Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells

Cell Cycle

Volumn 5, Issue 14, 2006, Pages 1569-1573

  Lehman, Norman L ^a,b   Verschuren, Emmy W ^a,b   Hsu, Jerry Y ^b   Cherry, Athena M ^a   Jackson, Peter K ^a,b,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c GENENTECH INC   (United States)

Author keywords

Anaphase promoting complex cyclosome; Emi1; Genomic instability; p53; Tetraploidy

Indexed keywords

ANAPHASE PROMOTING COMPLEX; PROTEIN; PROTEIN EMI1; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DEFENSE MECHANISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC MODEL; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOSIS; PROTEIN DEGRADATION; TETRAPLOIDY;

EID: 33746225420     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.14.2925     Document Type: Article

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