SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Nature

Volumn 471, Issue 7336, 2011, Pages 104-109

  Inuzuka, Hiroyuki ^a   Shaik, Shavali ^a   Onoyama, Ichiro ^b   Gao, Daming ^a   Tseng, Alan ^a   Maser, Richard S ^c,d   Zhai, Bo ^a   Wan, Lixin ^a   Gutierrez, Alejandro ^a   Lau, Alan W ^a   Xiao, Yonghong ^c   Christie, Amanda L ^a,c   Aster, Jon ^e   Settleman, Jeffrey ^a   Gygi, Steven P ^a   Kung, Andrew L ^a,c   Look, Thomas ^a   Nakayama, Keiichi I ^b   Depinho, Ronald A ^c   Wei, Wenyi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d JACKSON LABORATORY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; GLYCOGEN SYNTHASE KINASE 3; PROTEIN FBW7; PROTEIN MCL 1; SORAFENIB; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER; CYTOLOGY; ENZYME ACTIVITY; PROTEIN; RODENT; SURVIVAL; TUMOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BENZENESULFONATES; BIPHENYL COMPOUNDS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; F-BOX PROTEINS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NITROPHENOLS; PHOSPHORYLATION; PIPERAZINES; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; SKP CULLIN F-BOX PROTEIN LIGASES; SULFONAMIDES; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 79952261405     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09732     Document Type: Article

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