PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

American Journal of Physiology - Endocrinology and Metabolism

Volumn 298, Issue 4, 2010, Pages

  Iskandar, Kristy ^a   Cao, Yongheng ^a,f   Hayashi, Yoshitake ^a   Nakata, Masanori ^b   Takano, Eisuke ^b   Yada, Toshihiko ^b   Zhang, Changliang ^a   Ogawa, Wataru ^a   Oki, Miyo ^a   Chua Jr , Streamson ^c   Itoh, Hiroshi ^d   Noda, Tetsuo ^e   Kasuga, Masato ^a,f   Nakae, Jun ^a,d  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e CANCER INSTITUTE   (Japan)

^f NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Food intake; Forkhead box containing protein O1; Phosphoinositide dependent protein kinase 1; Pomc; Proopiomelanocortin neurons

Indexed keywords

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROOPIOMELANOCORTIN; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL NUCLEUS; CONTROLLED STUDY; ENERGY; FEMALE; FOOD INTAKE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HOMEOSTASIS; HYPERPHAGIA; MALE; METABOLISM; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CHROMATIN; EATING; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR ACTIVITY; NEURONS; OBESITY; OXYGEN CONSUMPTION; PLASMIDS; PRO-OPIOMELANOCORTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRPP CATION CHANNELS;

EID: 77949858304     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00512.2009     Document Type: Article

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