Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

Molecular Biology of the Cell

Volumn 22, Issue 2, 2011, Pages 165-178

  Lock, Rebecca ^a   Roy, Srirupa ^a   Kenific, Candia M ^a   Su, Judy S ^b   Salas, Eduardo ^a   Ronen, Sabrina M ^b,c   Debnath, Jayanta ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; K RAS PROTEIN; PROTEIN H RAS; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; ONCOGENE; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; RNA INTERFERENCE;

ANIMALS; ANOIKIS; AUTOPHAGY; CELL ADHESION; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GLYCOLYSIS; HUMANS; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; RAS PROTEINS; RNA INTERFERENCE; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; TUMOR CELLS, CULTURED; UBIQUITIN-ACTIVATING ENZYMES;

EID: 78751511180     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-06-0500     Document Type: Article

References (34)

1. Aki T, Yamaguchi K, Fujimiya T, Mizukami Y (2003). Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 22, 8529-8535.
2. Berry DL, Baehrecke EH (2007). Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 131, 1137-1148.
3. Chen N, Debnath J (2010). Autophagy and tumorigenesis. FEBS Lett 584, 1427-1435.
4. Chiaradonna F, Sacco E, Manzoni R, Giorgio M, Vanoni M, Alberghina L (2006). Ras-dependent carbon metabolism and transformation in mouse fibroblasts. Oncogene 25, 5391-5404.
5. Dai C, Whitesell L, Rogers AB, Lindquist S (2007). Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130, 1005-1018.
6. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS (2002). The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29-40.
7. Debnath J, Muthuswamy SK, Brugge JS (2003). Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256-268.
8. Degenhardt K et al. (2006). Autophagy promotes tumor cell survival and restricts necrosis, inflammation, tumorigenesis. Cancer Cell 10, 51-64.
9. DiPaola RS et al. (2008). Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate 68, 1743-1752.
10. Fimia GM et al. (2007). Ambra1 regulates autophagy and development of the nervous system. Nature 447, 1121-1125.
11. Frisch SM, Francis H (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124, 619-626.
12. Fung C, Lock R, Gao S, Salas E, Debnath J (2008). Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 19, 797-806.
13. Furuta S, Hidaka E, Ogata A, Yokota S, Kamata T (2004). Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 23, 3898-3904.
14. Gilmore AP (2005). Anoikis. Cell Death Differ 12 (suppl 2), 1473-1477.
15. Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E (2007). Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 21, 1621-1635.
16. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J (1997). Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16, 2783-2793.
17. Komatsu M et al. (2005). Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169, 425-434.
18. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N (2004). The role of autophagy during the early neonatal starvation period. Nature 432, 1032-1036.
19. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B (1999). Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676.
20. Maiuri MC, Tasdemir E, Criollo A, Morselli E, Vicencio JM, Carnuccio R, Kroemer G (2009). Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ 16, 87-93.
21. Mathew R et al. (2009). Autophagy suppresses tumorigenesis through elimination of p62. Cell 137, 1062-1075.
22. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E (2007). Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 21, 1367-1381.
23. Ohsumi Y (2001). Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2, 211-216.
24. Onodera J, Ohsumi Y (2005). Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem 280, 31582-31586.
25. Pattingre S, Bauvy C, Codogno P (2003). Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem 278, 16667-16674.
26. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B (2005). Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939.
27. Qu X et al. (2003). Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112, 1809-1820.
28. Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D (2009). Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol 11, 320-327.
29. Sou YS et al. (2008). The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 19, 4762-4775.
30. Tsukamoto S, Kuma A, Murakami M, Kishi C, Yamamoto A, Mizushima N (2008). Autophagy is essential for preimplantation development of mouse embryos. Science 321, 117-120.
31. Tyagi RK, Azrad A, Degani H, Salomon Y (1996). Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magn Reson Med 35, 194-200.
32. Vander Heiden MG, Cantley LC, Thompson CB (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033.
33. Young AR et al. (2009). Autophagy mediates the mitotic senescence transition. Genes Dev 23, 798-803.
34. Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003). Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100, 15077-15082.