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Volumn 150, Issue 12, 2009, Pages 5351-5361

Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR;

EID: 71949093692     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0804     Document Type: Article
Times cited : (93)

References (61)
  • 1
    • 4644240052 scopus 로고    scopus 로고
    • Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians
    • DOI 10.2337/diabetes.53.10.2696
    • Ma L, Tataranni PA, Bogardus C, Baier LJ 2004 Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians. Diabetes 53:2696-2699 (Pubitemid 39299281)
    • (2004) Diabetes , vol.53 , Issue.10 , pp. 2696-2699
    • Ma, L.1    Tataranni, P.A.2    Bogardus, C.3    Baier, L.J.4
  • 6
    • 0032400808 scopus 로고    scopus 로고
    • Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight
    • Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM 1998 Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J Neurosci 18:10128-10135
    • (1998) J Neurosci , vol.18 , pp. 10128-10135
    • Grill, H.J.1    Ginsberg, A.B.2    Seeley, R.J.3    Kaplan, J.M.4
  • 7
    • 46349108413 scopus 로고    scopus 로고
    • Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits
    • Skibicka KP, Grill HJ 2008 Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits. Endocrinology 149:3605-3616
    • (2008) Endocrinology , vol.149 , pp. 3605-3616
    • Skibicka, K.P.1    Grill, H.J.2
  • 8
    • 0035130527 scopus 로고    scopus 로고
    • Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects
    • DOI 10.1016/S0196-9781(00)00367-3, PII S0196978100003673
    • Wirth MM, Olszewski PK, Yu C, Levine AS, Giraudo SQ 2001 Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects. Peptides 22:129-134 (Pubitemid 32146692)
    • (2001) Peptides , vol.22 , Issue.1 , pp. 129-134
    • Wirth, M.M.1    Olszewski, P.K.2    Yu, C.3    Levine, A.S.4    Giraudo, S.Q.5
  • 10
    • 0037414623 scopus 로고    scopus 로고
    • Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure
    • DOI 10.1002/cne.10643
    • Cano G, Passerin AM, Schiltz JC, Card JP, Morrison SF, Sved AF 2003 Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure. J Comp Neurol 460:303-326 (Pubitemid 36514612)
    • (2003) Journal of Comparative Neurology , vol.460 , Issue.3 , pp. 303-326
    • Cano, G.1    Passerin, A.M.2    Schiltz, J.C.3    Card, J.P.4    Morrison, S.F.5    Sved, A.F.6
  • 11
    • 33947387967 scopus 로고    scopus 로고
    • Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue
    • DOI 10.1210/en.2006-1389
    • Voss-Andreae A, Murphy JG, Ellacott KL, Stuart RC, Nillni EA, Cone RD, Fan W 2007 Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology 148:1550-1560 (Pubitemid 46457101)
    • (2007) Endocrinology , vol.148 , Issue.4 , pp. 1550-1560
    • Voss-Andreae, A.1    Murphy, J.G.2    Ellacott, K.L.J.3    Stuart, R.C.4    Nillni, E.A.5    Cone, R.D.6    Fan, W.7
  • 13
    • 0242713017 scopus 로고    scopus 로고
    • Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat
    • Williams DL, Bowers RR, Bartness TJ, Kaplan JM, Grill HJ 2003 Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology 144:4692-4697
    • (2003) Endocrinology , vol.144 , pp. 4692-4697
    • Williams, D.L.1    Bowers, R.R.2    Bartness, T.J.3    Kaplan, J.M.4    Grill, H.J.5
  • 14
    • 0034456725 scopus 로고    scopus 로고
    • The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation
    • Williams DL, Kaplan JM, Grill HJ 2000 The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141:1332-1337
    • (2000) Endocrinology , vol.141 , pp. 1332-1337
    • Williams, D.L.1    Kaplan, J.M.2    Grill, H.J.3
  • 17
    • 0033976228 scopus 로고    scopus 로고
    • Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose
    • DOI 10.1016/S0006-8993(99)02327-6, PII S0006899399023276
    • Ritter S, Dinh TT, Zhang Y 2000 Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856:37-47 (Pubitemid 30085509)
    • (2000) Brain Research , vol.856 , Issue.1-2 , pp. 37-47
    • Ritter, S.1    Dinh, T.T.2    Zhang, Y.3
  • 18
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD 1994 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298-1308
    • (1994) Mol Endocrinol , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 19
    • 0032524392 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mRNA expression in the developing autonomic and central nervous systems
    • DOI 10.1016/S0165-3806(98)00015-7, PII S0165380698000157
    • Mountjoy KG, Wild JM 1998 Melanocortin-4 receptor mRNA expression in the developing autonomic and central nervous systems. Brain Res Dev Brain Res 107:309-314 (Pubitemid 28257163)
    • (1998) Developmental Brain Research , vol.107 , Issue.2 , pp. 309-314
    • Mountjoy, K.G.1    Wild, J.M.2
  • 20
    • 0141705413 scopus 로고    scopus 로고
    • Involvement of the parabrachial nucleus in thermogenesis induced by environmental cooling in the rat
    • DOI 10.1007/s00424-003-1119-7
    • Kobayashi A, Osaka T 2003 Involvement of the parabrachial nucleus in thermogenesis induced by environmental cooling in the rat. Pflugers Arch 446:760-765 (Pubitemid 37215012)
    • (2003) Pflugers Archiv European Journal of Physiology , vol.446 , Issue.6 , pp. 760-765
    • Kobayashi, A.1    Osaka, T.2
  • 22
    • 0030835909 scopus 로고    scopus 로고
    • Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars α demonstrated by iontophoretic application of choleratoxin (subunit b)
    • DOI 10.1016/S0891-0618(97)00019-7, PII S0891061897000197
    • Hermann DM, Luppi PH, Peyron C, Hinckel P, Jouvet M 1997 Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars α demonstrated by iontophoretic application of choleratoxin (subunit b). J Chem Neuroanat 13:1-21 (Pubitemid 27358987)
    • (1997) Journal of Chemical Neuroanatomy , vol.13 , Issue.1 , pp. 1-21
    • Hermann, D.M.1    Luppi, P.-H.2    Peyron, C.3    Hinckel, P.4    Jouvet, M.5
  • 23
    • 0142028265 scopus 로고    scopus 로고
    • Raphe pallidus neurons mediate prostaglandin E2-evoked increases in brown adipose tissue thermogenesis
    • Morrison SF 2003 Raphe pallidus neurons mediate prostaglandin E2-evoked increases in brown adipose tissue thermogenesis. Neuroscience 121:17-24
    • (2003) Neuroscience , vol.121 , pp. 17-24
    • Morrison, S.F.1
  • 24
    • 0037139340 scopus 로고    scopus 로고
    • The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    • DOI 10.1016/S0306-4522(01)00555-3, PII S0306452201005553
    • Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ 2002 The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110:515-526 (Pubitemid 34242779)
    • (2002) Neuroscience , vol.110 , Issue.3 , pp. 515-526
    • Oldfield, B.J.1    Giles, M.E.2    Watson, A.3    Anderson, C.4    Colvill, L.M.5    McKinley, M.J.6
  • 26
    • 0032958372 scopus 로고    scopus 로고
    • RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue
    • Morrison SF 1999 RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. Am J Physiol 276:R962-R973
    • (1999) Am J Physiol , vol.276
    • Morrison, S.F.1
  • 27
    • 0033542771 scopus 로고    scopus 로고
    • Differential control of sympathetic drive to the rat tail artery and kidney by medullary premotor cell groups
    • Rathner JA, McAllen RM 1999 Differential control of sympathetic drive to the rat tail artery and kidney by medullary premotor cell groups. Brain Res 834:196-199
    • (1999) Brain Res , vol.834 , pp. 196-199
    • Rathner, J.A.1    McAllen, R.M.2
  • 29
    • 0034937620 scopus 로고    scopus 로고
    • Differential regulation of sympathetic outflows to vasoconstrictor and thermoregulatory effectors
    • Morrison SF 2001 Differential regulation of sympathetic outflows to vasoconstrictor and thermoregulatory effectors. Ann NY Acad Sci 940:286-298
    • (2001) Ann NY Acad Sci , vol.940 , pp. 286-298
    • Morrison, S.F.1
  • 30
    • 33750707957 scopus 로고    scopus 로고
    • Forebrain parasympathetic control of heart activity: Retrograde transneuronal viral labeling in rats
    • Ter Horst GJ, Postema F 1997 Forebrain parasympathetic control of heart activity: retrograde transneuronal viral labeling in rats. Am J Physiol 273:H2926-H2930 (Pubitemid 127752728)
    • (1997) American Journal of Physiology , vol.273 , Issue.6 PART 2
    • Ter Horst, G.J.1    Postema, F.2
  • 31
    • 0029859833 scopus 로고    scopus 로고
    • Neuroanatomy of cardiac activity-regulating circuitry: A transneuronal retrograde viral labelling study in the rat
    • DOI 10.1111/j.1460-9568.1996.tb00723.x
    • Ter Horst GJ, Hautvast RW, De Jongste MJ, Korf J 1996 Neuroanatomy of cardiac activity-regulating circuitry: a transneuronal retrograde viral labelling study in the rat. Eur J Neurosci 8:2029-2041 (Pubitemid 26345775)
    • (1996) European Journal of Neuroscience , vol.8 , Issue.10 , pp. 2029-2041
    • Ter Horst, G.J.1    Hautvast, R.W.M.2    De Jongste, M.J.L.3    Korf, J.4
  • 33
    • 0021997983 scopus 로고
    • Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats
    • Brown DL, Guyenet PG 1985 Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ Res 56:359-369 (Pubitemid 15119512)
    • (1985) Circulation Research , vol.56 , Issue.3 , pp. 359-369
    • Les Brown, D.1    Guyenet, P.G.2
  • 34
    • 33746450908 scopus 로고    scopus 로고
    • Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the rat
    • DOI 10.1016/j.brainres.2006.05.002, PII S0006899306013242
    • Kawabe T, Chitravanshi VC, Kawabe K, Sapru HN 2006 Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the rat. Brain Res 1102:117-126 (Pubitemid 44121581)
    • (2006) Brain Research , vol.1102 , Issue.1 , pp. 117-126
    • Kawabe, T.1    Chitravanshi, V.C.2    Kawabe, K.3    Sapru, H.N.4
  • 35
    • 33751246466 scopus 로고    scopus 로고
    • Cardiovascular actions of adrenocorticotropin microinjections into the nucleus tractus solitarius of the rat
    • DOI 10.1016/j.neuroscience.2006.08.026, PII S0306452206011079
    • Brown S, Chitravanshi VC, Sapru HN 2006 Cardiovascular actions of adrenocorticotropin microinjections into the nucleus tractus solitarius of the rat. Neuroscience 143:863-874 (Pubitemid 44781286)
    • (2006) Neuroscience , vol.143 , Issue.3 , pp. 863-874
    • Brown, S.1    Chitravanshi, V.C.2    Sapru, H.N.3
  • 37
    • 0026089084 scopus 로고
    • Circulatory and respiratory responses to glutamate stimulation of the lateral parabrachial nucleus of the cat
    • Miura M, Takayama K 1991 Circulatory and respiratory responses to glutamate stimulation of the lateral parabrachial nucleus of the cat. J Auton Nerv Syst 32:121-133
    • (1991) J Auton Nerv Syst , vol.32 , pp. 121-133
    • Miura, M.1    Takayama, K.2
  • 38
    • 0020061249 scopus 로고
    • Role of the nucleus parabrachialis in cardiovascular regulation in cat
    • DOI 10.1016/0006-8993(82)90610-2
    • Mraovitch S, Kumada M, Reis DJ 1982 Role of the nucleus parabrachialis in cardiovascular regulation in cat. Brain Res 232:57-75 (Pubitemid 12196228)
    • (1982) Brain Research , vol.232 , Issue.1 , pp. 57-75
    • Mraovitch, S.1    Kumada, M.2    Reis, D.J.3
  • 41
    • 52649087371 scopus 로고    scopus 로고
    • α-Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?
    • Koo BB, Feng P, Dostal J, Strohl KP 2008 α-Melanocyte stimulating hormone and adrenocorticotropic hormone: an alternative approach when thinking about restless legs syndrome? Mov Disord 23:1234-1242
    • (2008) Mov Disord , vol.23 , pp. 1234-1242
    • Koo, B.B.1    Feng, P.2    Dostal, J.3    Strohl, K.P.4
  • 42
    • 0034881262 scopus 로고    scopus 로고
    • Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
    • Hwa JJ, Ghibaudi L, Gao J, Parker EM 2001 Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am J Physiol Regul Integr Comp Physiol 281:R444-R451
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Hwa, J.J.1    Ghibaudi, L.2    Gao, J.3    Parker, E.M.4
  • 43
    • 4644274876 scopus 로고    scopus 로고
    • Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats
    • DOI 10.1210/en.2004-0529
    • Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL, Tschöp M 2004 Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145:4645-4652 (Pubitemid 39281457)
    • (2004) Endocrinology , vol.145 , Issue.10 , pp. 4645-4652
    • Tang-Christensen, M.1    Vrang, N.2    Ortmann, S.3    Bidlingmaier, M.4    Horvath, T.L.5    Tschop, M.6
  • 44
    • 0032476779 scopus 로고    scopus 로고
    • Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands
    • Giraudo SQ, Billington CJ, Levine AS 1998 Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands. Brain Res 809:302-306
    • (1998) Brain Res , vol.809 , pp. 302-306
    • Giraudo, S.Q.1    Billington, C.J.2    Levine, A.S.3
  • 46
    • 0023499457 scopus 로고
    • Pro-opiomelanocortin-derived peptides (ACTH/β-endorphin/α-MSH) in brainstem baroreceptor areas of the rat
    • DOI 10.1016/0006-8993(87)91676-3
    • Palkovits M, Mezey E, Eskay RL 1987 Pro-opiomelanocortin-derived peptides (ACTH/β-endorphin/α-MSH) in brainstem baroreceptor areas of the rat. Brain Res 436:323-338 (Pubitemid 18003571)
    • (1987) Brain Research , vol.436 , Issue.2 , pp. 323-338
    • Palkovits, M.1    Mezey, E.2    Eskay, R.L.3
  • 47
    • 0023871301 scopus 로고
    • Efferent ACTH-IR opiocortin projections from nucleus tractus solitarius: A hypothalamic deafferentation study
    • Joseph SA, Michael GJ 1988 Efferent ACTH-IR opiocortin projections from nucleus tractus solitarius: a hypothalamic deafferentation study. Peptides 9:193-201
    • (1988) Peptides , vol.9 , pp. 193-201
    • Joseph, S.A.1    Michael, G.J.2
  • 48
    • 0028268875 scopus 로고
    • Efferents of the opiocortin-containing region of the commissural nucleus tractus solitarius
    • Sim LJ, Joseph SA 1994 Efferents of the opiocortin-containing region of the commissural nucleus tractus solitarius. Peptides 15:169-174
    • (1994) Peptides , vol.15 , pp. 169-174
    • Sim, L.J.1    Joseph, S.A.2
  • 49
    • 0028220015 scopus 로고
    • Connectivity between POMC systems and brainstem nuclei
    • Sim LJ, Joseph SA 1994 Connectivity between POMC systems and brainstem nuclei Regulatory Peptides 53:S135-S136
    • (1994) Regulatory Peptides , vol.53
    • Sim, L.J.1    Joseph, S.A.2
  • 50
    • 44949092261 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity
    • DOI 10.1677/JOE-08-0009
    • Garza JC, Kim CS, Liu J, Zhang W, Lu XY 2008 Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity. J Endocrinol 197:471-482 (Pubitemid 351803952)
    • (2008) Journal of Endocrinology , vol.197 , Issue.3 , pp. 471-482
    • Garza, J.C.1    Kim, C.S.2    Liu, J.3    Zhang, W.4    Lu, X.-Y.5
  • 51
    • 44949136337 scopus 로고    scopus 로고
    • Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons
    • Wan S, Browning KN, Coleman FH, Sutton G, Zheng H, Butler A, Berthoud HR, Travagli RA 2008 Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons. J Neurosci 28:4957-4966
    • (2008) J Neurosci , vol.28 , pp. 4957-4966
    • Wan, S.1    Browning, K.N.2    Coleman, F.H.3    Sutton, G.4    Zheng, H.5    Butler, A.6    Berthoud, H.R.7    Travagli, R.A.8
  • 52
    • 31644446219 scopus 로고    scopus 로고
    • Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis
    • Lechan RM, Fekete C 2006 Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides 27:310-325
    • (2006) Peptides , vol.27 , pp. 310-325
    • Lechan, R.M.1    Fekete, C.2
  • 53
    • 0020037646 scopus 로고
    • Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
    • Sawchenko PE, Swanson LW 1982 Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol 205:260-272
    • (1982) J Comp Neurol , vol.205 , pp. 260-272
    • Sawchenko, P.E.1    Swanson, L.W.2
  • 54
    • 33746561311 scopus 로고    scopus 로고
    • Effects of α-melanocyte-stimulating hormone on magnocellular oxytocin neurones and their activation at intromission in male rats
    • DOI 10.1111/j.1365-2826.2006.01465.x
    • Caquineau C, Leng G, Guan XM, Jiang M, Vander Ploeg L, Douglas AJ 2006 Effects of α-melanocyte-stimulating hormone on magnocellular oxytocin neurones and their activation at intromission in male rats. J Neuroendocrinol 18:685-691 (Pubitemid 44132616)
    • (2006) Journal of Neuroendocrinology , vol.18 , Issue.9 , pp. 685-691
    • Caquineau, C.1    Leng, G.2    Guan, X.M.M.3    Jiang, M.4    Van Der Ploeg, L.5    Douglas, A.J.6
  • 55
    • 33749043482 scopus 로고    scopus 로고
    • Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli
    • Paues J, Mackerlova L, Blomqvist A 2006 Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli. Neuroscience 141:287-297
    • (2006) Neuroscience , vol.141 , pp. 287-297
    • Paues, J.1    Mackerlova, L.2    Blomqvist, A.3
  • 56
    • 0032949410 scopus 로고    scopus 로고
    • Role of central melanocortins in endotoxin-induced anorexia
    • Huang QH, Hruby VJ, Tatro JB 1999 Role of central melanocortins in endotoxin-induced anorexia. Am J Physiol 276:R864-R871
    • (1999) Am J Physiol , vol.276
    • Huang, Q.H.1    Hruby, V.J.2    Tatro, J.B.3
  • 57
    • 0036162117 scopus 로고    scopus 로고
    • The neuroanatomical axis for control of energy balance
    • Grill HJ, Kaplan JM 2002 The neuroanatomical axis for control of energy balance. Front Neuroendocrinol 23:2-40
    • (2002) Front Neuroendocrinol , vol.23 , pp. 2-40
    • Grill, H.J.1    Kaplan, J.M.2
  • 58
    • 33746880281 scopus 로고    scopus 로고
    • The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action
    • Dube MG, Kalra SP, Kalra PS 2006 The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action. Peptides 27:2239-2248
    • (2006) Peptides , vol.27 , pp. 2239-2248
    • Dube, M.G.1    Kalra, S.P.2    Kalra, P.S.3
  • 59
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • DOI 10.1210/en.2004-0726
    • Münzberg H, Flier JS, Bjørbaek C 2004 Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-4889 (Pubitemid 39551104)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 60
    • 63849112609 scopus 로고    scopus 로고
    • Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
    • Skibicka KP, Grill HJ 2009 Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 150:1705-1711
    • (2009) Endocrinology , vol.150 , pp. 1705-1711
    • Skibicka, K.P.1    Grill, H.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.