Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: Correlation with Skp2 stability and degradation of p27Kip1

Human Pathology

Volumn 44, Issue 3, 2013, Pages 365-373

  Zhao, Yunhong ^a   Tang, Qiyun ^b   Ni, Runzhou ^a   Huang, Xiaodong ^a   Wang, Yuchan ^a   Lu, Cuihua ^a   Shen, Aiguo ^a   Wang, Yingying ^a   Li, Chunmiao ^a   Yuan, Qin ^a   Chen, Hongwei ^a   Cheng, Chun ^a   He, Song ^a  

^a NANTONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Emi1; Hepatocellular carcinoma; p27Kip1; Skp2

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EARLY MITOTIC INHIBITOR 1; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER SIZE; CANCER STAGING; CELL PROLIFERATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; UPREGULATION; WESTERN BLOTTING;

ADULT; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; F-BOX PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOSIS; PROTEIN STABILITY; PROTEOLYSIS; RNA, SMALL INTERFERING; S-PHASE KINASE-ASSOCIATED PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 84873704427     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.03.030     Document Type: Article

References (22)

1. X.H. Li, Y.L. Pan, and R. Fan Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo Carcinogenesis 29 2008 1587 1593
2. M. Shimoda, M. Takahashi, and T. Yoshimoto A homeobox protein, Prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma Clin Cancer Res 12 2006 6005 6011
3. Liver Cancer Study Group of Japan Primary liver cancer in Japan: clinicopathologic features and results of surgical treatment Ann Surg 211 1999 277 287
4. T. Friedmann Progress toward human gene therapy Science 244 1989 1275 1281
5. M. Strauss Liver-directed gene therapy: prospects and problems Gene Ther 1 1994 156 164
6. J.W. Harper, J.L. Burton, and M.J. Solomon The anaphase-promoting complex: it's not just for mitosis any more Genes Dev 16 2002 2179 2206
7. J.Y. Hsu, J.D. Reimann, and C.S. Sorensen E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC (Cdh1) Nat Cell Biol 4 2002 358 366
8. I. Gutgemann, N.L. Lehman, and P.K. Jackson Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma Mod Pathol 21 2008 445 454
9. N.L. Lehman, R. Tibshirani, and J.Y. Hsu Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors Am J Pathol 170 2007 1793 1805
10. T. Bashir, N.V. Dorrello, and V. Amador Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase Nature 428 2004 190 193
11. Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells Hepatology 37 2003 1086 1096
12. G. Yang, G. Ayala, and A.D. Marzo Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival Clin Cancer Res 8 2002 3419 3426
13. M. Gstaiger, R. Jordan, and M. Lim Skp2 is oncogenic and overexpressed in human cancers Proc Natl Acad Sci USA 98 2001 5043 5048
14. S. Signoretti, L. Di Marcotullio, and A. Richardson Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer J Clin Invest 110 2002 633 641
15. M. Shapira, E. Kakiashvili, and T. Rosenberg The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells Breast Cancer Res 8 2006 R46
16. 1 by the anaphase-promoting complex Nature 428 2004 194 198
17. Q. Ke, J. Ji, and C. Cheng Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma Exp Mol Pathol 87 2009 167 172
18. U. Woelfle, J. Cloos, and G. Sauter Molecular signature associated with bone marrow micrometastasis in human breast cancer Cancer Res 63 2003 5679 5684
19. B.D. Fiore, and J. Pines Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C J Cell Biol 177 2007 425 437
20. btrcp EMBO Rep 8 2007 91 98
21. Cdh1 Nat Cell Biol 4 2002 358 366
22. C.D. Mann, C.P. Neal, and G. Garcea Prognostic molecular markers in 362 hepatocellular carcinoma: a systematic review Eur J Cancer 43 2007 979 992