AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

Molecular Endocrinology

Volumn 15, Issue 1, 2001, Pages 164-171

  Nijenhuis, Wouter A J ^a   Oosterom, Julia ^a   Adan, Roger A H ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; LEPTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR;

ANIMAL CELL; ARTICLE; BODY WEIGHT; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; MELANOMA CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ALPHA-MSH; CELL LINE; FORSKOLIN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PEPTIDE FRAGMENTS; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN;

AGOUTI; ANIMALIA;

EID: 0035130843     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.15.1.164     Document Type: Article

References (46)

1. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
2. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
3. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
4. Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist
5. A frameshift mutation in human MC4R is associated with a dominant form of obesity
6. A frameshift mutation in MC4R associated with dominantly inherited human obesity
7. Anatomy of an endogenous antagonist: Relationship between agouti-related protein and proopiomelanocortin in brain
8. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
9. Molecular characterization of the mouse agouti locus
10. Agouti protein is an antagonist of the melanocortin-stimulating-hormone receptor
11. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
12. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
13. The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals
14. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
15. Modulation of murine melanocyte function in vitro by agouti signal protein
16. Agouti protein inhibits the production of eumelanin and phaeomelanin in the presence and absence of α-melanocyte stimulating hormone
17. Interactions of alpha-melanotropin and agouti on B16 melanoma cells: Evidence for inverse agonism of agouti
18. Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis
19. Agouti protein inhibits growth of B16 melanoma cells in vitro by acting through melanocortin receptors
20. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to α-melanotropin
21. ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors
22. Characterization of agouti-related protein binding to melanocortin receptors
23. Overexpression of Agrt leads to obesity in transgenic mice
24. A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo
25. The role of agouti-related protein in regulating body weight
26. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
27. Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein
28. A synthetic human Agouti-related protein-(83-132)-NH2 fragment is a potent inhibitor of melanocortin receptor function
29. B16-G4F mouse melanoma cells: An MSH receptor-deficient cell clone
30. Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active G(S)coupled receptors
31. Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo(Asp5,D-Phe7,Lys10)α-melanocyte stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high potency and selectivity at specific melanocortin receptors
32. Inverse agonism: Pharmacological curiosity or potential therapeutic strategy?
33. A mutation-induced activated state of the β 2-adrenergic receptor. Extending the ternary complex model
34. The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells
35. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene
36. Physiological and anatomical circuitry between agouti-related protein and leptin signaling
37. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
38. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin
39. Hypothalamic agouti-related protein messenger ribonucreic acid is inhibited by leptin and stimulated by fasting
40. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
41. Synthesis of cyclic a-MSH peptides
42. Molecular cloning of a novel melanocortin receptor
43. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor
44. Molecular cloning, expression, and characterization of a fifth melanocortin receptor
45. Adenylate cyclase assay
46. Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors