Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

Diabetes

Volumn 61, Issue 4, 2012, Pages 807-817

  Martínez De Morentin, Pablo B ^a,b   Whittle, Andrew J ^c   Fernø, Johan ^d,e   Nogueiras, Rubén ^a,b   Diéguez, Carlos ^a,b   Vidal Puig, Antonio ^c   López, Miguel ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF BERGEN   (Norway)

^e HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NICOTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FEEDING; GENE ACTIVATION; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THERMOGENESIS; WEIGHT REDUCTION;

ADIPOSE TISSUE, BROWN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APPETITE; EATING; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HYPOTHALAMUS; MALE; MOTOR ACTIVITY; NEUROPEPTIDE Y; NICOTINE; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; TEMAZEPAM; THERMOGENESIS;

EID: 84859557325     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1079     Document Type: Article

References (50)

1. Filozof C, Fernández Pinilla MC, Fernández-Cruz A. Smoking cessation and weight gain. Obes Rev 2004;5:95-103 (Pubitemid 38623163)
2. Grunberg NE. A neurobiological basis for nicotine withdrawal. Proc Natl Acad Sci USA 2007;104:17901-17902 (Pubitemid 350210792)
3. Mineur YS, Abizaid A, Rao Y, et al. Nicotine decreases food intake through activation of POMC neurons. Science 2011;332:1330-1332
4. Seeley RJ, Sandoval DA. Neuroscience: weight loss through smoking. Nature 2011;475:176-177
5. Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 2005;493:63-71 (Pubitemid 41636188)
6. Gao Q, Horvath TL. Neurobiology of feeding and energy expenditure. Annu Rev Neurosci 2007;30:367-398 (Pubitemid 47218761)
7. Xue B, Pulinilkunnil T, Murano I, et al. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol 2009;29:4563-4573
8. López M, Varela L, Vázquez MJ, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med 2010; 16:1001-1008
9. Lam TK, Pocai A, Gutierrez-Juarez R, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005;11:320-327 (Pubitemid 40460561)
10. Könner AC, Janoschek R, Plum L, et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007;5:438-449 (Pubitemid 46825497)
11. Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339-343 (Pubitemid 34087557)
12. Nogueiras R, Wiedmer P, Perez-Tilve D, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 2007; 117:3475-3488 (Pubitemid 350097003)
13. Fliers E, Klieverik LP, Kalsbeek A. Novel neural pathways for metabolic effects of thyroid hormone. Trends Endocrinol Metab 2010;21:230-236
14. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005;1:15-25 (Pubitemid 43960587)
15. Lage R, Diéguez C, Vidal-Puig A, López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 2008;14:539-549
16. Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574 (Pubitemid 38480541)
17. Andrews ZB, Liu ZW, Walllingford N, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008;454:846-851
18. López M, Lage R, Saha AK, et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 2008;7:389-399 (Pubitemid 351618114)
19. Jang MH, Shin MC, Kim KH, et al. Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. Brain Res 2003;964:311-315
20. Bishop C, Parker GC, Coscina DV. Nicotine and its withdrawal alter feeding induced by paraventricular hypothalamic injections of neuropeptide Y in Sprague-Dawley rats. Psychopharmacology (Berl) 2002;162:265-272 (Pubitemid 34762285)
21. Fornari A, Pedrazzi P, Lippi G, Picciotto MR, Zoli M, Zini I. Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice. Neurosci Lett 2007;411:72-76 (Pubitemid 44751946)
22. Hur YN, Hong GH, Choi SH, Shin KH, Chun BG. High fat diet altered the mechanism of energy homeostasis induced by nicotine and withdrawal in C57BL/6 mice. Mol Cells 2010;30:219-226
23. Arai K, Kim K, Kaneko K, et al. Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats. Am J Physiol Endocrinol Metab 2001;280:E867-E876
24. Mano-Otagiri A, Iwasaki-Sekino A, Ohata H, Arai K, Shibasaki T. Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor. Neurosci Lett 2009;455:26-29
25. Li MD, Kane JK, Parker SL, McAllen K, Matta SG, Sharp BM. Nicotine administration enhances NPY expression in the rat hypothalamus. Brain Res 2000;867:157-164 (Pubitemid 30317392)
26. López M, Lelliott CJ, Tovar S, et al. Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes 2006;55: 1327-1336 (Pubitemid 44195371)
27. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Sydney, Academic Press, 1986
28. Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006;116:1983-1993 (Pubitemid 44033322)
29. Sloan JW, Martin WR, Bostwick M. Mechanisms involved in the respiratory depressant actions of nicotine in anesthetized rats. Pharmacol Biochem Behav 1989;34:559-564 (Pubitemid 20025096)
30. Aberger K, Chitravanshi VC, Sapru HN. Cardiovascular responses to microinjections of nicotine into the caudal ventrolateral medulla of the rat. Brain Res 2001;892:138-146 (Pubitemid 32126577)
31. Dickson SL, Hrabovszky E, Hansson C, et al. Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents. Neuroscience 2010;171:1180-1186
32. Farooqi IS, O'Rahilly S. Monogenic obesity in humans. Annu Rev Med 2005;56:443-458 (Pubitemid 40299792)
33. Ropelle ER, Flores MB, Cintra DE, et al. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition. PLoS Biol 2010;8:e1000465
34. Foster-Schubert KE, Cummings DE. Emerging therapeutic strategies for obesity. Endocr Rev 2006;27:779-793 (Pubitemid 44936060)
35. Hampl JS, Betts NM. Cigarette use during adolescence: effects on nutritional status. Nutr Rev 1999;57:215-221 (Pubitemid 29383744)
36. Bize R, Willi C, Chiolero A, et al. Participation in a population-based physical activity programme as an aid for smoking cessation: a randomised trial. Tob Control 2010;19:488-494
37. Gross J, Stitzer ML, Maldonado J. Nicotine replacement: effects of postcessation weight gain. J Consult Clin Psychol 1989;57:87-92 (Pubitemid 19151648)
38. Yoshida T, Sakane N, Umekawa T, et al. Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice. Int J Obes Relat Metab Disord 1999;23:570-575 (Pubitemid 29276805)
39. Frankish HM, Dryden S, Wang Q, Bing C, MacFarlane IA, Williams G. Nicotine administration reduces neuropeptide Y and neuropeptide Y mRNA concentrations in the rat hypothalamus: NPY may mediate nicotine's effects on energy balance. Brain Res 1995;694:139-146
40. Chen H, Hansen MJ, Jones JE, et al. Regulation of hypothalamic NPY by diet and smoking. Peptides 2007;28:384-389 (Pubitemid 46176261)
41. Cannon B, Nedergaard J. Thyroid hormones: igniting brown fat via the brain. Nat Med 2010;16:965-967
42. Niijima A, Rohner-Jeanrenaud F, Jeanrenaud B. Role of ventromedial hypothalamus on sympathetic efferents of brown adipose tissue. Am J Physiol 1984;247:R650-R654 (Pubitemid 15200520)
43. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359 (Pubitemid 38054374)
44. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007;293:E444-E452 (Pubitemid 47205086)
45. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517
46. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360: 1500-1508
47. Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518-1525
48. Hofstetter A, Schutz Y, Jéquier E, Wahren J. Increased 24-hour energy expenditure in cigarette smokers. N Engl J Med 1986;314:79-82 (Pubitemid 16183083)
49. Newhouse PA, Potter A, Singh A. Effects of nicotinic stimulation on cognitive performance. Curr Opin Pharmacol 2004;4:36-46 (Pubitemid 38145836)
50. Thacker EL, O'Reilly EJ, Weisskopf MG, et al. Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology 2007;68:764-768 (Pubitemid 46667902)