FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

Nature Cell Biology

Volumn 15, Issue 5, 2013, Pages 472-480

  Kuchay, Shafi ^a,b   Duan, Shanshan ^a   Schenkein, Emily ^a   Peschiaroli, Angelo ^a,e   Saraf, Anita ^c   Florens, Laurence ^c   Washburn, Michael P ^c,d   Pagano, Michele ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^e CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

F BOX PROTEIN; F BOX PROTEIN L2; INSULIN RECEPTOR SUBSTRATE 1; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 13; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN P85 BETA; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

AUTOPHAGY; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME ACTIVATION; ENZYME STABILITY; F-BOX PROTEINS; GENE SILENCING; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; INSULIN RECEPTOR SUBSTRATE PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13; PROTEOLYSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TYROSINE; UBIQUITINATION;

EID: 84877577024     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2731     Document Type: Article

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