Fbw7 Repression by Hes5 Creates a Feedback Loop That Modulates Notch-Mediated Intestinal and Neural Stem Cell Fate Decisions

PLoS Biology

Volumn 11, Issue 6, 2013, Pages

  Sancho, Rocio ^a   Blake, Sophia M ^a   Tendeng, Christian ^a   Clurman, Bruce E ^b   Lewis, Julian ^a   Behrens, Axel ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; TRANSCRIPTION FACTOR HES 5; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EMBRYO; FBW7 GENE; FEEDBACK SYSTEM; GENE REPRESSION; HAPLOINSUFFICIENCY; HETEROZYGOSITY; INTESTINE CELL; MOUSE; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL COUNT; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; F-BOX PROTEINS; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; GENETIC LOCI; GOBLET CELLS; HAPLOINSUFFICIENCY; HCT116 CELLS; HUMANS; INTESTINES; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NEURAL STEM CELLS; RECEPTORS, NOTCH; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

MUS;

EID: 84879384549     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001586     Document Type: Article

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