Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity

Journal of Applied Physiology

Volumn 114, Issue 6, 2013, Pages 734-741

  Jayaram, Bhavaani ^a   Pan, Weihong ^a   Wang, Yuping ^a   Hsuchou, Hung ^a   MacE, Aurelien ^a   Cornelissen Guillaume, Germaine G ^b   Mishra, Pramod K ^a   Koza, Robert A ^a   Kastin, Abba J ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

ALKO; Astrocytes; Metabolic phenotype

Indexed keywords

BIOLOGICAL MARKER; INSULIN; ION CHANNEL; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR, MOUSE; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; ASTROCYTE; BLOOD; BODY WEIGHT; DISEASE MODEL; ENERGY METABOLISM; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; LIPID DIET; METABOLISM; MOTOR ACTIVITY; MOUSE; MOUSE MUTANT; OBESITY; PHENOTYPE; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; TIME;

ADIPOSITY; ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY WEIGHT; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GENOTYPE; HYPOTHALAMUS; INSULIN; ION CHANNELS; LEPTIN; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MOTOR ACTIVITY; OBESITY; PHENOTYPE; RECEPTORS, LEPTIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; TIME FACTORS; TRIGLYCERIDES;

EID: 84878586125     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01499.2012     Document Type: Article

References (27)

1. Aleshin S, Grabeklis S, Hanck T, Sergeeva M, Reiser G. Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels. Mol Pharmacol 76: 414-424, 2009.
2. Casper KB, Jones K, McCarthy KD. Characterization of astrocytespecific conditional knockouts. Genesis 45: 292-299, 2007.
3. Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 51: 2105-2112, 2002.
4. Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108: 1113-1121, 2001.
5. de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115: 3484-3493, 2005.
6. Hamby ME, Sofroniew MV. Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics 7: 494-506, 2010.
7. He Y, Kastin AJ, Hsuchou H, Pan W. The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling. J Mol Neurosci 39: 49-58, 2009.
8. Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB, Pan W. Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 132: 889-902, 2009.
9. Hsuchou H, Kastin AJ, Pan W. Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis. J Mol Neurosci 47: 267-277, 2012.
10. Hsuchou H, Kastin AJ, Tu H, Markadakis EN, Stone KP, Wang Y, Heymsfield SB, Chua SC Jr, Obici S, Magrisso IJ, Pan W. Effects of cell type-specific leptin receptor mutation on leptin transport across the BBB. Peptides 32: 1392-1399, 2011.
11. Hsuchou H, Pan W, Barnes MJ, Kastin AJ. Leptin receptor mRNA in rat brain astrocytes. Peptides 30: 2275-2280, 2009.
12. Kozak LP, Koza RA. Mitochondria uncoupling proteins and obesity: molecular and genetic aspects of UCP1. Int J Obes Relat Metab Disord 23 (Suppl 6): S33-S37, 1999.
13. Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J. Souble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 283: 982-988, 2001.
14. McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC Jr. An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome 15: 677-685, 2004.
15. McMinn JE, Liu SM, Liu H, Dragatsis I, Dietrich P, Ludwig T, Boozer CN, Chua SC Jr. Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility. Am J Physiol Endocrinol Metab 289: E403-E411, 2005.
16. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10: 739-743, 2004.
17. Okamatsu-Ogura Y, Nio-Kobayashi J, Iwanaga T, Terao A, Kimura K, Saito M. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood) 236: 1274-1281, 2011.
18. Pan W, Hsuchou H, Cornelissen-Guillaume GG, Jayaram B, Wang Y, Tu H, Halberg F, Wu X, Chua SC Jr, Kastin AJ. Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity. J Appl Physiol 112: 1410-1418, 2012.
19. Pan W, Hsuchou H, He Y, Kastin AJ. Glial leptin receptors and obesity. In: Modern Insights into Disease -from Molecules to Man: Adipokines, edited by Preedy VR. Enfield, NH: Science Publishers, 2011, p. 185-196.
20. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, Kastin AJ. Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology 149: 2798-2806, 2008.
21. Pan W, Hsuchou H, Jayaram B, Khan RS, Huang EY, Wu X, Chen C, Kastin AJ. Leptin action on nonneuronal cells in the CNS: potential clinical implications. Ann N Y Acad Sci 1264: 64-71, 2012.
22. Pan W, Hsuchou H, Tu H, Kastin AJ. Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology 149: 877-885, 2008.
23. Pan W, Hsuchou H, Xu CL, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice. J Mol Neurosci 43: 478-484, 2011.
24. Pan W, Kastin AJ. Mahogany, blood-brain barrier, and fat mass surge in AVY mice. Int J Obes (Lond) 31: 1030-1032, 2007.
25. Ricquier D, Miroux B, Larose M, Cassard-Doulcier AM, Bouillaud F. Endocrine regulation of uncoupling proteins and energy expenditure. Int J Obes Relat Metab Disord 24: S86-S88, 2000.
26. Tu H, Kastin AJ, Hsuchou H, Pan W. Soluble receptor inhibits leptin transport. J Cell Physiol 214: 301-305, 2008.
27. Wu X, Kastin AJ, He Y, Hsuchou H, Rood JC, Pan W. Essential role of interleukin-15 receptor in normal anxiety behavior. Brain Behav Immun 24: 1340-1346, 2010.