메뉴 건너뛰기




Volumn 113, Issue 14, 2009, Pages 3297-3306

Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; EVEROLIMUS; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLACEBO; RETINOBLASTOMA PROTEIN; VINCRISTINE;

EID: 65349114832     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-02-137752     Document Type: Article
Times cited : (109)

References (49)
  • 2
    • 32944461889 scopus 로고    scopus 로고
    • Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: Results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Munster Group 87
    • Einsiedel H, von Stackelberg A, Hartmann R, et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Munster Group 87. J Clin Oncol. 2005;23:7942-7950.
    • (2005) J Clin Oncol , vol.23 , pp. 7942-7950
    • Einsiedel, H.1    von Stackelberg, A.2    Hartmann, R.3
  • 3
    • 0022004185 scopus 로고
    • Evidence for clonal development of childhood acute lymphoblastic leukemia
    • Dow L, Martin P, Moohr J, et al. Evidence for clonal development of childhood acute lymphoblastic leukemia. Blood. 1985;66:902-907.
    • (1985) Blood , vol.66 , pp. 902-907
    • Dow, L.1    Martin, P.2    Moohr, J.3
  • 4
    • 11844295983 scopus 로고    scopus 로고
    • Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support
    • Bertrand F, Spengemen J, Shelton J, McCubrey J. Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support. Leukemia. 2005;19:98-102.
    • (2005) Leukemia , vol.19 , pp. 98-102
    • Bertrand, F.1    Spengemen, J.2    Shelton, J.3    McCubrey, J.4
  • 5
    • 2442590773 scopus 로고    scopus 로고
    • Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt
    • Wang L, Fortney J, Gibson L. Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt. Leuk Res. 2004;28:733-742.
    • (2004) Leuk Res , vol.28 , pp. 733-742
    • Wang, L.1    Fortney, J.2    Gibson, L.3
  • 6
    • 34447131774 scopus 로고    scopus 로고
    • Interaction of interleukin-7 and interleukin-3 with the CXCL-12-induced proliferation of B cell progenitor acute lymphoblastic leukemia
    • Juarez J, Baraz R, Gaundar S, Bradstock K, Bendall L. Interaction of interleukin-7 and interleukin-3 with the CXCL-12-induced proliferation of B cell progenitor acute lymphoblastic leukemia. Haematologica. 2007;92:450-459.
    • (2007) Haematologica , vol.92 , pp. 450-459
    • Juarez, J.1    Baraz, R.2    Gaundar, S.3    Bradstock, K.4    Bendall, L.5
  • 7
    • 23744494993 scopus 로고    scopus 로고
    • Rapa- mycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
    • Avellino R, Romano S, Parasole R, et al. Rapa- mycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood. 2005;106:1400-1406.
    • (2005) Blood , vol.106 , pp. 1400-1406
    • Avellino, R.1    Romano, S.2    Parasole, R.3
  • 8
    • 34547130295 scopus 로고    scopus 로고
    • RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model
    • Mabuchi S, Altomare D, Cheung M, et al. RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res. 2007;13:4261-4270.
    • (2007) Clin Cancer Res , vol.13 , pp. 4261-4270
    • Mabuchi, S.1    Altomare, D.2    Cheung, M.3
  • 9
    • 34248647440 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
    • Peponi E, Drakos E, Reyes G, Leventaki V, Rassidakis G, Medeiros L. Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma. Am J Pathol. 2006;169:2171-2180.
    • (2006) Am J Pathol , vol.169 , pp. 2171-2180
    • Peponi, E.1    Drakos, E.2    Reyes, G.3    Leventaki, V.4    Rassidakis, G.5    Medeiros, L.6
  • 10
    • 31544443832 scopus 로고    scopus 로고
    • The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
    • Teachey D, Obzut D, Cooperman J, et al. The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood. 2006;107:1149-1155.
    • (2006) Blood , vol.107 , pp. 1149-1155
    • Teachey, D.1    Obzut, D.2    Cooperman, J.3
  • 11
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of the mammalian target of rapamycin inhibitor Everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee K, Zeng Z, Konopleva M, et al. Phase I/II study of the mammalian target of rapamycin inhibitor Everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2006;12:5165-5173.
    • (2006) Clin Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.1    Zeng, Z.2    Konopleva, M.3
  • 12
    • 34147146014 scopus 로고    scopus 로고
    • Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
    • Zeng Z, Sarbassov dos D, Samudio I, et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood. 2007;109:3509-3512.
    • (2007) Blood , vol.109 , pp. 3509-3512
    • Zeng, Z.1    Sarbassov dos, D.2    Samudio, I.3
  • 13
    • 33646548305 scopus 로고    scopus 로고
    • The amino acid sensitive TOR pathway from yeast to mammals
    • Dann S, Thomas G. The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett. 2006;580:2821-2829.
    • (2006) FEBS Lett , vol.580 , pp. 2821-2829
    • Dann, S.1    Thomas, G.2
  • 14
    • 30644468118 scopus 로고    scopus 로고
    • mTOR and cancer: Reason for dancing at the crossroads?
    • Thomas G. mTOR and cancer: reason for dancing at the crossroads? Curr Opin Genet Dev. 2006;16:78-84
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 78-84
    • Thomas, G.1
  • 15
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol. 2005;16:525-537.
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 16
    • 0034790016 scopus 로고    scopus 로고
    • mTOR, a novel target in breast cancer: The effect of CCI- 779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, et al. mTOR, a novel target in breast cancer: the effect of CCI- 779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer. 2001;8:249-258.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3
  • 17
    • 33745245286 scopus 로고    scopus 로고
    • Everolimus (RAD) inhibits in vivo growth of murine squamous cell carcinoma (SCC VII)
    • Khariwala S, Kjaergaard J, Lorenz R, Van Lente F, Shu S, Strome M. Everolimus (RAD) inhibits in vivo growth of murine squamous cell carcinoma (SCC VII). Laryngoscope. 2006;116:814-820.
    • (2006) Laryngoscope , vol.116 , pp. 814-820
    • Khariwala, S.1    Kjaergaard, J.2    Lorenz, R.3    Van Lente, F.4    Shu, S.5    Strome, M.6
  • 18
    • 33645690146 scopus 로고    scopus 로고
    • In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer
    • Ito D, Fujimoto K, Mori T, et al. In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer. Int J Cancer. 2006;118:2337-2343.
    • (2006) Int J Cancer , vol.118 , pp. 2337-2343
    • Ito, D.1    Fujimoto, K.2    Mori, T.3
  • 19
    • 0036830256 scopus 로고    scopus 로고
    • Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells
    • Grunwald V, DeGraffenried L, Russel D, Friedrichs W, Ray R, Hidalgo M. Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. Cancer Res. 2002;62:6141-6145.
    • (2002) Cancer Res , vol.62 , pp. 6141-6145
    • Grunwald, V.1    DeGraffenried, L.2    Russel, D.3    Friedrichs, W.4    Ray, R.5    Hidalgo, M.6
  • 20
    • 13944269599 scopus 로고    scopus 로고
    • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblas- toma tumor growth inhibition
    • Goudar R, Shi Q, Hjelmeland M, et al. Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblas- toma tumor growth inhibition. Mol Cancer Ther. 2005;4:101-112.
    • (2005) Mol Cancer Ther , vol.4 , pp. 101-112
    • Goudar, R.1    Shi, Q.2    Hjelmeland, M.3
  • 21
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui C, Evans W. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354:166-178.
    • (2006) N Engl J Med , vol.354 , pp. 166-178
    • Pui, C.1    Evans, W.2
  • 22
    • 0027358691 scopus 로고
    • Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta 1 and beta 2 integrin mechanisms
    • Bendall LJ, Kortlepel K, Gottlieb DJ. Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta 1 and beta 2 integrin mechanisms. Blood. 1993;82:3125-3132.
    • (1993) Blood , vol.82 , pp. 3125-3132
    • Bendall, L.J.1    Kortlepel, K.2    Gottlieb, D.J.3
  • 23
    • 34249692617 scopus 로고    scopus 로고
    • CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment
    • Juarez J, Dela Pena A, Baraz R, et al. CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. Leukemia. 2007;21:1249-1257.
    • (2007) Leukemia , vol.21 , pp. 1249-1257
    • Juarez, J.1    Dela Pena, A.2    Baraz, R.3
  • 24
    • 17144384436 scopus 로고    scopus 로고
    • Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not prolif- erative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia
    • Bendall L, Baraz R, Juarez J, Shen W, Bradstock K. Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not prolif- erative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Res. 2005;65:3290-3298.
    • (2005) Cancer Res , vol.65 , pp. 3290-3298
    • Bendall, L.1    Baraz, R.2    Juarez, J.3    Shen, W.4    Bradstock, K.5
  • 25
    • 34447126400 scopus 로고    scopus 로고
    • Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia
    • Khan N, Bradstock K, Bendall L. Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia. Br J Haematol. 2007;138:338-348.
    • (2007) Br J Haematol , vol.138 , pp. 338-348
    • Khan, N.1    Bradstock, K.2    Bendall, L.3
  • 26
    • 9044244144 scopus 로고    scopus 로고
    • Cytoreduction and prognosis in acute lymphoblastic leukemia-the importance of early marrow response: Report from the Childrens Cancer Group
    • Steinherz P, Gaynon P, Breneman J, et al. Cytoreduction and prognosis in acute lymphoblastic leukemia-the importance of early marrow response: report from the Childrens Cancer Group. J Clin Oncol. 1996;14:389-398.
    • (1996) J Clin Oncol , vol.14 , pp. 389-398
    • Steinherz, P.1    Gaynon, P.2    Breneman, J.3
  • 27
    • 16444379884 scopus 로고    scopus 로고
    • Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
    • Aguirre D, Boya P, Bellet D, et al. Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma. Apoptosis. 2004;9:797-805.
    • (2004) Apoptosis , vol.9 , pp. 797-805
    • Aguirre, D.1    Boya, P.2    Bellet, D.3
  • 28
    • 35348886043 scopus 로고    scopus 로고
    • Physiological functions of Atg6/Beclin 1: A unique autophagy-related protein
    • Cao Y, Klionsky D. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res. 2007;17:839-849.
    • (2007) Cell Res , vol.17 , pp. 839-849
    • Cao, Y.1    Klionsky, D.2
  • 29
    • 0001652380 scopus 로고    scopus 로고
    • Long-term results of large prospective trials in childhood acute lymphoblastic leukemia
    • Schrappe M, Camitta B, Pui C, et al. Long-term results of large prospective trials in childhood acute lymphoblastic leukemia. Leukemia. 2000;14:2193-2194.
    • (2000) Leukemia , vol.14 , pp. 2193-2194
    • Schrappe, M.1    Camitta, B.2    Pui, C.3
  • 30
    • 34047253075 scopus 로고    scopus 로고
    • RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
    • Mabuchi S, Altomare D, Connolly D, et al. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res. 2007;67:2408-2413.
    • (2007) Cancer Res , vol.67 , pp. 2408-2413
    • Mabuchi, S.1    Altomare, D.2    Connolly, D.3
  • 31
    • 0033610455 scopus 로고    scopus 로고
    • A phase I study of a 4-week course of SDZ-RAD (RAD) quiescent cyclosporine-prednisone-treated renal transplant recipients
    • Kahan B, Wong R, Carter C, et al. A phase I study of a 4-week course of SDZ-RAD (RAD) quiescent cyclosporine-prednisone-treated renal transplant recipients. Transplantation. 1999;68:1100-1106.
    • (1999) Transplantation , vol.68 , pp. 1100-1106
    • Kahan, B.1    Wong, R.2    Carter, C.3
  • 32
    • 0037302058 scopus 로고    scopus 로고
    • Clinical development of an everolimus pediatric formulation: Relative bioavailability, food effect, and steady- state pharmacokinetics
    • Kovarik J, NoeA, BerthierS, et al. Clinical development of an everolimus pediatric formulation: relative bioavailability, food effect, and steady- state pharmacokinetics. J Clin Pharmacol. 2003;43:141-147.
    • (2003) J Clin Pharmacol , vol.43 , pp. 141-147
    • Kovarik, J.1    Noe, A.2    Berthier, S.3
  • 33
    • 34249871629 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic (PBPK) modeling of everolimus (RAD001) in rats involving nonlinear tissue uptake
    • Laplanche R, Meno-Tetang G, Kawai R. Physiologically based pharmacokinetic (PBPK) modeling of everolimus (RAD001) in rats involving nonlinear tissue uptake. J Pharmacokinet Pharmacodyn. 2007;34:373-400.
    • (2007) J Pharmacokinet Pharmacodyn , vol.34 , pp. 373-400
    • Laplanche, R.1    Meno-Tetang, G.2    Kawai, R.3
  • 34
    • 33750565745 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
    • Cao C, Subhawong T, Albert J, et al. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res. 2006;66:10040-10047.
    • (2006) Cancer Res , vol.66 , pp. 10040-10047
    • Cao, C.1    Subhawong, T.2    Albert, J.3
  • 35
    • 0033659651 scopus 로고    scopus 로고
    • Childhood ALL blasts retain phenotypic and genotypic characteristics upon long-term serial passage in NOD/SCID mice
    • Borgmann A, Baldy C, von Stackelberg A, et al. Childhood ALL blasts retain phenotypic and genotypic characteristics upon long-term serial passage in NOD/SCID mice. Pediatr Hematol Oncol. 2000;17:635-650.
    • (2000) Pediatr Hematol Oncol , vol.17 , pp. 635-650
    • Borgmann, A.1    Baldy, C.2    von Stackelberg, A.3
  • 36
    • 2342531648 scopus 로고    scopus 로고
    • Characterization of childhood acute lymphoblastic leukemia xenograft models for the pre-clinical evaluation of new therapies
    • Liem N, Papa R, Milross C, et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the pre-clinical evaluation of new therapies. Blood. 2004;103:3905-3914.
    • (2004) Blood , vol.103 , pp. 3905-3914
    • Liem, N.1    Papa, R.2    Milross, C.3
  • 37
    • 52649149525 scopus 로고    scopus 로고
    • mTOR inhibitors are synergistic with methotrexate: An effective combination to treat acute lymphoblastic leukemia
    • Teachey D, Sheen C, Hall J, et al. mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia. Blood. 2008;112:2020-2023.
    • (2008) Blood , vol.112 , pp. 2020-2023
    • Teachey, D.1    Sheen, C.2    Hall, J.3
  • 38
    • 4944236206 scopus 로고    scopus 로고
    • Promoter hypermethylation of cancer related genes: A strong independent prognostic factor in acute lymphoblastic leukemia
    • Roman-Gomez J, Jimenez-Velasco A, Castillejo J, et al. Promoter hypermethylation of cancer related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood. 2004;104:2492-2498.
    • (2004) Blood , vol.104 , pp. 2492-2498
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Castillejo, J.3
  • 39
    • 0141919562 scopus 로고    scopus 로고
    • PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lym- phoblastic leukemia cells
    • Zhou M, Gu L, Findley H, Jiang R, Woods W. PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lym- phoblastic leukemia cells. Cancer Res. 2003;63:6357-6362.
    • (2003) Cancer Res , vol.63 , pp. 6357-6362
    • Zhou, M.1    Gu, L.2    Findley, H.3    Jiang, R.4    Woods, W.5
  • 40
    • 33747874283 scopus 로고    scopus 로고
    • Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo
    • Wendel H, MalinaA, ZhaoZ, et al. Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Res. 2006;66:7639-7646.
    • (2006) Cancer Res , vol.66 , pp. 7639-7646
    • Wendel, H.1    Malina, A.2    Zhao, Z.3
  • 41
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycinmediated mammalian target of rapamycin inhibition
    • Sun S, Rosenberg L, Wang X, et al. Activation of Akt and eIF4E survival pathways by rapamycinmediated mammalian target of rapamycin inhibition. Cancer Res. 2005;65:7052-7058.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.1    Rosenberg, L.2    Wang, X.3
  • 42
    • 32244441908 scopus 로고    scopus 로고
    • From cell cycle to differentiation: An expanding role for cdk6
    • Grossel M, Hinds P. From cell cycle to differentiation: an expanding role for cdk6. Cell Cycle. 2006;5:266-270.
    • (2006) Cell Cycle , vol.5 , pp. 266-270
    • Grossel, M.1    Hinds, P.2
  • 43
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/ AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • Gao N, Zhang Z, Jiang B, Shi X. Role of PI3K/ AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun. 2003;310:1124-1132.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 1124-1132
    • Gao, N.1    Zhang, Z.2    Jiang, B.3    Shi, X.4
  • 44
    • 4043050174 scopus 로고    scopus 로고
    • G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    • Gao N, Flynn D, Zhang Z, et al. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol. 2004;287:C281-C291.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Gao, N.1    Flynn, D.2    Zhang, Z.3
  • 45
    • 0345166113 scopus 로고    scopus 로고
    • Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
    • Brown V, Fang J, Alcorn K, et al. Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proc Natl Acad Sci USA. 2003; 100:15113-15118.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15113-15118
    • Brown, V.1    Fang, J.2    Alcorn, K.3
  • 46
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004;23:2891-2906.
    • (2004) Oncogene , vol.23 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 47
    • 33749443714 scopus 로고    scopus 로고
    • Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    • Wei G, Twomey D, Lamb J, et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell. 2006;10:331-342.
    • (2006) Cancer Cell , vol.10 , pp. 331-342
    • Wei, G.1    Twomey, D.2    Lamb, J.3
  • 48
    • 0043173825 scopus 로고    scopus 로고
    • Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells
    • Gomez-Santos C, Ferrer I, Santidrian A, Barrachina M, Gil J, Ambrosio S. Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J Neurosci Res. 2003;73:341-350.
    • (2003) J Neurosci Res , vol.73 , pp. 341-350
    • Gomez-Santos, C.1    Ferrer, I.2    Santidrian, A.3    Barrachina, M.4    Gil, J.5    Ambrosio, S.6
  • 49
    • 33645521571 scopus 로고    scopus 로고
    • Autophagic programmed cell death by selective catalase degradation
    • Yu L, Wan F, Dutta S, et al. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A. 2006;103:4952- 4957.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4952-4957
    • Yu, L.1    Wan, F.2    Dutta, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.