-
1
-
-
0041419354
-
Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone
-
doi:10.1210/en.2003-0149
-
Abbott CR, Kennedy AR, Wren AM, Rossi M, Murphy KG, Seal LJ, Todd JF, Ghatei MA, Small CJ & Bloom SR 2003 Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone. Endocrinology 144 3943-3949. (doi:10.1210/en.2003-0149)
-
(2003)
Endocrinology
, vol.144
, pp. 3943-3949
-
-
Abbott, C.R.1
Kennedy, A.R.2
Wren, A.M.3
Rossi, M.4
Murphy, K.G.5
Seal, L.J.6
Todd, J.F.7
Ghatei, M.A.8
Small, C.J.9
Bloom, S.R.10
-
2
-
-
18044365777
-
Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake
-
doi:10.1016/j.brainres.2005.02.065
-
AbbottC R,Small CJ,Kennedy AR,Neary NM,Sajedi A,Ghatei MA & Bloom SR 2005 Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake. Brain Research 1043 139-144. (doi:10.1016/j.brainres.2005.02.065)
-
(2005)
Brain Research
, vol.1043
, pp. 139-144
-
-
Abbottc, R.1
Small, C.J.2
Kennedy, A.R.3
Neary, N.M.4
Sajedi, A.5
Ghatei, M.A.6
Bloom, S.R.7
-
3
-
-
0022398837
-
Human distribution and release of a putative new gut hormone, peptide YY
-
Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM & Bloom SR 1985 Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89 1070-1077.
-
(1985)
Gastroenterology
, vol.89
, pp. 1070-1077
-
-
Adrian, T.E.1
Ferri, G.L.2
Bacarese-Hamilton, A.J.3
Fuessl, H.S.4
Polak, J.M.5
Bloom, S.R.6
-
4
-
-
0036202441
-
Acute third ventricular administration of insulin decreases food intake in two paradigms
-
doi:10.1016/S0091-3057(01)00780-8
-
Air EL, Benoit SC, Blake Smith KA, Clegg DJ & Woods SC 2002 Acute third ventricular administration of insulin decreases food intake in two paradigms. Pharmacology, Biochemistry, and Behavior 72 423-429. (doi:10.1016/S0091-3057(01)00780-8)
-
(2002)
Pharmacology, Biochemistry, and Behavior
, vol.72
, pp. 423-429
-
-
Air, E.L.1
Benoit, S.C.2
Blake Smith, K.A.3
Clegg, D.J.4
Woods, S.C.5
-
5
-
-
70350389400
-
Dominant role of the p110b isoform of PI3K over p110a in energy homeostasis regulation by POMC and AgRP neurons
-
doi:10.1016/j.cmet.2009.09.008
-
Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S et al. 2009 Dominant role of the p110b isoform of PI3K over p110a in energy homeostasis regulation by POMC and AgRP neurons. Cell Metabolism 10 343-354. (doi:10.1016/j.cmet.2009.09.008)
-
(2009)
Cell Metabolism
, vol.10
, pp. 343-354
-
-
Al-Qassab, H.1
Smith, M.A.2
Irvine, E.E.3
Guillermet-Guibert, J.4
Claret, M.5
Choudhury, A.I.6
Selman, C.7
Piipari, K.8
Clements, M.9
Lingard, S.10
-
6
-
-
84863494403
-
MicroRNA expression profiling of hypothalamic arcuate and paraventricular nuclei from single rats using Illumina sequencing technology
-
doi:10.1016/j.jneumeth.2012.05.033
-
Amar L, Benoit C, Beaumont G, Vacher CM, Crepin D, Taouis M & Baroin-Tourancheau A 2012 MicroRNA expression profiling of hypothalamic arcuate and paraventricular nuclei from single rats using Illumina sequencing technology. Journal of Neuroscience Methods 209 134-143. (doi:10.1016/j.jneumeth.2012.05.033)
-
(2012)
Journal of Neuroscience Methods
, vol.209
, pp. 134-143
-
-
Amar, L.1
Benoit, C.2
Beaumont, G.3
Vacher, C.M.4
Crepin, D.5
Taouis, M.6
Baroin-Tourancheau, A.7
-
7
-
-
33751547729
-
Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion
-
doi:10.1210/en.2006-0820
-
Ao Y, Go VL, Toy N, Li T, Wang Y, Song MK, Reeve JR Jr, Liu Y & Yang H 2006 Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion. Endocrinology 147 6004-6010. (doi:10.1210/en.2006-0820)
-
(2006)
Endocrinology
, vol.147
, pp. 6004-6010
-
-
Ao, Y.1
Go, V.L.2
Toy, N.3
Li, T.4
Wang, Y.5
Song, M.K.6
Reeve Jr., J.R.7
Liu, Y.8
Yang, H.9
-
8
-
-
79951992387
-
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
-
doi:10.1038/nn.2739
-
Aponte Y, Atasoy D & Sternson SM 2011 AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nature Neuroscience 14 351-355. (doi:10.1038/nn.2739)
-
(2011)
Nature Neuroscience
, vol.14
, pp. 351-355
-
-
Aponte, Y.1
Atasoy, D.2
Sternson, S.M.3
-
9
-
-
0034802121
-
Absence of cocaine-and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet
-
doi:10.1210/en.142.10.4394
-
Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen YF, Hsiung HM & Koster A 2001 Absence of cocaine-and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology 142 4394-4400. (doi:10.1210/en.142.10.4394)
-
(2001)
Endocrinology
, vol.142
, pp. 4394-4400
-
-
Asnicar, M.A.1
Smith, D.P.2
Yang, D.D.3
Heiman, M.L.4
Fox, N.5
Chen, Y.F.6
Hsiung, H.M.7
Koster, A.8
-
10
-
-
84864711337
-
Deconstruction of a neural circuit for hunger
-
doi:10.1038/nature11270
-
Atasoy D, Betley JN, Su HH & Sternson SM2012 Deconstruction of a neural circuit for hunger. Nature 488 172-177. (doi:10.1038/nature11270)
-
(2012)
Nature
, vol.488
, pp. 172-177
-
-
Atasoy, D.1
Betley, J.N.2
Su, H.H.3
Sternson, S.M.4
-
11
-
-
0014142582
-
The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects
-
doi:10.1172/JCI105646
-
Bagdade JD, Bierman EL & Porte D Jr 1967 The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. Journal of Clinical Investigation 46 1549-1557. (doi:10.1172/JCI105646)
-
(1967)
Journal of Clinical Investigation
, vol.46
, pp. 1549-1557
-
-
Bagdade, J.D.1
Bierman, E.L.2
Porte Jr., D.3
-
12
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
doi:10.1016/j.neuron.2004.06.004
-
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK et al. 2004 Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42 983-991. (doi:10.1016/j.neuron.2004.06.004)
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
-
13
-
-
27544450765
-
Divergence of melanocortin pathways in the control of food intake and energy expenditure
-
doi:10.1016/j.cell.2005.08.035
-
Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD et al. 2005 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123 493-505. (doi:10.1016/j.cell.2005.08.035)
-
(2005)
Cell
, vol.123
, pp. 493-505
-
-
Balthasar, N.1
Dalgaard, L.T.2
Lee, C.E.3
Yu, J.4
Funahashi, H.5
Williams, T.6
Ferreira, M.7
Tang, V.8
McGovern, R.A.9
Kenny, C.D.10
-
14
-
-
77949673935
-
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
-
doi:10.1172/JCI39620
-
Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang W & Bence KK 2010 PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. Journal of Clinical Investigation 120 720-734. (doi:10.1172/JCI39620)
-
(2010)
Journal of Clinical Investigation
, vol.120
, pp. 720-734
-
-
Banno, R.1
Zimmer, D.2
De Jonghe, B.C.3
Atienza, M.4
Rak, K.5
Yang, W.6
Bence, K.K.7
-
15
-
-
0030931678
-
Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice
-
doi:10.1073/pnas. 94.19.10455
-
Barrachina MD, Martinez V, Wang L, Wei JY & Tache Y 1997 Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. PNAS 94 10455-10460. (doi:10.1073/pnas. 94.19.10455)
-
(1997)
PNAS
, vol.94
, pp. 10455-10460
-
-
Barrachina, M.D.1
Martinez, V.2
Wang, L.3
Wei, J.Y.4
Tache, Y.5
-
16
-
-
80052049014
-
GLP-1 and energy balance: an integrated model of short-term and long-term control
-
doi:10.1038/nrendo.2011.77
-
Barrera JG, Sandoval DA, D'Alessio DA & Seeley RJ 2011 GLP-1 and energy balance: an integrated model of short-term and long-term control. Nature Reviews. Endocrinology 7 507-516. (doi:10.1038/nrendo.2011.77)
-
(2011)
Nature Reviews. Endocrinology
, vol.7
, pp. 507-516
-
-
Barrera, J.G.1
Sandoval, D.A.2
D'Alessio, D.A.3
Seeley, R.J.4
-
17
-
-
0037043704
-
Gut hormone PYY(3-36) physiologically inhibits food intake
-
doi:10.1038/nature00887
-
Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA et al. 2002 Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418 650-654. (doi:10.1038/nature00887)
-
(2002)
Nature
, vol.418
, pp. 650-654
-
-
Batterham, R.L.1
Cowley, M.A.2
Small, C.J.3
Herzog, H.4
Cohen, M.A.5
Dakin, C.L.6
Wren, A.M.7
Brynes, A.E.8
Low, M.J.9
Ghatei, M.A.10
-
18
-
-
33748128913
-
Critical role for peptide YY in protein-mediated satiation and body-weight regulation
-
doi:10.1016/j.cmet.2006.08.001
-
Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD & Withers DJ 2006 Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metabolism 4 223-233. (doi:10.1016/j.cmet.2006.08.001)
-
(2006)
Cell Metabolism
, vol.4
, pp. 223-233
-
-
Batterham, R.L.1
Heffron, H.2
Kapoor, S.3
Chivers, J.E.4
Chandarana, K.5
Herzog, H.6
Le Roux, C.W.7
Thomas, E.L.8
Bell, J.D.9
Withers, D.J.10
-
19
-
-
0027361094
-
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
-
doi:10.1172/JCI116773
-
Baura GD, Foster DM, Porte D Jr, Kahn SE, Bergman RN, Cobelli C & Schwartz MW1993 Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. Journal of Clinical Investigation 92 1824-1830. (doi:10.1172/JCI116773)
-
(1993)
Journal of Clinical Investigation
, vol.92
, pp. 1824-1830
-
-
Baura, G.D.1
Foster, D.M.2
Porte Jr., D.3
Kahn, S.E.4
Bergman, R.N.5
Cobelli, C.6
Schwartz, M.W.7
-
20
-
-
0025046607
-
Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
-
doi:10.1016/0006-8993(90)91664-3
-
Beck B, Jhanwar-Uniyal M, Burlet A, Chapleur-Chateau M, Leibowitz SF & Burlet C 1990 Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Research 528 245-249. (doi:10.1016/0006-8993(90)91664-3)
-
(1990)
Brain Research
, vol.528
, pp. 245-249
-
-
Beck, B.1
Jhanwar-Uniyal, M.2
Burlet, A.3
Chapleur-Chateau, M.4
Leibowitz, S.F.5
Burlet, C.6
-
21
-
-
84860912504
-
Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning
-
doi:10.1096/fj.11-198762
-
Begum G, Stevens A, Smith EB, Connor K, Challis JR, Bloomfield F & WhiteA 2012 Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning. FASEB Journal 26 1694-1703. (doi:10.1096/fj.11-198762)
-
(2012)
FASEB Journal
, vol.26
, pp. 1694-1703
-
-
Begum, G.1
Stevens, A.2
Smith, E.B.3
Connor, K.4
Challis, J.R.5
Bloomfield, F.6
White, A.7
-
22
-
-
41549108590
-
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
-
doi:10.1016/j.cmet.2008.01.006
-
Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klockener T, Alessi D, Kloppenburg P & Bruning JC 2008 PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metabolism 7 291-301. (doi:10.1016/j.cmet.2008.01.006)
-
(2008)
Cell Metabolism
, vol.7
, pp. 291-301
-
-
Belgardt, B.F.1
Husch, A.2
Rother, E.3
Ernst, M.B.4
Wunderlich, F.T.5
Hampel, B.6
Klockener, T.7
Alessi, D.8
Kloppenburg, P.9
Bruning, J.C.10
-
23
-
-
0037109670
-
The catabolic action of insulin in the brain is mediated by melanocortins
-
Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ, Seeley RJ & Woods SC 2002 The catabolic action of insulin in the brain is mediated by melanocortins. Journal of Neuroscience 22 9048-9052.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 9048-9052
-
-
Benoit, S.C.1
Air, E.L.2
Coolen, L.M.3
Strauss, R.4
Jackman, A.5
Clegg, D.J.6
Seeley, R.J.7
Woods, S.C.8
-
24
-
-
84855500856
-
Metabolic and hedonic drives in the neural control of appetite: who is the boss?
-
doi:10.1016/j.conb.2011.09.004
-
Berthoud HR 2011 Metabolic and hedonic drives in the neural control of appetite: who is the boss? Current Opinion in Neurobiology 21 888-896. (doi:10.1016/j.conb.2011.09.004)
-
(2011)
Current Opinion in Neurobiology
, vol.21
, pp. 888-896
-
-
Berthoud, H.R.1
-
25
-
-
26444540359
-
Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
-
doi:10.1096/fj.04-3434fje
-
Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, Ghatei MA & Bloom SR 2005 Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB Journal 19 1680-1682. (doi:10.1096/fj.04-3434fje)
-
(2005)
FASEB Journal
, vol.19
, pp. 1680-1682
-
-
Bewick, G.A.1
Gardiner, J.V.2
Dhillo, W.S.3
Kent, A.S.4
White, N.E.5
Webster, Z.6
Ghatei, M.A.7
Bloom, S.R.8
-
27
-
-
42449086900
-
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
-
doi:10.1210/en.2007-1200
-
Bingham NC, Anderson KK, Reuter AL, Stallings NR & Parker KL 2008 Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149 2138-2148. (doi:10.1210/en.2007-1200)
-
(2008)
Endocrinology
, vol.149
, pp. 2138-2148
-
-
Bingham, N.C.1
Anderson, K.K.2
Reuter, A.L.3
Stallings, N.R.4
Parker, K.L.5
-
28
-
-
37449018122
-
PYY(3-36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of rats
-
doi:10.1016/j.peptides.2007.11.003
-
Blevins JE, Chelikani PK, Haver AC & Reidelberger RD 2008 PYY(3-36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of rats. Peptides 29 112-119. (doi:10.1016/j.peptides.2007.11.003)
-
(2008)
Peptides
, vol.29
, pp. 112-119
-
-
Blevins, J.E.1
Chelikani, P.K.2
Haver, A.C.3
Reidelberger, R.D.4
-
29
-
-
38549164620
-
PYY transgenicmice are protected against dietinduced and genetic obesity
-
doi:10.1016/j.npep.2007.11.003
-
Boey D, Lin S, Enriquez RF, LeeNJ, Slack K, CouzensM, Baldock PA,HerzogH & Sainsbury A 2008 PYY transgenicmice are protected against dietinduced and genetic obesity. Neuropeptides 42 19-30. (doi:10.1016/j.npep.2007.11.003)
-
(2008)
Neuropeptides
, vol.42
, pp. 19-30
-
-
Boey, D.1
Lin, S.2
Enriquez, R.F.3
Lee, N.J.4
Slack, K.5
Couzens, M.6
Baldock, P.A.7
Herzog, H.8
Sainsbury, A.9
-
30
-
-
84873162774
-
Hypothalamic tanycytes: potential roles in the control of feeding and energy balance
-
doi:10.1016/j.tins.2012.12.008
-
Bolborea M & Dale N 2013 Hypothalamic tanycytes: potential roles in the control of feeding and energy balance. Trends in Neurosciences 36 91-100. (doi:10.1016/j.tins.2012.12.008)
-
(2013)
Trends in Neurosciences
, vol.36
, pp. 91-100
-
-
Bolborea, M.1
Dale, N.2
-
31
-
-
0017276160
-
Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
-
doi:10.1002/cne. 901660302
-
Broadwell RD & Brightman MW 1976 Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. Journal of Comparative Neurology 166 257-283. (doi:10.1002/cne. 901660302)
-
(1976)
Journal of Comparative Neurology
, vol.166
, pp. 257-283
-
-
Broadwell, R.D.1
Brightman, M.W.2
-
32
-
-
0032443807
-
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
-
doi:10.1073/pnas.95.25.15043
-
Broberger C, Johansen J, Johansson C, Schalling M & Hokfelt T 1998 The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. PNAS 95 15043-15048. (doi:10.1073/pnas.95.25.15043)
-
(1998)
PNAS
, vol.95
, pp. 15043-15048
-
-
Broberger, C.1
Johansen, J.2
Johansson, C.3
Schalling, M.4
Hokfelt, T.5
-
33
-
-
0034456398
-
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
-
doi:10.1210/en.141.9.3518
-
Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M & Cone RD 2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141 3518-3521. (doi:10.1210/en.141.9.3518)
-
(2000)
Endocrinology
, vol.141
, pp. 3518-3521
-
-
Butler, A.A.1
Kesterson, R.A.2
Khong, K.3
Cullen, M.J.4
Pelleymounter, M.A.5
Dekoning, J.6
Baetscher, M.7
Cone, R.D.8
-
34
-
-
79954455756
-
PDK1-Foxo1 in agoutirelated peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
-
doi:10.1371/journal.pone.0018324
-
Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y et al. 2011 PDK1-Foxo1 in agoutirelated peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS ONE 6 e18324. (doi:10.1371/journal.pone.0018324)
-
(2011)
PLoS ONE
, vol.6
-
-
Cao, Y.1
Nakata, M.2
Okamoto, S.3
Takano, E.4
Yada, T.5
Minokoshi, Y.6
Hirata, Y.7
Nakajima, K.8
Iskandar, K.9
Hayashi, Y.10
-
35
-
-
84881643423
-
Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons
-
doi:10.1152/ajpregu.00518.2012
-
do Carmo JM, da Silva AA, Rushing JS, Pace BR & Hall JE 2010 Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 305 R359-R368. (doi:10.1152/ajpregu.00518.2012)
-
(2010)
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
, vol.305
-
-
do Carmo, J.M.1
da Silva, A.A.2
Rushing, J.S.3
Pace, B.R.4
Hall, J.E.5
-
36
-
-
77953710614
-
Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity
-
doi:10.1016/j.physbeh.2010.03.009
-
Cason AM, Smith RJ, Tahsili-Fahadan P, Moorman DE, Sartor GC & Aston-Jones G 2010 Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiology & Behavior 100 419-428. (doi:10.1016/j.physbeh.2010.03.009)
-
(2010)
Physiology & Behavior
, vol.100
, pp. 419-428
-
-
Cason, A.M.1
Smith, R.J.2
Tahsili-Fahadan, P.3
Moorman, D.E.4
Sartor, G.C.5
Aston-Jones, G.6
-
37
-
-
0242437949
-
Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse
-
doi:10.1016/j.bbrc.2003.10.089
-
Challis BG, Pinnock SB, Coll AP, Carter RN, Dickson SL & O'Rahilly S 2003 Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochemical and Biophysical Research Communications 311 915-919. (doi:10.1016/j.bbrc.2003.10.089)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.311
, pp. 915-919
-
-
Challis, B.G.1
Pinnock, S.B.2
Coll, A.P.3
Carter, R.N.4
Dickson, S.L.5
O'Rahilly, S.6
-
38
-
-
79955635264
-
Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
-
doi:10.1016/j.cmet.2011.02.019
-
Chao PT, Yang L, Aja S, Moran TH & Bi S 2011 Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metabolism 13 573-583. (doi:10.1016/j.cmet.2011.02.019)
-
(2011)
Cell Metabolism
, vol.13
, pp. 573-583
-
-
Chao, P.T.1
Yang, L.2
Aja, S.3
Moran, T.H.4
Bi, S.5
-
39
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
-
doi:10.1016/S0092-8674(00)81294-5
-
Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE et al. 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 491-495. (doi:10.1016/S0092-8674(00)81294-5)
-
(1996)
Cell
, vol.84
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
Woolf, E.A.4
Weng, X.5
Ellis, S.J.6
Lakey, N.D.7
Culpepper, J.8
Moore, K.J.9
Breitbart, R.E.10
-
40
-
-
2542475178
-
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
-
doi:10.1210/en.2003-1596
-
Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM et al. 2004 Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145 2607-2612. (doi:10.1210/en.2003-1596)
-
(2004)
Endocrinology
, vol.145
, pp. 2607-2612
-
-
Chen, H.Y.1
Trumbauer, M.E.2
Chen, A.S.3
Weingarth, D.T.4
Adams, J.R.5
Frazier, E.G.6
Shen, Z.7
Marsh, D.J.8
Feighner, S.D.9
Guan, X.M.10
-
41
-
-
0030928715
-
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
-
doi:10.1210/en.138.10.4489
-
Cheung CC, Clifton DK & Steiner RA 1997 Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138 4489-4492. (doi:10.1210/en.138.10.4489)
-
(1997)
Endocrinology
, vol.138
, pp. 4489-4492
-
-
Cheung, C.C.1
Clifton, D.K.2
Steiner, R.A.3
-
42
-
-
84874141984
-
Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH
-
doi:10.1002/cne.23226
-
Cheung CC, Kurrasch DM, Liang JK & Ingraham HA 2013 Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH. Journal of Comparative Neurology 521 1268-1288. (doi:10.1002/cne.23226)
-
(2013)
Journal of Comparative Neurology
, vol.521
, pp. 1268-1288
-
-
Cheung, C.C.1
Kurrasch, D.M.2
Liang, J.K.3
Ingraham, H.A.4
-
43
-
-
30444460361
-
Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors
-
doi:10.1002/glia.20239
-
Cheunsuang O & Morris R 2005 Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52 228-233. (doi:10.1002/glia.20239)
-
(2005)
Glia
, vol.52
, pp. 228-233
-
-
Cheunsuang, O.1
Morris, R.2
-
44
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and b cell function
-
doi:10.1172/JCI24445
-
Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G et al. 2005 The role of insulin receptor substrate 2 in hypothalamic and b cell function. Journal of Clinical Investigation 115 940-950. (doi:10.1172/JCI24445)
-
(2005)
Journal of Clinical Investigation
, vol.115
, pp. 940-950
-
-
Choudhury, A.I.1
Heffron, H.2
Smith, M.A.3
Al-Qassab, H.4
Xu, A.W.5
Selman, C.6
Simmgen, M.7
Clements, M.8
Claret, M.9
Maccoll, G.10
-
45
-
-
0142027120
-
Collateral axonal projections from hypothalamic hypocretin neurons to cardiovascular sites in nucleus ambiguus and nucleus tractus solitarius
-
doi:10.1016/j.brainres.2003.08.016
-
Ciriello J, McMurray JC, Babic T & de Oliveira CV 2003 Collateral axonal projections from hypothalamic hypocretin neurons to cardiovascular sites in nucleus ambiguus and nucleus tractus solitarius. Brain Research 991 133-141. (doi:10.1016/j.brainres.2003.08.016)
-
(2003)
Brain Research
, vol.991
, pp. 133-141
-
-
Ciriello, J.1
McMurray, J.C.2
Babic, T.3
de Oliveira, C.V.4
-
46
-
-
34547651092
-
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
-
doi:10.1172/JCI31516
-
Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW et al. 2007 AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. Journal of Clinical Investigation 117 2325-2336. (doi:10.1172/JCI31516)
-
(2007)
Journal of Clinical Investigation
, vol.117
, pp. 2325-2336
-
-
Claret, M.1
Smith, M.A.2
Batterham, R.L.3
Selman, C.4
Choudhury, A.I.5
Fryer, L.G.6
Clements, M.7
Al-Qassab, H.8
Heffron, H.9
Xu, A.W.10
-
47
-
-
79952399495
-
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice
-
doi:10.2337/db10-1055
-
Claret M, Smith MA, Knauf C, Al-Qassab H,Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P et al. 2011 Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 60 735-745. (doi:10.2337/db10-1055)
-
(2011)
Diabetes
, vol.60
, pp. 735-745
-
-
Claret, M.1
Smith, M.A.2
Knauf, C.3
Al-Qassab, H.4
Woods, A.5
Heslegrave, A.6
Piipari, K.7
Emmanuel, J.J.8
Colom, A.9
Valet, P.10
-
48
-
-
0021248888
-
Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
-
doi:10.1210/endo-115-1-427
-
Clark JT, Kalra PS, Crowley WR & Kalra SP 1984 Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115 427-429. (doi:10.1210/endo-115-1-427)
-
(1984)
Endocrinology
, vol.115
, pp. 427-429
-
-
Clark, J.T.1
Kalra, P.S.2
Crowley, W.R.3
Kalra, S.P.4
-
49
-
-
0344450708
-
Amutation inthehumanleptin receptor gene causes obesity and pituitary dysfunction
-
doi:10.1038/32911
-
Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM et al. 1998Amutation inthehumanleptin receptor gene causes obesity and pituitary dysfunction. Nature 392 398-401. (doi:10.1038/32911)
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
Cassuto, D.6
Gourmelen, M.7
Dina, C.8
Chambaz, J.9
Lacorte, J.M.10
-
50
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
doi:10.1056/NEJM199602013340503
-
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL et al. 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334 292-295. (doi:10.1056/NEJM199602013340503)
-
(1996)
New England Journal of Medicine
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
Ohannesian, J.P.7
Marco, C.C.8
McKee, L.J.9
Bauer, T.L.10
-
51
-
-
84890569997
-
Effects of neonatal programming on hypothalamic mechanisms controlling energy balance
-
doi:10.1055/s-0033-1351281
-
Contreras C, Novelle MG, Leis R, Dieguez C, Skrede S & Lopez M 2013 Effects of neonatal programming on hypothalamic mechanisms controlling energy balance. Hormone and Metabolic Research 45 935-944. (doi:10.1055/s-0033-1351281)
-
(2013)
Hormone and Metabolic Research
, vol.45
, pp. 935-944
-
-
Contreras, C.1
Novelle, M.G.2
Leis, R.3
Dieguez, C.4
Skrede, S.5
Lopez, M.6
-
52
-
-
79955412324
-
Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency
-
doi:10.1210/en.2010-1450
-
Corander MP, Rimmington D, Challis BG, O'Rahilly S & Coll AP 2011 Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency. Endocrinology 152 1819-1828. (doi:10.1210/en.2010-1450)
-
(2011)
Endocrinology
, vol.152
, pp. 1819-1828
-
-
Corander, M.P.1
Rimmington, D.2
Challis, B.G.3
O'Rahilly, S.4
Coll, A.P.5
-
53
-
-
0022555988
-
Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography
-
doi:10.1016/0304-3940(86)90430-1
-
Corp ES, Woods SC, Porte D Jr, Dorsa DM, Figlewicz DP & Baskin DG 1986 Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography. Neuroscience Letters 70 17-22. (doi:10.1016/0304-3940(86)90430-1)
-
(1986)
Neuroscience Letters
, vol.70
, pp. 17-22
-
-
Corp, E.S.1
Woods, S.C.2
Porte Jr., D.3
Dorsa, D.M.4
Figlewicz, D.P.5
Baskin, D.G.6
-
54
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
doi:10.1038/35078085
-
Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD & Low MJ 2001 Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 480-484. (doi:10.1038/35078085)
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
55
-
-
0037456519
-
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
-
doi:10.1016/S0896-6273(03)00063-1
-
Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML et al. 2003 The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37 649-661. (doi:10.1016/S0896-6273(03)00063-1)
-
(2003)
Neuron
, vol.37
, pp. 649-661
-
-
Cowley, M.A.1
Smith, R.G.2
Diano, S.3
Tschop, M.4
Pronchuk, N.5
Grove, K.L.6
Strasburger, C.J.7
Bidlingmaier, M.8
Esterman, M.9
Heiman, M.L.10
-
56
-
-
84881006702
-
Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: a translational study
-
doi:10.1016/j.regpep.2013.06.012
-
Crujeiras AB, Campion J, Diaz-Lagares A,Milagro FI, Goyenechea E, Abete I, Casanueva FF & Martinez JA 2013 Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: a translational study. Regulatory Peptides 186 1-6. (doi:10.1016/j.regpep.2013.06.012)
-
(2013)
Regulatory Peptides
, vol.186
, pp. 1-6
-
-
Crujeiras, A.B.1
Campion, J.2
Diaz-Lagares, A.3
Milagro, F.I.4
Goyenechea, E.5
Abete, I.6
Casanueva, F.F.7
Martinez, J.A.8
-
57
-
-
10744232925
-
Essential role of STAT3 in body weight and glucose homeostasis
-
doi:10.1128/MCB.24.1.258-269.2004
-
Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA et al. 2004 Essential role of STAT3 in body weight and glucose homeostasis. Molecular and Cellular Biology 24 258-269. (doi:10.1128/MCB.24.1.258-269.2004)
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 258-269
-
-
Cui, Y.1
Huang, L.2
Elefteriou, F.3
Yang, G.4
Shelton, J.M.5
Giles, J.E.6
Oz, O.K.7
Pourbahrami, T.8
Lu, C.Y.9
Richardson, J.A.10
-
58
-
-
84877275888
-
Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH
-
doi:10.1152/ajpendo.00448.2012
-
Cyr NE, Toorie AM, Steger JS, Sochat MM, Hyner S, Perello M, Stuart R & Nillni EA 2013 Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH. American Journal of Physiology. Endocrinology and Metabolism 304 E640-E650. (doi:10.1152/ajpendo.00448.2012)
-
(2013)
American Journal of Physiology. Endocrinology and Metabolism
, vol.304
-
-
Cyr, N.E.1
Toorie, A.M.2
Steger, J.S.3
Sochat, M.M.4
Hyner, S.5
Perello, M.6
Stuart, R.7
Nillni, E.A.8
-
59
-
-
84863535512
-
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on foodintake
-
doi:10.1016/j.cmet.2012.05.010
-
Dagon Y, Hur E, Zheng B,Wellenstein K, Cantley LC & Kahn BB 2012 p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on foodintake.CellMetabolism16104-112. (doi:10.1016/j.cmet.2012.05.010)
-
(2012)
Cell Metabolism
, vol.16
, pp. 104-112
-
-
Dagon, Y.1
Hur, E.2
Zheng, B.3
Wellenstein, K.4
Cantley, L.C.5
Kahn, B.B.6
-
60
-
-
3042793951
-
Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus
-
doi:10.1002/neu.20030
-
Davis AM, Seney ML, Stallings NR, Zhao L, Parker KL & Tobet SA 2004 Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus. Journal of Neurobiology 60 424-436. (doi:10.1002/neu.20030)
-
(2004)
Journal of Neurobiology
, vol.60
, pp. 424-436
-
-
Davis, A.M.1
Seney, M.L.2
Stallings, N.R.3
Zhao, L.4
Parker, K.L.5
Tobet, S.A.6
-
61
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
doi:10.1210/en.2004-1520
-
De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ & Velloso LA 2005 Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146 4192-4199. (doi:10.1210/en.2004-1520)
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
De Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine, R.4
Zollner, R.L.5
Boschero, A.C.6
Saad, M.J.7
Velloso, L.A.8
-
62
-
-
84873131782
-
Hypothalamic control of energy balance: insights into the role of synaptic plasticity
-
doi:10.1016/j.tins.2012.12.005
-
Dietrich MO & Horvath TL 2013 Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Trends in Neurosciences 36 65-73. (doi:10.1016/j.tins.2012.12.005)
-
(2013)
Trends in Neurosciences
, vol.36
, pp. 65-73
-
-
Dietrich, M.O.1
Horvath, T.L.2
-
63
-
-
84866666991
-
The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction
-
doi:10.1038/nn.3202
-
DiLeone RJ, Taylor JR & Picciotto MR 2012 The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction. Nature Neuroscience 15 1330-1335. (doi:10.1038/nn.3202)
-
(2012)
Nature Neuroscience
, vol.15
, pp. 1330-1335
-
-
DiLeone, R.J.1
Taylor, J.R.2
Picciotto, M.R.3
-
64
-
-
0032863991
-
Foodintake elicitedbycentral administration of orexins/hypocretins: identification of hypothalamic sites of action
-
doi:10.1016/S0006-8993(99)01824-7
-
Dube MG, Kalra SP & Kalra PS 1999 Foodintake elicitedbycentral administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Research 842 473-477. (doi:10.1016/S0006-8993(99)01824-7)
-
(1999)
Brain Research
, vol.842
, pp. 473-477
-
-
Dube, M.G.1
Kalra, S.P.2
Kalra, P.S.3
-
65
-
-
0026061245
-
Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats
-
Egawa M, Yoshimatsu H & Bray GA 1991 Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats. American Journal of Physiology 260 R328-R334.
-
(1991)
American Journal of Physiology
, vol.260
-
-
Egawa, M.1
Yoshimatsu, H.2
Bray, G.A.3
-
66
-
-
0032436307
-
Leptin activates hypothalamic CART neurons projecting to the spinal cord
-
doi:10.1016/S0896-6273(00)80656-X
-
Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB & Elmquist JK 1998 Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21 1375-1385. (doi:10.1016/S0896-6273(00)80656-X)
-
(1998)
Neuron
, vol.21
, pp. 1375-1385
-
-
Elias, C.F.1
Lee, C.2
Kelly, J.3
Aschkenasi, C.4
Ahima, R.S.5
Couceyro, P.R.6
Kuhar, M.J.7
Saper, C.B.8
Elmquist, J.K.9
-
67
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
doi:10.1016/S0896-6273(01)80035-0
-
Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB & Elmquist JK 1999 Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23 775-786. (doi:10.1016/S0896-6273(01)80035-0)
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
68
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
doi:10.1002/(SICI)1096-9861(19980615)395:4!535::AID-CNE9O3.0.CO;2-2
-
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS & Saper CB 1998 Distributions of leptin receptor mRNA isoforms in the rat brain. Journal of Comparative Neurology 395 535-547. (doi:10.1002/(SICI)1096-9861(19980615)395:4!535::AID-CNE9O3.0.CO;2-2)
-
(1998)
Journal of Comparative Neurology
, vol.395
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
69
-
-
70349151817
-
Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity
-
doi:10.1523/JNEUROSCI.5712-08.2009
-
Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Munzberg H, Hampel B et al. 2009 Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. Journal of Neuroscience 29 11582-11593. (doi:10.1523/JNEUROSCI.5712-08.2009)
-
(2009)
Journal of Neuroscience
, vol.29
, pp. 11582-11593
-
-
Ernst, M.B.1
Wunderlich, C.M.2
Hess, S.3
Paehler, M.4
Mesaros, A.5
Koralov, S.B.6
Kleinridders, A.7
Husch, A.8
Munzberg, H.9
Hampel, B.10
-
70
-
-
0030614331
-
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
-
doi:10.1038/385165a0
-
Fan W, Boston BA, Kesterson RA, Hruby VJ & Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 165-168. (doi:10.1038/385165a0)
-
(1997)
Nature
, vol.385
, pp. 165-168
-
-
Fan, W.1
Boston, B.A.2
Kesterson, R.A.3
Hruby, V.J.4
Cone, R.D.5
-
71
-
-
1842560331
-
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
-
doi:10.1038/nn1214
-
Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P & Cone RD 2004 Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nature Neuroscience 7 335-336. (doi:10.1038/nn1214)
-
(2004)
Nature Neuroscience
, vol.7
, pp. 335-336
-
-
Fan, W.1
Ellacott, K.L.2
Halatchev, I.G.3
Takahashi, K.4
Yu, P.5
Cone, R.D.6
-
72
-
-
43049130474
-
Monogenic human obesity
-
doi:10.1159/0000115333
-
Farooqi IS 2008 Monogenic human obesity. Frontiers of Hormone Research 36 1-11. (doi:10.1159/0000115333)
-
(2008)
Frontiers of Hormone Research
, vol.36
, pp. 1-11
-
-
Farooqi, I.S.1
-
73
-
-
0041820129
-
Hyperphagic effects of brainstem ghrelin administration
-
doi:10.2337/diabetes.52.9.2260
-
Faulconbridge LF, Cummings DE, Kaplan JM & Grill HJ 2003 Hyperphagic effects of brainstem ghrelin administration. Diabetes 52 2260-2265. (doi:10.2337/diabetes.52.9.2260)
-
(2003)
Diabetes
, vol.52
, pp. 2260-2265
-
-
Faulconbridge, L.F.1
Cummings, D.E.2
Kaplan, J.M.3
Grill, H.J.4
-
74
-
-
0342858793
-
α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormonesynthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
-
Fekete C, Legradi G, Mihaly E, Huang QH, Tatro JB, Rand WM, Emerson CH & Lechan RM 2000 α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormonesynthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. Journal of Neuroscience 20 1550-1558.
-
(2000)
Journal of Neuroscience
, vol.20
, pp. 1550-1558
-
-
Fekete, C.1
Legradi, G.2
Mihaly, E.3
Huang, Q.H.4
Tatro, J.B.5
Rand, W.M.6
Emerson, C.H.7
Lechan, R.M.8
-
75
-
-
9244234318
-
Effect of agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse
-
doi:10.1210/en.2004-0476
-
Fekete C, Marks DL, Sarkar S, Emerson CH, Rand WM, Cone RD & Lechan RM 2004 Effect of agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Endocrinology 145 4816-4821. (doi:10.1210/en.2004-0476)
-
(2004)
Endocrinology
, vol.145
, pp. 4816-4821
-
-
Fekete, C.1
Marks, D.L.2
Sarkar, S.3
Emerson, C.H.4
Rand, W.M.5
Cone, R.D.6
Lechan, R.M.7
-
76
-
-
0027158315
-
Adrenocorticotropin/α-melanocyte-stimulating hormone (ACTH/MSH)-like peptides modulate adenylate cyclase activity in rat brain slices: evidence for an ACTH/MSH receptor-coupled mechanism
-
doi:10.1111/j.1471-4159.1993.tb03506.x
-
Florijn WJ, Mulder AH, Versteeg DH & Gispen WH 1993 Adrenocorticotropin/α-melanocyte-stimulating hormone (ACTH/MSH)-like peptides modulate adenylate cyclase activity in rat brain slices: evidence for an ACTH/MSH receptor-coupled mechanism. Journal of Neurochemistry 60 2204-2211. (doi:10.1111/j.1471-4159.1993.tb03506.x)
-
(1993)
Journal of Neurochemistry
, vol.60
, pp. 2204-2211
-
-
Florijn, W.J.1
Mulder, A.H.2
Versteeg, D.H.3
Gispen, W.H.4
-
77
-
-
79953212635
-
ATP-mediated glucosensing by hypothalamic tanycytes
-
doi:10.1113/jphysiol.2010.202051
-
Frayling C, Britton R & Dale N 2011 ATP-mediated glucosensing by hypothalamic tanycytes. Journal of Physiology 589 2275-2286. (doi:10.1113/jphysiol.2010.202051)
-
(2011)
Journal of Physiology
, vol.589
, pp. 2275-2286
-
-
Frayling, C.1
Britton, R.2
Dale, N.3
-
78
-
-
84868629649
-
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
-
doi:10.1172/JCI64102
-
Fuente-Martin E, Garcia-Caceres C, Granado M, de Ceballos ML, Sanchez-Garrido MA, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizon P et al. 2012 Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. Journal of Clinical Investigation 122 3900-3913. (doi:10.1172/JCI64102)
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 3900-3913
-
-
Fuente-Martin, E.1
Garcia-Caceres, C.2
Granado, M.3
de Ceballos, M.L.4
Sanchez-Garrido, M.A.5
Sarman, B.6
Liu, Z.W.7
Dietrich, M.O.8
Tena-Sempere, M.9
Argente-Arizon, P.10
-
79
-
-
79955431010
-
Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels
-
doi:10.1210/en.2010-1252
-
Garcia-Caceres C, Fuente-Martin E, Burgos-Ramos E, Granado M, Frago LM, Barrios V, Horvath T, Argente J & Chowen JA 2011 Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels. Endocrinology 152 1809-1818. (doi:10.1210/en.2010-1252)
-
(2011)
Endocrinology
, vol.152
, pp. 1809-1818
-
-
Garcia-Caceres, C.1
Fuente-Martin, E.2
Burgos-Ramos, E.3
Granado, M.4
Frago, L.M.5
Barrios, V.6
Horvath, T.7
Argente, J.8
Chowen, J.A.9
-
80
-
-
0023184531
-
Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization
-
doi:10.1002/syn.890010106
-
Gehlert DR, Chronwall BM, Schafer MP & O'Donohue TL 1987 Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization. Synapse 1 25-31. (doi:10.1002/syn.890010106)
-
(1987)
Synapse
, vol.1
, pp. 25-31
-
-
Gehlert, D.R.1
Chronwall, B.M.2
Schafer, M.P.3
O'Donohue, T.L.4
-
83
-
-
84856909575
-
Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet
-
Gil K, Bugajski A & Thor P 2011 Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet. Journal of Physiology and Pharmacology 62 637-646.
-
(2011)
Journal of Physiology and Pharmacology
, vol.62
, pp. 637-646
-
-
Gil, K.1
Bugajski, A.2
Thor, P.3
-
84
-
-
46349110307
-
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
-
doi:10.1210/en.2007-0945
-
Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M & MacKenzie RG 2008 Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology 149 3346-3354. (doi:10.1210/en.2007-0945)
-
(2008)
Endocrinology
, vol.149
, pp. 3346-3354
-
-
Gong, L.1
Yao, F.2
Hockman, K.3
Heng, H.H.4
Morton, G.J.5
Takeda, K.6
Akira, S.7
Low, M.J.8
Rubinstein, M.9
MacKenzie, R.G.10
-
85
-
-
0031280002
-
Overexpression of Agrt leads to obesity in transgenic mice
-
doi:10.1038/ng1197-273
-
Graham M, Shutter JR, Sarmiento U, Sarosi I & Stark KL 1997 Overexpression of Agrt leads to obesity in transgenic mice. Nature Genetics 17 273-274. (doi:10.1038/ng1197-273)
-
(1997)
Nature Genetics
, vol.17
, pp. 273-274
-
-
Graham, M.1
Shutter, J.R.2
Sarmiento, U.3
Sarosi, I.4
Stark, K.L.5
-
86
-
-
77950216899
-
Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet
-
doi:10.1210/en.2009-1019
-
Grayson BE, Levasseur PR, Williams SM, Smith MS, Marks DL & Grove KL 2010 Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology 151 1622-1632. (doi:10.1210/en.2009-1019)
-
(2010)
Endocrinology
, vol.151
, pp. 1622-1632
-
-
Grayson, B.E.1
Levasseur, P.R.2
Williams, S.M.3
Smith, M.S.4
Marks, D.L.5
Grove, K.L.6
-
87
-
-
84879485588
-
Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior
-
doi:10.1210/me.2012-1344
-
Greenman Y, Kuperman Y, Drori Y,Asa SL,Navon I, ForkoshO,Gil S, SternN & Chen A 2013 Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior. Molecular Endocrinology 27 1091-1102. (doi:10.1210/me.2012-1344)
-
(2013)
Molecular Endocrinology
, vol.27
, pp. 1091-1102
-
-
Greenman, Y.1
Kuperman, Y.2
Drori, Y.3
Asa, S.L.4
Navon, I.5
Forkosh, O.6
Gil, S.7
Stern, N.8
Chen, A.9
-
88
-
-
27344433932
-
Agouti-related peptideexpressing neurons are mandatory for feeding
-
doi:10.1038/nn1548
-
Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A et al. 2005 Agouti-related peptideexpressing neurons are mandatory for feeding. Nature Neuroscience 8 1289-1291. (doi:10.1038/nn1548)
-
(2005)
Nature Neuroscience
, vol.8
, pp. 1289-1291
-
-
Gropp, E.1
Shanabrough, M.2
Borok, E.3
Xu, A.W.4
Janoschek, R.5
Buch, T.6
Plum, L.7
Balthasar, N.8
Hampel, B.9
Waisman, A.10
-
89
-
-
0032569615
-
Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
-
doi:10.1097/00001756-199810260-00015
-
Guan XM, Yu H, TrumbauerM, Frazier E, Van der Ploeg LH & Chen H 1998 Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport 9 3415-3419. (doi:10.1097/00001756-199810260-00015)
-
(1998)
Neuroreport
, vol.9
, pp. 3415-3419
-
-
Guan, X.M.1
Yu, H.2
Trumbauer, M.3
Frazier, E.4
Van der Ploeg, L.H.5
Chen, H.6
-
90
-
-
4143090543
-
N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin
-
doi:10.1073/pnas.0403165101
-
Guo L, Munzberg H, Stuart RC, Nillni EA & Bjorbaek C 2004 N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin. PNAS 101 11797-11802. (doi:10.1073/pnas.0403165101)
-
(2004)
PNAS
, vol.101
, pp. 11797-11802
-
-
Guo, L.1
Munzberg, H.2
Stuart, R.C.3
Nillni, E.A.4
Bjorbaek, C.5
-
91
-
-
0033870091
-
Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade
-
Hagan MM, Rushing PA, Pritchard LM, Schwartz MW, Strack AM, Van Der Ploeg LH, Woods SC & Seeley RJ 2000 Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 279 R47-R52.
-
(2000)
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
, vol.279
-
-
Hagan, M.M.1
Rushing, P.A.2
Pritchard, L.M.3
Schwartz, M.W.4
Strack, A.M.5
Van Der Ploeg, L.H.6
Woods, S.C.7
Seeley, R.J.8
-
92
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
doi:10.1126/science.7624777
-
Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK & Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 543-546. (doi:10.1126/science.7624777)
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
Cohen, S.L.4
Chait, B.T.5
Rabinowitz, D.6
Lallone, R.L.7
Burley, S.K.8
Friedman, J.M.9
-
93
-
-
0032968698
-
Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding
-
doi:10.2337/diabetes.48.2.267
-
Harrold JA, Widdowson PS & Williams G 1999 Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Diabetes 48 267-271. (doi:10.2337/diabetes.48.2.267)
-
(1999)
Diabetes
, vol.48
, pp. 267-271
-
-
Harrold, J.A.1
Widdowson, P.S.2
Williams, G.3
-
94
-
-
0035810771
-
Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor
-
doi:10.1016/S0167-0115(01)00234-8
-
Haskell-Luevano C & Monck EK 2001 Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regulatory Peptides 99 1-7. (doi:10.1016/S0167-0115(01)00234-8)
-
(2001)
Regulatory Peptides
, vol.99
, pp. 1-7
-
-
Haskell-Luevano, C.1
Monck, E.K.2
-
95
-
-
0018090354
-
Insulin receptors are widely distributed in the central nervous system of the rat
-
doi:10.1038/272827a0
-
Havrankova J, Roth J & Brownstein M 1978 Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272 827-829. (doi:10.1038/272827a0)
-
(1978)
Nature
, vol.272
, pp. 827-829
-
-
Havrankova, J.1
Roth, J.2
Brownstein, M.3
-
96
-
-
47949104953
-
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
-
doi:10.1210/en.2007-1743
-
Hayes MR, Skibicka KP & Grill HJ 2008 Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology 149 4059-4068. (doi:10.1210/en.2007-1743)
-
(2008)
Endocrinology
, vol.149
, pp. 4059-4068
-
-
Hayes, M.R.1
Skibicka, K.P.2
Grill, H.J.3
-
97
-
-
84869760976
-
Locked nucleic acid-based in situ hybridisation reveals miR-7a as a hypothalamus-enriched microRNA with a distinct expression pattern
-
doi:10.1111/j.1365-2826.2012.02358.x
-
Herzer S, Silahtaroglu A & Meister B 2012 Locked nucleic acid-based in situ hybridisation reveals miR-7a as a hypothalamus-enriched microRNA with a distinct expression pattern. Journal of Neuroendocrinology 24 1492-1504. (doi:10.1111/j.1365-2826.2012.02358.x)
-
(2012)
Journal of Neuroendocrinology
, vol.24
, pp. 1492-1504
-
-
Herzer, S.1
Silahtaroglu, A.2
Meister, B.3
-
98
-
-
43049116846
-
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
-
doi:10.1172/JCI32964
-
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB & Elmquist JK 2008 Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. Journal of Clinical Investigation 118 1796-1805. (doi:10.1172/JCI32964)
-
(2008)
Journal of Clinical Investigation
, vol.118
, pp. 1796-1805
-
-
Hill, J.W.1
Williams, K.W.2
Ye, C.3
Luo, J.4
Balthasar, N.5
Coppari, R.6
Cowley, M.A.7
Cantley, L.C.8
Lowell, B.B.9
Elmquist, J.K.10
-
99
-
-
70350317881
-
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis
-
doi:10.1210/en.2009-0454
-
Hill JW, Xu Y, Preitner F, FukudaM, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB et al. 2009 Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology 150 4874-4882. (doi:10.1210/en.2009-0454)
-
(2009)
Endocrinology
, vol.150
, pp. 4874-4882
-
-
Hill, J.W.1
Xu, Y.2
Preitner, F.3
Fukuda, M.4
Cho, Y.R.5
Luo, J.6
Balthasar, N.7
Coppari, R.8
Cantley, L.C.9
Kahn, B.B.10
-
100
-
-
77950264425
-
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
-
doi:10.1016/j.cmet.2010.03.002
-
HillJW,EliasCF, FukudaM,WilliamsKW, BerglundED,HollandWL,ChoYR, Chuang JC, Xu Y, ChoiM et al. 2010 Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metabolism 11 286-297. (doi:10.1016/j.cmet.2010.03.002)
-
(2010)
Cell Metabolism
, vol.11
, pp. 286-297
-
-
Hill, J.W.1
Elias, C.F.2
Fukuda, M.3
Williams, K.W.4
Berglund, E.D.5
Holland, W.L.6
Cho, Y.R.7
Chuang, J.C.8
Xu, Y.9
Choi, M.10
-
101
-
-
0030990363
-
Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
-
doi:10.1016/S0006-8993(97)00184-4
-
Horvath TL, Bechmann I, Naftolin F, Kalra SP & Leranth C 1997 Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Research 756 283-286. (doi:10.1016/S0006-8993(97)00184-4)
-
(1997)
Brain Research
, vol.756
, pp. 283-286
-
-
Horvath, T.L.1
Bechmann, I.2
Naftolin, F.3
Kalra, S.P.4
Leranth, C.5
-
102
-
-
77957053600
-
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
-
doi:10.1073/pnas.1004282107
-
Horvath TL, Sarman B, Garcia-Caceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D et al. 2010 Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. PNAS 107 14875-14880. (doi:10.1073/pnas.1004282107)
-
(2010)
PNAS
, vol.107
, pp. 14875-14880
-
-
Horvath, T.L.1
Sarman, B.2
Garcia-Caceres, C.3
Enriori, P.J.4
Sotonyi, P.5
Shanabrough, M.6
Borok, E.7
Argente, J.8
Chowen, J.A.9
Perez-Tilve, D.10
-
103
-
-
65249150732
-
Obesity induces functional astrocytic leptin receptors in hypothalamus
-
doi:10.1093/brain/awp029
-
Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB & Pan W 2009a Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 132 889-902. (doi:10.1093/brain/awp029)
-
(2009)
Brain
, vol.132
, pp. 889-902
-
-
Hsuchou, H.1
He, Y.2
Kastin, A.J.3
Tu, H.4
Markadakis, E.N.5
Rogers, R.C.6
Fossier, P.B.7
Pan, W.8
-
104
-
-
70449687899
-
Leptin receptor mRNA in rat brain astrocytes
-
doi:10.1016/j.peptides. 2009.08.023
-
Hsuchou H, PanW, Barnes MJ & Kastin AJ 2009b Leptin receptor mRNA in rat brain astrocytes. Peptides 30 2275-2280. (doi:10.1016/j.peptides. 2009.08.023)
-
(2009)
Peptides
, vol.30
, pp. 2275-2280
-
-
Hsuchou, H.1
Pan, W.2
Barnes, M.J.3
Kastin, A.J.4
-
105
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
doi:10.1016/S0092-8674(00)81865-6
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD et al. 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 131-141. (doi:10.1016/S0092-8674(00)81865-6)
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
-
107
-
-
77949858304
-
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
-
doi:10.1152/ajpendo. 00512.2009
-
Iskandar K, Cao Y,Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S Jr et al. 2010 PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. American Journal of Physiology. Endocrinology and Metabolism 298 E787-E798. (doi:10.1152/ajpendo. 00512.2009)
-
(2010)
American Journal of Physiology. Endocrinology and Metabolism
, vol.298
-
-
Iskandar, K.1
Cao, Y.2
Hayashi, Y.3
Nakata, M.4
Takano, E.5
Yada, T.6
Zhang, C.7
Ogawa, W.8
Oki, M.9
Chua Jr., S.10
-
108
-
-
84878586125
-
Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity
-
doi:10.1152/japplphysiol. 01499.2012
-
Jayaram B, Pan W, Wang Y,Hsuchou H, Mace A, Cornelissen-Guillaume GG, Mishra PK, Koza RA & Kastin AJ 2013 Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity. Journal of Applied Physiology 114 734-741. (doi:10.1152/japplphysiol. 01499.2012)
-
(2013)
Journal of Applied Physiology
, vol.114
, pp. 734-741
-
-
Jayaram, B.1
Pan, W.2
Wang, Y.3
Hsuchou, H.4
Mace, A.5
Cornelissen-Guillaume, G.G.6
Mishra, P.K.7
Koza, R.A.8
Kastin, A.J.9
-
109
-
-
0025721025
-
Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
-
doi:10.1073/pnas. 88.23.10931
-
Kalra SP, Dube MG, Sahu A, Phelps CP & Kalra PS 1991 Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. PNAS 88 10931-10935. (doi:10.1073/pnas. 88.23.10931)
-
(1991)
PNAS
, vol.88
, pp. 10931-10935
-
-
Kalra, S.P.1
Dube, M.G.2
Sahu, A.3
Phelps, C.P.4
Kalra, P.S.5
-
110
-
-
0035513696
-
Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats
-
doi:10.2337/diabetes.50.11.2438
-
Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H & Wakabayashi I 2001 Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 50 2438-2443. (doi:10.2337/diabetes.50.11.2438)
-
(2001)
Diabetes
, vol.50
, pp. 2438-2443
-
-
Kamegai, J.1
Tamura, H.2
Shimizu, T.3
Ishii, S.4
Sugihara, H.5
Wakabayashi, I.6
-
111
-
-
33746537247
-
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
-
doi:10.1016/j.cmet.2006.06.010
-
Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A & Flier JS 2006 Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metabolism 4 123-132. (doi:10.1016/j.cmet.2006.06.010)
-
(2006)
Cell Metabolism
, vol.4
, pp. 123-132
-
-
Kievit, P.1
Howard, J.K.2
Badman, M.K.3
Balthasar, N.4
Coppari, R.5
Mori, H.6
Lee, C.E.7
Elmquist, J.K.8
Yoshimura, A.9
Flier, J.S.10
-
112
-
-
0000573907
-
Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone
-
doi:10.2337/diabetes.49.2.177
-
Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, Edwards CM, Heath MM, Stanley SA, Seal LJ et al. 2000 Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone. Diabetes 49 177-182. (doi:10.2337/diabetes.49.2.177)
-
(2000)
Diabetes
, vol.49
, pp. 177-182
-
-
Kim, M.S.1
Rossi, M.2
Abusnana, S.3
Sunter, D.4
Morgan, D.G.5
Small, C.J.6
Edwards, C.M.7
Heath, M.M.8
Stanley, S.A.9
Seal, L.J.10
-
113
-
-
79960617185
-
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
-
doi:10.1073/pnas.1102364108
-
Kim KW, Zhao L, Donato J Jr, Kohno D, Xu Y, Elias CF, Lee C, Parker KL & Elmquist JK 2011 Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. PNAS 108 10673-10678. (doi:10.1073/pnas.1102364108)
-
(2011)
PNAS
, vol.108
, pp. 10673-10678
-
-
Kim, K.W.1
Zhao, L.2
Donato Jr., J.3
Kohno, D.4
Xu, Y.5
Elias, C.F.6
Lee, C.7
Parker, K.L.8
Elmquist, J.K.9
-
114
-
-
0023890753
-
PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome
-
doi:10.1016/0031-9384(88)90153-9
-
Kirchgessner AL & Sclafani A 1988 PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome. Physiology & Behavior 42 517-528. (doi:10.1016/0031-9384(88)90153-9)
-
(1988)
Physiology & Behavior
, vol.42
, pp. 517-528
-
-
Kirchgessner, A.L.1
Sclafani, A.2
-
115
-
-
0037430140
-
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
-
doi:10.1002/cne.10454
-
Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB & Elmquist JK 2003 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. Journal of Comparative Neurology 457 213-235. (doi:10.1002/cne.10454)
-
(2003)
Journal of Comparative Neurology
, vol.457
, pp. 213-235
-
-
Kishi, T.1
Aschkenasi, C.J.2
Lee, C.E.3
Mountjoy, K.G.4
Saper, C.B.5
Elmquist, J.K.6
-
117
-
-
33646590947
-
Forkhead protein FoxO1mediatesAgrp-dependent effects of leptin on food intake
-
doi:10.1038/nm1392
-
Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, Rossetti L & AcciliD2006 Forkhead protein FoxO1mediatesAgrp-dependent effects of leptin on food intake. Nature Medicine 12 534-540. (doi:10.1038/nm1392)
-
(2006)
Nature Medicine
, vol.12
, pp. 534-540
-
-
Kitamura, T.1
Feng, Y.2
Kitamura, Y.I.3
Chua Jr., S.C.4
Xu, A.W.5
Barsh, G.S.6
Rossetti, L.7
Accili, D.8
-
118
-
-
20244369116
-
The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats
-
doi:10.1210/en.2004-1266
-
Koda S, Date Y, Murakami N, Shimbara T, Hanada T, Toshinai K, Niijima A, Furuya M, Inomata N, Osuye K et al. 2005 The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146 2369-2375. (doi:10.1210/en.2004-1266)
-
(2005)
Endocrinology
, vol.146
, pp. 2369-2375
-
-
Koda, S.1
Date, Y.2
Murakami, N.3
Shimbara, T.4
Hanada, T.5
Toshinai, K.6
Niijima, A.7
Furuya, M.8
Inomata, N.9
Osuye, K.10
-
119
-
-
0033540056
-
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
-
doi:10.1038/45230
-
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660. (doi:10.1038/45230)
-
(1999)
Nature
, vol.402
, pp. 656-660
-
-
Kojima, M.1
Hosoda, H.2
Date, Y.3
Nakazato, M.4
Matsuo, H.5
Kangawa, K.6
-
120
-
-
0141483502
-
A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation
-
doi:10.1096/fj.02-0805
-
Kong W, Stanley S, Gardiner J, Abbott C, Murphy K, Seth A, Connoley I, Ghatei M, Stephens D & Bloom S 2003 A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation. FASEB Journal 17 1688-1690. (doi:10.1096/fj.02-0805fje)
-
(2003)
FASEB Journal
, vol.17
, pp. 1688-1690
-
-
Kong, W.1
Stanley, S.2
Gardiner, J.3
Abbott, C.4
Murphy, K.5
Seth, A.6
Connoley, I.7
Ghatei, M.8
Stephens, D.9
Bloom, S.10
-
121
-
-
84868012864
-
GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure
-
doi:10.1016/j.cell.2012.09.020
-
KongD,TongQ,Ye C,KodaS, FullerPM,KrashesMJ,VongL,RayRS,OlsonDP & Lowell BB 2012 GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 151 645-657. (doi:10.1016/j.cell.2012.09.020)
-
(2012)
Cell
, vol.151
, pp. 645-657
-
-
Kong, D.1
Tong, Q.2
Ye, C.3
Koda, S.4
Fuller, P.M.5
Krashes, M.J.6
Vong, L.7
Ray, R.S.8
Olson, D.P.9
Lowell, B.B.10
-
122
-
-
34249651956
-
Insulin action inAgRP-expressing neurons is required for suppression of hepatic glucose production
-
doi:10.1016/j.cmet.2007.05.004
-
Konner AC, Janoschek R, Plum L, Jordan SD, Rother E,Ma X, Xu C, Enriori P, Hampel B, Barsh GS et al. 2007 Insulin action inAgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabolism 5 438-449. (doi:10.1016/j.cmet.2007.05.004)
-
(2007)
Cell Metabolism
, vol.5
, pp. 438-449
-
-
Konner, A.C.1
Janoschek, R.2
Plum, L.3
Jordan, S.D.4
Rother, E.5
Ma, X.6
Xu, C.7
Enriori, P.8
Hampel, B.9
Barsh, G.S.10
-
123
-
-
0034056756
-
Effect of NPY in the hypothalamic paraventricular nucleus on uncoupling proteins 1, 2, and 3 in the rat
-
Kotz CM, Wang CF, Briggs JE, Levine AS & Billington CJ 2000 Effect of NPY in the hypothalamic paraventricular nucleus on uncoupling proteins 1, 2, and 3 in the rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 278 R494-R498.
-
(2000)
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
, vol.278
-
-
Kotz, C.M.1
Wang, C.F.2
Briggs, J.E.3
Levine, A.S.4
Billington, C.J.5
-
124
-
-
79953307878
-
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
-
doi:10.1172/JCI46229
-
KrashesMJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL & Lowell BB 2011 Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. Journal of Clinical Investigation 121 1424-1428. (doi:10.1172/JCI46229)
-
(2011)
Journal of Clinical Investigation
, vol.121
, pp. 1424-1428
-
-
Krashes, M.J.1
Koda, S.2
Ye, C.3
Rogan, S.C.4
Adams, A.C.5
Cusher, D.S.6
Maratos-Flier, E.7
Roth, B.L.8
Lowell, B.B.9
-
125
-
-
0023638829
-
Glucagon-like peptide-1 7-36: a physiological incretin in man
-
doi:10.1016/S0140-6736(87)91194-9
-
Kreymann B, Williams G, Ghatei MA & Bloom SR 1987 Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2 1300-1304. (doi:10.1016/S0140-6736(87)91194-9)
-
(1987)
Lancet
, vol.2
, pp. 1300-1304
-
-
Kreymann, B.1
Williams, G.2
Ghatei, M.A.3
Bloom, S.R.4
-
126
-
-
0032492893
-
Hypothalamic CART is a new anorectic peptide regulated by leptin
-
doi:10.1038/29993
-
Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N et al. 1998 Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393 72-76. (doi:10.1038/29993)
-
(1998)
Nature
, vol.393
, pp. 72-76
-
-
Kristensen, P.1
Judge, M.E.2
Thim, L.3
Ribel, U.4
Christjansen, K.N.5
Wulff, B.S.6
Clausen, J.T.7
Jensen, P.B.8
Madsen, O.D.9
Vrang, N.10
-
127
-
-
0035715675
-
Effects of continuous microchip (MC) vagal neuromodulation on gastrointestinal function in rats
-
Krolczyk G, Zurowski D, Sobocki J, Slowiaczek MP, Laskiewicz J, Matyja A, Zaraska K, Zaraska W & Thor PJ 2001 Effects of continuous microchip (MC) vagal neuromodulation on gastrointestinal function in rats. Journal of Physiology and Pharmacology 52 705-715.
-
(2001)
Journal of Physiology and Pharmacology
, vol.52
, pp. 705-715
-
-
Krolczyk, G.1
Zurowski, D.2
Sobocki, J.3
Slowiaczek, M.P.4
Laskiewicz, J.5
Matyja, A.6
Zaraska, K.7
Zaraska, W.8
Thor, P.J.9
-
128
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
doi:10.1038/509
-
Krude H, Biebermann H, Luck W, Horn R, Brabant G & Gruters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics 19 155-157. (doi:10.1038/509)
-
(1998)
Nature Genetics
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
Horn, R.4
Brabant, G.5
Gruters, A.6
-
129
-
-
84875883939
-
Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting
-
doi:10.1016/j.cmet.2013.03.004
-
Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P et al. 2013 Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metabolism 17 607-617. (doi:10.1016/j.cmet.2013.03.004)
-
(2013)
Cell Metabolism
, vol.17
, pp. 607-617
-
-
Langlet, F.1
Levin, B.E.2
Luquet, S.3
Mazzone, M.4
Messina, A.5
Dunn-Meynell, A.A.6
Balland, E.7
Lacombe, A.8
Mazur, D.9
Carmeliet, P.10
-
130
-
-
33645048441
-
A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance
-
doi:10.1016/j.cmet. 2006.01.006
-
Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D et al. 2006 A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance. Cell Metabolism 3 135-140. (doi:10.1016/j.cmet. 2006.01.006)
-
(2006)
Cell Metabolism
, vol.3
, pp. 135-140
-
-
Lee, Y.S.1
Challis, B.G.2
Thompson, D.A.3
Yeo, G.S.4
Keogh, J.M.5
Madonna, M.E.6
Wraight, V.7
Sims, M.8
Vatin, V.9
Meyre, D.10
-
132
-
-
79952754249
-
Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice
-
doi:10.1016/j.physbeh.2011.01.018
-
Lee J, Martin E, Paulino G, de Lartigue G & Raybould HE 2011 Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice. Physiology & Behavior 103 181-187. (doi:10.1016/j.physbeh.2011.01.018)
-
(2011)
Physiology & Behavior
, vol.103
, pp. 181-187
-
-
Lee, J.1
Martin, E.2
Paulino, G.3
de Lartigue, G.4
Raybould, H.E.5
-
133
-
-
84862776637
-
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
-
doi:10.1038/nn.3079
-
Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H et al. 2012 Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nature Neuroscience 15 700-702. (doi:10.1038/nn.3079)
-
(2012)
Nature Neuroscience
, vol.15
, pp. 700-702
-
-
Lee, D.A.1
Bedont, J.L.2
Pak, T.3
Wang, H.4
Song, J.5
Miranda-Angulo, A.6
Takiar, V.7
Charubhumi, V.8
Balordi, F.9
Takebayashi, H.10
-
134
-
-
84867051812
-
IKKb/NF-κ disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
-
doi:10.1038/ncb2562
-
Li J, Tang Y & Cai D 2012 IKKb/NF-κ disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nature Cell Biology 14 999-1012. (doi:10.1038/ncb2562)
-
(2012)
Nature Cell Biology
, vol.14
, pp. 999-1012
-
-
Li, J.1
Tang, Y.2
Cai, D.3
-
135
-
-
77449144768
-
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
-
doi:10.2337/db09-1303
-
Lin HV, Plum L, Ono H, Gutierrez-Juarez R, Shanabrough M, Borok E, Horvath TL, Rossetti L & Accili D 2010 Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 59 337-346. (doi:10.2337/db09-1303)
-
(2010)
Diabetes
, vol.59
, pp. 337-346
-
-
Lin, H.V.1
Plum, L.2
Ono, H.3
Gutierrez-Juarez, R.4
Shanabrough, M.5
Borok, E.6
Horvath, T.L.7
Rossetti, L.8
Accili, D.9
-
136
-
-
77956431307
-
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
-
doi:10.1038/nm.2207
-
Lopez M, Varela L, Vazquez MJ, Rodriguez-Cuenca S, Gonzalez CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R et al. 2010 Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine 16 1001-1008. (doi:10.1038/nm.2207)
-
(2010)
Nature Medicine
, vol.16
, pp. 1001-1008
-
-
Lopez, M.1
Varela, L.2
Vazquez, M.J.3
Rodriguez-Cuenca, S.4
Gonzalez, C.R.5
Velagapudi, V.R.6
Morgan, D.A.7
Schoenmakers, E.8
Agassandian, K.9
Lage, R.10
-
137
-
-
0035134670
-
Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
-
doi:10.1172/JCI10660
-
Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS & Maratos-Flier E 2001 Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. Journal of Clinical Investigation 107 379-386. (doi:10.1172/JCI10660)
-
(2001)
Journal of Clinical Investigation
, vol.107
, pp. 379-386
-
-
Ludwig, D.S.1
Tritos, N.A.2
Mastaitis, J.W.3
Kulkarni, R.4
Kokkotou, E.5
Elmquist, J.6
Lowell, B.7
Flier, J.S.8
Maratos-Flier, E.9
-
138
-
-
0021987575
-
The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord
-
doi:10.1016/0006-8993(85)90554-2
-
Luiten PG, ter Horst GJ, Karst H & Steffens AB 1985 The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Research 329 374-378. (doi:10.1016/0006-8993(85)90554-2)
-
(1985)
Brain Research
, vol.329
, pp. 374-378
-
-
Luiten, P.G.1
ter Horst, G.J.2
Karst, H.3
Steffens, A.B.4
-
139
-
-
27344431720
-
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
-
doi:10.1126/science.1115524
-
Luquet S, Perez FA, Hnasko TS & Palmiter RD 2005 NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310 683-685. (doi:10.1126/science.1115524)
-
(2005)
Science
, vol.310
, pp. 683-685
-
-
Luquet, S.1
Perez, F.A.2
Hnasko, T.S.3
Palmiter, R.D.4
-
140
-
-
33846597193
-
NPY/AgRP neurons are not essential for feeding responses to glucoprivation
-
doi:10.1016/j.peptides.2006.08.036
-
Luquet S, Phillips CT & Palmiter RD 2007 NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides 28 214-225. (doi:10.1016/j.peptides.2006.08.036)
-
(2007)
Peptides
, vol.28
, pp. 214-225
-
-
Luquet, S.1
Phillips, C.T.2
Palmiter, R.D.3
-
141
-
-
0033592920
-
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
-
doi:10.1073/pnas.96.26.15239
-
Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE & Tessarollo L 1999 Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. PNAS 96 15239-15244. (doi:10.1073/pnas.96.26.15239)
-
(1999)
PNAS
, vol.96
, pp. 15239-15244
-
-
Lyons, W.E.1
Mamounas, L.A.2
Ricaurte, G.A.3
Coppola, V.4
Reid, S.W.5
Bora, S.H.6
Wihler, C.7
Koliatsos, V.E.8
Tessarollo, L.9
-
142
-
-
0025612094
-
Localization of insulin receptor mRNA in rat brain by in situ hybridization
-
doi:10.1210/endo-127-6-3234
-
Marks JL, Porte D Jr, Stahl WL & Baskin DG 1990 Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127 3234-3236. (doi:10.1210/endo-127-6-3234)
-
(1990)
Endocrinology
, vol.127
, pp. 3234-3236
-
-
Marks, J.L.1
Porte Jr., D.2
Stahl, W.L.3
Baskin, D.G.4
-
143
-
-
0037022667
-
Melaninconcentrating hormone 1 receptor-deficientmice are lean, hyperactive, and hyperphagic and have altered metabolism
-
doi:10.1073/pnas.052706899
-
Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE et al. 2002 Melaninconcentrating hormone 1 receptor-deficientmice are lean, hyperactive, and hyperphagic and have altered metabolism. PNAS 99 3240-3245. (doi:10.1073/pnas.052706899)
-
(2002)
PNAS
, vol.99
, pp. 3240-3245
-
-
Marsh, D.J.1
Weingarth, D.T.2
Novi, D.E.3
Chen, H.Y.4
Trumbauer, M.E.5
Chen, A.S.6
Guan, X.M.7
Jiang, M.M.8
Feng, Y.9
Camacho, R.E.10
-
144
-
-
84859557325
-
Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
-
doi:10.2337/db11-1079
-
Martinez de Morentin PB, Whittle AJ, Ferno J, Nogueiras R, Dieguez C, Vidal-Puig A & Lopez M 2012 Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes 61 807-817. (doi:10.2337/db11-1079)
-
(2012)
Diabetes
, vol.61
, pp. 807-817
-
-
Martinez de Morentin, P.B.1
Whittle, A.J.2
Ferno, J.3
Nogueiras, R.4
Dieguez, C.5
Vidal-Puig, A.6
Lopez, M.7
-
145
-
-
0027524524
-
Chronic intrahypothalamic insulin infusion in the rat: behavioral specificity
-
doi:10.1016/0031-9384(93)90320-F
-
McGowan MK, Andrews KM, Fenner D & Grossman SP 1993 Chronic intrahypothalamic insulin infusion in the rat: behavioral specificity. Physiology & Behavior 54 1031-1034. (doi:10.1016/0031-9384(93)90320-F)
-
(1993)
Physiology & Behavior
, vol.54
, pp. 1031-1034
-
-
McGowan, M.K.1
Andrews, K.M.2
Fenner, D.3
Grossman, S.P.4
-
146
-
-
0031891391
-
PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats
-
McMahon LR & Wellman PJ 1998 PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats. American Journal of Physiology 274 R23-R29.
-
(1998)
American Journal of Physiology
, vol.274
-
-
McMahon, L.R.1
Wellman, P.J.2
-
148
-
-
0033545166
-
Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
-
doi:10.1002/(SICI)1096-9861(19990111)403:2!261::AIDCNE8O3.0. CO;2-5
-
Merchenthaler I, Lane M & Shughrue P 1999 Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. Journal of Comparative Neurology 403 261-280. (doi:10.1002/(SICI)1096-9861(19990111)403:2!261::AIDCNE8O3.0. CO;2-5)
-
(1999)
Journal of Comparative Neurology
, vol.403
, pp. 261-280
-
-
Merchenthaler, I.1
Lane, M.2
Shughrue, P.3
-
149
-
-
39749142664
-
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity
-
doi:10.1016/j.cmet.2008.01.007
-
Mesaros A, Koralov SB, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K & Bruning JC 2008 Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metabolism 7 236-248. (doi:10.1016/j.cmet.2008.01.007)
-
(2008)
Cell Metabolism
, vol.7
, pp. 236-248
-
-
Mesaros, A.1
Koralov, S.B.2
Rother, E.3
Wunderlich, F.T.4
Ernst, M.B.5
Barsh, G.S.6
Rajewsky, K.7
Bruning, J.C.8
-
150
-
-
58849149821
-
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
-
doi:10.1523/JNEUROSCI.2760-08.2009
-
Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK et al. 2009 Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Journal of Neuroscience 29 359-370. (doi:10.1523/JNEUROSCI.2760-08.2009)
-
(2009)
Journal of Neuroscience
, vol.29
, pp. 359-370
-
-
Milanski, M.1
Degasperi, G.2
Coope, A.3
Morari, J.4
Denis, R.5
Cintra, D.E.6
Tsukumo, D.M.7
Anhe, G.8
Amaral, M.E.9
Takahashi, H.K.10
-
151
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
doi:10.1038/nature02440
-
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ et al. 2004 AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428 569-574. (doi:10.1038/nature02440)
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
Kim, Y.B.4
Lee, A.5
Xue, B.6
Mu, J.7
Foufelle, F.8
Ferre, P.9
Birnbaum, M.J.10
-
152
-
-
0032915413
-
Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
-
doi:10.1210/en.140.2.814
-
Mizuno TM & Mobbs CV 1999 Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140 814-817. (doi:10.1210/en.140.2.814)
-
(1999)
Endocrinology
, vol.140
, pp. 814-817
-
-
Mizuno, T.M.1
Mobbs, C.V.2
-
153
-
-
0031888157
-
Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin
-
doi:10.2337/diab.47.2.294
-
Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA & Mobbs CV 1998 Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47 294-297. (doi:10.2337/diab.47.2.294)
-
(1998)
Diabetes
, vol.47
, pp. 294-297
-
-
Mizuno, T.M.1
Kleopoulos, S.P.2
Bergen, H.T.3
Roberts, J.L.4
Priest, C.A.5
Mobbs, C.V.6
-
154
-
-
0242300570
-
Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
-
doi:10.2337/diabetes.52.11.2675
-
Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL & Mobbs CV 2003 Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52 2675-2683. (doi:10.2337/diabetes.52.11.2675)
-
(2003)
Diabetes
, vol.52
, pp. 2675-2683
-
-
Mizuno, T.M.1
Kelley, K.A.2
Pasinetti, G.M.3
Roberts, J.L.4
Mobbs, C.V.5
-
155
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
doi:10.1038/43185
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA et al. 1997 Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387 903-908. (doi:10.1038/43185)
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
Sewter, C.P.7
Digby, J.E.8
Mohammed, S.N.9
Hurst, J.A.10
-
157
-
-
0038747134
-
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
-
doi:10.1210/en.2002-221037
-
Munzberg H, Huo L, Nillni EA, Hollenberg AN & Bjorbaek C 2003 Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144 2121-2131. (doi:10.1210/en.2002-221037)
-
(2003)
Endocrinology
, vol.144
, pp. 2121-2131
-
-
Munzberg, H.1
Huo, L.2
Nillni, E.A.3
Hollenberg, A.N.4
Bjorbaek, C.5
-
158
-
-
0035843183
-
A role for ghrelin in the central regulation of feeding
-
doi:10.1038/35051587
-
Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K & Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409 194-198. (doi:10.1038/35051587)
-
(2001)
Nature
, vol.409
, pp. 194-198
-
-
Nakazato, M.1
Murakami, N.2
Date, Y.3
Kojima, M.4
Matsuo, H.5
Kangawa, K.6
Matsukura, S.7
-
159
-
-
27744593324
-
Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens
-
doi:10.1016/j.peptides.2005.04.025
-
Naleid AM, Grace MK, Cummings DE & Levine AS 2005 Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 26 2274-2279. (doi:10.1016/j.peptides.2005.04.025)
-
(2005)
Peptides
, vol.26
, pp. 2274-2279
-
-
Naleid, A.M.1
Grace, M.K.2
Cummings, D.E.3
Levine, A.S.4
-
160
-
-
84863092267
-
Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice
-
doi:10.1371/journal.pone. 0040191
-
Nguyen AD, Mitchell NF, Lin S, Macia L, Yulyaningsih E, Baldock PA, Enriquez RF, Zhang L, Shi YC, Zolotukhin S et al. 2012 Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice. PLoS ONE 7 e40191. (doi:10.1371/journal.pone. 0040191)
-
(2012)
PLoS ONE
, vol.7
-
-
Nguyen, A.D.1
Mitchell, N.F.2
Lin, S.3
Macia, L.4
Yulyaningsih, E.5
Baldock, P.A.6
Enriquez, R.F.7
Zhang, L.8
Shi, Y.C.9
Zolotukhin, S.10
-
161
-
-
0035130843
-
AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
-
doi:10.1210/me.15.1.164
-
Nijenhuis WA, Oosterom J & Adan RA 2001 AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Molecular Endocrinology 15 164-171. (doi:10.1210/me.15.1.164)
-
(2001)
Molecular Endocrinology
, vol.15
, pp. 164-171
-
-
Nijenhuis, W.A.1
Oosterom, J.2
Adan, R.A.3
-
162
-
-
0030764741
-
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
-
doi:10.1126/science. 278.5335.135
-
Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I & Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278 135-138. (doi:10.1126/science. 278.5335.135)
-
(1997)
Science
, vol.278
, pp. 135-138
-
-
Ollmann, M.M.1
Wilson, B.D.2
Yang, Y.K.3
Kerns, J.A.4
Chen, Y.5
Gantz, I.6
Barsh, G.S.7
-
163
-
-
84874236315
-
Modulation of AgRPneuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance
-
doi:10.1073/pnas.1218284110
-
Olofsson LE, Unger EK, Cheung CC & Xu AW 2013 Modulation of AgRPneuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. PNAS 110 E697-E706. (doi:10.1073/pnas.1218284110)
-
(2013)
PNAS
, vol.110
-
-
Olofsson, L.E.1
Unger, E.K.2
Cheung, C.C.3
Xu, A.W.4
-
164
-
-
0023103395
-
Distribution and possible origin of bendorphin and ACTH in discrete brainstem nuclei of rats
-
doi:10.1016/0143-4179(87)90051-5
-
Palkovits M & Eskay RL 1987 Distribution and possible origin of bendorphin and ACTH in discrete brainstem nuclei of rats. Neuropeptides 9 123-137. (doi:10.1016/0143-4179(87)90051-5)
-
(1987)
Neuropeptides
, vol.9
, pp. 123-137
-
-
Palkovits, M.1
Eskay, R.L.2
-
165
-
-
0031623307
-
Life without neuropeptide Y
-
Palmiter RD, Erickson JC, Hollopeter G, Baraban SC & Schwartz MW 1998 Life without neuropeptide Y. Recent Progress in Hormone Research 53 163-199.
-
(1998)
Recent Progress in Hormone Research
, vol.53
, pp. 163-199
-
-
Palmiter, R.D.1
Erickson, J.C.2
Hollopeter, G.3
Baraban, S.C.4
Schwartz, M.W.5
-
166
-
-
82755170405
-
Evidence for the role of hindbrain orexin-1 receptors in the control ofmeal size
-
doi:10.1152/ajpregu. 00044.2011
-
Parise EM, Lilly N, Kay K, Dossat AM, Seth R, Overton JM & Williams DL 2011 Evidence for the role of hindbrain orexin-1 receptors in the control ofmeal size. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 301 R1692-R1699. (doi:10.1152/ajpregu. 00044.2011)
-
(2011)
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
, vol.301
-
-
Parise, E.M.1
Lilly, N.2
Kay, K.3
Dossat, A.M.4
Seth, R.5
Overton, J.M.6
Williams, D.L.7
-
167
-
-
18544386359
-
Steroidogenic factor 1: an essential mediator of endocrine development
-
doi:10.1210/rp.57.1.19
-
Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA et al. 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Progress in Hormone Research 57 19-36. (doi:10.1210/rp.57.1.19)
-
(2002)
Recent Progress in Hormone Research
, vol.57
, pp. 19-36
-
-
Parker, K.L.1
Rice, D.A.2
Lala, D.S.3
Ikeda, Y.4
Luo, X.5
Wong, M.6
Bakke, M.7
Zhao, L.8
Frigeri, C.9
Hanley, N.A.10
-
168
-
-
84870254039
-
Transcriptomic and epigenetic changes in the hypothalamus are involved in an increased susceptibility to a high-fat-sucrose diet in prenatally stressed female rats
-
doi:10.1159/000341684
-
Paternain L, Batlle MA, De la Garza AL, Milagro FI, Martinez JA & Campion J 2012 Transcriptomic and epigenetic changes in the hypothalamus are involved in an increased susceptibility to a high-fat-sucrose diet in prenatally stressed female rats. Neuroendocrinology 96 249-260. (doi:10.1159/000341684)
-
(2012)
Neuroendocrinology
, vol.96
, pp. 249-260
-
-
Paternain, L.1
Batlle, M.A.2
De la Garza, A.L.3
Milagro, F.I.4
Martinez, J.A.5
Campion, J.6
-
169
-
-
0032402181
-
Neurons containing hypocretin (orexin) project to multiple neuronal systems
-
Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG & Kilduff TS 1998 Neurons containing hypocretin (orexin) project to multiple neuronal systems. Journal of Neuroscience 18 9996-10015.
-
(1998)
Journal of Neuroscience
, vol.18
, pp. 9996-10015
-
-
Peyron, C.1
Tighe, D.K.2
van den Pol, A.N.3
de Lecea, L.4
Heller, H.C.5
Sutcliffe, J.G.6
Kilduff, T.S.7
-
170
-
-
1842529267
-
Rapid rewiring of arcuate nucleus feeding circuits by leptin
-
doi:10.1126/science.1089459
-
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM & Horvath TL 2004 Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304 110-115. (doi:10.1126/science.1089459)
-
(2004)
Science
, vol.304
, pp. 110-115
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
Friedman, J.M.7
Horvath, T.L.8
-
171
-
-
70350674919
-
Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: anepigeneticmodel of obesity and themetabolic syndrome
-
doi:10.1113/jphysiol.2009.176156
-
Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K et al. 2009 Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: anepigeneticmodel of obesity and themetabolic syndrome. Journal of Physiology 587 4963-4976. (doi:10.1113/jphysiol.2009.176156)
-
(2009)
Journal of Physiology
, vol.587
, pp. 4963-4976
-
-
Plagemann, A.1
Harder, T.2
Brunn, M.3
Harder, A.4
Roepke, K.5
Wittrock-Staar, M.6
Ziska, T.7
Schellong, K.8
Rodekamp, E.9
Melchior, K.10
-
172
-
-
77954601343
-
Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding
-
doi:10.1515/jpm.2010.051
-
Plagemann A, Roepke K, Harder T, Brunn M, Harder A, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K et al. 2010 Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding. Journal of Perinatal Medicine 38 393-400. (doi:10.1515/jpm.2010.051)
-
(2010)
Journal of Perinatal Medicine
, vol.38
, pp. 393-400
-
-
Plagemann, A.1
Roepke, K.2
Harder, T.3
Brunn, M.4
Harder, A.5
Wittrock-Staar, M.6
Ziska, T.7
Schellong, K.8
Rodekamp, E.9
Melchior, K.10
-
173
-
-
70350369729
-
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
-
doi:10.1038/nm.2026
-
Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP et al. 2009 The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nature Medicine 15 1195-1201. (doi:10.1038/nm.2026)
-
(2009)
Nature Medicine
, vol.15
, pp. 1195-1201
-
-
Plum, L.1
Lin, H.V.2
Dutia, R.3
Tanaka, J.4
Aizawa, K.S.5
Matsumoto, M.6
Kim, A.J.7
Cawley, N.X.8
Paik, J.H.9
Loh, Y.P.10
-
174
-
-
0023005899
-
ACTH-(1-24) and α-MSH antagonize feeding behavior stimulated by kappa opiate agonists
-
doi:10.1016/0196-9781(86)90104-X
-
Poggioli R, Vergoni AV & Bertolini A 1986 ACTH-(1-24) and α-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides 7 843-848. (doi:10.1016/0196-9781(86)90104-X)
-
(1986)
Peptides
, vol.7
, pp. 843-848
-
-
Poggioli, R.1
Vergoni, A.V.2
Bertolini, A.3
-
175
-
-
65549091103
-
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons
-
doi:10.1523/JNEUROSCI.3249-08.2009
-
van den Pol AN, Yao Y, Fu LY, Foo K, Huang H, Coppari R, Lowell BB & Broberger C 2009 Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. Journal of Neuroscience 29 4622-4639. (doi:10.1523/JNEUROSCI.3249-08.2009)
-
(2009)
Journal of Neuroscience
, vol.29
, pp. 4622-4639
-
-
van den Pol, A.N.1
Yao, Y.2
Fu, L.Y.3
Foo, K.4
Huang, H.5
Coppari, R.6
Lowell, B.B.7
Broberger, C.8
-
176
-
-
0036288345
-
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice
-
doi:10.1128/MCB.22.14.5027-5035.2002
-
Qian S, Chen H, Weingarth D, Trumbauer ME, Novi DE, Guan X, Yu H, Shen Z, Feng Y, Frazier E et al. 2002 Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Molecular and Cellular Biology 22 5027-5035. (doi:10.1128/MCB.22.14.5027-5035.2002)
-
(2002)
Molecular and Cellular Biology
, vol.22
, pp. 5027-5035
-
-
Qian, S.1
Chen, H.2
Weingarth, D.3
Trumbauer, M.E.4
Novi, D.E.5
Guan, X.6
Yu, H.7
Shen, Z.8
Feng, Y.9
Frazier, E.10
-
177
-
-
75349092316
-
Leptin excites proopiomelanocortin neurons via activation of TRPC channels
-
doi:10.1523/JNEUROSCI.4816-09.2010
-
Qiu J, Fang Y, Ronnekleiv OK & Kelly MJ 2010 Leptin excites proopiomelanocortin neurons via activation of TRPC channels. Journal of Neuroscience 30 1560-1565. (doi:10.1523/JNEUROSCI.4816-09.2010)
-
(2010)
Journal of Neuroscience
, vol.30
, pp. 1560-1565
-
-
Qiu, J.1
Fang, Y.2
Ronnekleiv, O.K.3
Kelly, M.J.4
-
178
-
-
13344279395
-
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
-
doi:10.1038/380243a0
-
Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R & Maratos-Flier E 1996 A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380 243-247. (doi:10.1038/380243a0)
-
(1996)
Nature
, vol.380
, pp. 243-247
-
-
Qu, D.1
Ludwig, D.S.2
Gammeltoft, S.3
Piper, M.4
Pelleymounter, M.A.5
Cullen, M.J.6
Mathes, W.F.7
Przypek, R.8
Kanarek, R.9
Maratos-Flier, E.10
-
179
-
-
77951194676
-
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
-
doi:10.2337/db09-1024
-
Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG Jr & Xu AW 2010 Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes 59 894-906. (doi:10.2337/db09-1024)
-
(2010)
Diabetes
, vol.59
, pp. 894-906
-
-
Reed, A.S.1
Unger, E.K.2
Olofsson, L.E.3
Piper, M.L.4
Myers Jr., M.G.5
Xu, A.W.6
-
180
-
-
84861976352
-
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
-
doi:10.1016/j.cell.2012.04.032
-
RenH,Orozco IJ, Su Y, SuyamaS,Gutierrez-Juarez R,HorvathTL,WardlawSL, Plum L, Arancio O & Accili D 2012 FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell 149 1314-1326. (doi:10.1016/j.cell.2012.04.032)
-
(2012)
Cell
, vol.149
, pp. 1314-1326
-
-
Ren, H.1
Orozco, I.J.2
Su, Y.3
Suyama, S.4
Gutierrez-Juarez, R.5
Horvath, T.L.6
Wardlaw, S.L.7
Plum, L.8
Arancio, O.9
Accili, D.10
-
181
-
-
4644299524
-
Circuitries involved in the control of energy homeostasis and the hypothalamic-pituitary-adrenal axis activity
-
doi:10.2165/00024677-200403050-00001
-
Richard D & Baraboi D 2004 Circuitries involved in the control of energy homeostasis and the hypothalamic-pituitary-adrenal axis activity. Treatments in Endocrinology 3 269-277. (doi:10.2165/00024677-200403050-00001)
-
(2004)
Treatments in Endocrinology
, vol.3
, pp. 269-277
-
-
Richard, D.1
Baraboi, D.2
-
182
-
-
45349098372
-
Molecular and neural mediators of leptin action
-
doi:10.1016/j.physbeh.2008.04.005
-
Robertson SA, Leinninger GM & Myers MG Jr 2008 Molecular and neural mediators of leptin action. Physiology & Behavior 94 637-642. (doi:10.1016/j.physbeh.2008.04.005)
-
(2008)
Physiology & Behavior
, vol.94
, pp. 637-642
-
-
Robertson, S.A.1
Leinninger, G.M.2
Myers Jr., M.G.3
-
183
-
-
1542358816
-
Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice
-
doi:10.1016/S0896-6273(04)00074-1
-
Roseberry AG, Liu H, Jackson AC, Cai X & Friedman JM2004 Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41 711-722. (doi:10.1016/S0896-6273(04)00074-1)
-
(2004)
Neuron
, vol.41
, pp. 711-722
-
-
Roseberry, A.G.1
Liu, H.2
Jackson, A.C.3
Cai, X.4
Friedman, J.M.5
-
184
-
-
79551555006
-
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
-
doi:10.1016/j.cmet.2011.01.010
-
Rossi J, Balthasar N, OlsonD, Scott M, BerglundE, LeeCE,ChoiMJ, LauzonD, Lowell BB & Elmquist JK 2011 Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metabolism 13 195-204. (doi:10.1016/j.cmet.2011.01.010)
-
(2011)
Cell Metabolism
, vol.13
, pp. 195-204
-
-
Rossi, J.1
Balthasar, N.2
Olson, D.3
Scott, M.4
Berglund, E.5
Lee, C.E.6
Choi, M.J.7
Lauzon, D.8
Lowell, B.B.9
Elmquist, J.K.10
-
185
-
-
84868122218
-
Acute selective ablation of rat insulin promoterexpressing (RIPHER) neurons defines their orexigenic nature
-
doi:10.1073/pnas.1206147109
-
Rother E, Belgardt BF, Tsaousidou E, Hampel B, Waisman A, MyersMG Jr & Bruning JC 2012 Acute selective ablation of rat insulin promoterexpressing (RIPHER) neurons defines their orexigenic nature. PNAS 109 18132-18137. (doi:10.1073/pnas.1206147109)
-
(2012)
PNAS
, vol.109
, pp. 18132-18137
-
-
Rother, E.1
Belgardt, B.F.2
Tsaousidou, E.3
Hampel, B.4
Waisman, A.5
Myers Jr., M.G.6
Bruning, J.C.7
-
186
-
-
20244380014
-
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
doi:10.1016/S0092-8674(00)80949-6
-
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S et al. 1998 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 573-585. (doi:10.1016/S0092-8674(00)80949-6)
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
-
187
-
-
3843114437
-
Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice
-
doi:10.1210/en.2004-0263
-
Savontaus E, Breen TL, Kim A, Yang LM, Chua SC Jr & Wardlaw SL 2004 Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145 3881-3891. (doi:10.1210/en.2004-0263)
-
(2004)
Endocrinology
, vol.145
, pp. 3881-3891
-
-
Savontaus, E.1
Breen, T.L.2
Kim, A.3
Yang, L.M.4
Chua Jr., S.C.5
Wardlaw, S.L.6
-
188
-
-
0020037646
-
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
-
doi:10.1002/cne.902050306
-
Sawchenko PE & Swanson LW 1982 Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. Journal of Comparative Neurology 205 260-272. (doi:10.1002/cne.902050306)
-
(1982)
Journal of Comparative Neurology
, vol.205
, pp. 260-272
-
-
Sawchenko, P.E.1
Swanson, L.W.2
-
189
-
-
84877659963
-
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity
-
doi:10.1016/j.molmet.2012.10.001
-
Schneeberger M, Altirriba J, Garcia A, Esteban Y, Castaño C, Garcia-Lavandeira M, Alvarez CV, Gomis R & Claret M 2013 Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Molecular Metabolism 2 74-85. (doi:10.1016/j.molmet.2012.10.001)
-
(2013)
Molecular Metabolism
, vol.2
, pp. 74-85
-
-
Schneeberger, M.1
Altirriba, J.2
Garcia, A.3
Esteban, Y.4
Castaño, C.5
Garcia-Lavandeira, M.6
Alvarez, C.V.7
Gomis, R.8
Claret, M.9
-
190
-
-
0026710057
-
Inhibition of hypothalamic neuropeptide Y gene expression by insulin
-
doi:10.1210/en.130.6.3608
-
Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP et al. 1992 Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130 3608-3616. (doi:10.1210/en.130.6.3608)
-
(1992)
Endocrinology
, vol.130
, pp. 3608-3616
-
-
Schwartz, M.W.1
Sipols, A.J.2
Marks, J.L.3
Sanacora, G.4
White, J.D.5
Scheurink, A.6
Kahn, S.E.7
Baskin, D.G.8
Woods, S.C.9
Figlewicz, D.P.10
-
191
-
-
13344280346
-
Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
-
doi:10.2337/diab.45.4.531
-
Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ et al. 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45 531-535. (doi:10.2337/diab.45.4.531)
-
(1996)
Diabetes
, vol.45
, pp. 531-535
-
-
Schwartz, M.W.1
Baskin, D.G.2
Bukowski, T.R.3
Kuijper, J.L.4
Foster, D.5
Lasser, G.6
Prunkard, D.E.7
Porte Jr., D.8
Woods, S.C.9
Seeley, R.J.10
-
192
-
-
0030775971
-
Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
-
doi:10.2337/diab.46.12.2119
-
Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P & Baskin DG 1997 Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 2119-2123. (doi:10.2337/diab.46.12.2119)
-
(1997)
Diabetes
, vol.46
, pp. 2119-2123
-
-
Schwartz, M.W.1
Seeley, R.J.2
Woods, S.C.3
Weigle, D.S.4
Campfield, L.A.5
Burn, P.6
Baskin, D.G.7
-
193
-
-
0033067578
-
Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression
-
Schwartz GJ, Salorio CF, Skoglund C & Moran TH 1999 Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression. American Journal of Physiology 276 R1623-R1629.
-
(1999)
American Journal of Physiology
, vol.276
-
-
Schwartz, G.J.1
Salorio, C.F.2
Skoglund, C.3
Moran, T.H.4
-
194
-
-
21044443911
-
Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour
-
doi:10.1111/j.1365-2826.2005.01330.x
-
Scott V, Kimura N, Stark JA & Luckman SM 2005 Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour. Journal of Neuroendocrinology 17 452-457. (doi:10.1111/j.1365-2826.2005.01330.x)
-
(2005)
Journal of Neuroendocrinology
, vol.17
, pp. 452-457
-
-
Scott, V.1
Kimura, N.2
Stark, J.A.3
Luckman, S.M.4
-
195
-
-
20244363653
-
Use of laser-capture microdissection for the identification ofmarker genes for the ventromedial hypothalamic nucleus
-
doi:10.1523/JNEUROSCI. 0158-05.2005
-
Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK et al. 2005 Use of laser-capture microdissection for the identification ofmarker genes for the ventromedial hypothalamic nucleus. Journal of Neuroscience 25 4181-4188. (doi:10.1523/JNEUROSCI. 0158-05.2005)
-
(2005)
Journal of Neuroscience
, vol.25
, pp. 4181-4188
-
-
Segal, J.P.1
Stallings, N.R.2
Lee, C.E.3
Zhao, L.4
Socci, N.5
Viale, A.6
Harris, T.M.7
Soares, M.B.8
Childs, G.9
Elmquist, J.K.10
-
196
-
-
84873362255
-
ArcuateNPY controls sympathetic output andBATfunction via a relay of tyrosine hydroxylaseneurons in the PVN
-
doi:10.1016/j.cmet.2013.01.006
-
Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF et al. 2013 ArcuateNPY controls sympathetic output andBATfunction via a relay of tyrosine hydroxylaseneurons in the PVN. Cell Metabolism 17 236-248. (doi:10.1016/j.cmet.2013.01.006)
-
(2013)
Cell Metabolism
, vol.17
, pp. 236-248
-
-
Shi, Y.C.1
Lau, J.2
Lin, Z.3
Zhang, H.4
Zhai, L.5
Sperk, G.6
Heilbronn, R.7
Mietzsch, M.8
Weger, S.9
Huang, X.F.10
-
197
-
-
0028924906
-
Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression
-
doi:10.2337/diab.44.2.147
-
Sipols AJ, Baskin DG & Schwartz MW 1995 Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44 147-151. (doi:10.2337/diab.44.2.147)
-
(1995)
Diabetes
, vol.44
, pp. 147-151
-
-
Sipols, A.J.1
Baskin, D.G.2
Schwartz, M.W.3
-
198
-
-
63849112609
-
Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
-
doi:10.1210/en.2008-1316
-
Skibicka KP & Grill HJ 2009a Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 150 1705-1711. (doi:10.1210/en.2008-1316)
-
(2009)
Endocrinology
, vol.150
, pp. 1705-1711
-
-
Skibicka, K.P.1
Grill, H.J.2
-
199
-
-
71949093692
-
Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins
-
doi:10.1210/en.2009-0804
-
Skibicka KP & Grill HJ 2009b Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins. Endocrinology 150 5351-5361. (doi:10.1210/en.2009-0804)
-
(2009)
Endocrinology
, vol.150
, pp. 5351-5361
-
-
Skibicka, K.P.1
Grill, H.J.2
-
200
-
-
0041944526
-
Chronic CNS administration of agouti-related protein (Agrp) reduces energy expenditure
-
doi:10.1038/sj.ijo.0802253
-
Small CJ, Liu YL, Stanley SA, Connoley IP, Kennedy A, Stock MJ & Bloom SR 2003 Chronic CNS administration of agouti-related protein (Agrp) reduces energy expenditure. International Journal of Obesity and Related Metabolic Disorders 27 530-533. (doi:10.1038/sj.ijo.0802253)
-
(2003)
International Journal of Obesity and Related Metabolic Disorders
, vol.27
, pp. 530-533
-
-
Small, C.J.1
Liu, Y.L.2
Stanley, S.A.3
Connoley, I.P.4
Kennedy, A.5
Stock, M.J.6
Bloom, S.R.7
-
201
-
-
32444449631
-
Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
-
doi:10.1172/JCI25243
-
Smart JL, Tolle V & Low MJ 2006 Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. Journal of Clinical Investigation 116 495-505. (doi:10.1172/JCI25243)
-
(2006)
Journal of Clinical Investigation
, vol.116
, pp. 495-505
-
-
Smart, J.L.1
Tolle, V.2
Low, M.J.3
-
202
-
-
33846191084
-
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
-
doi:10.1113/jphysiol.2006.119479
-
Smith MA, Hisadome K, Al-Qassab H, Heffron H,Withers DJ & Ashford ML 2007 Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. Journal of Physiology 578 425-438. (doi:10.1113/jphysiol.2006.119479)
-
(2007)
Journal of Physiology
, vol.578
, pp. 425-438
-
-
Smith, M.A.1
Hisadome, K.2
Al-Qassab, H.3
Heffron, H.4
Withers, D.J.5
Ashford, M.L.6
-
203
-
-
77649189116
-
Astrocytes: biology and pathology
-
doi:10.1007/s00401-009-0619-8
-
Sofroniew MV & Vinters HV 2010 Astrocytes: biology and pathology. Acta Neuropathologica 119 7-35. (doi:10.1007/s00401-009-0619-8)
-
(2010)
Acta Neuropathologica
, vol.119
, pp. 7-35
-
-
Sofroniew, M.V.1
Vinters, H.V.2
-
204
-
-
84883808778
-
Neuronal circuits that regulate feeding behavior and metabolism
-
doi:10.1016/j.tins.2013.05.003
-
Sohn JW, Elmquist JK & Williams KW 2013 Neuronal circuits that regulate feeding behavior and metabolism. Trends in Neurosciences 36 504-512. (doi:10.1016/j.tins.2013.05.003)
-
(2013)
Trends in Neurosciences
, vol.36
, pp. 504-512
-
-
Sohn, J.W.1
Elmquist, J.K.2
Williams, K.W.3
-
205
-
-
0022873040
-
Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity
-
doi:10.1016/0196-9781(86)90149-X
-
Stanley BG, Kyrkouli SE, Lampert S & Leibowitz SF 1986 Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7 1189-1192. (doi:10.1016/0196-9781(86)90149-X)
-
(1986)
Peptides
, vol.7
, pp. 1189-1192
-
-
Stanley, B.G.1
Kyrkouli, S.E.2
Lampert, S.3
Leibowitz, S.F.4
-
206
-
-
0029098589
-
The role of neuropeptideYin theantiobesity actionof the obese geneproduct
-
doi:10.1038/377530a0
-
Stephens TW, BasinskiM, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A et al. 1995 The role of neuropeptideYin theantiobesity actionof the obese geneproduct.Nature 377 530-532. (doi:10.1038/377530a0)
-
(1995)
Nature
, vol.377
, pp. 530-532
-
-
Stephens, T.W.1
Basinski, M.2
Bristow, P.K.3
Bue-Valleskey, J.M.4
Burgett, S.G.5
Craft, L.6
Hale, J.7
Hoffmann, J.8
Hsiung, H.M.9
Kriauciunas, A.10
-
207
-
-
84876435089
-
Hypothalamic survival circuits: blueprints for purposive behaviors
-
doi:10.1016/j.neuron.2013.02.018
-
Sternson SM 2013 Hypothalamic survival circuits: blueprints for purposive behaviors. Neuron 77 810-824. (doi:10.1016/j.neuron.2013.02.018)
-
(2013)
Neuron
, vol.77
, pp. 810-824
-
-
Sternson, S.M.1
-
208
-
-
77954890700
-
Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition
-
doi:10.1210/en.2010-0094
-
Stevens A, Begum G, Cook A, Connor K, Rumball C, Oliver M, Challis J, Bloomfield F & White A 2010 Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition. Endocrinology 151 3652-3664. (doi:10.1210/en.2010-0094)
-
(2010)
Endocrinology
, vol.151
, pp. 3652-3664
-
-
Stevens, A.1
Begum, G.2
Cook, A.3
Connor, K.4
Rumball, C.5
Oliver, M.6
Challis, J.7
Bloomfield, F.8
White, A.9
-
209
-
-
1842480284
-
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
-
doi:10.1073/pnas.0305930101
-
Sun Y, Wang P, Zheng H & Smith RG 2004 Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. PNAS 101 4679-4684. (doi:10.1073/pnas.0305930101)
-
(2004)
PNAS
, vol.101
, pp. 4679-4684
-
-
Sun, Y.1
Wang, P.2
Zheng, H.3
Smith, R.G.4
-
210
-
-
0029859220
-
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
-
Tang-Christensen M, Larsen PJ, Goke R, Fink-Jensen A, Jessop DS, MollerM & Sheikh SP 1996 Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. American Journal of Physiology 271 R848-R856.
-
(1996)
American Journal of Physiology
, vol.271
-
-
Tang-Christensen, M.1
Larsen, P.J.2
Goke, R.3
Fink-Jensen, A.4
Jessop, D.S.5
Moller, M.6
Sheikh, S.P.7
-
211
-
-
79952677635
-
Activation ofmicroglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition
-
doi:10.1111/j.1365-2826.2011.02113.x
-
Tapia-Gonzalez S, Garcia-Segura LM, Tena-Sempere M, Frago LM, Castellano JM,Fuente-Martin E, Garcia-Caceres C, Argente J& Chowen JA 2011 Activation ofmicroglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition. Journal of Neuroendocrinology 23 365-370. (doi:10.1111/j.1365-2826.2011.02113.x)
-
(2011)
Journal of Neuroendocrinology
, vol.23
, pp. 365-370
-
-
Tapia-Gonzalez, S.1
Garcia-Segura, L.M.2
Tena-Sempere, M.3
Frago, L.M.4
Castellano, J.M.5
Fuente-Martin, E.6
Garcia-Caceres, C.7
Argente, J.8
Chowen, J.A.9
-
212
-
-
0019310264
-
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
-
doi:10.1038/285417a0
-
Tatemoto K & Mutt V 1980 Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature 285 417-418. (doi:10.1038/285417a0)
-
(1980)
Nature
, vol.285
, pp. 417-418
-
-
Tatemoto, K.1
Mutt, V.2
-
213
-
-
72449128492
-
Hypothalamic inflammation and energy homeostasis: resolving the paradox
-
doi:10.1016/j.yfrne.2009.10.002
-
Thaler JP, Choi SJ, Schwartz MW & Wisse BE 2010 Hypothalamic inflammation and energy homeostasis: resolving the paradox. Frontiers in Neuroendocrinology 31 79-84. (doi:10.1016/j.yfrne.2009.10.002)
-
(2010)
Frontiers in Neuroendocrinology
, vol.31
, pp. 79-84
-
-
Thaler, J.P.1
Choi, S.J.2
Schwartz, M.W.3
Wisse, B.E.4
-
214
-
-
84855459760
-
Obesity is associated with hypothalamic injury in rodents and humans
-
doi:10.1172/JCI59660
-
Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR et al. 2012 Obesity is associated with hypothalamic injury in rodents and humans. Journal of Clinical Investigation 122 153-162. (doi:10.1172/JCI59660)
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 153-162
-
-
Thaler, J.P.1
Yi, C.X.2
Schur, E.A.3
Guyenet, S.J.4
Hwang, B.H.5
Dietrich, M.O.6
Zhao, X.7
Sarruf, D.A.8
Izgur, V.9
Maravilla, K.R.10
-
215
-
-
0030729210
-
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
-
doi:10.1210/en.138.11.5063
-
Thornton JE, Cheung CC, Clifton DK & Steiner RA 1997 Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138 5063-5066. (doi:10.1210/en.138.11.5063)
-
(1997)
Endocrinology
, vol.138
, pp. 5063-5066
-
-
Thornton, J.E.1
Cheung, C.C.2
Clifton, D.K.3
Steiner, R.A.4
-
216
-
-
38449087113
-
In vivo evidence for inverse agonism of agoutirelated peptide in the central nervous system of proopiomelanocortindeficient mice
-
doi:10.2337/db07-0733
-
Tolle V & Low MJ 2008 In vivo evidence for inverse agonism of agoutirelated peptide in the central nervous system of proopiomelanocortindeficient mice. Diabetes 57 86-94. (doi:10.2337/db07-0733)
-
(2008)
Diabetes
, vol.57
, pp. 86-94
-
-
Tolle, V.1
Low, M.J.2
-
217
-
-
50249120768
-
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
-
doi:10.1038/nn.2167
-
Tong Q, Ye CP, Jones JE, Elmquist JK & Lowell BB 2008 Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nature Neuroscience 11 998-1000. (doi:10.1038/nn.2167)
-
(2008)
Nature Neuroscience
, vol.11
, pp. 998-1000
-
-
Tong, Q.1
Ye, C.P.2
Jones, J.E.3
Elmquist, J.K.4
Lowell, B.B.5
-
218
-
-
2142758640
-
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
-
doi:10.1038/nn1226
-
van den Top M, Lee K, Whyment AD, Blanks AM & Spanswick D 2004 Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nature Neuroscience 7 493-494. (doi:10.1038/nn1226)
-
(2004)
Nature Neuroscience
, vol.7
, pp. 493-494
-
-
van den Top, M.1
Lee, K.2
Whyment, A.D.3
Blanks, A.M.4
Spanswick, D.5
-
220
-
-
0034687376
-
Ghrelin induces adiposity in rodents
-
doi:10.1038/35038090
-
Tschop M, Smiley DL & Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407 908-913. (doi:10.1038/35038090)
-
(2000)
Nature
, vol.407
, pp. 908-913
-
-
Tschop, M.1
Smiley, D.L.2
Heiman, M.L.3
-
221
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
doi:10.1038/379069a0
-
Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD et al. 1996 A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69-72. (doi:10.1038/379069a0)
-
(1996)
Nature
, vol.379
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
Beak, S.A.4
Edwards, C.M.5
Meeran, K.6
Choi, S.J.7
Taylor, G.M.8
Heath, M.M.9
Lambert, P.D.10
-
222
-
-
79960190012
-
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
-
doi:10.1016/j.neuron.2011. 05.028
-
Vong L, Ye C, Yang Z, Choi B, Chua S Jr & Lowell BB 2011 Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71 142-154. (doi:10.1016/j.neuron.2011. 05.028)
-
(2011)
Neuron
, vol.71
, pp. 142-154
-
-
Vong, L.1
Ye, C.2
Yang, Z.3
Choi, B.4
Chua Jr., S.5
Lowell, B.B.6
-
223
-
-
41549111593
-
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
-
doi:10.1210/en.2007-1132
-
van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ et al. 2008 Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149 1773-1785. (doi:10.1210/en.2007-1132)
-
(2008)
Endocrinology
, vol.149
, pp. 1773-1785
-
-
van de Wall, E.1
Leshan, R.2
Xu, A.W.3
Balthasar, N.4
Coppari, R.5
Liu, S.M.6
Jo, Y.H.7
MacKenzie, R.G.8
Allison, D.B.9
Dun, N.J.10
-
224
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
doi:10.1016/j.cell.2012.02.066
-
Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vazquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S et al. 2012 BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149 871-885. (doi:10.1016/j.cell.2012.02.066)
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.J.1
Carobbio, S.2
Martins, L.3
Slawik, M.4
Hondares, E.5
Vazquez, M.J.6
Morgan, D.7
Csikasz, R.I.8
Gallego, R.9
Rodriguez-Cuenca, S.10
-
225
-
-
0032744366
-
Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
-
doi:10.1159/000054491
-
Willesen MG, Kristensen P & Romer J 1999 Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70 306-316. (doi:10.1159/000054491)
-
(1999)
Neuroendocrinology
, vol.70
, pp. 306-316
-
-
Willesen, M.G.1
Kristensen, P.2
Romer, J.3
-
226
-
-
0034456725
-
The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation
-
doi:10.1210/en.141.4.1332
-
Williams DL, Kaplan JM & Grill HJ 2000 The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141 1332-1337. (doi:10.1210/en.141.4.1332)
-
(2000)
Endocrinology
, vol.141
, pp. 1332-1337
-
-
Williams, D.L.1
Kaplan, J.M.2
Grill, H.J.3
-
227
-
-
0035130527
-
Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects
-
doi:10.1016/S0196-9781(00)00367-3
-
Wirth MM, Olszewski PK, Yu C, Levine AS & Giraudo SQ 2001 Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects. Peptides 22 129-134. (doi:10.1016/S0196-9781(00)00367-3)
-
(2001)
Peptides
, vol.22
, pp. 129-134
-
-
Wirth, M.M.1
Olszewski, P.K.2
Yu, C.3
Levine, A.S.4
Giraudo, S.Q.5
-
228
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
doi:10.1038/282503a0
-
Woods SC, Lotter EC, McKay LD & Porte D Jr 1979 Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282 503-505. (doi:10.1038/282503a0)
-
(1979)
Nature
, vol.282
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte Jr., D.4
-
229
-
-
0035216623
-
Ghrelin enhances appetite and increases food intake in humans
-
doi:10.1210/jc.86.12.5992
-
Wren AM, Seal LJ, CohenMA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA & Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism 86 5992. (doi:10.1210/jc.86.12.5992)
-
(2001)
Journal of Clinical Endocrinology and Metabolism
, vol.86
, pp. 5992
-
-
Wren, A.M.1
Seal, L.J.2
Cohen, M.A.3
Brynes, A.E.4
Frost, G.S.5
Murphy, K.G.6
Dhillo, W.S.7
Ghatei, M.A.8
Bloom, S.R.9
-
230
-
-
79951999061
-
GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism
-
doi:10.1016/j.ejphar.2010.10.110
-
Wu Q & Palmiter RD 2011 GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism. European Journal of Pharmacology 660 21-27. (doi:10.1016/j.ejphar.2010.10.110)
-
(2011)
European Journal of Pharmacology
, vol.660
, pp. 21-27
-
-
Wu, Q.1
Palmiter, R.D.2
-
231
-
-
67549112681
-
Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
-
doi:10.1016/j.cell.2009.04.022
-
Wu Q, Boyle MP & Palmiter RD 2009 Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137 1225-1234. (doi:10.1016/j.cell.2009.04.022)
-
(2009)
Cell
, vol.137
, pp. 1225-1234
-
-
Wu, Q.1
Boyle, M.P.2
Palmiter, R.D.3
-
232
-
-
84859215897
-
Deciphering a neuronal circuit that mediates appetite
-
doi:10.1038/nature10899
-
Wu Q, Clark MS & Palmiter RD 2012 Deciphering a neuronal circuit that mediates appetite. Nature 483 594-597. (doi:10.1038/nature10899)
-
(2012)
Nature
, vol.483
, pp. 594-597
-
-
Wu, Q.1
Clark, M.S.2
Palmiter, R.D.3
-
233
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
doi:10.1038/nn1073
-
Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH & Reichardt LF 2003 Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nature Neuroscience 6 736-742. (doi:10.1038/nn1073)
-
(2003)
Nature Neuroscience
, vol.6
, pp. 736-742
-
-
Xu, B.1
Goulding, E.H.2
Zang, K.3
Cepoi, D.4
Cone, R.D.5
Jones, K.R.6
Tecott, L.H.7
Reichardt, L.F.8
-
234
-
-
29144519352
-
Effects of hypothalamic neurodegeneration on energy balance
-
doi:10.1371/journal.pbio.0030415
-
Xu AW, Kaelin CB,Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW & Barsh GS 2005a Effects of hypothalamic neurodegeneration on energy balance. PLoS Biology 3 e415. (doi:10.1371/journal.pbio.0030415)
-
(2005)
PLoS Biology
, vol.3
-
-
Xu, A.W.1
Kaelin, C.B.2
Morton, G.J.3
Ogimoto, K.4
Stanhope, K.5
Graham, J.6
Baskin, D.G.7
Havel, P.8
Schwartz, M.W.9
Barsh, G.S.10
-
235
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
doi:10.1172/JCI24301
-
Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW & Barsh GS 2005b PI3K integrates the action of insulin and leptin on hypothalamic neurons. Journal of Clinical Investigation 115 951-958. (doi:10.1172/JCI24301)
-
(2005)
Journal of Clinical Investigation
, vol.115
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
236
-
-
33845867730
-
Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
-
doi:10.1210/en.2006-1119
-
Xu AW, Ste-Marie L, Kaelin CB & Barsh GS 2007 Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148 72-80. (doi:10.1210/en.2006-1119)
-
(2007)
Endocrinology
, vol.148
, pp. 72-80
-
-
Xu, A.W.1
Ste-Marie, L.2
Kaelin, C.B.3
Barsh, G.S.4
-
237
-
-
80052922112
-
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
-
doi:10.1016/j.cell.2011.07.039
-
Yang Y, Atasoy D, Su HH & Sternson SM 2011 Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 146 992-1003. (doi:10.1016/j.cell.2011.07.039)
-
(2011)
Cell
, vol.146
, pp. 992-1003
-
-
Yang, Y.1
Atasoy, D.2
Su, H.H.3
Sternson, S.M.4
-
238
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
doi:10.1038/12506
-
Yaswen L, Diehl N, Brennan MB & Hochgeschwender U 1999 Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nature Medicine 5 1066-1070. (doi:10.1038/12506)
-
(1999)
Nature Medicine
, vol.5
, pp. 1066-1070
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hochgeschwender, U.4
-
239
-
-
7044262828
-
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
-
doi:10.1038/nn1336
-
Yeo GS, Connie Hung CC, Rochford J, Keogh J, Gray J, Sivaramakrishnan S, O'Rahilly S & Farooqi IS 2004 A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nature Neuroscience 7 1187-1189. (doi:10.1038/nn1336)
-
(2004)
Nature Neuroscience
, vol.7
, pp. 1187-1189
-
-
Yeo, G.S.1
Connie Hung, C.C.2
Rochford, J.3
Keogh, J.4
Gray, J.5
Sivaramakrishnan, S.6
O'Rahilly, S.7
Farooqi, I.S.8
-
240
-
-
84860565985
-
Exercise protects against high-fat diet-induced hypothalamic inflammation
-
doi:10.1016/j.physbeh.2012.03.021
-
Yi CX, Al-Massadi O, Donelan E, Lehti M, Weber J, Ress C, Trivedi C, Muller TD, Woods SC & Hofmann SM 2012 Exercise protects against high-fat diet-induced hypothalamic inflammation. Physiology & Behavior 106 485-490. (doi:10.1016/j.physbeh.2012.03.021)
-
(2012)
Physiology & Behavior
, vol.106
, pp. 485-490
-
-
Yi, C.X.1
Al-Massadi, O.2
Donelan, E.3
Lehti, M.4
Weber, J.5
Ress, C.6
Trivedi, C.7
Muller, T.D.8
Woods, S.C.9
Hofmann, S.M.10
-
241
-
-
84866686337
-
Synaptic plasticity in neuronal circuits regulating energy balance
-
doi:10.1038/nn.3219
-
Zeltser LM, Seeley RJ & Tschop MH 2012 Synaptic plasticity in neuronal circuits regulating energy balance. Nature Neuroscience 15 1336-1342. (doi:10.1038/nn.3219)
-
(2012)
Nature Neuroscience
, vol.15
, pp. 1336-1342
-
-
Zeltser, L.M.1
Seeley, R.J.2
Tschop, M.H.3
-
242
-
-
84874215150
-
Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively
-
doi:10.1523/JNEUROSCI.2742-12.2013
-
Zhan C, Zhou J, Feng Q, Zhang JE, Lin S, Bao J, Wu P & Luo M 2013 Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. Journal of Neuroscience 33 3624-3632. (doi:10.1523/JNEUROSCI.2742-12.2013)
-
(2013)
Journal of Neuroscience
, vol.33
, pp. 3624-3632
-
-
Zhan, C.1
Zhou, J.2
Feng, Q.3
Zhang, J.E.4
Lin, S.5
Bao, J.6
Wu, P.7
Luo, M.8
-
243
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
doi:10.1038/372425a0
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432. (doi:10.1038/372425a0)
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
244
-
-
54349113070
-
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
-
doi:10.1210/en.2008-0805
-
Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E & Flier JS 2008 Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 149 5654-5661. (doi:10.1210/en.2008-0805)
-
(2008)
Endocrinology
, vol.149
, pp. 5654-5661
-
-
Zhang, R.1
Dhillon, H.2
Yin, H.3
Yoshimura, A.4
Lowell, B.B.5
Maratos-Flier, E.6
Flier, J.S.7
-
245
-
-
84879252220
-
Food-intake dysregulation in type 2 diabetic Goto-Kakizaki rats: hypothesized role of dysfunctional brainstem thyrotropin-releasing hormone and impaired vagal output
-
doi:10.1016/j.neuroscience. 2013.05.017
-
Zhao K, Ao Y, Harper RM, Go VL & Yang H 2013 Food-intake dysregulation in type 2 diabetic Goto-Kakizaki rats: hypothesized role of dysfunctional brainstem thyrotropin-releasing hormone and impaired vagal output. Neuroscience 247 43-54. (doi:10.1016/j.neuroscience. 2013.05.017)
-
(2013)
Neuroscience
, vol.247
, pp. 43-54
-
-
Zhao, K.1
Ao, Y.2
Harper, R.M.3
Go, V.L.4
Yang, H.5
-
246
-
-
77749316808
-
A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake
-
doi:10.1152/ajpregu.00619.2009
-
Zheng H, Patterson LM, Rhodes CJ, Louis GW, Skibicka KP, Grill HJ, Myers MG Jr & Berthoud HR 2010 A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 298 R720-R728. (doi:10.1152/ajpregu.00619.2009)
-
(2010)
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
, vol.298
-
-
Zheng, H.1
Patterson, L.M.2
Rhodes, C.J.3
Louis, G.W.4
Skibicka, K.P.5
Grill, H.J.6
Myers Jr., M.G.7
Berthoud, H.R.8
|