Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency

Endocrinology

Volumn 152, Issue 5, 2011, Pages 1819-1828

  Corander, Marcus P ^a   Rimmington, Debra ^a   Challis, Benjamin G ^a   O'Rahilly, Stephen ^a   Coll, Anthony P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; CORTICOSTERONE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ARTICLE; BODY FAT; BODY HEIGHT; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENERGY EXPENDITURE; FOOD INTAKE; GENOTYPE; HYPERPHAGIA; LEAN BODY WEIGHT; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; WEIGHT GAIN;

ADIPOSE TISSUE; AGOUTI-RELATED PROTEIN; ANIMALS; BODY WEIGHT; CORTICOSTERONE; EATING; ENERGY METABOLISM; FEMALE; GENE EXPRESSION; GENOTYPE; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; PHENOTYPE; PRO-OPIOMELANOCORTIN; PROTEIN BINDING; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 79955412324     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1450     Document Type: Article

References (46)

1. Mountjoy KG 2010 Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes. Biochem J 428:305-324
2. Poggioli R, Vergoni AV, Bertolini A 1986 ACTH-(1-24) and α-MSH antagonize feeding behavior stimulated by κ opiate agonists. Peptides 7:843-848 (Pubitemid 17182352)
3. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168 (Pubitemid 27034218)
4. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157 (Pubitemid 28248796)
5. Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S 2004 Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY (3-36). Proc Natl Acad Sci USA 101:4695-4700 (Pubitemid 38437473)
6. Farooqi IS, Volders K, Stanhope R, Heuschkel R, White A, Lank E, Keogh J, O'Rahilly S, Creemers JW 2007 Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1β. J Clin Endocrinol Metab 92:3369-3373 (Pubitemid 47435306)
7. Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ, Holst JJ, Brubaker PL, Corvol P, Polonsky KS, Ostrega D, Becker KL, Bertagna X, Hutton JC, White A, Dattani MT, Hus-sain K, Middleton SJ, Nicole TM, Milla PJ, Lindley KJ, O'Rahilly S 2003 Small-intestinal dysfunction accompanies the complex endo-crinopathy of human proprotein convertase 1 deficiency. J Clin Invest 112:1550-1560 (Pubitemid 38056281)
8. Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT, Hutton JC, O'Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16:303-306 (Pubitemid 27280217)
9. Creemers JW, Pritchard LE, Gyte A, Le Rouzic P, Meulemans S, Wardlaw SL, Zhu X, Steiner DF, Davies N, Armstrong D, Lawrence CB, Luckman SM, Schmitz CA, Davies RA, Brennand JC, White A 2006 Agouti-related protein is posttranslationally cleaved by pro-protein convertase 1 to generate agouti-related protein (AGRP) 83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. Endocrinology 147:1621-1631
10. Rossi M, Kim MS, Morgan DG, Small CJ, Edwards CM, Sunter D, Abusnana S, Goldstone AP, Russell SH, Stanley SA, Smith DM, Yagaloff K, Ghatei MA, Bloom SR 1998 A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139:4428-4431 (Pubitemid 28513735)
11. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138 (Pubitemid 27446294)
12. Cone RD 2005 Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578 (Pubitemid 40594196)
13. Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV 1999 Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140:4551-4557 (Pubitemid 30666120)
14. Hagan MM, Rushing PA, Pritchard LM, Schwartz MW, Strack AM, Van der Ploeg LH, Woods SC, Seeley RJ 2000 Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol 279:R47-R52 (Pubitemid 30625415)
15. Nijenhuis WA, Oosterom J, Adan RA 2001 AgRP (83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol 15:164-171 (Pubitemid 32156049)
16. Haskell-Luevano C, Monck EK 2001 Agouti-related protein functions as an inverse agonist at a constitutively active brain melano-cortin-4 receptor. Regul Pept 99:1-7 (Pubitemid 32232121)
17. Tolle V, Low MJ 2008 In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomel-anocortin- deficient mice. Diabetes 57:86-94
18. Coll AP, Challis BG, Yeo GS, Snell K, Piper SJ, Halsall D, Thresher RR, O'Rahilly S 2004 The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adre-nocorticotropin. Endocrinology 145:4721-4727 (Pubitemid 39281466)
19. Coll AP, Challis BG, López M, Piper S, Yeo GS, O'Rahilly S 2005 Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54:2269-2276 (Pubitemid 41134252)
20. Tung YC, Piper SJ, Yeung D, O'Rahilly S, Coll AP 2006 A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice. Endocrinology 147:5940-5947 (Pubitemid 44833512)
21. Qian S, Chen H, Weingarth D, Trumbauer ME, Novi DE, Guan X, Yu H, Shen Z, Feng Y, Frazier E, Chen A, Camacho RE, Shearman LP, Gopal-Truter S, MacNeil DJ, Van der Ploeg LH, Marsh DJ 2002 Neither agouti-related protein nor neuropeptide y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 22:5027-5035 (Pubitemid 34700694)
22. Kim MS, Small CJ, Stanley SA, Morgan DG, Seal LJ, Kong WM, Edwards CM, Abusnana S, Sunter D, Ghatei MA, Bloom SR 2000 The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 105:1005-1011 (Pubitemid 30203073)
23. Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, Edwards CM, Heath MM, Stanley SA, Seal LJ, Bhatti JR, Smith DM, Ghatei MA, Bloom SR 2000 Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone. Diabetes 49:177-182 (Pubitemid 30070994)
24. -/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production. J Endocrinol 190:515-525 (Pubitemid 44288387)
25. Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL 1997 Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11:593-602 (Pubitemid 27133379)
26. Graham M, Shutter JR, Sarmiento U, Sarosi I, Stark KL 1997 Over-expression of Agrt leads to obesity in transgenic mice. Nat Genet 17:273-274
27. Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, Yancopoulos GD, Wiegand SJ, Sleeman MW 2005 Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab 2:421-427
28. Smart JL, Tolle V, Low MJ 2006 Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-de-ficient mice. J Clin Invest 116:495-505 (Pubitemid 43228367)
29. Marsh DJ, Miura GI, Yagaloff KA, Schwartz MW, Barsh GS, Palmiter RD 1999 Effects of neuropeptide y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Brain Res 848:66-77 (Pubitemid 30001655)
30. Fekete C, Marks DL, Sarkar S, Emerson CH, Rand WM, Cone RD, Lechan RM 2004 Effect of Agouti-related protein in regulation of the hypothalamic- pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Endocrinology 145:4816-4821 (Pubitemid 39551096)
31. Costa T, Herz A 1989 Antagonists with negative intrinsic activity at Δ opioid receptors coupled to GTP-bindingproteins. Proc Natl Acad Sci USA 86:7321-7325 (Pubitemid 19254452)
32. Bond RA, Ijzerman AP 2006 Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends Pharmacol Sci 27:92-96 (Pubitemid 43184030)
33. Parnot C, Miserey-Lenkei S, Bardin S, Corvol P, Clauser E 2002 Lessons from constitutively active mutants of G protein-coupled receptors. Trends Endocrinol Metab 13:336-343 (Pubitemid 36733949)
34. Arrang JM, Morisset S, Gbahou F 2007 Constitutive activity of the histamine H3 receptor. Trends Pharmacol Sci 28:350-357
35. Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C 2004 Constitutive activity of the melano-cortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest 1141158-1164 (Pubitemid 39578705)
36. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB 2005 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505 (Pubitemid 41546678)
37. Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, Ghatei MA, Bloom SR 2005 Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J 19:1680-1682 (Pubitemid 41429528)
38. Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC 2005 Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci 8:1289-1291 (Pubitemid 41630413)
39. Luquet S, Perez FA, Hnasko TS, Palmiter RD 2005 NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310:683-685 (Pubitemid 41528162)
40. Xu AW, Kaelin CB, Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW, Barsh GS 2005 Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol 3:e415
41. Flier JS 2006 AgRPinenergy balance: willthereal AgRP please stand up? Cell Metab 3:83-85
42. Wu Q, Howell MP, Cowley MA, Palmiter RD 2008 Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci USA 105:2687-2692 (Pubitemid 351520574)
43. Wu Q, Boyle MP, Palmiter RD 2009 Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137:1225-1234
44. Navarro M, Cubero I, Chen AS, Chen HY, Knapp DJ, Breese GR, Marsh DJ, Thiele TE 2005 Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the mela-nocortin-4 receptor. Alcohol Clin Exp Res 29:949-957 (Pubitemid 40934198)
45. Navarro M, Cubero I, Ko L, Thiele TE 2009 Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice. Genes Brain Behav 8:450-458
46. Barnes MJ, Argyropoulos G, Bray GA 2010 Preference forahigh fat diet, but not hyperphagia following activation of mu opioid receptors is blocked in AgRP knockout mice. Brain Res 1317:100-107