SCF FBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

Nature

Volumn 496, Issue 7443, 2013, Pages 64-68

  Xing, Weiman ^a,b   Busino, Luca ^c   Hinds, Thomas R ^a   Marionni, Samuel T ^b   Saifee, Nabiha H ^a   Bush, Matthew F ^b   Pagano, Michele ^c   Zheng, Ning ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; F BOX PROTEIN; FLAVINE ADENINE NUCLEOTIDE; UBIQUITIN PROTEIN LIGASE;

CHEMICAL BINDING; CRYSTAL STRUCTURE; ENZYME ACTIVITY; PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DNA DAMAGE; EMBRYO; F BOX MOTIF; FIBROBLAST; GENE FUSION; GENETIC TRANSCRIPTION; HYDROGEN BOND; MAMMAL CELL; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; REGULATORY MECHANISM; UBIQUITINATION;

ANIMALS; APOPROTEINS; BINDING SITES; CRYPTOCHROMES; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; DROSOPHILA MELANOGASTER; F-BOX PROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; S-PHASE KINASE-ASSOCIATED PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; SUBSTRATE SPECIFICITY;

HEXAPODA; MAMMALIA;

EID: 84875899177     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11964     Document Type: Article

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