Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Kratzat, Susanne ^a   Nikolova, Viktoriya ^a   Miething, Cornelius ^a   Hoellein, Alexander ^a   Schoeffmann, Stephanie ^a   Gorka, Oliver ^a   Pietschmann, Elke ^a   Illert, Anna Lena ^a   Ruland, Jürgen ^a   Peschel, Christian ^a   Nilsson, Jonas ^b   Duyster, Justus ^a   Keller, Ulrich ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 1; MYC PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; CKS1 PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE; GREEN FLUORESCENT PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; BONE MARROW TRANSPLANTATION; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSDUCTION; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL; LYMPHOCYTE PROLIFERATION; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PROTEIN EXPRESSION; RETROVIRUS; T LYMPHOCYTE; TUMOR CELL; TUMOR GROWTH; ANIMAL; BLOOD DISEASE; BONE MARROW; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW; CDC2-CDC28 KINASES; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HEMATOLOGIC NEOPLASMS; IMMUNOBLOTTING; LYMPHOMA, B-CELL; MICE; MICE, TRANSGENIC; NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RETROVIRIDAE;

EID: 84862070506     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037433     Document Type: Article

References (41)

1. Slingerland J, Pagano M, (2000) Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 183: 10-17.
2. Sherr CJ, Roberts JM, (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512.
3. Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, et al. (1996) Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85: 721-732.
4. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, et al. (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85: 733-744.
5. Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, et al. (1996) Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707-720.
6. Coats S, Whyte P, Fero ML, Lacy S, Chung G, et al. (1999) A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr Biol 9: 163-173.
7. Chu IM, Hengst L, Slingerland JM, (2008) The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 8: 253-267.
8. Carrano AC, Eytan E, Hershko A, Pagano M, (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1: 193-199.
9. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, et al. (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269: 682-685.
10. Krek W, (1998) Proteolysis and the G1-S transition: the SCF connection. Curr Opin Genet Dev 8: 36-42.
11. Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, et al. (2005) Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell 20: 9-19.
12. Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, et al. (2001) The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 3: 321-324.
13. Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, et al. (2001) A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell 7: 639-650.
14. Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, et al. (2000) Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 19: 2069-2081.
15. Bourne Y, Watson MH, Hickey MJ, Holmes W, Rocque W, et al. (1996) Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell 84: 863-874.
16. Morris MC, Heitz F, Divita G, (1998) Kinetics of dimerization and interactions of p13suc1 with cyclin-dependent kinases. Biochemistry 37: 14257-14266.
17. Wolthuis R, Clay-Farrace L, van Zon W, Yekezare M, Koop L, et al. (2008) Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol Cell 30: 290-302.
18. Wang XC, Tian LL, Tian J, Wu HL, Meng AM, (2009) Overexpression of Cks1 is associated with poor survival by inhibiting apoptosis in breast cancer (Retracted Article. See vol 136, pg 637, 2010). Journal of Cancer Research and Clinical Oncology 135: 1393-1401.
19. Slotky M, Shapira M, Ben-Izhak O, Linn S, Futerman B, et al. (2005) The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. Breast Cancer Research 7: R737-R744.
20. Su AI, Welsh JB, Sapinoso LM, Kern SG, Dimitrov P, et al. (2001) Molecular classification of human carcinomas by use of gene expression signatures. Cancer Research 61: 7388-7393.
21. Inui N, Kitagawa K, Miwa S, Hattori T, Chida K, et al. (2003) High expression of Cks1 in human non-small cell lung carcinomas. Biochemical and Biophysical Research Communications 303: 978-984.
22. Lan YS, Zhang YY, Wang JH, Lin CH, Ittmann MM, et al. (2008) Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. International Journal of Cancer 123: 543-551.
23. Wong YF, Cheung TH, Tsao GSW, Lo KWK, Yim SF, et al. (2006) Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. International Journal of Cancer 118: 2461-2469.
24. Li MH, Lin YM, Hasegawa S, Shimokawa T, Murata K, et al. (2004) Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. International Journal of Oncology 24: 305-312.
25. Chang H, Jiang N, Jiang H, Saha MN, Qi C, et al. (2010) CKS1B nuclear expression is inversely correlated with p27Kip1 expression and is predictive of an adverse survival in patients with multiple myeloma. Haematologica 95: 1542-1547.
26. Chang H, Qi X, Trieu Y, Xu W, Reader JC, et al. (2006) Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantation. Br J Haematol 135: 486-491.
27. Keller UB, Old JB, Dorsey FC, Nilsson JA, Nilsson L, et al. (2007) Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J 26: 2562-2574.
28. Old JB, Kratzat S, Hoellein A, Graf S, Nilsson JA, et al. (2010) Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. Mol Cancer Res 8: 353-362.
29. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, et al. (1985) The C-Myc Oncogene Driven by Immunoglobulin Enhancers Induces Lymphoid Malignancy in Transgenic Mice. Nature 318: 533-538.
30. Miething C, Feihl S, Mugler C, Grundler R, von Bubnoff N, et al. (2006) The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib. Leukemia 20: 650-657.
31. Frescas D, Pagano M, (2008) Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 8: 438-449.
32. Bloom J, Pagano M, (2003) Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol 13: 41-47.
33. Nakayama KI, Nakayama K, (2005) Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol 16: 323-333.
34. Martins CP, Berns A, (2002) Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J 21: 3739-3748.
35. Lin HK, Chen Z, Wang G, Nardella C, Lee SW, et al. (2010) Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 464: 374-379.
36. Latres E, Chiarle R, Schulman BA, Pavletich NP, Pellicer A, et al. (2001) Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A 98: 2515-2520.
37. Shim EH, Johnson L, Noh HL, Kim YJ, Sun H, et al. (2003) Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Cancer Res 63: 1583-1588.
38. Liberal V, Martinsson-Ahlzen HS, Liberal J, Spruck CH, Widschwendter M, et al. (2011) Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins. Proc Natl Acad Sci U S A.
39. Supriatno, Harada K, Kawaguchi S, Yoshida H, Sato M, (2003) Effect of p27Kip1 on the ability of invasion and metastasis of an oral cancer cell line. Oncol Rep 10: 527-532.
40. Oostendorp RA, Harvey KN, Kusadasi N, de Bruijn MF, Saris C, et al. (2002) Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity. Blood 99: 1183-1189.
41. den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, et al. (2010) Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood.