p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

Nature Cell Biology

Volumn 1, Issue 4, 1999, Pages 207-214

  Sutterlüty, Hedwig ^a   Chatelain, Eric ^a   Marti, Alain ^a   Wirbelauer, Christiane ^a   Senften, Matthias ^a   Müller, Uli ^a   Krek, Wilhelm ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CDKN1B PROTEIN, RAT; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MICROTUBULE ASSOCIATED PROTEIN; RECOMBINANT PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; BINDING SITE; CELL CYCLE; CELL CYCLE S PHASE; CELL LINE; CHEMISTRY; CULTURE MEDIUM; DNA REPLICATION; GENE EXPRESSION; GENETICS; HUMAN; INTERPHASE; METABOLISM; MUTATION; PHYSIOLOGY; RAT;

ANIMALS; APOPTOSIS; BINDING SITES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CULTURE MEDIA, SERUM-FREE; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; GENE EXPRESSION; HUMANS; INTERPHASE; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; RATS; RECOMBINANT PROTEINS; S PHASE; S-PHASE KINASE-ASSOCIATED PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033174070     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/12027     Document Type: Article

References (43)

1. Nigg, E. A. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17, 471-480 (1995).
2. Sherr, C. J. Cancer cell cycles. Science 274, 1672-1677 (1996).
3. Heichman, K. A. & Roberts, J. M. Rules to replicate by. Cell 79, 557-562 (1994).
4. Pines, J. & Hunter, T. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature 346, 760-763 (1990).
5. Cardoso, M. C., Leonhardt, H. & Nadal-Ginard, B. Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell 74, 979-992 (1993).
6. Krude, T., Jackman, M., Pines, J. & Laskey, R. A. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88, 109-119 (1997).
7. Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. & Draetta, G. Cyclin As required at two points in the human cell cycle. EMBO J. 11, 961-971 (1992).
8. Zindy, F. et al. Cyclin A is required in S phase in normal epithelial cells. Biochem. Biophys. Res. Commun. 182, 1144-1154 (1992).
9. Girard, F., Strausfeld, U., Fernandez, A. & Lamb, N. J. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179 (1991).
10. Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382, 325-331. (1996).
11. Schulman, B. A., Lindstrom, D. L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc. Natl Acad. Sci. USA 95, 10453-10458 (1998).
12. 27Kip1 Mol. Cell. Biol. 15, 4347-4352 (1995).
13. 45SKP2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915-925 (1995).
14. Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274 (1996).
15. Koepp, D. M., Harper, J. W. & Elledge, S. J. How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97, 431-434 (1999).
16. Patton, E. E., Willems, A. R. & Tyers, M. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet. 14, 236-243 (1998).
17. 4SKP2:vidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 17, 368-383 (1998).
18. Lyapina, S. A., Correll, C. C., Kipreos, E. T. & Deshaies, R. J. Human CULl forms an evolutionary conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proc. Natl Acad. Sci. USA 95, 7451-7456 (1998).
19. Michel, J. J. & Xiong, Y. Human Cul-1, but not other cullin family members selectively interacts with SKP1 to form a complex with SKP2 and Cyclin A. Cell Growth Differ. 9,435-449 (1998).
20. Yu, Z. K., Gervais, J. L M. & Zhang, H. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc. Natl Acad. Sci. USA 95, 11324-11329 (1998).
21. SKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nature Cell Biol 1, 14-19 (1999).
22. Kato, J., Matsuoka, M., Polyak, K., Massague, I. & Cherr, C. J. Cyclic-AMP-induced G1 arrest mediated by an inhibitor, p27(Kip1), of cyclin-dependent kinase 4 activation. Cell 79, 487-496 (1994).
23. Nourse, J. et al. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372, 570-573 (1994).
24. Pagano, M. et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269, 682-685 (1995).
25. Kip1 for restriction point control of the fibroblast cell cycle. Science 272, 877-880 (1996).
26. Kip2 a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59-66 (1994).
27. Kip1 is abrogated by c-Myc. EMBO J. 15, 6595-6604 (1996).
28. Kip1. Genes Dev 11, 1464-1478 (1997).
29. Kip1. EMBO J. 16, 5334-5344 (1997).
30. Montagnoli, A. et al. Ubiquitination of p27 is regulated by cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13, 1181-1189 (1999).
31. Kip1, a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol. Cell. Biol. 19, 1190-1201 (1999).
32. Shirane, M. et al. Down-regulation of p27(Kip1) by two mechanisms ubiquitin-mediated degradation and proteolytic processing. J. Biol. Chem. 274, 13886-13893 (1999).
33. Johnson, D. G., Schwarz, J. K., Cress, W. D. & Nevins, J. R. Expression of transcription factor E2F-1 induced quiescent cells to enter S phase. Nature 365, 349-352 (1993).
34. Eilers, M., Schirm, S. & Bishop, J. M. The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J. 10, 133-141 (1991).
35. Connell-Crowley, L., Elledge, S. J. & Harper, J. W. G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts. Curr. Biol. 8, 65-68 (1998).
36. Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature Med. 3, 222-226 (1997).
37. Loda, M. et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggessive colorectal carcinomas. Nature Med. 3, 231-234 (1997).
38. Kip1 protein: Prognostic implications in primary breast cancer. Nature Med. 3, 227-230 (1997).
39. Kip1 is haplo-insufficient for tumor suppression. Nature 396, 177-180 (1998).
40. Hurford, R. K., Cobrinik, D., Lee, M. H. & Dyson, N. pRB and pl07/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11, 1447-1463 (1997).
41. Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y. & Phipps, M. L. Construction of adenovirus vectors through Cre-lox recombination. J. Virol. 71, 1842-1849 (1997).
42. Krek, W., Xu, G. & Livingston, D. M. Cyclin A-kinase regulation of E2F-1DNA binding function underlies suppression of an S phase checkpoint. Cell 83, 1149-1158 (1995).
43. Ludin, B., Doll, T., Meili, R., Kaech, S. & Matus, A. Application of novel vectors for GFP-tagging of proteins to study microtubule-associated proteins. Gene 173, 107-111 (1996).