Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma

Experimental Hematology

Volumn 36, Issue 4, 2008, Pages 443-450

  Yazbeck, Victor Y ^a   Buglio, Daniela ^a   Georgakis, Georgios V ^a   Li, Yang ^a   Iwado, Eiji ^a   Romaguera, Jorge E ^a   Kondo, Seiji ^a   Younes, Anas ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CASPASE 3; CYCLIN D1; HISTONE DEACETYLASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAK; PROTEIN BAX; PROTEIN P21; PROTEIN P27; PROTEIN S6; TEMSIROLIMUS; VORINOSTAT;

ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; MANTLE CELL LYMPHOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SYNERGISM; G1 PHASE; HUMANS; HYDROXAMIC ACIDS; LYMPHOMA, MANTLE-CELL; SIROLIMUS;

MAMMALIA;

EID: 40749094917     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.12.008     Document Type: Article

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