Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Lomonosov, Mikhail ^a   Meziane, El Kahina ^a   Ye, Hongtao ^a,b   Nelson, David E ^a   Randle, Suzanne J ^a   Laman, Heike ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; F BOX PROTEIN; PROTEIN FBXO7; PROTEIN P53; STEM CELL FACTOR; UNCLASSIFIED DRUG; FBXO7 PROTEIN, HUMAN; ONCOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; HEMATOPOIETIC STEM CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOMAGENESIS; MEMBRANE RECONSTITUTION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T CELL LYMPHOMA; TRANSCRIPTION REGULATION; ANIMAL; CELL DIVISION; CYTOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LYMPHOMA; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; F-BOX PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; LYMPHOMA; MICE; ONCOGENE PROTEINS; STEM CELL FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79959260925     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021165     Document Type: Article

References (43)

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, et al. (1999) Identification of a family of human F-box proteins. Curr Biol 9: 1177-9.
2. Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C, (2000) cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Genomics 67: 40-7.
3. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW, (1999) A family of mammalian F-box proteins. Curr Biol 9: 1180-2.
4. Ho MS, Ou C, Chan YR, Chien CT, Pi H, (2008) The utility F-box for protein destruction. Cell Mol Life Sci 65: 1977-2000.
5. Ang XL, Wade HJ, (2005) SCF-mediated protein degradation and cell cycle control. Oncogene 24: 2860-2870.
6. Hershko A, (1997) Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr Opin Cell Biol 9: 788-99.
7. Hershko A, Ciechanover A, (1998) The ubiquitin system. Annu Rev Biochem 67: 425-479.
8. Hermand D, (2006) F-box proteins: more than baits for the SCF? Cell Div 1: 30.
9. Hsu JM, Lee YC, Yu CT, Huang CY, (2004) Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J Biol Chem 279: 32592-602.
10. Chang YF, Cheng CM, Chang LK, Jong YJ, Yuo CY, (2006) The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem Biophys Res Commun 342: 1022-1026.
11. Laman H, Funes JM, Ye H, Henderson S, Galinanes-Garcia L, et al. (2005) Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. Embo J 24: 3104-16.
12. Laman H, (2006) Fbxo7 gets proactive with cyclin D/cdk6. Cell Cycle 2006 Feb; 5 (3): 279-82 Epub 2006 Feb 8 5: 279-282.
13. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, et al. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 14: 2066-76.
14. Fujimoto T, Anderson K, Jacobsen SE, Nishikawa SI, Nerlov C, (2007) Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. Embo J 26: 2361-2370.
15. Grossel MJ, Hinds PW, (2006) From Cell Cycle to Differentiation: An Expanding Role for Cdk6. Cell Cycle 5: 266-270.
16. Grossel MJ, Hinds PW, (2006) Beyond the cell cycle: a new role for Cdk6 in differentiation. J Cell Biochem 97: 485-493.
17. Matushansky I, Radparvar F, Skoultchi AI, (2003) CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 22: 4143-4149.
18. Brown G, Hughes PJ, Michell RH, (2003) Cell differentiation and proliferation-simultaneous but independent? Exp Cell Res 291: 282-288.
19. Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, et al. (2004) Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6. Cell 118: 493-504.
20. Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, et al. (2009) A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res 69: 810-818.
21. Hayette S, Tigaud I, Callet-Bauchu E, Ffrench M, Gazzo S, et al. (2003) In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene. Blood 102: 1549-1550.
22. Corcoran MM, Mould SJ, Orchard JA, Ibbotson RE, Chapman RM, et al. (1999) Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. Oncogene 18: 6271-6277.
23. Heyworth CM, Whetton AD, Nicholls S, Zsebo K, Dexter TM, (1992) Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors. Blood 80: 2230-2236.
24. Cherry SR, Biniszkiewicz D, van Parijs L, Baltimore D, Jaenisch R, (2000) Retroviral expression in embryonic stem cells and hematopoietic stem cells. Mol Cell Biol 20: 7419-7426.
25. Lorincz MC, Schubeler D, Hutchinson SR, Dickerson DR, Groudine M, (2002) DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation. Mol Cell Biol 22: 7572-7580.
26. Lorincz MC, Schubeler D, Goeke SC, Walters M, Groudine M, et al. (2000) Dynamic analysis of proviral induction and De Novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression. Mol Cell Biol 20: 842-850.
27. Osborne CS, Pasceri P, Singal R, Sukonnik T, Ginder GD, et al. (1999) Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells. J Virol 73: 5490-5496.
28. Swindle CS, Kim HG, Klug CA, (2004) Mutation of CpGs in the murine stem cell virus retroviral vector long terminal repeat represses silencing in embryonic stem cells. J Biol Chem 279: 34-41.
29. Ostrand-Rosenberg S, Sinha P, (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182: 4499-4506.
30. Ribechini E, Greifenberg V, Sandwick S, Lutz MB, (2010) Subsets, expansion and activation of myeloid-derived suppressor cells. Med Microbiol Immunol.
31. Gabrilovich DI, Nagaraj S, (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9: 162-174.
32. Nagaraj S, Gabrilovich DI, (2010) Myeloid-derived suppressor cells in human cancer. Cancer J 16: 348-353.
33. Condamine T, Gabrilovich DI, (2011) Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol 32: 19-25.
34. Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, et al. (2005) p53 is a suppressor of inflammatory response in mice. FASEB J 19: 1030-1032.
35. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, et al. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
36. Sun SC, (2011) Non-canonical NF-kappaB signaling pathway. Cell Res 21: 71-85.
37. Gyrd-Hansen M, Meier P, (2010) IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 10: 561-574.
38. Varfolomeev E, Vucic D, (2008) (Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways. Cell Cycle 7: 1511-1521.
39. Liu X, Wang B, Ma X, Guo Y, (2009) NF-kappaB activation through the alternative pathway correlates with chemoresistance and poor survival in extranodal NK/T-cell lymphoma, nasal type. Jpn J Clin Oncol 39: 418-424.
40. Schneider G, Kramer OH, (2011) NFkappaB/p53 crosstalk-a promising new therapeutic target. Biochim Biophys Acta 1815: 90-103.
41. Hawley RG, Lieu FH, Fong AZ, Hawley TS, (1994) Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1: 136-138.
42. Muller AJ, Young JC, Pendergast AM, Pondel M, Landau NR, et al. (1991) BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol Cell Biol 11: 1785-1792.
43. Card GL, Knowles P, Laman H, Jones N, McDonald NQ, (2000) Crystal structure of a γ-herpesvirus cyclin-cdk complex. EMBO J 19: 1-12.