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Volumn 106, Issue 4, 2012, Pages 485-490

Exercise protects against high-fat diet-induced hypothalamic inflammation

Author keywords

Exercise; Hypothalamus; Inflammation; Obesity; Treadmill

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860565985     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2012.03.021     Document Type: Article
Times cited : (102)

References (41)
  • 1
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 2
    • 1842477221 scopus 로고    scopus 로고
    • Neuroscience. The fat-brain axis enters a new dimension
    • Elmquist J.K., Flier J.S. Neuroscience. The fat-brain axis enters a new dimension. Science 2004, 304:63-64.
    • (2004) Science , vol.304 , pp. 63-64
    • Elmquist, J.K.1    Flier, J.S.2
  • 3
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz M.W., Porte D. Diabetes, obesity, and the brain. Science 2005, 307:375-379.
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte, D.2
  • 4
    • 77956013253 scopus 로고    scopus 로고
    • Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up
    • Thaler J.P., Schwartz M.W. Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 2010, 151:4109-4115.
    • (2010) Endocrinology , vol.151 , pp. 4109-4115
    • Thaler, J.P.1    Schwartz, M.W.2
  • 5
    • 84927516964 scopus 로고    scopus 로고
    • Rapid onset of hypothalamic inflammation, reactive gliosis and microglial accumulation during high-fat diet-induced obesity
    • The Endocrine Society 2011 Annual Meeting, Boston, MS, June 4-7, OR-33-1
    • Thaler J., Yi C.-X., Hwang B.H., Zhao X., Guyenet S.J., Sarruf D.A., et al. Rapid onset of hypothalamic inflammation, reactive gliosis and microglial accumulation during high-fat diet-induced obesity. Endocrine reviews 2011, 32.
    • (2011) Endocrine reviews , pp. 32
    • Thaler, J.1    Yi, C.-X.2    Hwang, B.H.3    Zhao, X.4    Guyenet, S.J.5    Sarruf, D.A.6
  • 7
    • 77952650737 scopus 로고    scopus 로고
    • Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids
    • Choi S.J., Kim F., Schwartz M.W., Wisse B.E. Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiol Endocrinol Metab 2010, 298:E1122-E1130.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Choi, S.J.1    Kim, F.2    Schwartz, M.W.3    Wisse, B.E.4
  • 8
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • Kleinridders A., Schenten D., Konner A.C., Belgardt B.F., Mauer J., Okamura T., et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 2009, 10:249-259.
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Konner, A.C.3    Belgardt, B.F.4    Mauer, J.5    Okamura, T.6
  • 10
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • Ozcan L., Ergin A.S., Lu A., Chung J., Sarkar S., Nie D., et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 2009, 9:35-51.
    • (2009) Cell Metab , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3    Chung, J.4    Sarkar, S.5    Nie, D.6
  • 11
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 12
    • 0034866550 scopus 로고    scopus 로고
    • Microglia: activation and their significance in the central nervous system
    • Nakajima K., Kohsaka S. Microglia: activation and their significance in the central nervous system. J Biochem 2001, 130:169-175.
    • (2001) J Biochem , vol.130 , pp. 169-175
    • Nakajima, K.1    Kohsaka, S.2
  • 13
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 15
    • 77950216899 scopus 로고    scopus 로고
    • Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet
    • Grayson B.E., Levasseur P.R., Williams S.M., Smith M.S., Marks D.L., Grove K.L. Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology 2010, 151:1622-1632.
    • (2010) Endocrinology , vol.151 , pp. 1622-1632
    • Grayson, B.E.1    Levasseur, P.R.2    Williams, S.M.3    Smith, M.S.4    Marks, D.L.5    Grove, K.L.6
  • 16
    • 34447339100 scopus 로고    scopus 로고
    • Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism
    • Pinteaux E., Inoue W., Schmidt L., Molina-Holgado F., Rothwell N.J., Luheshi G.N. Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism. J Neurochem 2007, 102:826-833.
    • (2007) J Neurochem , vol.102 , pp. 826-833
    • Pinteaux, E.1    Inoue, W.2    Schmidt, L.3    Molina-Holgado, F.4    Rothwell, N.J.5    Luheshi, G.N.6
  • 17
    • 34548763920 scopus 로고    scopus 로고
    • Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia
    • Tang C.H., Lu D.Y., Yang R.S., Tsai H.Y., Kao M.C., Fu W.M., et al. Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 2007, 179:1292-1302.
    • (2007) J Immunol , vol.179 , pp. 1292-1302
    • Tang, C.H.1    Lu, D.Y.2    Yang, R.S.3    Tsai, H.Y.4    Kao, M.C.5    Fu, W.M.6
  • 18
    • 77951622892 scopus 로고    scopus 로고
    • Leptin modulates cell morphology and cytokine release in microglia
    • Lafrance V., Inoue W., Kan B., Luheshi G.N. Leptin modulates cell morphology and cytokine release in microglia. Brain Behav Immun 2010, 24:358-365.
    • (2010) Brain Behav Immun , vol.24 , pp. 358-365
    • Lafrance, V.1    Inoue, W.2    Kan, B.3    Luheshi, G.N.4
  • 19
    • 77951675090 scopus 로고    scopus 로고
    • Effects of lifestyle measures, antiobesity agents, and bariatric surgery on serological markers of inflammation in obese patients
    • Tziomalos K., Dimitroula H.V., Katsiki N., Savopoulos C., Hatzitolios A.I. Effects of lifestyle measures, antiobesity agents, and bariatric surgery on serological markers of inflammation in obese patients. Mediators Inflamm 2010, 2010:364957.
    • (2010) Mediators Inflamm , vol.2010 , pp. 364957
    • Tziomalos, K.1    Dimitroula, H.V.2    Katsiki, N.3    Savopoulos, C.4    Hatzitolios, A.I.5
  • 20
    • 79955549652 scopus 로고    scopus 로고
    • Exercise in obesity, metabolic syndrome, and diabetes
    • Church T. Exercise in obesity, metabolic syndrome, and diabetes. Prog Cardiovasc Dis 2011, 53:412-418.
    • (2011) Prog Cardiovasc Dis , vol.53 , pp. 412-418
    • Church, T.1
  • 21
    • 0036084568 scopus 로고    scopus 로고
    • Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
    • Lerman I., Harrison B.C., Freeman K., Hewett T.E., Allen D.L., Robbins J., et al. Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol 2002, 92:2245-2255.
    • (2002) J Appl Physiol , vol.92 , pp. 2245-2255
    • Lerman, I.1    Harrison, B.C.2    Freeman, K.3    Hewett, T.E.4    Allen, D.L.5    Robbins, J.6
  • 22
    • 0036785954 scopus 로고    scopus 로고
    • Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy
    • Kemi O.J., Loennechen J.P., Wisloff U., Ellingsen O. Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. J Appl Physiol 2002, 93:1301-1309.
    • (2002) J Appl Physiol , vol.93 , pp. 1301-1309
    • Kemi, O.J.1    Loennechen, J.P.2    Wisloff, U.3    Ellingsen, O.4
  • 23
    • 69549096366 scopus 로고    scopus 로고
    • Endurance capacity of mice selectively bred for high voluntary wheel running
    • Meek T.H., Lonquich B.P., Hannon R.M., Garland T. Endurance capacity of mice selectively bred for high voluntary wheel running. J Exp Biol 2009, 212:2908-2917.
    • (2009) J Exp Biol , vol.212 , pp. 2908-2917
    • Meek, T.H.1    Lonquich, B.P.2    Hannon, R.M.3    Garland, T.4
  • 24
    • 38449108309 scopus 로고    scopus 로고
    • Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice
    • Hofmann S.M., Perez-Tilve D., Greer T.M., Coburn B.A., Grant E., Basford J.E., et al. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes 2008, 57:5-12.
    • (2008) Diabetes , vol.57 , pp. 5-12
    • Hofmann, S.M.1    Perez-Tilve, D.2    Greer, T.M.3    Coburn, B.A.4    Grant, E.5    Basford, J.E.6
  • 25
    • 36049022385 scopus 로고    scopus 로고
    • Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice
    • Hofmann S.M., Zhou L., Perez-Tilve D., Greer T., Grant E., Wancata L., et al. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest 2007, 117:3271-3282.
    • (2007) J Clin Invest , vol.117 , pp. 3271-3282
    • Hofmann, S.M.1    Zhou, L.2    Perez-Tilve, D.3    Greer, T.4    Grant, E.5    Wancata, L.6
  • 26
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • Bonora E., Targher G., Alberiche M., Bonadonna R.C., Saggiani F., Zenere M.B., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000, 23:57-63.
    • (2000) Diabetes Care , vol.23 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3    Bonadonna, R.C.4    Saggiani, F.5    Zenere, M.B.6
  • 27
    • 50949096935 scopus 로고    scopus 로고
    • Association of insulin resistance and inflammation with peripheral arterial disease: the National Health and Nutrition Examination Survey, 1999 to 2004
    • Pande R.L., Perlstein T.S., Beckman J.A., Creager M.A. Association of insulin resistance and inflammation with peripheral arterial disease: the National Health and Nutrition Examination Survey, 1999 to 2004. Circulation 2008, 118:33-41.
    • (2008) Circulation , vol.118 , pp. 33-41
    • Pande, R.L.1    Perlstein, T.S.2    Beckman, J.A.3    Creager, M.A.4
  • 28
    • 0036849026 scopus 로고    scopus 로고
    • Intracellular signaling in M-CSF-induced microglia activation: role of Iba1
    • Imai Y., Kohsaka S. Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 2002, 40:164-174.
    • (2002) Glia , vol.40 , pp. 164-174
    • Imai, Y.1    Kohsaka, S.2
  • 30
    • 0035900626 scopus 로고    scopus 로고
    • Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus
    • Shen H., Tong L., Balazs R., Cotman C.W. Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus. Neuroscience 2001, 107:219-229.
    • (2001) Neuroscience , vol.107 , pp. 219-229
    • Shen, H.1    Tong, L.2    Balazs, R.3    Cotman, C.W.4
  • 31
    • 77957940963 scopus 로고    scopus 로고
    • Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice
    • Kawanishi N., Yano H., Yokogawa Y., Suzuki K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev 2010, 16:105-118.
    • (2010) Exerc Immunol Rev , vol.16 , pp. 105-118
    • Kawanishi, N.1    Yano, H.2    Yokogawa, Y.3    Suzuki, K.4
  • 32
    • 77957712861 scopus 로고    scopus 로고
    • Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARgamma and Th2 cytokines
    • Yakeu G., Butcher L., Isa S., Webb R., Roberts A.W., Thomas A.W., et al. Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARgamma and Th2 cytokines. Atherosclerosis 2010, 212:668-673.
    • (2010) Atherosclerosis , vol.212 , pp. 668-673
    • Yakeu, G.1    Butcher, L.2    Isa, S.3    Webb, R.4    Roberts, A.W.5    Thomas, A.W.6
  • 33
    • 53249149104 scopus 로고    scopus 로고
    • Forced and voluntary exercise differentially affect brain and behavior
    • Leasure J.L., Jones M. Forced and voluntary exercise differentially affect brain and behavior. Neuroscience 2008, 156:456-465.
    • (2008) Neuroscience , vol.156 , pp. 456-465
    • Leasure, J.L.1    Jones, M.2
  • 34
    • 0024542888 scopus 로고
    • Variations in running activity and enzymatic adaptations in voluntary running rats
    • Rodnick K.J., Reaven G.M., Haskell W.L., Sims C.R., Mondon C.E. Variations in running activity and enzymatic adaptations in voluntary running rats. J Appl Physiol 1989, 66:1250-1257.
    • (1989) J Appl Physiol , vol.66 , pp. 1250-1257
    • Rodnick, K.J.1    Reaven, G.M.2    Haskell, W.L.3    Sims, C.R.4    Mondon, C.E.5
  • 35
    • 39749138227 scopus 로고    scopus 로고
    • Forced, not voluntary, exercise effectively induces neuroprotection in stroke
    • Hayes K., Sprague S., Guo M., Davis W., Friedman A., Kumar A., et al. Forced, not voluntary, exercise effectively induces neuroprotection in stroke. Acta Neuropathol 2008, 115:289-296.
    • (2008) Acta Neuropathol , vol.115 , pp. 289-296
    • Hayes, K.1    Sprague, S.2    Guo, M.3    Davis, W.4    Friedman, A.5    Kumar, A.6
  • 36
    • 29044439363 scopus 로고    scopus 로고
    • Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia
    • Ploughman M., Granter-Button S., Chernenko G., Tucker B.A., Mearow K.M., Corbett D. Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia. Neuroscience 2005, 136:991-1001.
    • (2005) Neuroscience , vol.136 , pp. 991-1001
    • Ploughman, M.1    Granter-Button, S.2    Chernenko, G.3    Tucker, B.A.4    Mearow, K.M.5    Corbett, D.6
  • 37
    • 33744945012 scopus 로고    scopus 로고
    • Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats
    • Fediuc S., Campbell J.E., Riddell M.C. Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats. J Appl Physiol 2006, 100:1867-1875.
    • (2006) J Appl Physiol , vol.100 , pp. 1867-1875
    • Fediuc, S.1    Campbell, J.E.2    Riddell, M.C.3
  • 38
    • 29244481976 scopus 로고    scopus 로고
    • Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation
    • Nair A., Bonneau R.H. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroimmunol 2006, 171:72-85.
    • (2006) J Neuroimmunol , vol.171 , pp. 72-85
    • Nair, A.1    Bonneau, R.H.2
  • 39
    • 34247880267 scopus 로고    scopus 로고
    • Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18
    • Sugama S., Fujita M., Hashimoto M., Conti B. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience 2007, 146:1388-1399.
    • (2007) Neuroscience , vol.146 , pp. 1388-1399
    • Sugama, S.1    Fujita, M.2    Hashimoto, M.3    Conti, B.4
  • 41
    • 79551510124 scopus 로고    scopus 로고
    • The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex
    • Wu J., Ruas J.L., Estall J.L., Rasbach K.A., Choi J.H., Ye L., et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex. Cell Metab 2011, 13:160-169.
    • (2011) Cell Metab , vol.13 , pp. 160-169
    • Wu, J.1    Ruas, J.L.2    Estall, J.L.3    Rasbach, K.A.4    Choi, J.H.5    Ye, L.6


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