-
1
-
-
34250864795
-
Protein turnover via autophagy: implications for metabolism
-
Mizushima N., Klionsky D.J. Protein turnover via autophagy: implications for metabolism. Annu. Rev. Nutr. 2007, 27:19-40.
-
(2007)
Annu. Rev. Nutr.
, vol.27
, pp. 19-40
-
-
Mizushima, N.1
Klionsky, D.J.2
-
2
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
Kondo Y., Kanzawa T., Sawaya R., Kondo S. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 2005, 5:726-734.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
3
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
4
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin1
-
Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin1. Nature 1999, 402:672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
5
-
-
0345166111
-
Beclin1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z., Jin S., Yang C., Levine A.J., Heintz N. Beclin1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 2003, 100:15077-15082.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
6
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin1 autophagy gene
-
Qu X., et al. Promotion of tumorigenesis by heterozygous disruption of the beclin1 autophagy gene. J. Clin. Invest. 2003, 112:1809-1820.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
-
7
-
-
67349138549
-
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies
-
Iqbal J., et al. Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia 2009, 23:1139-1151.
-
(2009)
Leukemia
, vol.23
, pp. 1139-1151
-
-
Iqbal, J.1
-
8
-
-
1242296021
-
Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability
-
Ionov Y., Nowak N., Perucho M., Markowitz S., Cowell J.K. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. Oncogene 2004, 23:639-645.
-
(2004)
Oncogene
, vol.23
, pp. 639-645
-
-
Ionov, Y.1
Nowak, N.2
Perucho, M.3
Markowitz, S.4
Cowell, J.K.5
-
9
-
-
45049083880
-
Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
-
Kim M.S., Jeong E.G., Ahn C.H., Kim S.S., Lee S.H., Yoo N.J. Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum. Pathol. 2008, 39:1059-1063.
-
(2008)
Hum. Pathol.
, vol.39
, pp. 1059-1063
-
-
Kim, M.S.1
Jeong, E.G.2
Ahn, C.H.3
Kim, S.S.4
Lee, S.H.5
Yoo, N.J.6
-
10
-
-
55849126198
-
Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
-
Coppola D., Khalil F., Eschrich S.A., Boulware D., Yeatman T., Wang H.G. Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer 2008, 113:2665-2670.
-
(2008)
Cancer
, vol.113
, pp. 2665-2670
-
-
Coppola, D.1
Khalil, F.2
Eschrich, S.A.3
Boulware, D.4
Yeatman, T.5
Wang, H.G.6
-
11
-
-
34547132328
-
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3
-
Marino G., Salvador-Montoliu N., Fueyo A., Knecht E., Mizushima N., Lopez-Otin C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J. Biol. Chem. 2007, 282:18573-18583.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 18573-18583
-
-
Marino, G.1
Salvador-Montoliu, N.2
Fueyo, A.3
Knecht, E.4
Mizushima, N.5
Lopez-Otin, C.6
-
12
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
Degenhardt K., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006, 10:51-64.
-
(2006)
Cancer Cell.
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
-
13
-
-
34249863298
-
Autophagy suppresses tumor progression by limiting chromosomal instability
-
Mathew R., et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 2007, 21:1367-1381.
-
(2007)
Genes Dev.
, vol.21
, pp. 1367-1381
-
-
Mathew, R.1
-
14
-
-
34347404887
-
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
-
Karantza-Wadsworth V., Patel S., Kravchuk O., Chen G., Mathew R., Jin S., White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev. 2007, 21:1621-1635.
-
(2007)
Genes Dev.
, vol.21
, pp. 1621-1635
-
-
Karantza-Wadsworth, V.1
Patel, S.2
Kravchuk, O.3
Chen, G.4
Mathew, R.5
Jin, S.6
White, E.7
-
15
-
-
70349438994
-
Tumour suppression by p53: a role for the DNA damage response?
-
Meek D.W. Tumour suppression by p53: a role for the DNA damage response?. Nat. Rev. Cancer 2009, 9:714-723.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 714-723
-
-
Meek, D.W.1
-
16
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Mathew R., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137:1062-1075.
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
-
17
-
-
27944504351
-
P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
19
-
-
67651160649
-
CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
-
DeNardo D.G., Barreto J.B., Andreu P., Vasquez L., Tawfik D., Kolhatkar N., Coussens L.M. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009, 16:91-102.
-
(2009)
Cancer Cell
, vol.16
, pp. 91-102
-
-
DeNardo, D.G.1
Barreto, J.B.2
Andreu, P.3
Vasquez, L.4
Tawfik, D.5
Kolhatkar, N.6
Coussens, L.M.7
-
20
-
-
0036187615
-
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
-
Bingle L., Brown N.J., Lewis C.E. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 2002, 196:254-265.
-
(2002)
J. Pathol.
, vol.196
, pp. 254-265
-
-
Bingle, L.1
Brown, N.J.2
Lewis, C.E.3
-
21
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young A.R., et al. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009, 23:798-803.
-
(2009)
Genes Dev.
, vol.23
, pp. 798-803
-
-
Young, A.R.1
-
22
-
-
41449109334
-
Induction of autophagy during extracellular matrix detachment promotes cell survival
-
Fung C., Lock R., Gao S., Salas E., Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol. Biol. Cell 2008, 19:797-806.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 797-806
-
-
Fung, C.1
Lock, R.2
Gao, S.3
Salas, E.4
Debnath, J.5
-
23
-
-
57449121645
-
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
-
Lu Z., et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest. 2008, 118:3917-3929.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3917-3929
-
-
Lu, Z.1
-
24
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 2009, 43:67-93.
-
(2009)
Annu. Rev. Genet.
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
25
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
26
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 2003, 13:1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
27
-
-
50049125036
-
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events
-
Nardella C., et al. Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev. 2008, 22:2172-2177.
-
(2008)
Genes Dev.
, vol.22
, pp. 2172-2177
-
-
Nardella, C.1
-
28
-
-
67049158203
-
Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy
-
Zhou X., Ikenoue T., Chen X., Li L., Inoki K., Guan K.L. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc. Natl. Acad. Sci. USA 2009, 106:8923-8928.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 8923-8928
-
-
Zhou, X.1
Ikenoue, T.2
Chen, X.3
Li, L.4
Inoki, K.5
Guan, K.L.6
-
29
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
-
Petiot A., Ogier-Denis E., Blommaart E.F., Meijer A.J., Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 2000, 275:992-998.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.3
Meijer, A.J.4
Codogno, P.5
-
30
-
-
53749104349
-
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
-
Degtyarev M., et al. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J. Cell Biol. 2008, 183:101-116.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 101-116
-
-
Degtyarev, M.1
-
31
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Arico S., Petiot A., Bauvy C., Dubbelhuis P.F., Meijer A.J., Codogno P., Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 2001, 276:35243-35246.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
Dubbelhuis, P.F.4
Meijer, A.J.5
Codogno, P.6
Ogier-Denis, E.7
-
32
-
-
67749111502
-
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
-
Shackelford D.B., Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 2009, 9:563-575.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
33
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti M.N., Inoki K., Bardeesy N., DePinho R.A., Guan K.L. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004, 18:1533-1538.
-
(2004)
Genes Dev.
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
34
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126:955-968.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
-
35
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 2008, 30:214-226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
36
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J., et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat. Cell Biol. 2007, 9:218-224.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 218-224
-
-
Liang, J.1
-
37
-
-
69249229790
-
Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation
-
Kumar S.H., Rangarajan A. Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. J. Virol. 2009, 83:8565-8574.
-
(2009)
J. Virol.
, vol.83
, pp. 8565-8574
-
-
Kumar, S.H.1
Rangarajan, A.2
-
38
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin1-dependent autophagy
-
Pattingre S., et al. Bcl-2 antiapoptotic proteins inhibit Beclin1-dependent autophagy. Cell 2005, 122:927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
-
39
-
-
70349919804
-
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
-
Simonsen A., Tooze S.A. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J. Cell Biol. 2009, 186:773-782.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 773-782
-
-
Simonsen, A.1
Tooze, S.A.2
-
40
-
-
59249089394
-
Beclin1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Itakura E., Kishi C., Inoue K., Mizushima N. Beclin1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 2008, 19:5360-5372.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
41
-
-
32244442749
-
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
-
Zeng X., Overmeyer J.H., Maltese W.A. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J. Cell Sci. 2006, 119:259-270.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 259-270
-
-
Zeng, X.1
Overmeyer, J.H.2
Maltese, W.A.3
-
42
-
-
39049194057
-
The evolutionarily conserved domain of Beclin1 is required for Vps34 binding, autophagy and tumor suppressor function
-
Furuya N., Yu J., Byfield M., Pattingre S., Levine B. The evolutionarily conserved domain of Beclin1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005, 1:46-52.
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
Yu, J.2
Byfield, M.3
Pattingre, S.4
Levine, B.5
-
43
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang C., Feng P., Ku B., Dotan I., Canaani D., Oh B.H., Jung J.U. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006, 8:688-699.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 688-699
-
-
Liang, C.1
Feng, P.2
Ku, B.3
Dotan, I.4
Canaani, D.5
Oh, B.H.6
Jung, J.U.7
-
44
-
-
46449120732
-
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
-
Liang C., et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 2008, 10:776-787.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 776-787
-
-
Liang, C.1
-
45
-
-
34848899280
-
Bif-1 interacts with Beclin1 through UVRAG and regulates autophagy and tumorigenesis
-
Takahashi Y., et al. Bif-1 interacts with Beclin1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 2007, 9:1142-1151.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
-
46
-
-
33748288113
-
BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature
-
Itoh T., De Camilli P. BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature. Biochim. Biophys. Acta 2006, 1761:897-912.
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 897-912
-
-
Itoh, T.1
De Camilli, P.2
-
47
-
-
58049192897
-
Identification of Barkor as a mammalian autophagy-specific factor for Beclin1 and class III phosphatidylinositol 3-kinase
-
Sun Q., Fan W., Chen K., Ding X., Chen S., Zhong Q. Identification of Barkor as a mammalian autophagy-specific factor for Beclin1 and class III phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 2008, 105:19211-19216.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19211-19216
-
-
Sun, Q.1
Fan, W.2
Chen, K.3
Ding, X.4
Chen, S.5
Zhong, Q.6
-
48
-
-
64049086758
-
Two Beclin1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
Matsunaga K., et al. Two Beclin1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 2009, 11:385-396.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 385-396
-
-
Matsunaga, K.1
-
49
-
-
64049113909
-
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin1-phosphatidylinositol-3-kinase complex
-
Zhong Y., Wang Q.J., Li X., Yan Y., Backer J.M., Chait B.T., Heintz N., Yue Z. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 2009, 11:468-476.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 468-476
-
-
Zhong, Y.1
Wang, Q.J.2
Li, X.3
Yan, Y.4
Backer, J.M.5
Chait, B.T.6
Heintz, N.7
Yue, Z.8
-
50
-
-
34248998801
-
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
-
Maiuri M.C., et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. Embo J. 2007, 26:2527-2539.
-
(2007)
Embo J.
, vol.26
, pp. 2527-2539
-
-
Maiuri, M.C.1
-
51
-
-
35848962530
-
Differential interactions between Beclin1 and Bcl-2 family members
-
Erlich S., et al. Differential interactions between Beclin1 and Bcl-2 family members. Autophagy 2007, 3:561-568.
-
(2007)
Autophagy
, vol.3
, pp. 561-568
-
-
Erlich, S.1
-
52
-
-
0034520466
-
Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells
-
Saeki K., Yuo A., Okuma E., Yazaki Y., Susin S.A., Kroemer G., Takaku F. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ. 2000, 7:1263-1269.
-
(2000)
Cell Death Differ.
, vol.7
, pp. 1263-1269
-
-
Saeki, K.1
Yuo, A.2
Okuma, E.3
Yazaki, Y.4
Susin, S.A.5
Kroemer, G.6
Takaku, F.7
-
53
-
-
48249087666
-
Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
-
Akar U., et al. Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells. Autophagy 2008, 4:669-679.
-
(2008)
Autophagy
, vol.4
, pp. 669-679
-
-
Akar, U.1
-
54
-
-
44949237240
-
JNK 1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei Y., Pattingre S., Sinha S., Bassik M., Levine B. JNK 1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 2008, 30:678-688.
-
(2008)
Mol. Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
55
-
-
61849102389
-
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin1 promotes dissociation of beclin1 from Bcl-XL and induction of autophagy
-
Zalckvar E., et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin1 promotes dissociation of beclin1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009, 10:285-292.
-
(2009)
EMBO Rep.
, vol.10
, pp. 285-292
-
-
Zalckvar, E.1
-
56
-
-
59149096565
-
ARF induces autophagy by virtue of interaction with Bcl-xl
-
Pimkina J., Humbey O., Zilfou J.T., Jarnik M., Murphy M.E. ARF induces autophagy by virtue of interaction with Bcl-xl. J. Biol. Chem. 2009, 284:2803-2810.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2803-2810
-
-
Pimkina, J.1
Humbey, O.2
Zilfou, J.T.3
Jarnik, M.4
Murphy, M.E.5
-
57
-
-
67549101188
-
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
-
Zhang J., Ney P.A. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ. 2009, 16:939-946.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 939-946
-
-
Zhang, J.1
Ney, P.A.2
-
58
-
-
67650745428
-
PUMA- and Bax-induced autophagy contributes to apoptosis
-
Yee K.S., Wilkinson S., James J., Ryan K.M., Vousden K.H. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009, 16:1135-1145.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1135-1145
-
-
Yee, K.S.1
Wilkinson, S.2
James, J.3
Ryan, K.M.4
Vousden, K.H.5
-
59
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk J.E., Kuwana T., Bouchier-Hayes L., Droin N.M., Newmeyer D.D., Schuler M., Green D.R. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004, 303:1010-1014.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
60
-
-
34248194200
-
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
-
Feng Z., Hu W., de Stanchina E., Teresky A.K., Jin S., Lowe S., Levine A.J. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 2007, 67:3043-3053.
-
(2007)
Cancer Res.
, vol.67
, pp. 3043-3053
-
-
Feng, Z.1
Hu, W.2
de Stanchina, E.3
Teresky, A.K.4
Jin, S.5
Lowe, S.6
Levine, A.J.7
-
61
-
-
48449101433
-
P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
-
Budanov A.V., Karin M. P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008, 134:451-460.
-
(2008)
Cell
, vol.134
, pp. 451-460
-
-
Budanov, A.V.1
Karin, M.2
-
62
-
-
66849111716
-
Stimulation of autophagy by the p53 target gene Sestrin2
-
Maiuri M.C., Malik S.A., Morselli E., Kepp O., Criollo A., Mouchel P.L., Carnuccio R., Kroemer G. Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 2009, 8:1571-1576.
-
(2009)
Cell Cycle
, vol.8
, pp. 1571-1576
-
-
Maiuri, M.C.1
Malik, S.A.2
Morselli, E.3
Kepp, O.4
Criollo, A.5
Mouchel, P.L.6
Carnuccio, R.7
Kroemer, G.8
-
63
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton D., et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006, 126:121-134.
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
-
64
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
Tasdemir E., et al. Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 2008, 10:676-687.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
-
65
-
-
0031593675
-
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
-
Yamamoto A., Tagawa Y., Yoshimori T., Moriyama Y., Masaki R., Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct. 1998, 23:33-42.
-
(1998)
Cell Struct. Funct.
, vol.23
, pp. 33-42
-
-
Yamamoto, A.1
Tagawa, Y.2
Yoshimori, T.3
Moriyama, Y.4
Masaki, R.5
Tashiro, Y.6
-
66
-
-
0030059716
-
The role of the intralysosomal pH in the control of autophagic proteolytic flux in rat hepatocytes
-
Luiken J.J., Aerts J.M., Meijer A.J. The role of the intralysosomal pH in the control of autophagic proteolytic flux in rat hepatocytes. Eur. J. Biochem. 1996, 235:564-573.
-
(1996)
Eur. J. Biochem.
, vol.235
, pp. 564-573
-
-
Luiken, J.J.1
Aerts, J.M.2
Meijer, A.J.3
-
67
-
-
33846794896
-
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
-
Amaravadi R.K., Yu D., Lum J.J., Bui T., Christophorou M.A., Evan G.I., Thomas-Tikhonenko A., Thompson C.B. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 2007, 117:326-336.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 326-336
-
-
Amaravadi, R.K.1
Yu, D.2
Lum, J.J.3
Bui, T.4
Christophorou, M.A.5
Evan, G.I.6
Thomas-Tikhonenko, A.7
Thompson, C.B.8
-
68
-
-
38149141767
-
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
-
Maclean K.H., Dorsey F.C., Cleveland J.L., Kastan M.B. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J. Clin. Invest. 2008, 118:79-88.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 79-88
-
-
Maclean, K.H.1
Dorsey, F.C.2
Cleveland, J.L.3
Kastan, M.B.4
-
69
-
-
21444442926
-
Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells
-
Ito H., Daido S., Kanzawa T., Kondo S., Kondo Y. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int. J. Oncol. 2005, 26:1401-1410.
-
(2005)
Int. J. Oncol.
, vol.26
, pp. 1401-1410
-
-
Ito, H.1
Daido, S.2
Kanzawa, T.3
Kondo, S.4
Kondo, Y.5
-
70
-
-
67650095390
-
The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
-
Lomonaco S.L., Finniss S., Xiang C., Decarvalho A., Umansky F., Kalkanis S.N., Mikkelsen T., Brodie C. The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int. J. Cancer 2009, 125:717-722.
-
(2009)
Int. J. Cancer
, vol.125
, pp. 717-722
-
-
Lomonaco, S.L.1
Finniss, S.2
Xiang, C.3
Decarvalho, A.4
Umansky, F.5
Kalkanis, S.N.6
Mikkelsen, T.7
Brodie, C.8
-
71
-
-
66349119373
-
Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity
-
Shingu T., et al. Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy 2009, 5:537-539.
-
(2009)
Autophagy
, vol.5
, pp. 537-539
-
-
Shingu, T.1
-
72
-
-
70350417601
-
Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine
-
Shanmugam M., et al. Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine. J. Biol. Chem. 2009, 284:26816-26830.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26816-26830
-
-
Shanmugam, M.1
-
73
-
-
67650885510
-
Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab
-
Vazquez-Martin A., Oliveras-Ferraros C., Menendez J.A. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009, 4:e6251.
-
(2009)
PLoS One
, vol.4
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Menendez, J.A.3
-
74
-
-
33847026354
-
Autophagy delays apoptotic death in breast cancer cells following DNA damage
-
Abedin M.J., Wang D., McDonnell M.A., Lehmann U., Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ. 2007, 14:500-510.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 500-510
-
-
Abedin, M.J.1
Wang, D.2
McDonnell, M.A.3
Lehmann, U.4
Kelekar, A.5
-
75
-
-
77950690637
-
-
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. J. Cell Mol. Med.
-
Carew, J.S. et al. (2009) Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. J. Cell Mol. Med.
-
(2009)
-
-
Carew, J.S.1
-
76
-
-
40449086885
-
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
-
Apel A., Herr I., Schwarz H., Rodemann H.P., Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res. 2008, 68:1485-1494.
-
(2008)
Cancer Res.
, vol.68
, pp. 1485-1494
-
-
Apel, A.1
Herr, I.2
Schwarz, H.3
Rodemann, H.P.4
Mayer, A.5
-
77
-
-
58349098150
-
Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis
-
Kim R.H., et al. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res. 2009, 69:700-708.
-
(2009)
Cancer Res.
, vol.69
, pp. 700-708
-
-
Kim, R.H.1
-
78
-
-
48249156591
-
Autophagy: an emerging target for cancer therapy
-
Hoyer-Hansen M., Jaattela M. Autophagy: an emerging target for cancer therapy. Autophagy 2008, 4:574-580.
-
(2008)
Autophagy
, vol.4
, pp. 574-580
-
-
Hoyer-Hansen, M.1
Jaattela, M.2
-
79
-
-
62449287501
-
The paradox of autophagy and its implication in cancer etiology and therapy
-
Eisenberg-Lerner A., Kimchi A. The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 2009, 14:376-391.
-
(2009)
Apoptosis
, vol.14
, pp. 376-391
-
-
Eisenberg-Lerner, A.1
Kimchi, A.2
-
80
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C., et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J. Clin. Invest. 2009, 119:1109-1123.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1109-1123
-
-
Bellodi, C.1
-
81
-
-
34347394714
-
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
-
Carew J.S., et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007, 110:313-322.
-
(2007)
Blood
, vol.110
, pp. 313-322
-
-
Carew, J.S.1
-
82
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M., et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006, 107:4532-4539.
-
(2006)
Blood
, vol.107
, pp. 4532-4539
-
-
Copland, M.1
-
83
-
-
34247646062
-
The anticancer drug imatinib induces cellular autophagy
-
Ertmer A., Huber V., Gilch S., Yoshimori T., Erfle V., Duyster J., Elsasser H.P., Schatzl H.M. The anticancer drug imatinib induces cellular autophagy. Leukemia 2007, 21:936-942.
-
(2007)
Leukemia
, vol.21
, pp. 936-942
-
-
Ertmer, A.1
Huber, V.2
Gilch, S.3
Yoshimori, T.4
Erfle, V.5
Duyster, J.6
Elsasser, H.P.7
Schatzl, H.M.8
-
84
-
-
54049135563
-
The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias
-
Kamitsuji Y., et al. The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias. Cell Death Differ. 2008, 15:1712-1722.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1712-1722
-
-
Kamitsuji, Y.1
-
85
-
-
34247329753
-
Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
-
Jorgensen H.G., Allan E.K., Jordanides N.E., Mountford J.C., Holyoake T.L. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood 2007, 109:4016-4019.
-
(2007)
Blood
, vol.109
, pp. 4016-4019
-
-
Jorgensen, H.G.1
Allan, E.K.2
Jordanides, N.E.3
Mountford, J.C.4
Holyoake, T.L.5
-
86
-
-
0024602207
-
Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma
-
Geser A., Brubaker G., Draper C.C. Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma. Am. J. Epidemiol. 1989, 129:740-752.
-
(1989)
Am. J. Epidemiol.
, vol.129
, pp. 740-752
-
-
Geser, A.1
Brubaker, G.2
Draper, C.C.3
-
87
-
-
56749170677
-
Autophagic cell death: the story of a misnomer
-
Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol. 2008, 9:1004-1010.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 1004-1010
-
-
Kroemer, G.1
Levine, B.2
-
88
-
-
45849147350
-
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
-
Turcotte S., Chan D.A., Sutphin P.D., Hay M.P., Denny W.A., Giaccia A.J. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 2008, 14:90-102.
-
(2008)
Cancer Cell
, vol.14
, pp. 90-102
-
-
Turcotte, S.1
Chan, D.A.2
Sutphin, P.D.3
Hay, M.P.4
Denny, W.A.5
Giaccia, A.J.6
-
89
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
Salazar M., et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 2009, 119:1359-1372.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
-
90
-
-
67651152483
-
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells
-
Tormo D., et al. Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 2009, 16:103-114.
-
(2009)
Cancer Cell
, vol.16
, pp. 103-114
-
-
Tormo, D.1
-
91
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
Kanzawa T., Germano I.M., Komata T., Ito H., Kondo Y., Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 2004, 11:448-457.
-
(2004)
Cell Death Differ.
, vol.11
, pp. 448-457
-
-
Kanzawa, T.1
Germano, I.M.2
Komata, T.3
Ito, H.4
Kondo, Y.5
Kondo, S.6
-
92
-
-
41949125675
-
Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus
-
Wang Y., et al. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J. Biol. Chem. 2008, 283:4766-4777.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4766-4777
-
-
Wang, Y.1
-
93
-
-
48249091611
-
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy
-
Kaushik S., Massey A.C., Mizushima N., Cuervo A.M. Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol. Biol. Cell 2008, 19:2179-2192.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2179-2192
-
-
Kaushik, S.1
Massey, A.C.2
Mizushima, N.3
Cuervo, A.M.4
-
94
-
-
58149390639
-
Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation
-
Watanabe M., et al. Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation. Int. J. Cancer 2009, 124:55-67.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 55-67
-
-
Watanabe, M.1
|