCADIAN RHYTHM; F-BOX PROTEINS; FLAVOPROTEINS; HELA CELLS; HUMANS; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; SKP CULLIN F-BOX PROTEIN LIGASES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; UBIQUITIN;

EID: 34248566788     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1141194     Document Type: Article

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22. We thank L. DiMarcotullio, J. Blau, D. Frescas, J. Rappsilber, and J. Skaar for suggestions; D. Virshup and P. Minoo for reagents; I. Takakashi for Tim cDNA and for communicating unpublished results; and T. M. Thor for support. This work was supported by NIH grants R37-CA76584, R01-GMS7S87, and R21-CA125173, the New York State Breast Cancer Research and Education Fund, the American Italian Cancer Foundation, and the Deutsche Forschungsgemeinschaft.