Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. © 2012 Elsevier Inc.

Cell Host and Microbe

Volumn 11, Issue 5, 2012, Pages 457-468

  Kim, Jwa Jin ^a   Lee, Hye Mi ^a   Shin, Dong Min ^a   Kim, Wonho ^b   Yuk, Jae Min ^a   Jin, Hyo Sun ^a   Lee, Sang Hee ^a,f   Cha, Guang Ho ^a   Kim, Jin Man ^a   Lee, Zee Won ^c   Shin, Sung Jae ^a,g   Yoo, Heekyung ^d   Park, Young Kil ^d   Park, Jin Bong ^a   Chung, Jongkyeong ^b   Yoshimori, Tamotsu ^e   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

^b Seoul National University   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

^d Korean Institute of Tuberculosis   (South Korea)

^e OSAKA UNIVERSITY   (Japan)

^f Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^g Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCOBACTERIAL AGENT; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; HYDROXYL RADICAL; ISONIAZID; PYRAZINAMIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; AUTOPHAGY; CELL ACTIVATION; CONTROLLED STUDY; DROSOPHILA; DRUG EFFICACY; HOST CELL; IMMUNE RESPONSE; MACROPHAGE; MITOCHONDRION; MOUSE; MUTANT; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; SURVIVAL RATE; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; AUTOPHAGY; CELLS, CULTURED; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; ISONIAZID; MACROPHAGES; MICE; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; PYRAZINAMIDE; REACTIVE OXYGEN SPECIES; SURVIVAL ANALYSIS;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 84861180818     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.03.008     Document Type: Article

References (47)

1. R.K. Amaravadi, D. Yu, J.J. Lum, T. Bui, M.A. Christophorou, G.I. Evan, A. Thomas-Tikhonenko, and C.B. Thompson Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma J. Clin. Invest. 117 2007 326 336
2. M.B. Azad, Y. Chen, and S.B. Gibson Regulation of autophagy by reactive oxygen species (ROS), implications for cancer progression and treatment Antioxid. Redox Signal. 11 2009 777 790
3. E.F. Blommaart, U. Krause, J.P. Schellens, H. Vreeling- Sindelárová, and A.J. Meijer The phosphatidylinositol 3-kinase inhibitors wortmannin, and LY294002 inhibit autophagy in isolated rat hepatocytes Eur. J. Biochem. 243 1997 240 246
4. K. Cadwell, K.K. Patel, M. Komatsu, H.W. Virgin 4th, and T.S. Stappenbeck A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease Autophagy 5 2009 250 252
5. G. Chamilos, G. Samonis, and D.P. Kontoyiannis Drosophila melanogaster as a model host for the study of microbial pathogenicity and the discovery of novel antimicrobial compounds Curr. Pharm. Des. 17 2011 1246 1253
6. V. Deretic Autophagy in infection Curr. Opin. Cell Biol. 22 2010 252 262
7. V. Deretic, E. Pagán-Ramos, Y. Zhang, S. Dhandayuthapani, and L.E. Via The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid Nat. Biotechnol. 14 1996 1557 1561
8. M.S. Dionne, N. Ghori, and D.S. Schneider Drosophila melanogaster is a genetically tractable model host for Mycobacterium marinum Infect. Immun. 71 2003 3540 3550
9. M. Fabri, S.E. Realegeno, E.K. Jo, and R.L. Modlin Role of autophagy in the host response to microbial infection and potential for therapy Curr. Opin. Immunol. 23 2011 65 70
10. M.G. Gutierrez, S.S. Master, S.B. Singh, G.A. Taylor, M.I. Colombo, and V. Deretic Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages Cell 119 2004 753 766
11. M. Hoyer-Hansen, and M. Jäättelä AMP-activated protein kinase: a universal regulator of autophagy? Autophagy 3 2007 381 383
12. M. Hoyer-Hansen, L. Bastholm, P. Szyniarowski, M. Campanella, G. Szabadkai, T. Farkas, K. Bianchi, N. Fehrenbacher, F. Elling, and R. Rizzuto Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2 Mol. Cell 25 2007 193 205
13. J. Huang, V. Canadien, G.Y. Lam, B.E. Steinberg, M.C. Dinauer, M.A. Magalhaes, M. Glogauer, S. Grinstein, and J.H. Brumell Activation of antibacterial autophagy by NADPH oxidases Proc. Natl. Acad. Sci. USA 106 2009 6226 6231
14. K.K. Huynh, and S. Grinstein Regulation of vacuolar pH and its modulation by some microbial species Microbiol. Mol. Biol. Rev. 71 2007 452 462
15. E.K. Jo Innate immunity to mycobacteria, vitamin D and autophagy Cell. Microbiol. 12 2010 1026 1035
16. G. Juhász, B. Erdi, M. Sass, and T.P. Neufeld Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila Genes Dev. 21 2007 3061 3066
17. G. Juhász, J.H. Hill, Y. Yan, M. Sass, E.H. Baehrecke, J.M. Backer, and T.P. Neufeld The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila J. Cell Biol. 19 2008 655 666
18. Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E. Kominami, Y. Ohsumi, and T. Yoshimori LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J. 19 2000 5720 5728
19. V. Kaminskyy, A. Abdi, and B. Zhivotovsky A quantitative assay for the monitoring of autophagosome accumulation in different phases of the cell cycle Autophagy 7 2011 83 90
20. M.A. Kohanski, D.J. Dwyer, B. Hayete, C.A. Lawrence, and J.J. Collins A common mechanism of cellular death induced by bactericidal antibiotics Cell 130 2007 797 810
21. M.A. Kohanski, D.J. Dwyer, J. Wierzbowski, G. Cottarel, and J.J. Collins Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death Cell 135 2008 679 690
22. H.M. Lee, D.M. Shin, J.M. Yuk, G. Shi, D.K. Choi, S.H. Lee, S.M. Huang, J.M. Kim, C.D. Kim, and J.H. Lee Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1 J. Immunol. 186 2011 1248 1258
23. B. Lemaitre, E. Nicolas, L. Michaut, J.M. Reichhart, and J.A. Hoffmann The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 1996 973 983
24. B. Levine, N. Mizushima, and H.W. Virgin Autophagy in immunity and inflammation Nature 469 2011 323 335
25. C. Lienhardt, S.V. Cook, M. Burgos, V. Yorke-Edwards, L. Rigouts, G. Anyo, S.J. Kim, A. Jindani, D.A. Enarson, A.J. Nunn Study C Trial Group Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis, the Study C randomized controlled trial JAMA 305 2011 1415 1423
26. R. Mathew, C.M. Karp, B. Beaudoin, N. Vuong, G. Chen, H.Y. Chen, K. Bray, A. Reddy, G. Bhanot, and C. Gelinas Autophagy suppresses tumorigenesis through elimination of p62 Cell 137 2009 1062 1075
27. W. McDermott, and R. Tompsett Activation of pyrazinamide and nicotinamide in acid environments in vitro Am. Rev. Tuberc. 70 1954 748 754
28. D.A. Mitchison, and J.B. Selkon The bactericidal activities of antituberculous drugs Am. Rev. Tuberc. 74 1956 109 116
29. N. Mizushima, A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, K. Suzuki, T. Tokuhisa, Y. Ohsumi, and T. Yoshimori Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells J. Cell Biol. 152 2001 657 668
30. M. Nakamura, Y. Kikukawa, M. Takeya, H. Mitsuya, and H. Hata Clarithromycin attenuates autophagy in myeloma cells Int. J. Oncol. 37 2010 815 820
31. K. Nakahira, J.A. Haspel, V.A. Rathinam, S.J. Lee, T. Dolinay, H.C. Lam, J.A. Englert, M. Rabinovitch, M. Cernadas, and H.P. Kim Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Nat. Immunol. 12 2011 222 230
32. Y. Pan, Y. Gao, L. Chen, G. Gao, H. Dong, Y. Yang, B. Dong, and X. Chen Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy Clin. Cancer Res. 17 2011 3248 3258
33. D.A. Rozwarski, G.A. Grant, D.H. Barton, W.R. Jacobs Jr., and J.C. Sacchettini Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis Science 279 1998 98 102
34. D.G. Russell, C.E. Barry 3rd, and J.L. Flynn Tuberculosis, what we don't know can, and does, hurt us Science 328 2010 852 856
35. T. Saitoh, N. Fujita, M.H. Jang, S. Uematsu, B.G. Yang, T. Satoh, H. Omori, T. Noda, N. Yamamoto, and M. Komatsu Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production Nature 456 2008 264 268
36. R. Scherz-Shouval, and Z. Elazar Regulation of autophagy by ROS, physiology and pathology Trends Biochem. Sci. 36 2011 30 38
37. R. Sharma, P. Muttil, A.B. Yadav, S.K. Rath, V.K. Bajpai, U. Mani, and A. Misra Uptake of inhalable microparticles affects defence responses of macrophages infected with Mycobacterium tuberculosis H37Ra J. Antimicrob. Chemother. 59 2007 499 506
38. D.M. Shin, J.M. Yuk, H.M. Lee, S.H. Lee, J.W. Son, C.V. Harding, J.M. Kim, R.L. Modlin, and E.K. Jo Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signaling Cell. Microbiol. 12 2010 1648 1665
39. D.M. Shin, B.Y. Jeon, H.M. Lee, H.S. Jin, J.M. Yuk, C.H. Song, S.H. Lee, Z.W. Lee, S.N. Cho, and J.M. Kim Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling PLoS Pathog. 6 2010 e1001230 10.1371/journal.ppat.1001230
40. C. Vilchèze, and W.R. Jacobs Jr. The mechanism of isoniazid killing, clarity through the scope of genetics Annu. Rev. Microbiol. 61 2007 35 50
41. A. Walubo, P.J. Smith, and P.I. Folb Oxidative stress during antituberculous therapy in young and elderly patients Biomed. Environ. Sci. 8 1995 106 113
42. A.P. West, I.E. Brodsky, C. Rahner, D.K. Woo, H. Erdjument-Bromage, P. Tempst, M.C. Walsh, Y. Choi, G.S. Shadel, and S. Ghosh TLR signalling augments macrophage bactericidal activity through mitochondrial ROS Nature 472 2011 476 480
43. World Health Organization Global Tuberculosis Control: Epidemiology, Strategy, Financing: WHO Report 2009 2009 World Health Organization Press Genova
44. T. Yoshimori, and T. Noda Toward unraveling membrane biogenesis in mammalian autophagy Curr. Opin. Cell Biol. 20 2008 401 407
45. J. Youatt A review of the action of isoniazid Am. Rev. Respir. Dis. 99 1969 729 749
46. J.M. Yuk, D.M. Shin, H.M. Lee, C.S. Yang, H.S. Jin, K.K. Kim, Z.W. Lee, S.H. Lee, J.M. Kim, and E.K. Jo Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin Cell Host Microbe 6 2009 231 243
47. Y. Zhang, and D. Mitchison The curious characteristics of pyrazinamide: a review Int. J. Tuberc. Lung Dis. 7 2003 6 21