Therapeutic targeting of autophagy in disease: Biology and pharmacology

Pharmacological Reviews

Volumn 65, Issue 4, 2013, Pages 1162-1197

  Cheng, Yan ^a   Ren, Xingcong ^a   Hait, William N ^b   Yang, Jin Ming ^a  

^a PENN STATE CANCER INSTITUTE   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AMIODARONE; AZD 8055; BORTEZOMIB; DACINOSTAT; DASATINIB; DEOXYGLUCOSE; EVEROLIMUS; FLUOXETINE; HYDROXYCHLOROQUINE; IMATINIB; LONAFARNIB; MAPROTILINE; METFORMIN; NICLOSAMIDE; PANOBINOSTAT; PERHEXILINE; RAPAMYCIN; RESVERATROL; RIDAFOROLIMUS; ROTTLERIN; SALINOSPORAMIDE A; TAMOXIFEN; TEMOZOLOMIDE; TEMSIROLIMUS; UNINDEXED DRUG; VORINOSTAT;

ADVANCED SOLID TUMOR; AGING; ALZHEIMER DISEASE; ANTIGEN PRESENTATION; AORTA VALVE DISEASE; APOPTOSIS; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; BENIGN TUMOR; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CANCER THERAPY; CARDIOMYOPATHY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL DIFFERENTIATION; CELL INCLUSION; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL STRESS; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; COLON CANCER; COLORECTAL CANCER; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; CROHN DISEASE; CYTOTOXICITY; DANON DISEASE; DEGENERATIVE DISEASE; DISEASES; DNA DAMAGE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FIBROSARCOMA; GENE MUTATION; GENE OVEREXPRESSION; GENETIC MANIPULATION; GENOTYPE; GLIOBLASTOMA; GLUCOSE INTOLERANCE; HEART DISEASE; HEART MUSCLE CELL; HEART VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; HUMAN; HUNTINGTON CHOREA; HYPERTENSION; IMMUNOPATHOLOGY; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INFECTION; INFLAMMATION; INSULIN DEFICIENCY; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY CANCER; KIDNEY CARCINOMA; LIFE EXTENSION; LIPID METABOLISM; LIVER CARCINOGENESIS; LIVER TUMOR; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LYMPHOMA; LYSOSOME MEMBRANE; MACROAUTOPHAGY; MANTLE CELL LYMPHOMA; MELANOMA; MEMBRANE VESICLE; MICROAUTOPHAGY; MITOPHAGY; MOLECULAR BIOLOGY; MULTIMODALITY CANCER THERAPY; MULTIPLE MYELOMA; MURINE HEPATITIS CORONAVIRUS; NEGATIVE FEEDBACK; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OBSERVATIONAL STUDY; OVARY CANCER; OXIDATIVE STRESS; PANCREAS CANCER; PANCREAS ISLET BETA CELL; PARKINSON DISEASE; PATHOPHYSIOLOGY; PEXOPHAGY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; QUALITY CONTROL; REVIEW; RHEUMATOID ARTHRITIS; RIBOPHAGY; RNA TRANSLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SOLID TUMOR; SYSTEMIC LUPUS ERYTHEMATOSUS; THERAPY EFFECT; TISSUE INJURY; TRANSCRIPTION INITIATION; TUBEROUS SCLEROSIS; TUMOR CELL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; WILD TYPE; XENOGRAFT; XENOPHAGY;

EID: 84888161072     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.112.007120     Document Type: Review

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