Steroidogenic factor 1: An essential mediator of endocrine development

Recent Progress in Hormone Research

Volumn 57, Issue , 2002, Pages 19-36

  Parker, Keith L ^a   Rice, Douglas A ^a   Lala, Deepak S ^a   Ikeda, Yayoi ^a   Luo, Xunrong ^a   Wong, Margaret ^a   Bakke, Marit ^a   Zhao, Liping ^a   Frigeri, Claudia ^b   Hanley, Neil A ^a   Stallings, Nancy ^a   Schimmer, Bernard P ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; GONADOTROPIN; STEROID MONOOXYGENASE; STEROIDOGENIC FACTOR 1;

ADRENAL GLAND; ADRENAL INSUFFICIENCY; ARTICLE; ENDOCRINE FUNCTION; GENE EXPRESSION REGULATION; GONAD; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SEX DIFFERENTIATION; SEX TRANSFORMATION; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; ENDOCRINE GLANDS; FUSHI TARAZU TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 18544386359     PISSN: 00799963     EISSN: None     Source Type: Journal    
DOI: 10.1210/rp.57.1.19     Document Type: Article

References (73)

1. A mutation in the gene encoding steroidogenic factor-1 causes 46,XY sex reversal and adrenal failure in humans
2. Targeted mutagenesis of the endogenous mouse Mis gene promoter: In vivo definition of genetic pathways of vertebrate sexual development
3. Apparently normal ovarian differentiation in a prepubertal girl with transcriptionally inactive steroidogenic factor 1 (NR5A1/SF-1) and adrenocortical insufficiency
4. The LIM homeobox gene Lhx9 is essential for mouse gonad formation
5. Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response
6. Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process
7. Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions
8. The activation function-2 hexamer of steroidogenic factor-1 is required but not sufficient for potentiation by SRC-1
9. Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage
10. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
11. Cre-mediated recombination in the pituitary gland
12. Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region
13. Direct interaction of SRY-related protein SOX9 and steroidogenic factor I regulates transcription of the human anti-Mullerian hormone gene
14. Expression and subcellular localization of SF-1, SOX9, WTI, and AMH proteins during early human testicular development
15. Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1
16. Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells
17. The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian inhibiting substance, in vivo
18. Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit
19. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone signaling in reproduction and stress
20. An enhancer element and a functional cAMP-dependent protein kinase are required for expression of adrenocortical 21-hydroxylase
21. Expression of steroidogenic factor I and Wilms' tumour 1 during early human gonadal development and sex determination
22. The basic helix-loop-helix, leucine zipper transcription factor. USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells
23. Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development
24. Identical origin of adrenal cortex and gonads as revealed by expression profiles of Ad4BP/SF-1
25. Ad4BP regulating steroidogenic P-450 gene is a member of the steroid receptor superfamily
26. Developmental expression of mouse steroidogenic factor 1, an essential regulator of the steroid hydroxylases
27. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
28. The nuclear receptor SF-1 acts at multiple levels of the reproductive axis
29. DAX-1 inhibits SF-1-mediated transactivation via a carboxyterminal domain that is deleted in adrenal hypoplasia congenita
30. Identification and characterization of cDNA clones specific for cholesterol side chain cleavage cytochrome P450
31. The role of human MBF1 as a transcriptional coactivator
32. Dax-1 as one of the target genes of Ad4BP/SF-1
33. A steroidogenic factor-1 binding site is required for activity of the luteinizing hormone beta subunit promoter in gonadotropes of transgenic mice
34. Identification of novel first exons in Ad4BP/SF-1 (NR5A1) gene and their tissue- and species-specific usage
35. Orphan nuclear receptors: Shifting endocrinology into reverse
36. Steroidogenic factor 1, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor 1
37. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols
38. Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers
39. Effects of mutating different steroidogenic factor-1 protein regions on gene regulation
40. A cell specific nuclear receptor is required for adrenal and gonadal development and for male sexual differentiation
41. Molecular cloning of DNA complementary to bovine adrenal P450scc mRNA
42. 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1)
43. Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300
44. Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex
45. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s
46. Functional differences between Ad4BP and ELP and their distributions in steroidogenic tissues
47. Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse
48. Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression
49. Genomic organization and isoforms of the mouse ELP gene
50. An E box element is required for expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development
51. Structural characterization of human Ad4BP (SF-1) gene
52. Gene regulation of steroidogenesis
53. Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases
54. Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y-1 adrenocortical tumor cells
55. Characterization of a regulatory region of the steroid 21-hydroxylase gene
56. Gene interactions in gonadal development
57. A shared promoter element regulates the expression of three steroidogenic enzymes
58. Transcriptional control of cell phenotypes in the neuroendocrine system
59. Mice deficient in the orphan receptor steroidogenic factor I lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
60. Isolation of ACTH-resistant Y1 adrenal tumor cells
61. Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz-F1-disrupted mice
62. Homologs of Drosophila fushi tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33
63. Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1
64. Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain
65. Embryonal long terminal repeat binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily
66. Two steroid 21-hydroxylase genes are located in the murine S region
67. Cloning and expression of cDNA encoding a bovine adrenal cytochrome P-450 specific for steroid 21-hydroxylafion 2 1-hydroxylation
68. Cloning and sequence analysis of the human gene encoding steroidogenic factor I
69. Characterization of the promoter of SF-1, an orphan nuclear receptor required for adrenal and gonadal development
70. Coactivator and corepressor complexes in nuclear receptor function
71. The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor-1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor regulatory element
72. The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3′,5′-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase)
73. Steroidogenic factor I is essential for pituitary gonadotrope function