CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 42, 2013, Pages 16868-16873

  Kim, Tai Young ^a,b   Jackson, Sarah ^a,b   Xiong, Yue ^a,b   Whitsett, Timothy G ^c   Lobello, Janine R ^c   Weiss, Glen J ^c,d   Le Tran, Nhan ^c   Bang, Yung Jue ^e   Der, Channing J ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^d CANCER TREATMENT CENTERS OF AMERICA   (United States)

^e Seoul National University   (South Korea)

Author keywords

Rho GTPase activating protein 7; Rho selective GTPase activating protein; STARD12

Indexed keywords

CULLIN 4A RING UBIQUITIN LIGASE; DDB1 PROTEIN; DELETED IN HUMAN LIVER CANCER 1 PROTEIN; DNA BINDING PROTEIN; F BOX PROTEIN; FBXW5 PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MESSENGER RNA; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME DEGRADATION; GENE DELETION; GENE FUNCTION; GENE SILENCING; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PROCESSING; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

RHO GTPASE-ACTIVATING PROTEIN 7; RHO-SELECTIVE GTPASE-ACTIVATING PROTEIN; STARD12;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CULLIN PROTEINS; DNA-BINDING PROTEINS; F-BOX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MULTIENZYME COMPLEXES; PROTEOLYSIS; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

EID: 84885706043     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306358110     Document Type: Article

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