Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation

Biochemical and Biophysical Research Communications

Volumn 426, Issue 1, 2012, Pages 59-64

  Kanei Ishii, Chie ^a   Nomura, Teruaki ^a   Egoh, Ayako ^a   Ishii, Shunsuke ^a  

^a RIKEN TSUKUBA INSTITUTE   (Japan)

Author keywords

C Myb; Fbxw5; Sumoylation; Ubiquitination

Indexed keywords

F BOX PROTEIN; FBXW5 PROTEIN; PROTEIN C MYB; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOSOL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SUMOYLATION; UBIQUITINATION; WILD TYPE;

ANIMALS; CARRIER PROTEINS; CELL LINE; CULLIN PROTEINS; DNA-BINDING PROTEINS; F-BOX PROTEINS; HEK293 CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-MYB; SUMOYLATION; UBIQUITIN-PROTEIN LIGASES;

EID: 84866322433     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.032     Document Type: Article

References (29)

1. Mucenski M.L., McLain K., Kier A.B., Swerdlow S.H., Schereiner C.M., Miller T.A., Pietryga D.W., Scott W.J., Potter S.S. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 1991, 65:677-689.
2. Malaterre J., Carpinelli M., Ernst M., Alexander W., Cooke M., Sutton S., Dworkin S., Heath J.K., Frampton J., McArthur G., Clevers H., Hilton D., Mantamadiotis T., Ramsay R.G. c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc. Natl. Acad. Sci. USA 2007, 104:3829-3834.
3. Drabsch Y., Hugo H., Zhang R., Dowhan D.H., Miao Y.R., Gewirtz A.M., Barry S.C., Ramsay R.G., Gonda T.J. Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc. Natl. Acad. Sci. USA 2007, 104:13762-13767.
4. Bender T.P., Kremer C.S., Kraus M., Buch T., Rajewsky K. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat. Immunol. 2004, 5:721-729.
5. Sakura H., Kanei-Ishii C., Nagase T., Nakagoshi H., Gonda T.J., Ishii S. Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proc. Natl. Acad. Sci. USA 1989, 86:5758-5762.
6. Ogata K., Morikawa S., Nakamura H., Sekikawa A., Inoue T., Kanai H., Sarai A., Ishii S., Nishimura Y. Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell 1994, 79:639-648.
7. Dai P., Akimaru H., Tanaka Y., Hou D.X., Yasukawa T., Kanei-Ishii C., Takahashi T., Ishii S. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 1996, 10:528-540.
8. Nakagoshi H., Kanei-Ishii C., Sawazaki T., Mizuguchi G., Ishii S. Transcriptional activation of the c-myc gene by the c-myb and B-myb gene products. Oncogene 1992, 7:1233-1240.
9. Frampton J., Ramqvist T., Graf T. V-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells. Genes Dev. 1996, 10:2720-2731.
10. Taylor D., Badiani P., Weston K. A dominant interfering Myb mutant causes apoptosis in T cells. Genes Dev. 1996, 10:2732-2744.
11. Kowenz-Leutz E., Herr P., Niss K., Leutz A. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. Cell 1997, 91:185-195.
12. Klempnauer K.H., Gonda T.J., Bishop J.M. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell 1982, 31:453-463.
13. Gonda T.J., Buckmaster C., Ramsay R.G. Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro. EMBO J. 1989, 8:1777-1783.
14. Hu Y.L., Ramsay R.G., Kanei-Ishii C., Ishii S., Gonda T.J. Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain. Oncogene 1991, 6:1549-1553.
15. Ladendorff N.E., Wu S., Lipsick J.S. BS69, an adenovirus E1A-associated protein, inhibits the transcriptional activity of c-Myb. Oncogene. 2001, 20:125-132.
16. Nomura T., Tanikawa J., Akimaru H., Kanei-Ishii C., Ichikawa-Iwata E., Khan M.M., Ito H., Ishii S. Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1β and Ski. J. Biol. Chem. 2004, 279:16715-16726.
17. Kanei-Ishii C., Ninomiya-Tsuji J., Tanikawa J., Nomura T., Ishitani T., Kishida S., Kokura K., Kurahashi T., Ichikawa-Iwata E., Kim Y., Matsumoto K., Ishii S. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004, 18:816-829.
18. Kanei-Ishii C., Nomura T., Takagi T., Watanabe N., Nakayama K.I., Ishii S. Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J. Biol. Chem. 2008, 283:30540-30548.
19. Kanei-Ishii C., Nomura T., Tanikawa J., Ichikawa-Iwata E., Ishii S. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J. Biol. Chem. 2004, 279:44582-44589.
20. Bies J., Markus J., Wolff L. Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J. Biol. Chem. 2002, 277:8999-9009.
21. Dahle Ø., Andersen T.Ø., Nordgård O., Matre V., Del Sal G., Gabrielsen O.S. Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner. Eur. J. Biochem. 2003, 270:1338-1348.
22. Sramko M., Markus J., Kabát J., Wolff L., Bies J. Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins. J. Biol. Chem. 2006, 281:40065-40075.
23. Morita Y., Kanei-Ishii C., Nomura T., Ishii S. TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Mol. Biol. Cell 2005, 16:5433-5444.
24. Hu J., Zacharek S., He Y.J., Lee H., Shumway S., Duronio R.J., Xiong Y. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev. 2008, 22:866-871.
25. Hay R.T. SUMO: A history of modification. Mol. Cell 2005, 18:1-12.
26. Rajendra R., Malegaonkar D., Pungaliya P., Marshall H., Rasheed Z., Brownell J., Liu L.F., Lutzker S., Saleem A., Rubin E.H. Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J. Biol. Chem. 2004, 279:36440-36444.
27. Weger S., Hammer E., Heilbronn R. Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. FEBS Lett. 2005, 579:5007-5012.
28. Heun P. SUMOrganization of the nucleus. Curr. Opin. Cell Biol. 2007, 19:350-355.
29. Saitoh H., Hinchey J. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J. Biol. Chem. 2000, 275:6252-6258.