Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 305, Issue 4, 2013, Pages

  do Carmo, Jussara M ^a   da Silva, Alexandre A ^a   Rushing, John S ^a   Pace, Benjamin ^a   Hall, John E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; Energy expenditure; Heart rate; Hypertension; Melanocortin; Obesity; Sympathetic nervous system

Indexed keywords

MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; ALPHA INTERMEDIN; CRE RECOMBINASE; CYCLOPEPTIDE; DRUG DERIVATIVE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; INTEGRASE; INTERMEDIN; ION CHANNEL; MC4R PROTEIN, MOUSE; MELANOCORTIN; MELANOTAN II; MELANOTAN-II; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY TEMPERATURE; BODY WEIGHT; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; HEART RATE; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; ADRENERGIC SYSTEM; AMBULATORY MONITORING; ANIMAL; BLOOD PRESSURE; BRAIN; BROWN ADIPOSE TISSUE; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; EATING; ENERGY METABOLISM; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HEMODYNAMICS; HYPERTENSION; INTRAABDOMINAL FAT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KNOCKOUT MOUSE; METABOLISM; METHODOLOGY; NERVE CELL; OBESITY; PHYSIOLOGICAL STRESS; TELEMETRY; TIME; TRANSGENIC MOUSE; WEIGHT GAIN; ACUTE STRESS; ANIMAL TISSUE; BODY TEMPERATURE MEASUREMENT; CARDIOVASCULAR RESPONSE; CONTROL; ENERGY BALANCE; FAT CONTENT; GLUCOSE TOLERANCE; LATERAL BRAIN VENTRICLE; LONG TERM CARE; LOXP SITE; PROTEIN EXPRESSION; VENTRICULAR CANNULA (BRAIN);

BLOOD PRESSURE; ENERGY EXPENDITURE; HEART RATE; HYPERTENSION; MELANOCORTIN; OBESITY; SYMPATHETIC NERVOUS SYSTEM;

ADIPOSE TISSUE, BROWN; ADIPOSITY; ALPHA-MSH; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY TEMPERATURE; BRAIN; EATING; ENERGY METABOLISM; GLUCOSE TOLERANCE TEST; GREEN FLUORESCENT PROTEINS; HEART RATE; HEMODYNAMICS; INFUSIONS, INTRAVENTRICULAR; INTEGRASES; INTRA-ABDOMINAL FAT; ION CHANNELS; MALE; MELANOCYTE-STIMULATING HORMONES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; MONITORING, AMBULATORY; NEURONS; OXYGEN CONSUMPTION; PEPTIDES, CYCLIC; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 4; RECOMBINANT FUSION PROTEINS; STRESS, PHYSIOLOGICAL; TELEMETRY; TIME FACTORS; WEIGHT GAIN;

EID: 84881643423     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00518.2012     Document Type: Article

References (24)

1. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasci C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123: 493-505, 2005.
2. Boghossian S, Park M, York DA. Melanocortin activity in the amygdala controls appetite for dietary fat. Am J Physiol Regul Integr Comp Physiol 298: R385-R393, 2010.
3. Castro MG, Morrison E. Post-translational processing of proopiomelano-cortin in the pituitary and in the brain. Crit Rev Neurobiol 11: 35-57, 1997.
4. da Silva AA, Kuo JJ, Tallam LS, Hall JE. Does obesity induce resistance to the long-term cardiovascular and metabolic actions of mela-nocortin 3/4 receptor activation? Hypertension 47: 259-264, 2006.
5. da Silva AA, do Carmo JM, Kanyicska B, Dubinion J, Brandon E, Hall JE. Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneous hypertensive rats. Hypertension 51: 884-890, 2008.
6. da Silva AA, Kuo JJ, Hall JE. Role of hypothalamic melanocortin 3/4 receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin. Hypertension 43: 1312-17, 2004.
7. do carmo JM, da Silva AA, Cai Z, Lin S, Dubinion JH, Hall JE. Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons. Hypertension 57: 918-926, 2011.
8. do Carmo JM, Tallam LS, Roberts JV, Biglane J, da Silva AA, Hall JE. Impact of obesity on renal structure and function in the presence and absence of hypertension: evidence from melanocortin-4 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 297: R803-R812, 2009.
9. Fan W, Morrison SF, Cao WH, Yu Pinxuan. Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area. Brain Res 1179: 61-69, 2007.
10. Farooqi IS, O'Rahilly S. Monogenic human obesity syndromes. Recent Prog Horm Res 59: 409-424, 2004.
11. Greenfield JR, Miller JW, Kepgh JM, Henning E, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, O'Rahilly S, Farooqi IS. Modulation of blood pressure by central melanocortinergic pathway. N Engl J Med 360: 44-52, 2009.
12. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Berke-meier LR, Gu W, Kesterson RA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Target disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-41, 1997.
13. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 (MC4R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8: 1298-1308, 1994.
14. Padilla SL, Carmody JS, Zeltser L. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med 16: 403-405, 2010.
15. Pavia JM, Schioth HB, Morris MJ. Role of the MC4R receptors in the depressor and bradycardia effects of alpha-MSH in the nucleus tractus solitarii of the rat. Neuroreport 15: 703-707, 2003.
16. Plum M, Ma X, Hampel B, Balthasar N, Coppari R, Munzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Bruning JC. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest 116: 1886-901, 2006.
17. Pritchard LE, Turnbull AV, White A. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signaling and obesity. J Endocrinol 172: 411-21, 2002.
18. Smith MA, Hisadome K, Al-Qassab H, Hefron H, Withers DJ, Ashford M. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron population by alteration of resting potassium conductance. J Physiol 578: 425-438, 2007.
19. Song CK, Vaughan CH, Keen-Rhinehart E, Harris RBS, Richard D, Bartness TJ. Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. Am J Physiol Regul Integr Comp Physiol 295: R417-R428, 2008.
20. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 23: 531-543, 2001.
21. Tai MH, Weng WT, Lo WC, Chan JY, Lin CJ, Lam HC, Tseng CJ. Role of nitric oxide in alpha-melanocyte-stimulating hormone-induced hypotension in the nucleus tractus solitarii of the spontaneously hypertensive rats. J Pharmacol Exp Ther 321: 455-461, 2007.
22. Tallam LS, da Silva AA, Hall JE. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 48: 58-64, 2006.
23. Williams DL, Kaplan JM, Grill HJ. The role of the dorsal vagal complex and the vagus in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141: 1332-1337, 2000.
24. Zheng H, Patterson LM, Rhodes CJ, Louis GW, Skibicka KP, Grill HJ, Myers MG Jr, Berthoud HR. A potential role for hypothalamomed-ullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol 298: R270-R278, 2010.