The Novel Ubiquitin Ligase Complex, SCFFbxw4, Interacts with the COP9 Signalosome in an F-Box Dependent Manner, Is Mutated, Lost and Under-Expressed in Human Cancers

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Lockwood, William W ^b   Chandel, Sahiba K ^a   Stewart, Greg L ^c   Erdjument Bromage, Hediye ^d   Beverly, Levi J ^a  

^a University of Louisville School of Medicine   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COP9 SIGNALOSOME; CULLIN; F BOX PROTEIN; ONCOPROTEIN; PROTEIN SCF FBXW4; S PHASE KINASE ASSOCIATED PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CELL SURVIVAL; CHEMOLUMINESCENCE; CONTROLLED STUDY; FBXW4 GENE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MUTATION; GENETIC DATABASE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MAMMARY GLAND; MOUSE; MUTAGENESIS; NEDDYLATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSPOSON; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; F-BOX MOTIFS; F-BOX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MULTIPROTEIN COMPLEXES; MUTATION; NEOPLASMS; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITINATION;

MURINAE;

EID: 84877064688     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063610     Document Type: Article

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