F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

Nature

Volumn 459, Issue 7247, 2009, Pages 722-725

  Santra, Manas K ^a   Wajapeyee, Narendra ^a   Green, Michael R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CYCLIN D1; DNA; F BOX PROTEIN; F BOX PROTEIN 31; PROTEASOME; RNA; THREONINE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; CELL CYCLE PROTEIN; CYSTEINE PROTEINASE INHIBITOR; DNA BINDING PROTEIN; DRUG DERIVATIVE; FBXO31 PROTEIN, HUMAN; LACTACYSTIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

CANCER; DNA; GENE EXPRESSION; GROWTH RESPONSE; HETEROZYGOSITY; INHIBITION; PROTEIN; TUMOR;

ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GAMMA IRRADIATION; GENOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; STRESS; DRUG EFFECT; GENETICS; MELANOMA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE; UBIQUITINATION;

EUKARYOTA;

ACETYLCYSTEINE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN D1; CYSTEINE PROTEINASE INHIBITORS; DNA DAMAGE; DNA-BINDING PROTEINS; F-BOX PROTEINS; G1 PHASE; HUMANS; MELANOMA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

EID: 66649117243     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08011     Document Type: Article

References (23)

1. Bartkova, J. et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637 (2006).
2. Di Micco, R. et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642 (2006).
3. Mallette, F. A., Gaumont-Leclerc, M. F. & Ferbeyre, G. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev. 21, 43-48 (2007).
4. Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M. & Green, M. R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132, 363-374 (2008).
5. Lin, Y. W. et al. Deletion mapping of chromosome 16q24 in hepatocellular carcinoma in Taiwan and mutational analysis of the 17b-HSD gene localized to the region. Int. J. Cancer 93, 74-79 (2001).
6. Launonen, V. et al. Loss of heterozygosity at chromosomes 3, 6, 8, 11, 16, and 17 in ovarian cancer: correlation to clinicopathological variables. Cancer Genet. Cytogenet. 122, 49-54 (2000).
7. Harkonen, P., Kyllonen, A. P., Nordling, S. & Vihko, P. Loss of heterozygosity in chromosomal region 16q24.3 associated with progression of prostate cancer. Prostate 62, 267-274 (2005).
8. Miller, B. J., Wang, D., Krahe, R. & Wright, F. A. Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions. Am. J. Hum. Genet. 73, 748-767 (2003).
9. Kumar, R. et al. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res. 65, 11304-11313 (2005).
10. Ho, M. S., Tsai, P. I. & Chien, C. T. F-box proteins: the key to protein degradation. J. Biomed. Sci. 13, 181-191 (2006).
11. Alao, J. P. The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol. Cancer 6, 24 (2007).
12. Diehl, J. A., Zindy, F. & Sherr, C. J. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11, 957-972 (1997).
13. Diehl, J. A., Cheng, M., Roussel, M. F. & Sherr, C. J. Glycogen synthase kinase-3b regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12, 3499-3511 (1998).
14. Okabe, H. et al. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1, e128 (2006).
15. Agami, R. & Bernards, R. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102, 55-66 (2000).
16. Shiloh, Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem. Sci. 31, 402-410 (2006).
17. Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672 (1996).
18. Zhou, B. B. & Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
19. Matsuoka, S. et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166 (2007).
20. FBX4-αB crystallin complex. Mol. Cell 24, 355-366 (2006).
21. Newman, R. M. et al. Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J. Biol. Chem. 279, 41504-41511 (2004).
22. Gazin, C., Wajapeyee, N., Gobeil, S., Virabasius, C. M. & Green, M. R. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449, 1073-1077 (2007).
23. Canman, C. E. et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679 (1998).