Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice

Neuron

Volumn 41, Issue 5, 2004, Pages 711-722

  Roseberry, Aaron G ^a   Liu, Hongyan ^a   Jackson, Alexander C ^b   Cai, Xiaoli ^a   Friedman, Jeffrey M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; ELECTROPHYSIOLOGY; FEEDING BEHAVIOR; FOOD INTAKE; HYPERPOLARIZATION; HYPOTHALAMUS; MOUSE; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACTION POTENTIALS; ANIMALS; ARCUATE NUCLEUS; BACLOFEN; ENKEPHALIN, METHIONINE; MICE; MICE, OBESE; MICE, TRANSGENIC; NEURAL INHIBITION; NEURONS; NEUROPEPTIDE Y; PRO-OPIOMELANOCORTIN;

EID: 1542358816     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(04)00074-1     Document Type: Article

References (39)

1. Bagnol D., Lu X.Y., Kaelin C.B., Day H.E., Ollmann M., Gantz I., Akil H., Barsh G.S., Watson S.J. Anatomy of an endogenous antagonist. relationship between Agouti-related protein and proopiomelanocortin in brain J. Neurosci. 19:1999;RC26.
2. Bai F.L., Yamano M., Shiotani Y., Emson P.C., Smith A.D., Powell J.F., Tohyama M. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res. 331:1985;172-175.
3. Baker R.A., Herkenham M. Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus. neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat J. Comp. Neurol. 358:1995;518-530.
4. Blomqvist A.G., Herzog H. Y-receptor subtypes - how many more? Trends Neurosci. 20:1997;294-298.
5. Broberger C., Landry M., Wong H., Walsh J.N., Hokfelt T. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology. 66:1997;393-408.
6. Broberger C., De Lecea L., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus. relationship to the neuropeptide Y and agouti gene-related protein systems J. Comp. Neurol. 402:1998;460-474.
7. Cheung C.C., Clifton D.K., Steiner R.A. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology. 138:1997;4489-4492.
8. Coleman D.L. Obese and diabetes. two mutant genes causing diabetes-obesity syndromes in mice Diabetologia. 14:1978;141-148.
9. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411:2001;480-484.
10. Csiffary A., Gorcs T.J., Palkovits M. Neuropeptide Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats. a correlated light and electron microscopic double immunolabeling study Brain Res. 506:1990;215-222.
11. Elias C.F., Aschkenasi C., Lee C., Kelly J., Ahima R.S., Bjorbaek C., Flier J.S., Saper C.B., Elmquist J.K. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 23:1999;775-786.
12. Elmquist J.K., Bjorbaek C., Ahima R.S., Flier J.S., Saper C.B. Distributions of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395:1998;535-547.
13. Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin. hypothalamic control of food intake and body weight Neuron. 22:1999;221-232.
14. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
15. Fei H., Okano H.J., Li C., Lee G.H., Zhao C., Darnell R., Friedman J.M. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. USA. 94:1997;7001-7005.
16. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L.et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171.
17. Glaum S.R., Hara M., Bindokas V.P., Lee C.C., Polonsky K.S., Bell G.I., Miller R.J. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol. Pharmacol. 50:1996;230-235.
18. Gong S., Zheng C., Doughty M.L., Losos K., Didkovsky N., Schambra U.B., Nowak N.J., Joyner A., Leblanc G., Hatten M.E., Heintz N. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature. 425:2003;917-925.
19. Horvath T.L., Naftolin F., Kalra S.P., Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus. a light and electron microscopic double immunostaining analysis Endocrinology. 131:1992;2461-2467.
20. Kelly M.J., Loose M.D., Ronnekleiv O.K. Opioids hyperpolarize beta-endorphin neurons via mu-receptor activation of a potassium conductance. Neuroendocrinology. 52:1990;268-275.
21. Loose M.D., Ronnekleiv O.K., Kelly M.J. Neurons in the rat arcuate nucleus are hyperpolarized by GABAB and mu-opioid receptor agonists. evidence for convergence at a ligand-gated potassium conductance Neuroendocrinology. 54:1991;537-544.
22. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8:1996;733-735. a.
23. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:1996;113-116. b.
24. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., Westfall T. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50:1998;143-150.
25. Mizuno T.M., Kleopoulos S.P., Bergen H.T., Roberts J.L., Priest C.A., Mobbs C.V. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes. 47:1998;294-297.
26. Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 278:1997;135-138.
27. Powis J.E., Bains J.S., Ferguson A.V. Leptin depolarizes rat hypothalamic paraventricular nucleus neurons. Am. J. Physiol. 274:1998;R1468-R1472.
28. Ricardo J.A., Koh E.T. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res. 153:1978;1-26.
29. Sawchenko P.E., Swanson L.W., Joseph S.A. The distribution and cells of origin of ACTH(1-39)-stained varicosities in the paraventricular and supraoptic nuclei. Brain Res. 232:1982;365-374.
30. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1996;1101-1106.
31. Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., Baskin D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123.
32. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525.
33. Stanley B.G., Kyrkouli S.E., Lampert S., Leibowitz S.F. Neuropeptide Y chronically injected into the hypothalamus. a powerful neurochemical inducer of hyperphagia and obesity Peptides. 7:1986;1189-1192.
34. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., Hale J., Hoffmann J., Hsiung H.M., Kriauciunas A.et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532.
35. Taddese A., Bean B.P. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 33:2002;587-600.
36. Thornton J.E., Cheung C.C., Clifton D.K., Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology. 138:1997;5063-5066.
37. Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E. Jr., Stoffel M., Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14:1996;95-97.
38. Yang X.W., Model P., Heintz N. Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat. Biotechnol. 15:1997;859-865.
39. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.