Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor

Molecular and Cellular Biology

Volumn 27, Issue 21, 2007, Pages 7615-7622

  Umanskaya, Karina ^a   Radke, Susanne ^a   Chander, Harish ^a   Monardo, Rosie ^a   Xu, Xinsong ^a   Pan, Zhen Qiang ^a   O'Connell, Matthew J ^a   Germain, Doris ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; F BOX PROTEIN; REPRESSOR OF THE ESTROGEN RECEPTOR; S PHASE KINASE ASSOCIATED PROTEIN 2; S PHASE KINASE ASSOCIATED PROTEIN 2B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; HETEROZYGOTE; MAMMARY GLAND; MOUSE; NONHUMAN; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE;

ADIPOSE TISSUE; ANIMALS; CELL DIFFERENTIATION; CYSTS; FEMALE; HUMANS; HYPERPLASIA; MAMMARY GLANDS, ANIMAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; NEOPLASMS; PROTEIN BINDING; RECEPTORS, ESTROGEN; REPRESSOR PROTEINS; S-PHASE KINASE-ASSOCIATED PROTEINS; SEXUAL BEHAVIOR; SEXUAL MATURATION; TRANSCRIPTION, GENETIC; UBIQUITIN;

MOUSE MAMMARY TUMOR VIRUS; MUS; MUS MUSCULUS;

EID: 35648940733     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01239-07     Document Type: Article

References (21)

1. Allar, M. A., and T. L. Wood. 2004. Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland. Endocrinology 145:2467-2477.
2. Boutinaud, M., J. H. Shand, M. A. Park, K. Phillips, J. Beattie, D. J. Flint, and G. J. Allan. 2004. A quantitative RT-PCR study of the mRNA expression profile of the IGF axis during mammary gland development. J. Mol. Endocrinol. 33:195-207.
3. Brennan, K. R., and A. M. Brown. 2004. Wnt proteins in mammary development and cancer. J. Mammary Gland Biol. Neoplasia 9:119-131.
4. Bruzzi, P., L. Dogliotti, C. Naldoni, L. Bucchi, M. Costantini, A. Cicognani, M. Torta, G. F. Buzzi, and A. Angeli. 1997. Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast. BMJ 314:925-928.
5. Carrano, A. C., E. Eytan, A. Hershko, and M. Pagano. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1:193-199.
6. Couse, J. F., and K. S. Korach. 1999. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr. Rev. 20:358-417.
7. Ganiatsas, S., R. Dow, A. Thompson, B. Schulman, and D. Germain. 2001. A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT. Oncogene 20:3641-3650.
8. Gavin, B. J., and A. P. McMahon. 1992. Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol. Cell. Biol. 12:2418-2423.
9. Hao, B., N. Zheng, B. A. Schulman, G. Wu, J. J. Miller, M. Pagano, and N. P. Pavletich. 2005. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol. Cell 20:9-19.
10. Hengstermann, A., L. K. Linares, A. Ciechanover, N. J. Whitaker, and M. Scheffner. 2001. Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc. Natl. Acad. Sci. USA 98:1218-1223.
11. Hennighausen, L., and G. W. Robinson. 2001. Signaling pathways in mammary gland development. Dev. Cell 1:467-475.
12. Hennighausen, L., and G. W. Robinson. 1998. Think globally, act locally: the making of a mouse mammary gland. Genes Dev. 12:449-455.
13. Huang, A. L., M. C. Ostrowski, D. Berard, and G. L. Hager. 1981. Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from mouse mammary tumor virus. Cell 27:245-255.
14. Montano, M. M., K. Ekena, R. Delage-Mourroux, W. Chang, P. Martini, and B. S. Katzenellenbogen. 1999. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. Proc. Natl. Acad. Sci. USA 96:6947-6952.
15. Mussi, P., L. Liao, S. E. Park, P. Ciana, A. Maggi, B. S. Katzenellenbogen, J. Xu, and B. W. O'Malley. 2006. Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc. Natl. Acad. Sci. USA 103:16716- 16721.
16. Pirkmaier, A., R. Dow, S. Ganiatsas, P. Waring, K. Warren, A. Thompson, J. Hendley, and D. Germain. 2003. Alternative mammary oncogenic pathways are induced by D-type cyclins; MMTV-cyclin D3 transgenic mice develop squamous cell carcinoma. Oncogene 22:4425-4433.
17. Radke, S., A. Pirkmaier, and D. Germain. 2005. Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer. Oncogene 24:3448-3458.
18. Schulman, B. A., A. C. Carrano, P. D. Jeffrey, Z. Bowen, E. R. Kinnucan, M. S. Finnin, S. J. Elledge, J. W. Harper, M. Pagano, and N. P. Pavletich. 2000. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature 408:381-386.
19. Signoretti, S., L. Di Marcotullio, A. Richardson, S. Ramaswamy, B. Isaac, M. Rue, F. Monti, M. Loda, and M. Pagano. 2002. Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J. Clin. Investig. 110:633-641.
20. Sutterluty, H., E. Chatelain, A. Marti, C. Wirbelauer, M. Senften, U. Muller, and W. Krek. 1999. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1:207-214.
21. Tan, P., S. Y. Fuchs, A. Chen, K. Wu, C. Gomez, Z. Ronai, and Z. Q. Pan. 1999. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Mol. Cell 3:527-533.