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Volumn 293, Issue 1, 2007, Pages

Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet

Author keywords

Diabetes; Hepatic steatosis; Melanocortins; Melanocyte stimulating hormone; Obesity; Proopiomelanocortin

Indexed keywords

CORTICOSTERONE; GLUCOSE; INTERMEDIN; MELANOCORTIN; MESSENGER RNA; PROOPIOMELANOCORTIN;

EID: 34547122875     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00555.2006     Document Type: Article
Times cited : (39)

References (62)
  • 2
    • 0031471301 scopus 로고    scopus 로고
    • Brain melanocortin receptors: From cloning to function
    • Adan RA, Gispen WH. Brain melanocortin receptors: from cloning to function. Peptides 18: 1279-1287, 1997.
    • (1997) Peptides , vol.18 , pp. 1279-1287
    • Adan, R.A.1    Gispen, W.H.2
  • 5
    • 32844463470 scopus 로고    scopus 로고
    • Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes
    • Bradley RL, Mansfield JP, Maratos-Flier E. Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes. Obes Res 13: 653-661, 2005.
    • (2005) Obes Res , vol.13 , pp. 653-661
    • Bradley, R.L.1    Mansfield, J.P.2    Maratos-Flier, E.3
  • 6
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • Butler AA. The melanocortin system and energy balance. Peptides 27: 281-290, 2006.
    • (2006) Peptides , vol.27 , pp. 281-290
    • Butler, A.A.1
  • 8
    • 0034981271 scopus 로고    scopus 로고
    • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
    • Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4: 605-611, 2001.
    • (2001) Nat Neurosci , vol.4 , pp. 605-611
    • Butler, A.A.1    Marks, D.L.2    Fan, W.3    Kuhn, C.M.4    Bartolome, M.5    Cone, R.D.6
  • 9
    • 0036096230 scopus 로고    scopus 로고
    • The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats
    • Cettour-Rose P, Rohner-Jeanrenaud F. The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats. Endocrinology 143: 2277-2283, 2002.
    • (2002) Endocrinology , vol.143 , pp. 2277-2283
    • Cettour-Rose, P.1    Rohner-Jeanrenaud, F.2
  • 12
    • 23644453797 scopus 로고    scopus 로고
    • Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids
    • Coll AP, Challis BG, Lopez M, Piper S, Yeo GS, O'Rahilly S. Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54: 2269-2276, 2005.
    • (2005) Diabetes , vol.54 , pp. 2269-2276
    • Coll, A.P.1    Challis, B.G.2    Lopez, M.3    Piper, S.4    Yeo, G.S.5    O'Rahilly, S.6
  • 14
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8: 571-578, 2005.
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 15
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24: 155-163, 1999.
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 16
    • 0032727759 scopus 로고    scopus 로고
    • Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
    • Dunbar JC, Lu H. Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products. Brain Res Bull 50: 215-221, 1999.
    • (1999) Brain Res Bull , vol.50 , pp. 215-221
    • Dunbar, J.C.1    Lu, H.2
  • 20
    • 0342858793 scopus 로고    scopus 로고
    • alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
    • Fekete C, Legradi G, Mihaly E, Huang QH, Tatro JB, Rand WM, Emerson CH, Lechan RM. alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J Neurosci 20: 1550-1558, 2000.
    • (2000) J Neurosci , vol.20 , pp. 1550-1558
    • Fekete, C.1    Legradi, G.2    Mihaly, E.3    Huang, Q.H.4    Tatro, J.B.5    Rand, W.M.6    Emerson, C.H.7    Lechan, R.M.8
  • 21
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509, 1957.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 22
    • 9644307899 scopus 로고    scopus 로고
    • Melanocortin-independent effects of leptin on hepatic glucose fluxes
    • Gutierrez-Juarez R, Obici S, Rossetti L. Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem 279: 49704-49715, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 49704-49715
    • Gutierrez-Juarez, R.1    Obici, S.2    Rossetti, L.3
  • 23
    • 0036515969 scopus 로고    scopus 로고
    • Chronic application of MTII in a rat model of obesity results in sustained weight loss
    • Hamilton BS, Doods HN. Chronic application of MTII in a rat model of obesity results in sustained weight loss. Obes Res 10: 182-187, 2002.
    • (2002) Obes Res , vol.10 , pp. 182-187
    • Hamilton, B.S.1    Doods, H.N.2
  • 24
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • Haynes WG, Morgan DA, Djalali A, Sivitz WI, Mark AL. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33: 542-547, 1999.
    • (1999) Hypertension , vol.33 , pp. 542-547
    • Haynes, W.G.1    Morgan, D.A.2    Djalali, A.3    Sivitz, W.I.4    Mark, A.L.5
  • 26
    • 11244325044 scopus 로고    scopus 로고
    • Peripherally administered [Nle4,D-Phe7]-alpha-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice
    • Hoggard N, Rayner DV, Johnston SL, Speakman JR. Peripherally administered [Nle4,D-Phe7]-alpha-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice. J Mol Endocrinol 33: 693-703, 2004.
    • (2004) J Mol Endocrinol , vol.33 , pp. 693-703
    • Hoggard, N.1    Rayner, D.V.2    Johnston, S.L.3    Speakman, J.R.4
  • 27
    • 0242353028 scopus 로고    scopus 로고
    • Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity
    • Huang XF, Han M, South T, Storlien L. Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity. Brain Res 992: 9-19, 2003.
    • (2003) Brain Res , vol.992 , pp. 9-19
    • Huang, X.F.1    Han, M.2    South, T.3    Storlien, L.4
  • 29
    • 0034881262 scopus 로고    scopus 로고
    • Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
    • Hwa JJ, Ghibaudi L, Gao J, Parker EM. Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am J Physiol Regul Integr Comp Physiol 281: R444-R451, 2001.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Hwa, J.J.1    Ghibaudi, L.2    Gao, J.3    Parker, E.M.4
  • 30
    • 0036299479 scopus 로고    scopus 로고
    • Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats
    • Jonsson L, Skarphedinsson JO, Skuladottir GV, Watanobe H, Schioth HB. Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J Endocrinol 173: 517-523, 2002.
    • (2002) J Endocrinol , vol.173 , pp. 517-523
    • Jonsson, L.1    Skarphedinsson, J.O.2    Skuladottir, G.V.3    Watanobe, H.4    Schioth, H.B.5
  • 31
    • 0346121596 scopus 로고    scopus 로고
    • Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression
    • Korner J, Wissig S, Kim A, Conwell IM, Wardlaw SL. Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression. J Neuroendocrinol 15: 1116-1121, 2003.
    • (2003) J Neuroendocrinol , vol.15 , pp. 1116-1121
    • Korner, J.1    Wissig, S.2    Kim, A.3    Conwell, I.M.4    Wardlaw, S.L.5
  • 32
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19: 155-157, 1998.
    • (1998) Nat Genet , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 33
    • 0033304761 scopus 로고    scopus 로고
    • Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
    • Legradi G, Lechan RM. Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 140: 3643-3652, 1999.
    • (1999) Endocrinology , vol.140 , pp. 3643-3652
    • Legradi, G.1    Lechan, R.M.2
  • 34
    • 0042767613 scopus 로고    scopus 로고
    • Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
    • Li G, Mobbs CV, Scarpace PJ. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 52: 1951-1957, 2003.
    • (2003) Diabetes , vol.52 , pp. 1951-1957
    • Li, G.1    Mobbs, C.V.2    Scarpace, P.J.3
  • 35
    • 27744596351 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats
    • Li G, Zhang Y, Wilsey JT, Scarpace PJ. Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Diabetologia 48: 2376-2385, 2005.
    • (2005) Diabetologia , vol.48 , pp. 2376-2385
    • Li, G.1    Zhang, Y.2    Wilsey, J.T.3    Scarpace, P.J.4
  • 37
    • 0023858233 scopus 로고
    • Neuropeptide-Y and ACTH-immunoreactive innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. An immunocytochemical analysis at the light and electron microscopic levels
    • Liposits Z, Sievers L, Paull WK. Neuropeptide-Y and ACTH-immunoreactive innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. An immunocytochemical analysis at the light and electron microscopic levels. Histochemistry 88: 227-234, 1988.
    • (1988) Histochemistry , vol.88 , pp. 227-234
    • Liposits, Z.1    Sievers, L.2    Paull, W.K.3
  • 39
    • 31544474029 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis
    • Martin NM, Smith KL, Bloom SR, Small CJ. Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis. Peptides 27: 333-339, 2006.
    • (2006) Peptides , vol.27 , pp. 333-339
    • Martin, N.M.1    Smith, K.L.2    Bloom, S.R.3    Small, C.J.4
  • 41
    • 0242300570 scopus 로고    scopus 로고
    • Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
    • Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52: 2675-2683, 2003.
    • (2003) Diabetes , vol.52 , pp. 2675-2683
    • Mizuno, T.M.1    Kelley, K.A.2    Pasinetti, G.M.3    Roberts, J.L.4    Mobbs, C.V.5
  • 42
    • 0141924530 scopus 로고    scopus 로고
    • The physiological function of the agouti-related peptide gene: The control of weight and metabolic rate
    • Mizuno TM, Makimura H, Mobbs CV. The physiological function of the agouti-related peptide gene: the control of weight and metabolic rate. Ann Med 35: 425-433, 2003.
    • (2003) Ann Med , vol.35 , pp. 425-433
    • Mizuno, T.M.1    Makimura, H.2    Mobbs, C.V.3
  • 44
    • 18244384200 scopus 로고    scopus 로고
    • Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
    • Okamoto H, Obici S, Accili D, Rossetti L. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 115: 1314-1322, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 1314-1322
    • Okamoto, H.1    Obici, S.2    Accili, D.3    Rossetti, L.4
  • 45
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278: 135-138, 1997.
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 46
    • 0036312394 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity
    • Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 51: 1337-1345, 2002.
    • (2002) Diabetes , vol.51 , pp. 1337-1345
    • Pierroz, D.D.1    Ziotopoulou, M.2    Ungsunan, L.3    Moschos, S.4    Flier, J.S.5    Mantzoros, C.S.6
  • 47
  • 49
    • 0032547042 scopus 로고    scopus 로고
    • Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
    • Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, Nakao K. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett 249: 107-110, 1998.
    • (1998) Neurosci Lett , vol.249 , pp. 107-110
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3    Numata, Y.4    Masuzaki, H.5    Yoshimasa, Y.6    Nakao, K.7
  • 50
    • 3843114437 scopus 로고    scopus 로고
    • Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice
    • Savontaus E, Breen TL, Kim A, Yang LM, Chua SC Jr, Wardlaw SL. Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145: 3881-3891, 2004.
    • (2004) Endocrinology , vol.145 , pp. 3881-3891
    • Savontaus, E.1    Breen, T.L.2    Kim, A.3    Yang, L.M.4    Chua Jr, S.C.5    Wardlaw, S.L.6
  • 52
    • 32444449631 scopus 로고    scopus 로고
    • Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
    • Smart JL, Tolle V, Low MJ. Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J Clin Invest 116: 495-505, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 495-505
    • Smart, J.L.1    Tolle, V.2    Low, M.J.3
  • 55
    • 0028177382 scopus 로고
    • Central administration of alpha-melanocyte-stimulating hormone inhibits corticotropin-releasing factor release in adrenalectomized rats
    • Tozawa F, Suda T, Dobashi I, Ohmori N, Kasagi Y, Demura H. Central administration of alpha-melanocyte-stimulating hormone inhibits corticotropin-releasing factor release in adrenalectomized rats. Neurosci Lett 174: 117-119, 1994.
    • (1994) Neurosci Lett , vol.174 , pp. 117-119
    • Tozawa, F.1    Suda, T.2    Dobashi, I.3    Ohmori, N.4    Kasagi, Y.5    Demura, H.6
  • 56
    • 9444243357 scopus 로고    scopus 로고
    • Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet
    • Tulipano G, Vergoni AV, Soldi D, Muller EE, Cocchi D. Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet. J Endocrinol 183: 289-298, 2004.
    • (2004) J Endocrinol , vol.183 , pp. 289-298
    • Tulipano, G.1    Vergoni, A.V.2    Soldi, D.3    Muller, E.E.4    Cocchi, D.5
  • 57
    • 0033927916 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    • Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106: 253-262, 2000.
    • (2000) J Clin Invest , vol.106 , pp. 253-262
    • Vaisse, C.1    Clement, K.2    Durand, E.3    Hercberg, S.4    Guy-Grand, B.5    Froguel, P.6
  • 58
    • 0035041922 scopus 로고    scopus 로고
    • Obesity as a neuroendocrine disease: Lessons to be learned from proopiomelanocortin and melanocortin receptor mutations in mice and men
    • Wardlaw SL. Obesity as a neuroendocrine disease: lessons to be learned from proopiomelanocortin and melanocortin receptor mutations in mice and men. J Clin Endocrinol Metab 86: 1442-1446, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1442-1446
    • Wardlaw, S.L.1
  • 60
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L, Diehl N, Brennan MB, Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5: 1066-1070, 1999.
    • (1999) Nat Med , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 61
    • 0027379074 scopus 로고
    • Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1 beta and alpha MSH: Studies in rats with different susceptibility to inflammatory disease
    • Zelazowski P, Patchev VK, Zelazowska EB, Chrousos GP, Gold PW, Sternberg EM. Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1 beta and alpha MSH: studies in rats with different susceptibility to inflammatory disease. Brain Res 631: 22-26, 1993.
    • (1993) Brain Res , vol.631 , pp. 22-26
    • Zelazowski, P.1    Patchev, V.K.2    Zelazowska, E.B.3    Chrousos, G.P.4    Gold, P.W.5    Sternberg, E.M.6
  • 62
    • 0033695523 scopus 로고    scopus 로고
    • Differential expression of hypothalamic neuropeptides in the early phase of dietinduced obesity in mice
    • Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of dietinduced obesity in mice. Am J Physiol Endocrinol Metab 279: E838-E845, 2000.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Ziotopoulou, M.1    Mantzoros, C.S.2    Hileman, S.M.3    Flier, J.S.4


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