Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

European Journal of Cancer

Volumn 46, Issue 10, 2010, Pages 1900-1909

  Li, Jie ^a   Hou, Ni ^b   Faried, Ahmad ^a,c   Tsutsumi, Soichi ^a   Kuwano, Hiroyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c PADJADJARAN UNIVERSITY   (Indonesia)

Author keywords

5 FU; Apoptosis; Autophagy; Colon cancer cells

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 3 METHYLADENINE; ATG 7 PROTEIN; BETA ACTIN; CASPASE 3; FLUOROURACIL; HOE 33342; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PROTEIN; PROTEIN BCL XL; PROTEIN P62; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; AMP-ACTIVATED PROTEIN KINASE KINASE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; ATG7 PROTEIN, HUMAN; ENZYME INHIBITOR; PROTEIN KINASE; PROTEIN P53; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER ADJUVANT THERAPY; CANCER CELL CULTURE; CELL ASSAY; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAINING; TUMOR GROWTH; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; CANCER TRANSPLANTATION; COLONIC NEOPLASMS; DRUG EFFECTS; NUDE MOUSE; PHYSIOLOGY; RANDOMIZATION; TUMOR CELL LINE; XENOGRAFT;

ADENINE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG SYNERGISM; ENZYME INHIBITORS; FLUOROURACIL; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTEIN KINASES; RANDOM ALLOCATION; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-ACTIVATING ENZYMES;

EID: 77953289524     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.02.021     Document Type: Article

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