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Volumn 100, Issue 5, 2010, Pages 419-428

Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity

Author keywords

Addiction; Conditioned stimuli; Obesity; Orexin; Palatable food; Reward based feeding

Indexed keywords

ALCOHOL; COCAINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; OREXIN; PROTEIN FOS;

EID: 77953710614     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2010.03.009     Document Type: Article
Times cited : (200)

References (95)
  • 2
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6
  • 3
    • 0042565939 scopus 로고    scopus 로고
    • Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
    • Zhu Y., Miwa Y., Yamanaka A., Yada T., Shibahara M., Abe Y., et al. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci 2003, 92:259-266.
    • (2003) J Pharmacol Sci , vol.92 , pp. 259-266
    • Zhu, Y.1    Miwa, Y.2    Yamanaka, A.3    Yada, T.4    Shibahara, M.5    Abe, Y.6
  • 5
    • 0036580756 scopus 로고    scopus 로고
    • The hypocretins: setting the arousal threshold
    • Sutcliffe J.G., de Lecea L. The hypocretins: setting the arousal threshold. Nat Rev Neurosci 2002, 3:339-349.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 339-349
    • Sutcliffe, J.G.1    de Lecea, L.2
  • 6
    • 0035908282 scopus 로고    scopus 로고
    • Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems
    • Kilduff T.S., de Lecea L. Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems. J Comp Neurol 2001, 435:1-5.
    • (2001) J Comp Neurol , vol.435 , pp. 1-5
    • Kilduff, T.S.1    de Lecea, L.2
  • 7
    • 0033921449 scopus 로고    scopus 로고
    • Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting
    • Lu X.Y., Bagnol D., Burke S., Akil H., Watson S.J. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm Behav 2000, 37:335-344.
    • (2000) Horm Behav , vol.37 , pp. 335-344
    • Lu, X.Y.1    Bagnol, D.2    Burke, S.3    Akil, H.4    Watson, S.J.5
  • 10
    • 0034704445 scopus 로고    scopus 로고
    • A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
    • Haynes A.C., Jackson B., Chapman H., Tadayyon M., Johns A., Porter R.A., et al. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Peptides 2000, 96:45-51.
    • (2000) Regul Peptides , vol.96 , pp. 45-51
    • Haynes, A.C.1    Jackson, B.2    Chapman, H.3    Tadayyon, M.4    Johns, A.5    Porter, R.A.6
  • 11
    • 1842523043 scopus 로고    scopus 로고
    • Differential effects of the selective orexin-1 receptor anagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats
    • Ishii Y., Blundell J.E., Halford J.C., Upton N., Porter R., Johns A., et al. Differential effects of the selective orexin-1 receptor anagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats. Physiol Behav 2004, 81:129-140.
    • (2004) Physiol Behav , vol.81 , pp. 129-140
    • Ishii, Y.1    Blundell, J.E.2    Halford, J.C.3    Upton, N.4    Porter, R.5    Johns, A.6
  • 12
    • 17044417223 scopus 로고    scopus 로고
    • Satiety enhancement by selective orexin-1 receptor anagonist SB-334867: influence of test context and profile comparison with CCK8-S
    • Ishii Y., Blundell J.E., Halford J.C., Upton N., Porter R., Johns A., et al. Satiety enhancement by selective orexin-1 receptor anagonist SB-334867: influence of test context and profile comparison with CCK8-S. Behav Brain Res 2005, 160:11-24.
    • (2005) Behav Brain Res , vol.160 , pp. 11-24
    • Ishii, Y.1    Blundell, J.E.2    Halford, J.C.3    Upton, N.4    Porter, R.5    Johns, A.6
  • 14
    • 0035055943 scopus 로고    scopus 로고
    • SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    • Rodgers R.J., Halford J.C., Nunes de Souza R.L., Canto de Souza A.L., Piper D.C., Arch J.R., et al. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J NeuroSci 2001, 13:1444-1452.
    • (2001) Eur J NeuroSci , vol.13 , pp. 1444-1452
    • Rodgers, R.J.1    Halford, J.C.2    Nunes de Souza, R.L.3    Canto de Souza, A.L.4    Piper, D.C.5    Arch, J.R.6
  • 15
    • 0032729636 scopus 로고    scopus 로고
    • Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight
    • Yamanaka A., Sakurai T., Katsumoto T., Yanagisawa M., Goto K. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res 1999, 849:248-252.
    • (1999) Brain Res , vol.849 , pp. 248-252
    • Yamanaka, A.1    Sakurai, T.2    Katsumoto, T.3    Yanagisawa, M.4    Goto, K.5
  • 16
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent hypothalamus: relationship to neuropeptide Y and agouti gene-related protein systems
    • Broberger C., de Lecea L., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent hypothalamus: relationship to neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 1998, 402:460-474.
    • (1998) J Comp Neurol , vol.402 , pp. 460-474
    • Broberger, C.1    de Lecea, L.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 17
    • 0033552658 scopus 로고    scopus 로고
    • Strong hypocretin (orexin) innervation of the locus coeruleus activates noradrenergic cells
    • Horvath T.L., Peyron C., Sabrina D., Ivanov A., Aston-Jones G., Kilduff T., et al. Strong hypocretin (orexin) innervation of the locus coeruleus activates noradrenergic cells. J Comp Neurol 1999, 415:145-159.
    • (1999) J Comp Neurol , vol.415 , pp. 145-159
    • Horvath, T.L.1    Peyron, C.2    Sabrina, D.3    Ivanov, A.4    Aston-Jones, G.5    Kilduff, T.6
  • 20
    • 27744547829 scopus 로고    scopus 로고
    • Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity
    • White C.L., Ishii Y., Mendoza T., Upton N., Stasi L.P., Bray G.A., et al. Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity. Peptides 2005, 26:2331-2338.
    • (2005) Peptides , vol.26 , pp. 2331-2338
    • White, C.L.1    Ishii, Y.2    Mendoza, T.3    Upton, N.4    Stasi, L.P.5    Bray, G.A.6
  • 21
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    • Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999, 98:437-451.
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3    Elmquist, J.K.4    Scammell, T.5    Lee, C.6
  • 22
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999, 98:365-376.
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3    Kadotani, H.4    Rogers, W.5    Lin, X.6
  • 24
    • 34248149838 scopus 로고    scopus 로고
    • Clinical and neurobiological aspects of narcolepsy
    • Nishino S. Clinical and neurobiological aspects of narcolepsy. Sleep Med 2007, 8:373-399.
    • (2007) Sleep Med , vol.8 , pp. 373-399
    • Nishino, S.1
  • 25
    • 70349143485 scopus 로고    scopus 로고
    • Localized loss of hypocretin (orexin) cells in narcolepsy with cataplexy
    • Thannickal T.C., Nienhuis R., Siegel J.M. Localized loss of hypocretin (orexin) cells in narcolepsy with cataplexy. Sleep 2009, 32:993-998.
    • (2009) Sleep , vol.32 , pp. 993-998
    • Thannickal, T.C.1    Nienhuis, R.2    Siegel, J.M.3
  • 28
    • 0035576310 scopus 로고    scopus 로고
    • Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus
    • Eriksson K.S., Sergeeva O., Brown R.E., Haas H.L. Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci 2001, 21:9273-9279.
    • (2001) J Neurosci , vol.21 , pp. 9273-9279
    • Eriksson, K.S.1    Sergeeva, O.2    Brown, R.E.3    Haas, H.L.4
  • 29
    • 0034608355 scopus 로고    scopus 로고
    • Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons
    • Ivanov A., Aston-Jones G. Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. NeuroReport 2000, 11:1755-1758.
    • (2000) NeuroReport , vol.11 , pp. 1755-1758
    • Ivanov, A.1    Aston-Jones, G.2
  • 30
    • 58049174958 scopus 로고    scopus 로고
    • Role of lateral hypothalamic orexin neurons in reward processing and addiction
    • Aston-Jones G., Smith R.J., Moorman D.E., Richardson K.A. Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 2009, 56:112-121.
    • (2009) Neuropharmacology , vol.56 , pp. 112-121
    • Aston-Jones, G.1    Smith, R.J.2    Moorman, D.E.3    Richardson, K.A.4
  • 32
    • 75149159966 scopus 로고    scopus 로고
    • Convergent actions of orexin/hypocretin and CRF on dopamine neurons: emerging players and addiction. Brain Res;1314:139-44.
    • Borgland SL, Ungless MA, Bonci A. Convergent actions of orexin/hypocretin and CRF on dopamine neurons: emerging players and addiction. Brain Res 2010;1314:139-44.
    • (2010)
    • Borgland, S.L.1    Ungless, M.A.2    Bonci, A.3
  • 33
    • 75149187818 scopus 로고    scopus 로고
    • Role of orexin/hypocretin in dependence and addiction. Brain Res;1314:130-8.
    • Sharf R, Sarhan M, Dileone RJ. Role of orexin/hypocretin in dependence and addiction. Brain Res 2010;1314:130-8.
    • (2010)
    • Sharf, R.1    Sarhan, M.2    Dileone, R.J.3
  • 34
    • 17844398708 scopus 로고    scopus 로고
    • How can drug addiction help us understand obesity?
    • Volkow N.D., Wise R.A. How can drug addiction help us understand obesity?. Nat Neurosci 2005, 8:555-560.
    • (2005) Nat Neurosci , vol.8 , pp. 555-560
    • Volkow, N.D.1    Wise, R.A.2
  • 35
    • 0037390212 scopus 로고    scopus 로고
    • Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network
    • Will M.J., Franzblau E.B., Kelley A.E. Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network. J Neurosci 2003, 123:2882-2888.
    • (2003) J Neurosci , vol.123 , pp. 2882-2888
    • Will, M.J.1    Franzblau, E.B.2    Kelley, A.E.3
  • 37
    • 35348824334 scopus 로고    scopus 로고
    • Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    • Zheng H., Patterson L.M., Berthoud H.-R. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 2007, 27:11075-11082.
    • (2007) J Neurosci , vol.27 , pp. 11075-11082
    • Zheng, H.1    Patterson, L.M.2    Berthoud, H.-R.3
  • 38
    • 0033573532 scopus 로고    scopus 로고
    • Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior
    • Stratford T.R., Kelley A.E. Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J Neurosci 1999, 19:11040-11048.
    • (1999) J Neurosci , vol.19 , pp. 11040-11048
    • Stratford, T.R.1    Kelley, A.E.2
  • 39
    • 0842330416 scopus 로고    scopus 로고
    • Activation of a subpopulation of orexin/hypocretin-containing hypothalamic neurons by GABA A receptr-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment
    • Baldo B.A., Gual-Bonilla L., Sijapati K., Daniel R.A., Landry C.F., Kelley A.E. Activation of a subpopulation of orexin/hypocretin-containing hypothalamic neurons by GABA A receptr-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment. Eur J NeuroSci 2004, 19:376-386.
    • (2004) Eur J NeuroSci , vol.19 , pp. 376-386
    • Baldo, B.A.1    Gual-Bonilla, L.2    Sijapati, K.3    Daniel, R.A.4    Landry, C.F.5    Kelley, A.E.6
  • 40
    • 25844504320 scopus 로고    scopus 로고
    • Centrally administered orexin A increases motivation for sweet pellets in rats
    • Thorpe A.J., Cleary J.P., Levine A.S., Kotz C.M. Centrally administered orexin A increases motivation for sweet pellets in rats. Psychopharmacol (Berl) 2005, 182:75-83.
    • (2005) Psychopharmacol (Berl) , vol.182 , pp. 75-83
    • Thorpe, A.J.1    Cleary, J.P.2    Levine, A.S.3    Kotz, C.M.4
  • 41
    • 46149118191 scopus 로고    scopus 로고
    • Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evan rats
    • Richards J.K., Simms J.A., Steensland P., Taha S.A., Borgland S.L., Bonci A., et al. Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evan rats. Psychopharmacol (Berl.) 2008, 199:109-117.
    • (2008) Psychopharmacol (Berl.) , vol.199 , pp. 109-117
    • Richards, J.K.1    Simms, J.A.2    Steensland, P.3    Taha, S.A.4    Borgland, S.L.5    Bonci, A.6
  • 42
    • 77953716394 scopus 로고    scopus 로고
    • Effects of the orexin/hypocretin 1 receptor antagonist SB-334867 on sucrose-seeking in rats
    • Society fo Neuroscience, Chicago, IL, Online
    • Cason A.M., Fallon R., Aston-Jones G. Effects of the orexin/hypocretin 1 receptor antagonist SB-334867 on sucrose-seeking in rats. 755.10 2009 Neuroscience meeting planner 2009, Society fo Neuroscience, Chicago, IL, Online.
    • (2009) 755.10 2009 Neuroscience meeting planner
    • Cason, A.M.1    Fallon, R.2    Aston-Jones, G.3
  • 43
    • 68249087462 scopus 로고    scopus 로고
    • Orexin/hypocretin signaling at the OX1 receptor regulates cue-elicited cocaine-seeking
    • Smith R., See R., Aston-Jones G. Orexin/hypocretin signaling at the OX1 receptor regulates cue-elicited cocaine-seeking. Eur J NeuroSci 2009, 30:493-503.
    • (2009) Eur J NeuroSci , vol.30 , pp. 493-503
    • Smith, R.1    See, R.2    Aston-Jones, G.3
  • 44
    • 43449109190 scopus 로고    scopus 로고
    • Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats
    • Nair S.G., Golden S.A., Shaham Y. Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats. Br J Pharmacol 2008, 154:406-416.
    • (2008) Br J Pharmacol , vol.154 , pp. 406-416
    • Nair, S.G.1    Golden, S.A.2    Shaham, Y.3
  • 46
    • 25644432796 scopus 로고    scopus 로고
    • A role for lateral hypothalamic orexin neurons in reward seeking
    • Harris G.C., Wimmer M., Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 2005, 437:556-559.
    • (2005) Nature , vol.437 , pp. 556-559
    • Harris, G.C.1    Wimmer, M.2    Aston-Jones, G.3
  • 47
    • 37349004777 scopus 로고    scopus 로고
    • Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse
    • Dayas C.V., McGranahan T.M., Martin-Fardon R., Weiss F. Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 2008, 63:152-157.
    • (2008) Biol Psychiatry , vol.63 , pp. 152-157
    • Dayas, C.V.1    McGranahan, T.M.2    Martin-Fardon, R.3    Weiss, F.4
  • 48
    • 77953722762 scopus 로고    scopus 로고
    • Increased preference for cocaine during protracted forced abstinence: relationship with orexin/hypocretin neurons
    • Society for Neuroscience, Washington, DC, Online
    • Aston-Jones G., Liu S. Increased preference for cocaine during protracted forced abstinence: relationship with orexin/hypocretin neurons. Program no. 63.18, 2008 neuroscience meeting planner 2008, Society for Neuroscience, Washington, DC, Online.
    • (2008) Program no. 63.18, 2008 neuroscience meeting planner
    • Aston-Jones, G.1    Liu, S.2
  • 49
    • 70349132632 scopus 로고    scopus 로고
    • Obese adults have visual attention bias for food cue images: evidence for altered reward system function
    • Castellanos E.H., Charboneau E., Dietrich M.S., Park S., Bradley B.P., Mogg K., et al. Obese adults have visual attention bias for food cue images: evidence for altered reward system function. Int J Obes (London) 2009, 33:1063-1073.
    • (2009) Int J Obes (London) , vol.33 , pp. 1063-1073
    • Castellanos, E.H.1    Charboneau, E.2    Dietrich, M.S.3    Park, S.4    Bradley, B.P.5    Mogg, K.6
  • 50
    • 0027458144 scopus 로고
    • Bidirectional modulation of stimulated cortical acetylcholine release by benzodiazephine receptor ligands
    • Moore H., Sater M., Bruno J.P. Bidirectional modulation of stimulated cortical acetylcholine release by benzodiazephine receptor ligands. Brain Res 1993, 627:267-274.
    • (1993) Brain Res , vol.627 , pp. 267-274
    • Moore, H.1    Sater, M.2    Bruno, J.P.3
  • 51
    • 0028036501 scopus 로고
    • Enhanced acetylcholine release in hippocampus and cortex during anticipation and consumption of a palatable meal
    • Inglis F.M., Day J.C., Fibiger H.C. Enhanced acetylcholine release in hippocampus and cortex during anticipation and consumption of a palatable meal. Neuroscience 1994, 62:1049-1056.
    • (1994) Neuroscience , vol.62 , pp. 1049-1056
    • Inglis, F.M.1    Day, J.C.2    Fibiger, H.C.3
  • 52
    • 0029794368 scopus 로고    scopus 로고
    • Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents
    • Fadel J., Moore H., Sarter M., Bruno J.P. Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents. J Neurosci 1996, 16:6592-6600.
    • (1996) J Neurosci , vol.16 , pp. 6592-6600
    • Fadel, J.1    Moore, H.2    Sarter, M.3    Bruno, J.P.4
  • 53
    • 35448996142 scopus 로고    scopus 로고
    • Food-elicited increases in cortical acetylcholine release require orexin transmission
    • Frederick-Duus D., Guyton M.F., Fadel J. Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 2007, 149:499-507.
    • (2007) Neuroscience , vol.149 , pp. 499-507
    • Frederick-Duus, D.1    Guyton, M.F.2    Fadel, J.3
  • 54
    • 34249004342 scopus 로고    scopus 로고
    • The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking
    • McLaughlin R.J., Floresco S.B. The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking. Neuroscience 2007, 146(4):1484-1494.
    • (2007) Neuroscience , vol.146 , Issue.4 , pp. 1484-1494
    • McLaughlin, R.J.1    Floresco, S.B.2
  • 55
    • 41949115175 scopus 로고    scopus 로고
    • Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior
    • Floresco S.B., McLaughlin R.J., Haluk D.M. Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior. Behav Brain Res 2008, 190(1):85-96.
    • (2008) Behav Brain Res , vol.190 , Issue.1 , pp. 85-96
    • Floresco, S.B.1    McLaughlin, R.J.2    Haluk, D.M.3
  • 56
    • 0036812537 scopus 로고    scopus 로고
    • Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eating
    • Petrovich G.D., Setlow B., Holland P.C., Gallagher M. Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eating. J Neurosci 2002, 22:8748-8753.
    • (2002) J Neurosci , vol.22 , pp. 8748-8753
    • Petrovich, G.D.1    Setlow, B.2    Holland, P.C.3    Gallagher, M.4
  • 57
    • 0029077748 scopus 로고
    • Topographical organization of the nucleus accumbens afferents from the basolateral amygdala and efferents to the lateral hypothalamus
    • Kirouac G.J., Ganguly P.K. Topographical organization of the nucleus accumbens afferents from the basolateral amygdala and efferents to the lateral hypothalamus. Neuroscience 1995, 67(3):625-630.
    • (1995) Neuroscience , vol.67 , Issue.3 , pp. 625-630
    • Kirouac, G.J.1    Ganguly, P.K.2
  • 58
    • 33750503795 scopus 로고    scopus 로고
    • Renewal of an extinguished instrumental response: neural correlates and the role of D1 dopamine receptors
    • Hamlin A.S., Blatchford K.E., McNally G.P. Renewal of an extinguished instrumental response: neural correlates and the role of D1 dopamine receptors. Neuroscience 2006, 143(1):25-38.
    • (2006) Neuroscience , vol.143 , Issue.1 , pp. 25-38
    • Hamlin, A.S.1    Blatchford, K.E.2    McNally, G.P.3
  • 59
    • 59649091214 scopus 로고    scopus 로고
    • Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking
    • Marchant N.J., Hamlin A.S., McNally G.P. Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking. J Neurosci 2009, 29:1331-1342.
    • (2009) J Neurosci , vol.29 , pp. 1331-1342
    • Marchant, N.J.1    Hamlin, A.S.2    McNally, G.P.3
  • 60
    • 0036898927 scopus 로고    scopus 로고
    • Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues
    • Crombag H.S., Grimm J.W., Shaham Y. Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology 2002, 27:1006-1015.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 1006-1015
    • Crombag, H.S.1    Grimm, J.W.2    Shaham, Y.3
  • 61
    • 12344256768 scopus 로고    scopus 로고
    • The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats
    • Fuchs R.A., Evans K.A., Ledford C.C., Parker M.P., Case J.M., Mehta R.H., et al. The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharmacology 2005, 30:296-309.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 296-309
    • Fuchs, R.A.1    Evans, K.A.2    Ledford, C.C.3    Parker, M.P.4    Case, J.M.5    Mehta, R.H.6
  • 62
    • 75849126020 scopus 로고    scopus 로고
    • Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization. Brain Res;1317:24-32.
    • Sharf R, Guarnieri DJ, Taylor JR, Dileone RJ. Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization. Brain Res 2010;1317:24-32.
    • (2010)
    • Sharf, R.1    Guarnieri, D.J.2    Taylor J.R3    Dileone, R.J.4
  • 63
    • 71549139716 scopus 로고    scopus 로고
    • Orexin/hypocretin is necessary for context-driven cocaine-seeking
    • Smith R.J., Tahsili-Fahadan P., Aston-Jones G. Orexin/hypocretin is necessary for context-driven cocaine-seeking. Neuropharmacology 2010, 58(1):179-184.
    • (2010) Neuropharmacology , vol.58 , Issue.1 , pp. 179-184
    • Smith, R.J.1    Tahsili-Fahadan, P.2    Aston-Jones, G.3
  • 65
    • 20444386232 scopus 로고    scopus 로고
    • Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats
    • Akanmu M.A., Honda K. Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats. Brain Res 2005, 1048:138-145.
    • (2005) Brain Res , vol.1048 , pp. 138-145
    • Akanmu, M.A.1    Honda, K.2
  • 66
    • 0038724250 scopus 로고    scopus 로고
    • Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes
    • Willie J.T., Chemelli R.M., Sinton C.M., Tokita S., Williams S.C., Kisanuki Y.Y., et al. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron 2003, 38:715-730.
    • (2003) Neuron , vol.38 , pp. 715-730
    • Willie, J.T.1    Chemelli, R.M.2    Sinton, C.M.3    Tokita, S.4    Williams, S.C.5    Kisanuki, Y.Y.6
  • 67
    • 67649867893 scopus 로고    scopus 로고
    • Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat
    • Dugovic C., Shelton J.E., Aluisio L.E., Fraser I.C., Jiang X., Sutton S.W., et al. Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J Pharmacol Exp Ther 2009, 330:142-151.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 142-151
    • Dugovic, C.1    Shelton, J.E.2    Aluisio, L.E.3    Fraser, I.C.4    Jiang, X.5    Sutton, S.W.6
  • 71
    • 68149156295 scopus 로고    scopus 로고
    • Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague Dawley rats
    • Moorman D.E., Aston-Jones G. Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague Dawley rats. Alcohol 2009, 43:379-386.
    • (2009) Alcohol , vol.43 , pp. 379-386
    • Moorman, D.E.1    Aston-Jones, G.2
  • 72
    • 52149123699 scopus 로고    scopus 로고
    • Intermittent access to 20% ethanol induced high ethanol consumption in Long-Evans and Wistar rats
    • Simms J.A., Steensland P., Medina B., Abernathy K.E., Chandler L.J., Wise R., et al. Intermittent access to 20% ethanol induced high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 2008, 32:1816-1823.
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 1816-1823
    • Simms, J.A.1    Steensland, P.2    Medina, B.3    Abernathy, K.E.4    Chandler, L.J.5    Wise, R.6
  • 73
    • 4644271813 scopus 로고    scopus 로고
    • Brain substrates for increased drug seeking during protracted withdrawal
    • Aston-Jones G., Harris G.C. Brain substrates for increased drug seeking during protracted withdrawal. Neuropharmacology 2004, 47(S1):167-179.
    • (2004) Neuropharmacology , vol.47 , Issue.1 , pp. 167-179
    • Aston-Jones, G.1    Harris, G.C.2
  • 74
    • 0035209296 scopus 로고    scopus 로고
    • Augmented accumbal serotonin levels decrease the preference for a morphine associated environment during withdrawal
    • Harris G.C., Aston-Jones G. Augmented accumbal serotonin levels decrease the preference for a morphine associated environment during withdrawal. Neuropsychopharmacology 2001, 24:75-85.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 75-85
    • Harris, G.C.1    Aston-Jones, G.2
  • 75
    • 0037308887 scopus 로고    scopus 로고
    • Enhanced morphine preference following prolonged abstinence: association with increased Fos expression in the extended amygdala
    • Harris G.C., Aston-Jones G. Enhanced morphine preference following prolonged abstinence: association with increased Fos expression in the extended amygdala. Neuropsychopharmacology 2003, 28:292-299.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 292-299
    • Harris, G.C.1    Aston-Jones, G.2
  • 76
    • 0038389054 scopus 로고    scopus 로고
    • Altered motivation and learning following opiate withdrawal: evidence for prolonged dysregulation of reward processing
    • Harris G.C., Aston-Jones G. Altered motivation and learning following opiate withdrawal: evidence for prolonged dysregulation of reward processing. Neuropsychopharmacology 2003, 28:865-871.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 865-871
    • Harris, G.C.1    Aston-Jones, G.2
  • 77
    • 34547870546 scopus 로고    scopus 로고
    • Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward
    • Harris G.C., Wimmer M., Randall-Thompson J.F., Aston-Jones G. Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward. Behav Brain Res 2007, 183:43-51.
    • (2007) Behav Brain Res , vol.183 , pp. 43-51
    • Harris, G.C.1    Wimmer, M.2    Randall-Thompson, J.F.3    Aston-Jones, G.4
  • 79
    • 33748806552 scopus 로고    scopus 로고
    • Arousal and reward: a dichotomy in orexin function
    • Harris G., Aston-Jones G. Arousal and reward: a dichotomy in orexin function. Trends Neurosci 2006, 29:571-577.
    • (2006) Trends Neurosci , vol.29 , pp. 571-577
    • Harris, G.1    Aston-Jones, G.2
  • 81
    • 0036703780 scopus 로고    scopus 로고
    • Differential activation of orexin neurons by antipsychotic drugs associated with weight gain
    • Fadel J., Bubser M., Deutch A.Y. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J Neurosci 2002, 22:6742-6746.
    • (2002) J Neurosci , vol.22 , pp. 6742-6746
    • Fadel, J.1    Bubser, M.2    Deutch, A.Y.3
  • 82
    • 46249085450 scopus 로고    scopus 로고
    • Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell
    • Sharf R., Sarhan M., Dileone R.J. Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell. Biol Psychiatry 2008, 64:175-183.
    • (2008) Biol Psychiatry , vol.64 , pp. 175-183
    • Sharf, R.1    Sarhan, M.2    Dileone, R.J.3
  • 83
    • 0037052657 scopus 로고    scopus 로고
    • Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area
    • Fadel J., Deutch A.Y. Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience 2002, 111:379-387.
    • (2002) Neuroscience , vol.111 , pp. 379-387
    • Fadel, J.1    Deutch, A.Y.2
  • 85
    • 77953716201 scopus 로고    scopus 로고
    • Orexin neurons that project to the ventral tegmental area (VTA) are activated by morphine preference during protracted forced abstinence
    • Society for Neuroscience, San Diego, CA, Online
    • Richardson K.A., Knackstedt P.T., Aston-Jones G. Orexin neurons that project to the ventral tegmental area (VTA) are activated by morphine preference during protracted forced abstinence. Program no. 916.4. 2007 neuroscience meeting planner 2007, Society for Neuroscience, San Diego, CA, Online.
    • (2007) Program no. 916.4. 2007 neuroscience meeting planner
    • Richardson, K.A.1    Knackstedt, P.T.2    Aston-Jones, G.3
  • 86
    • 77953690599 scopus 로고    scopus 로고
    • Activation of VTA-projecting orexin/hypocretin neurons in the lateral, but not the dorsomedial and perifornical hypothalamus, correlates with morphine preference after prolonged forced abstinence
    • Society for Neuroscience, Washington, DC, Online
    • Richardson K.A., Knackstedt P.T., Aston-Jones G. Activation of VTA-projecting orexin/hypocretin neurons in the lateral, but not the dorsomedial and perifornical hypothalamus, correlates with morphine preference after prolonged forced abstinence. Program no. 63.16. 2008 neuroscience meeting planner 2008, Society for Neuroscience, Washington, DC, Online.
    • (2008) Program no. 63.16. 2008 neuroscience meeting planner
    • Richardson, K.A.1    Knackstedt, P.T.2    Aston-Jones, G.3
  • 87
    • 77953711095 scopus 로고    scopus 로고
    • Morphine conditioning activates orexin/hypocretin neurons that project to rostral VTA: effects of protracted abstinence
    • Society for Neuroscience, Chicago, IL, Online
    • Richardson K.A., Aston-Jones G. Morphine conditioning activates orexin/hypocretin neurons that project to rostral VTA: effects of protracted abstinence. Program no. 751.12. 2009 neuroscience meeting planner 2009, Society for Neuroscience, Chicago, IL, Online.
    • (2009) Program no. 751.12. 2009 neuroscience meeting planner
    • Richardson, K.A.1    Aston-Jones, G.2
  • 88
    • 77953696241 scopus 로고    scopus 로고
    • Afferents that regulate lateral hypothalamic orexin/hypocretin neurons during drug seeking behaviors
    • Society for Neuroscience, Washington, DC, Online
    • Sartor G.C., Aston-Jones G., Sartor G.C., Aston-Jones G. Afferents that regulate lateral hypothalamic orexin/hypocretin neurons during drug seeking behaviors. Program no. 63.13. 2008 neuroscience meeting planner 2008, Society for Neuroscience, Washington, DC, Online.
    • (2008) Program no. 63.13. 2008 neuroscience meeting planner
    • Sartor, G.C.1    Aston-Jones, G.2    Sartor, G.C.3    Aston-Jones, G.4
  • 90
    • 0035881405 scopus 로고    scopus 로고
    • A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues
    • Schroeder B.E., Binzark J.M., Kelley A.E. A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues. Neuroscience 2001, 105:535-545.
    • (2001) Neuroscience , vol.105 , pp. 535-545
    • Schroeder, B.E.1    Binzark, J.M.2    Kelley, A.E.3
  • 91
    • 0035990481 scopus 로고    scopus 로고
    • Conditioned Fos expression following morphine-paired contextual cue exposure is environment specific
    • Schroeder B.E., Kelley A.E. Conditioned Fos expression following morphine-paired contextual cue exposure is environment specific. Behav Neurosci 2002, 116:727-732.
    • (2002) Behav Neurosci , vol.116 , pp. 727-732
    • Schroeder, B.E.1    Kelley, A.E.2
  • 92
    • 0037209246 scopus 로고    scopus 로고
    • Neural activation profile elicited by cues associated with the anxiogenic drug yohimbine differs from that observed for reward-paired cues
    • Schroeder B.E., Schiltz C.A., Kelley A.E. Neural activation profile elicited by cues associated with the anxiogenic drug yohimbine differs from that observed for reward-paired cues. Neuropsychopharmacology 2003, 28:14-21.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 14-21
    • Schroeder, B.E.1    Schiltz, C.A.2    Kelley, A.E.3
  • 93
    • 24944519344 scopus 로고    scopus 로고
    • Neural systems recruited by drug- and food-related cues: studies of gene activation in corticolimbic regions
    • Kelley A.E., Schlitz C.A., Landry C.F. Neural systems recruited by drug- and food-related cues: studies of gene activation in corticolimbic regions. Physiol Behav 2005, 86:11-14.
    • (2005) Physiol Behav , vol.86 , pp. 11-14
    • Kelley, A.E.1    Schlitz, C.A.2    Landry, C.F.3
  • 94
    • 32344453801 scopus 로고    scopus 로고
    • Direct involvement of orexigenic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    • Narita M., Nagumo Y., Hashimoto S., Narita M., Khotib J., Miyatake M., et al. Direct involvement of orexigenic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 2006, 26:398-405.
    • (2006) J Neurosci , vol.26 , pp. 398-405
    • Narita, M.1    Nagumo, Y.2    Hashimoto, S.3    Narita, M.4    Khotib, J.5    Miyatake, M.6
  • 95
    • 77953705485 scopus 로고    scopus 로고
    • Modulation of ventral tegmental area neural responses to prefrontal stimulation by local orexin application in vivo
    • Society for Neuroscience, San Diego, CA, Online
    • Moorman D.E., Aston-Jones G. Modulation of ventral tegmental area neural responses to prefrontal stimulation by local orexin application in vivo. Program no. 916.2. 2007 neuroscience meeting planner 2007, Society for Neuroscience, San Diego, CA, Online.
    • (2007) Program no. 916.2. 2007 neuroscience meeting planner
    • Moorman, D.E.1    Aston-Jones, G.2


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