PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 1 43-1, 1998, Pages

  McMahon, Lance R ^a   Wellman, Paul J ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Food intake; Gut brain interactions; Paraventricular nucleus; Peptides; Saccharin; Satiety

Indexed keywords

GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONDITIONING; CONTROLLED STUDY; DRINKING BEHAVIOR; FEEDING BEHAVIOR; FLUID INTAKE; FOOD INTAKE; HORMONE ACTION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TASTE AVERSION;

EID: 0031891391     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.1.r23     Document Type: Article

References (37)

1. Antin, J., J. Gibbs, J. Holt, R. C. Young, and G. P. Smith. Cholecystokinin elicits the complete behavioral sequence of satiety in rats. J. Comp. Physiol. Psychol. 89: 784-790, 1975.
2. Aponte, G., P. Leung, D. Gross, and T. Yamada. Effects of somatostatin on food intake in rats. Life Sci. 35: 741-746, 1984.
3. Asarian, L., A. M. Cuomo, E. Corp, B. Hrupka, and N. Geary. Glucagon-like peptide-1-(7-36 amide) elicits behavioral satiety in sham feeding rats. Soc. Neurosci. Abstr. 22: 16, 1996.
4. Creutzfeldt, W. The incretin concept today. Diabetologia 16: 75-85, 1979.
5. D'Allesio, D. A., W. J. Fujimoto, and J. W. Ensinck. Effects of glucagon-like peptide 1-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer culture. Diabetes 38: 1534-1539, 1989.
6. Day, H. E., A. T. McKnight, J. A. Poat, and J. Hughes. Evidence that cholecystokinin induces immediate early gene expression in the brain stem, hypothalamus, and amygdala of the rat by a CCKA receptor mechanism. Neuropharmacology 33: 719-727, 1994.
7. Dourish, C. T., W. Rycroft, and S. D. Iversen. Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors. Science 245: 1509-1511, 1989.
8. Elliott, R. M., L. M. Morgan, J. A. Tredger, S. Deacon, J. Wright, and V. Marks. Glucagon-like peptide-1-(7-36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J. Endocrinol. 138: 159-166, 1993.
9. Fehmann, H.-C., and J. F. Habener. Insulinotropic glucagon-like peptide-1-(7-37)/(7-36) amide: a new incretin hormone. Trends Endocrinol. Metab. 3: 158-163, 1992.
10. Garcia, J., F. R. Erving, and R. A. Koelling. Learning with prolonged delay of reinforcement. Psychon. Sci. 5: 16-20, 1966.
11. Goke, R., P. J. Larsen, J. D. Mikkelsen, and S. P. Sheikh. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur. J. Neurosci. 7: 2294-2300, 1995.
12. Halford, J. C. G., and J. E. Blundell. Direct and continuous behavioural analysis for the diagnosis of drug action on feeding. In: Current Protocols in Neuroscience, edited by J. Crawley, C. Gerfen, R. McKay, M. Rogawski, D. Sibley, and P. Slovnick. New York: Wiley. In press.
13. Holst, J. J. Glucagon-like peptide 1: a newly discovered gastrointestinal hormone. Gastroenterology 107: 1848-1855, 1994.
14. Holst, J. J., A. C. Orskov, T. W. Schwartz, and O. V. Nielsen. Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut. FEBS Lett. 211: 169-174, 1987.
15. Jin, S. L., V. K. M. Han, J. G. Simmons, A. C. Towle, J. M. Lauder, and P. K. Lund. Distribution of glucagon-like peptide 1 (GLP-1), glucagon, and glicentin, in the rat brain: an immunocytochemical study. J. Comp. Neurol. 271: 519-532, 1988.
16. Larsen, P. J., M. Tang-Christensen, J. J. Holst, and C. Orskov. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 77: 257-270, 1997.
17. Li, B. H., and N. E. Rowland. Cholecystokinin- and dexfenfluramine-induced anorexia compared using devazepide and c-fos expression in the rat brain. Regul. Pept. 50: 223-233, 1994.
18. McMahon, L. R. Glucagon-Like Peptide-1: A Feeding-Inhibitory Peptide Within the Hypothalamic Paraventricular Nucleus (PhD thesis). College Station, TX: Texas A&M University, 1997.
19. McMahon, L. R., and P. J. Wellman. Decreased intake of a liquid diet in non-food deprived rats following PVN injections of GLP-1-(7-36) amide. Pharmacol. Biochem. Behav. 58: 673-677, 1997.
20. Moran, T. H., A. Wohn, G. J. Schwartz, and E. E. Ladenheim. Fourth ventricular administration of glucagon-like peptide-1-(7-36) amide (GLP-1) inhibits food intake in rats. Soc. Neurosci. Abstr. 22: 15, 1996.
21. Navarro, M., F. Rodriquez de Fonseca, E. Alvarez, J. A. Chowen, J. A. Zueco, R. Gomez, J. Eng, and E. Blazquez. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J. Neurochem. 67: 1982-1991, 1996.
22. Orskov, C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia 35: 701-711, 1992.
23. Paxinos, G, and C. Watson. The Rat Brain in Stereotaxic Coordinates (2nd ed.). New York: Academic, 1986.
24. Riley, A. L., and D. L. Tuck. Conditioned taste aversions: a behavioral index of toxicity. Ann. NY Acad. Sci. 443: 272-292, 1985.
25. Roland, C. R., R. L. Oppenheimer, K. Chang, and S. F. Leibowitz. Hypophysectomy disturbs the noradrenergic feeding system of the paraventricular nucleus. Psychoneuroendocrinology 10: 109-120, 1985.
26. Shughrue, P. J., M. V. Lane, and I. Merchenthaler. Glucagon-like peptide-1 receptor (GLP-R) mRNA in the rat hypothalamus. Endocrinology 137: 5159-5162, 1996.
27. Suzuki, S., K. Kawai, S. Ohashi, H. Mukai, and K. Yamashita. Comparison of the effects of various C-terminal and N-terminal fragment peptides of glucagon-like peptide-1 on insulin and glucagon release from the isolated perfused rat pancreas. Endocrinology 125: 3109-3114, 1989.
28. Swank, M. W., G. E. Schafe, and I. L. Bernstein. c-Fos induction in response to taste stimuli previously paired with amphetamine or LiCl during taste aversion learning. Brain Res. 673: 251-261, 1995.
29. Tang-Christensen, M., P. J. Larsen, R. Goke, A. Fink-Jensen, D. S. Jessop, M. Moller, and S. P. Sheikh. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R848-R856, 1996.
30. Thiele, T. E., G. Van Dijk, L. A. Campfield, F. J. Smith, P. Burn, S. C. Woods, I. L. Bernstein, and R. J. Seeley. Central infusion of GLP-1, but not leptin, produces conditioned taste aversion in rats. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R726-R730, 1997.
31. 2 in the paraventricular nucleus of the hypothalamus increases feeding. J. Endocrinology 148, Suppl.: P126, 1996.
32. Turton, M. D., D. O'Shea, I. Gunn, S. A. Beak, C. M. B. Edwards, K. Meeran, S. J. Choi, G. M. Taylor, M. M. Heath, P. D. Lambert, J. P. H. Wilding, D. M. Smith, M. A. Ghatei, J. Herbert, and S. R. Bloom. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379: 69-72, 1996.
33. Van Dijk, G., T. E. Thiele, J. C. K. Donahey, L. A. Campfield, F. J. Smith, P. Burn, I. L. Bernstein, S. C. Woods, and R. J. Seeley. Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1096-R1100, 1996.
34. Van Dijk, G., T. E. Thiele, R. J. Seeley, S. C. Woods, and I. L. Bernstein. Glucagon-like peptide-1 and satiety. Nature 385: 214, 1997.
35. Verbalis, J. G., C. M. McHale, T. W. Gardiner, and E. M. Stricker. Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats. Behav. Neurosci. 100: 466-475, 1986.
36. Wellman, P. J., and B. T. Davies. Suppression of feeding induced by phenylephrine microinjections within the paraventricular hypothalamus in rats. Appetite 17: 121-128, 1991.
37. Woods, S. C., M. Chavez, C. R. Park, C. Riedy, K. Kaiyala, R. D. Richardson, D. P. Figlewicz, M. W. Schwartz, D. Porte, and R. J. Seeley. The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neurosci. Biobehav. Rev. 20: 139-144, 1996.