Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 281, Issue 2 50-2, 2001, Pages

  Hwa, Joyce J ^a   Ghibaudi, Lorraine ^a   Gao, Jun ^a   Parker, Eric M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Agonist; Antagonist; Indirect calorimetry; Obesity; Oxygen consumption; Respiratory quotient

Indexed keywords

MELANOCORTIN; MELANOCORTIN RECEPTOR; N ACETYL 10 ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (DEXTRO PHENYLALANINE)] 10 LYSINAMIDE]; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CALORIMETRY; CONTROLLED STUDY; ENERGY EXPENDITURE; FEEDING BEHAVIOR; MALE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RESPIRATORY QUOTIENT; WEIGHT REDUCTION;

EID: 0034881262     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2001.281.2.r444     Document Type: Article

References (48)

1. Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor
2. Differential effects of melanocortin peptides on neural melanocortin receptors
3. Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat
4. Leptin sensitive neurons in the hypothalamus
5. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences
6. The Zucker-fatty rat: A review
7. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
8. The OB protein (leptin) pathway-a link between adipose tissue mass and central neural networks
9. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
10. Integration of NPY AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
11. Functional properties of leptin receptor isoforms containing the Gln→Pro extracellular domain mutation of the fatty rat
12. Chemical characterization of leptin-activated neurons in the rat brain
13. Energy expenditure and fuel selection in biological systems: The theory and practice of calculations based on indirect calorimetry and tracer methods
14. Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands
15. Melanocortins and the treatment of nervous system disease. Potential relevance to the skin?
16. Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats
17. Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat
18. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
19. Systematic mutation screening of the proopiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes
20. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
21. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
22. Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation
23. Substitution at codon 269 (glutamine→proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat
24. ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean zucker rats
25. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone
26. Effects of leptin receptor mutation on AGRP gene expression in fed and fasted lean and obese (LA/N-faf) rats
27. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
28. 3 subtype dominates in the medial rat brain
29. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
30. Control of food intake via leptin receptors in the hypothalamus
31. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
32. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
33. Obesity, diabetes and functions for proopiomelanocortin-derived peptides
34. The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity
35. Centrally administered MTII affects feeding, drinking, temperature, and activity in the sprague-dawley rat
36. Melanocortin mediated inhibition of feeding behavior in rats
37. Zucker rat (fa/fa), a model for the study of immune function in type-II diabetes mellitus: Effect of exercise and caloric restriction on the phagocytic activity of macrophages
38. Glycyl-L-glutamine antagonizes alpha-MSH-elicited thermogenesis
39. Identification of targets of leptin action in rat hypothalamus
40. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
41. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene
42. Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides
43. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
44. Two important systems in energy homeostasis: Melanocortins and melanin-concentrating hormone
45. fak.
46. Physiological and anatomical circuitry between Agouti-related protein and leptin signaling
47. Characterization of Agouti-related protein binding to melanocortin receptors
48. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: Study of 24-h RQ