-
1
-
-
33646782954
-
p53 and disease: When the guardian angel fails
-
Royds, J. A. & Iacopetta, B. p53 and disease: when the guardian angel fails. Cell Death Differ. 13, 1017-1026 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 1017-1026
-
-
Royds, J.A.1
Iacopetta, B.2
-
2
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307-310 (2000).
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
3
-
-
0030265337
-
The p53-deficient mouse: A model for basic and applied cancer studies
-
Donehower, L. A. The p53-deficient mouse: a model for basic and applied cancer studies. Sem. Cancer Biol. 7, 269-278 (1996).
-
(1996)
Sem. Cancer Biol
, vol.7
, pp. 269-278
-
-
Donehower, L.A.1
-
4
-
-
33645117454
-
Polymorphisms in the p53 pathway
-
Pietsch, E. C., Humbey, O. & Murphey, M. E. Polymorphisms in the p53 pathway. Oncogene 25, 1602-1611 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 1602-1611
-
-
Pietsch, E.C.1
Humbey, O.2
Murphey, M.E.3
-
5
-
-
33646807491
-
Transcriptional regulation by p53: One protein, many possibilities
-
Lapenko, O. & Prives, C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13, 951-961 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 951-961
-
-
Lapenko, O.1
Prives, C.2
-
6
-
-
10744226888
-
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
-
Cawley, S. et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116, 499-509 (2004).
-
(2004)
Cell
, vol.116
, pp. 499-509
-
-
Cawley, S.1
-
7
-
-
30344478870
-
A global map of p53 transcriptionfactor binding sites in the human genome
-
Wei, C. -L. et al. A global map of p53 transcriptionfactor binding sites in the human genome. Cell 124, 207-219 (2006).
-
(2006)
Cell
, vol.124
, pp. 207-219
-
-
Wei, C.-L.1
-
8
-
-
33745149291
-
-
Matoba, S. et al. p53 regulates mitochondrial respiration. Science 312, 1650-1653 (2006). This paper provides evidence that loss of p53 might contribute to the Warburg effect.
-
Matoba, S. et al. p53 regulates mitochondrial respiration. Science 312, 1650-1653 (2006). This paper provides evidence that loss of p53 might contribute to the Warburg effect.
-
-
-
-
9
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad, K. et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120 (2006).
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
-
10
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton, D. et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 14, 121-134 (2006).
-
(2006)
Cell
, vol.14
, pp. 121-134
-
-
Crighton, D.1
-
11
-
-
33644927601
-
p53 in recombination and repair
-
Gatz, S. A. & Wiesmuller, L. p53 in recombination and repair. Cell Death Differ. 13, 1003-1016 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 1003-1016
-
-
Gatz, S.A.1
Wiesmuller, L.2
-
12
-
-
28644448262
-
Savior and slayer: The two faces of p53
-
Bensaad, K. & Vousden, K. H. Savior and slayer: the two faces of p53. Nature Med. 11, 1278-1279 (2005).
-
(2005)
Nature Med
, vol.11
, pp. 1278-1279
-
-
Bensaad, K.1
Vousden, K.H.2
-
13
-
-
33644758292
-
Control of cell migration: A tumour suppressor function for p53?
-
Roger, L., Gadea, G. & Roux, P. Control of cell migration: a tumour suppressor function for p53? Biol. Cell 98, 141-152 (2006).
-
(2006)
Biol. Cell
, vol.98
, pp. 141-152
-
-
Roger, L.1
Gadea, G.2
Roux, P.3
-
14
-
-
33746616991
-
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
-
Kortleverm, R. M., Higgins, P. J. & Bernards, R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nature Cell Biol. 8, 877-884 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 877-884
-
-
Kortleverm, R.M.1
Higgins, P.J.2
Bernards, R.3
-
15
-
-
33747619857
-
p53-mediated inhibtion of angiogenesis through upregulation of a collagen prolyl hydroxylase
-
Toeodoro, J. G., Parker, A. E., Zhu, X. & Green, M. R. p53-mediated inhibtion of angiogenesis through upregulation of a collagen prolyl hydroxylase. Science 313, 968-971 (2006).
-
(2006)
Science
, vol.313
, pp. 968-971
-
-
Toeodoro, J.G.1
Parker, A.E.2
Zhu, X.3
Green, M.R.4
-
16
-
-
33646798450
-
p53/p63/p73 isoforms: An orchestra of isoforms to harmonise cell differentiation and response to stress
-
Murray-Zmijewski, F., Lane, D. P. & Bourdon, J. C. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ. 13, 962-972 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 962-972
-
-
Murray-Zmijewski, F.1
Lane, D.P.2
Bourdon, J.C.3
-
17
-
-
29944437296
-
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
-
Wang, X. et al. p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J. Cell Biol. 172, 115-125 (2006).
-
(2006)
J. Cell Biol
, vol.172
, pp. 115-125
-
-
Wang, X.1
-
18
-
-
24644457314
-
Complicating the complexity of p53
-
Yee, K. S. & Vousden, K. H. Complicating the complexity of p53. Carcinogenesis 26, 1317-1322 (2005).
-
(2005)
Carcinogenesis
, vol.26
, pp. 1317-1322
-
-
Yee, K.S.1
Vousden, K.H.2
-
19
-
-
27544486327
-
Transcription-independent pro-apoptotic functions of p53
-
Moll, U. M., Wolff, S., Speidel, D. & Deppert, W. Transcription-independent pro-apoptotic functions of p53. Curr. Opin. Cell Biol. 17, 631-636 (2005).
-
(2005)
Curr. Opin. Cell Biol
, vol.17
, pp. 631-636
-
-
Moll, U.M.1
Wolff, S.2
Speidel, D.3
Deppert, W.4
-
20
-
-
0142227023
-
No PUMA, no death: Implications for p53-dependent apoptosis
-
Yu, J. & Zhang, L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell 4, 248-249 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 248-249
-
-
Yu, J.1
Zhang, L.2
-
21
-
-
33747620737
-
Small-molecule inhibitor of p53 binding to mitochondria protects mice from γ radiation
-
Strom, E. et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from γ radiation. Nature Chem. Biol. 2, 474-479 (2006).
-
(2006)
Nature Chem. Biol
, vol.2
, pp. 474-479
-
-
Strom, E.1
-
22
-
-
24644436766
-
-
Chipuk, J. E., Bouchier-Hayes, L., Kuwana, T., Newmeyer, D. D. & Green, D. R. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309, 1732-1735 (2005). An elegant study that consolidates the transcriptionally dependent and independent activities of p53 into a single model.
-
Chipuk, J. E., Bouchier-Hayes, L., Kuwana, T., Newmeyer, D. D. & Green, D. R. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309, 1732-1735 (2005). An elegant study that consolidates the transcriptionally dependent and independent activities of p53 into a single model.
-
-
-
-
23
-
-
33646807832
-
The p53 pathway: What questions remain to be explored?
-
Levine, A. J., Hu, W. & Feng, Z. The p53 pathway: what questions remain to be explored? Cell Death Differ. 13, 1027-1036 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 1027-1036
-
-
Levine, A.J.1
Hu, W.2
Feng, Z.3
-
24
-
-
31544457877
-
p53 ubiquitination: Mdm2 and beyond
-
Brooks, C. L. & Gu, W. p53 ubiquitination: Mdm2 and beyond. Mol. Cell 21, 307-315 (2006).
-
(2006)
Mol. Cell
, vol.21
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
25
-
-
33646817444
-
Some p53-binding proteins that can function as arbiters of life and death
-
Braithwaite, A. W., Del Sal, G. & Lu, X. Some p53-binding proteins that can function as arbiters of life and death. Cell Death Differ. 13, 984-993 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 984-993
-
-
Braithwaite, A.W.1
Del Sal, G.2
Lu, X.3
-
26
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris, S. L. & Levine, A. J. The p53 pathway: positive and negative feedback loops. Oncogene 24, 2899-2908 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
27
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
Marine, J. C. et al. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 13, 927-934 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
-
28
-
-
0033694317
-
Guardian ancestry: Fly p53 and damage-inducible apoptosis
-
Nordstrom, W. & Abrams, J. M. Guardian ancestry: fly p53 and damage-inducible apoptosis. Cell Death Differ. 7, 1035-1038 (2000).
-
(2000)
Cell Death Differ
, vol.7
, pp. 1035-1038
-
-
Nordstrom, W.1
Abrams, J.M.2
-
29
-
-
0035913975
-
Caenorhabditis elegans p53: Role in apoptosis, meiosis and stress resistance
-
Derry, W. B., Putzke, A. P. & Rothman, J. H. Caenorhabditis elegans p53: role in apoptosis, meiosis and stress resistance. Science 294, 591-595 (2001).
-
(2001)
Science
, vol.294
, pp. 591-595
-
-
Derry, W.B.1
Putzke, A.P.2
Rothman, J.H.3
-
30
-
-
0035975986
-
-
Schumacher, B., Hofmann, K., Boulton, S. & Gartner, A. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr. Biol. 11, 1722-1727 (2001).
-
Schumacher, B., Hofmann, K., Boulton, S. & Gartner, A. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr. Biol. 11, 1722-1727 (2001).
-
-
-
-
31
-
-
0033562997
-
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
-
Kamijo, T. et al. Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer Res. 59, 2464-2469 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 2464-2469
-
-
Kamijo, T.1
-
32
-
-
0038724615
-
Regulation of HDM2 activity by the ribosomal protein L11
-
Lohrum, M. A., Ludwig, R. L., Kubbutat, M. H. G., Hanlon, M. & Vousden, K. H. Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell 3, 577-587 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 577-587
-
-
Lohrum, M.A.1
Ludwig, R.L.2
Kubbutat, M.H.G.3
Hanlon, M.4
Vousden, K.H.5
-
33
-
-
33748670457
-
The pathological p53-mediated response to DNA damage is distinct from p53-mediated tumor suppression
-
Christophorou, M. A., Ringhausen, I., Finch, A. J., Brown Swigart, L. & Evan, G. I. The pathological p53-mediated response to DNA damage is distinct from p53-mediated tumor suppression. Nature 14, 214-217 (2006).
-
(2006)
Nature
, vol.14
, pp. 214-217
-
-
Christophorou, M.A.1
Ringhausen, I.2
Finch, A.J.3
Brown Swigart, L.4
Evan, G.I.5
-
34
-
-
33748674375
-
-
Efeyan, A., Garcia-Cao, I., Herranz, D., Velasco-Miguel, S. & Serrano, M. Policing of oncogene activity by p53. Nature 443, 159 (2006). References 33 and 34 suggest that the response to oncogene activation, but not to DNA damage, is crucial for p53-mediated tumour suppression.
-
Efeyan, A., Garcia-Cao, I., Herranz, D., Velasco-Miguel, S. & Serrano, M. Policing of oncogene activity by p53. Nature 443, 159 (2006). References 33 and 34 suggest that the response to oncogene activation, but not to DNA damage, is crucial for p53-mediated tumour suppression.
-
-
-
-
35
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigensis
-
Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigensis. Nature 434, 864-870 (2005).
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
-
36
-
-
17244366865
-
-
Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (2005). Two studies that, in contrast to 33 and 34, show the importance of the DNA-damage signal to tumour suppression.
-
Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (2005). Two studies that, in contrast to 33 and 34, show the importance of the DNA-damage signal to tumour suppression.
-
-
-
-
37
-
-
0029814061
-
Anti-apoptotic activity of low levels of wild type p53
-
Lassus, P., Ferlin, M., Piette, J. & Hibner, U. Anti-apoptotic activity of low levels of wild type p53. EMBO J. 15, 4566-4573 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 4566-4573
-
-
Lassus, P.1
Ferlin, M.2
Piette, J.3
Hibner, U.4
-
38
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
Jones, R. G. et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18, 283-293 (2005).
-
(2005)
Mol. Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
-
39
-
-
33751009381
-
Regulation of AIF expression by p53
-
Stambolsky, P. et al. Regulation of AIF expression by p53. Cell Death Differ. 13, 2140-2149 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 2140-2149
-
-
Stambolsky, P.1
-
40
-
-
0029958381
-
Reactive oxygen species are downstream mediators of p53-dependent apoptosis
-
Johnson, T. M., Yu, Z.-X., Ferrans, V. J., Lowenstein, R. A. & Finkel, T. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl Acad. Sci. USA 93, 11848-11852 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 11848-11852
-
-
Johnson, T.M.1
Yu, Z.-X.2
Ferrans, V.J.3
Lowenstein, R.A.4
Finkel, T.5
-
41
-
-
0030930366
-
A model for p53-induced apoptosis
-
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W. & Vogelstein, B. A model for p53-induced apoptosis. Nature 389, 300-305 (1997).
-
(1997)
Nature
, vol.389
, pp. 300-305
-
-
Polyak, K.1
Xia, Y.2
Zweier, J.L.3
Kinzler, K.W.4
Vogelstein, B.5
-
42
-
-
0033531264
-
PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
-
Velasco-Miguel, S. et al. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. Oncogene 18, 127-137 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 127-137
-
-
Velasco-Miguel, S.1
-
43
-
-
2142815107
-
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
-
Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V. & Chumakov, P. M. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304, 596-600 (2004).
-
(2004)
Science
, vol.304
, pp. 596-600
-
-
Budanov, A.V.1
Sablina, A.A.2
Feinstein, E.3
Koonin, E.V.4
Chumakov, P.M.5
-
44
-
-
1942520427
-
Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses
-
Yoon, K. A., Nakamura, Y. & Arakawa, H. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J. Hum. Genet. 49, 134-140 (2004).
-
(2004)
J. Hum. Genet
, vol.49
, pp. 134-140
-
-
Yoon, K.A.1
Nakamura, Y.2
Arakawa, H.3
-
45
-
-
11144333835
-
Global investigation of p53-induced apoptosis through quantitative proteomic profiling using comparative amino acid-coded tagging
-
Gu, S. et al. Global investigation of p53-induced apoptosis through quantitative proteomic profiling using comparative amino acid-coded tagging. Mol. Cell. Proteomics 3, 998-1008 (2006).
-
(2006)
Mol. Cell. Proteomics
, vol.3
, pp. 998-1008
-
-
Gu, S.1
-
46
-
-
28644447272
-
-
Sablina, A. A. et al. The antioxidant function of the p53 tumor suppressor gene. Nature Med. 11, 1306-1313 (2005). A demonstration of the antioxidant activity of basal levels of p53.
-
Sablina, A. A. et al. The antioxidant function of the p53 tumor suppressor gene. Nature Med. 11, 1306-1313 (2005). A demonstration of the antioxidant activity of basal levels of p53.
-
-
-
-
47
-
-
3042601281
-
Suppression of tumorigenesis by the p53 target PUMA
-
Hemann, M. T. et al. Suppression of tumorigenesis by the p53 target PUMA. Proc. Natl Acad. Sci. USA 101, 9333-9338 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 9333-9338
-
-
Hemann, M.T.1
-
48
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307-315 (2004).
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
49
-
-
0346455759
-
Chromosomal stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
-
Liu, G. et al. Chromosomal stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nature Genet. 36, 63-68 (2004).
-
(2004)
Nature Genet
, vol.36
, pp. 63-68
-
-
Liu, G.1
-
50
-
-
20444370974
-
What has senescence got to do with cancer?
-
Dimri, G. P. What has senescence got to do with cancer? Cancer Cell 7, 505-512 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 505-512
-
-
Dimri, G.P.1
-
52
-
-
17444390129
-
Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
-
Flores, E. R. et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 7, 363-373 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 363-373
-
-
Flores, E.R.1
-
53
-
-
2542431130
-
Of flies and men; p53, a tumour suppressor
-
Sutcliffe, J. E. & Brehm, A. Of flies and men; p53, a tumour suppressor. FEBS Lett. 567, 86-91 (2004).
-
(2004)
FEBS Lett
, vol.567
, pp. 86-91
-
-
Sutcliffe, J.E.1
Brehm, A.2
-
54
-
-
24944495794
-
-
Mills, A. A. p53: link to the past, bridge to the future. Genes Dev. 19, 2091-2099 (2005).
-
Mills, A. A. p53: link to the past, bridge to the future. Genes Dev. 19, 2091-2099 (2005).
-
-
-
-
55
-
-
0033027549
-
p53 in embryonic development: Maintaining a fine balance
-
Chio, J. & Donehower, L. A. p53 in embryonic development: maintaining a fine balance. CMLS Cell. Mol. Life Sci. 55, 38-47 (1999).
-
(1999)
CMLS Cell. Mol. Life Sci
, vol.55
, pp. 38-47
-
-
Chio, J.1
Donehower, L.A.2
-
56
-
-
0029347164
-
High-frequency developmental abnormalities in p53-deficient mice
-
Armstrong, J. F., Kaufman, M. H., Harrison, D. J. & Clarke, A. R. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol. 5, 931-936 (1995).
-
(1995)
Curr. Biol
, vol.5
, pp. 931-936
-
-
Armstrong, J.F.1
Kaufman, M.H.2
Harrison, D.J.3
Clarke, A.R.4
-
57
-
-
0029007405
-
A subset of p53-deficient embyos exhibit exencephaly
-
Sah, V. P. et al. A subset of p53-deficient embyos exhibit exencephaly. Nature Genet. 10, 175-180 (1995).
-
(1995)
Nature Genet
, vol.10
, pp. 175-180
-
-
Sah, V.P.1
-
58
-
-
0030951637
-
Tumor suppressors: A developing role for p53?
-
Hall, P. A. & Lane, D. P. Tumor suppressors: a developing role for p53? Curr. Biol. 7, R144-R147 (1997).
-
(1997)
Curr. Biol
, vol.7
-
-
Hall, P.A.1
Lane, D.P.2
-
59
-
-
0035988722
-
Developmental abnormalities induced by X-irradiation in p53 deficient mice
-
Baatout, S. et al. Developmental abnormalities induced by X-irradiation in p53 deficient mice. In Vivo. 16, 215-221 (2002).
-
(2002)
In Vivo
, vol.16
, pp. 215-221
-
-
Baatout, S.1
-
60
-
-
33744959048
-
Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system
-
Azuma, M., Toyama, R., Laver, E. & Dawid, I. B. Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system. J. Biol. Chem. 281, 13309-13316 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 13309-13316
-
-
Azuma, M.1
Toyama, R.2
Laver, E.3
Dawid, I.B.4
-
61
-
-
30844447720
-
p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase δ1
-
Plaster, N., Sonntag, C., Busse, C. E. & Hammerschmidt, M. p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase δ1. Cell Death Differ. 13, 223-235 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 223-235
-
-
Plaster, N.1
Sonntag, C.2
Busse, C.E.3
Hammerschmidt, M.4
-
62
-
-
28444434535
-
Loss of function of def selectively upregulates ?113p53 expression to arrest expansion growth of digestive organs in zebrafish
-
Chen, J. et al. Loss of function of def selectively upregulates ?113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev. 19, 2900-2911 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2900-2911
-
-
Chen, J.1
-
63
-
-
33645101015
-
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss
-
Campbell, W. A. et al. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J. Neurochem. 96, 1423-1440 (2006).
-
(2006)
J. Neurochem
, vol.96
, pp. 1423-1440
-
-
Campbell, W.A.1
-
64
-
-
0029006469
-
A teratologic suppressor role for p53 in benzo(a)pyrene-treated transgenic p53-deficient mice
-
Nicol, C. J., Harrison, M. L., Laposa, R. R., Gimelshtein, I. L. & Well, P. G. A teratologic suppressor role for p53 in benzo(a)pyrene-treated transgenic p53-deficient mice. Nature Genet. 10, 181-187 (1995).
-
(1995)
Nature Genet
, vol.10
, pp. 181-187
-
-
Nicol, C.J.1
Harrison, M.L.2
Laposa, R.R.3
Gimelshtein, I.L.4
Well, P.G.5
-
65
-
-
0029874308
-
p53-dependent apoptosis suppresses radiation-induced teratogenesis
-
Norimura, T., Nomoto, S., Katsuki, M., Gondo, Y. & Kondo, S. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nature Med. 2, 577-580 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 577-580
-
-
Norimura, T.1
Nomoto, S.2
Katsuki, M.3
Gondo, Y.4
Kondo, S.5
-
66
-
-
0037222381
-
Germline TP53 mutations and Li-Fraumeni syndrome
-
Varley, J. M. Germline TP53 mutations and Li-Fraumeni syndrome. Hum. Mutat. 21, 313-320 (2003).
-
(2003)
Hum. Mutat
, vol.21
, pp. 313-320
-
-
Varley, J.M.1
-
67
-
-
33746901108
-
Blocking the path to death: Anti-apoptotic molecules in ischemia/reperfusion injury of the liver
-
Georgiev, P., Dahm, F., Graf, R. & Clavien, P. A. Blocking the path to death: anti-apoptotic molecules in ischemia/reperfusion injury of the liver. Curr. Pharm. Des. 12, 2911-2921 (2006).
-
(2006)
Curr. Pharm. Des
, vol.12
, pp. 2911-2921
-
-
Georgiev, P.1
Dahm, F.2
Graf, R.3
Clavien, P.A.4
-
68
-
-
10244264754
-
Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress
-
Fiskum, G. et al. Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J. Bioenerg. Biomembr. 36, 347-352 (2004).
-
(2004)
J. Bioenerg. Biomembr
, vol.36
, pp. 347-352
-
-
Fiskum, G.1
-
69
-
-
3242752773
-
-
Dagher, P. C. Apoptosis in ischemic renal injury: roles of GTP depletion and p53. Kidney Int. 66, 506-509 (2004).
-
Dagher, P. C. Apoptosis in ischemic renal injury: roles of GTP depletion and p53. Kidney Int. 66, 506-509 (2004).
-
-
-
-
70
-
-
33646514473
-
Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice
-
Matsusaka, H. et al. Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice. Cardiovasc. Res. 70, 457-465 (2006).
-
(2006)
Cardiovasc. Res
, vol.70
, pp. 457-465
-
-
Matsusaka, H.1
-
71
-
-
33745016466
-
The p53 family in nervous system development and disease
-
Jacobs, W. B., Kaplan, D. R. & Miller, F. D. The p53 family in nervous system development and disease. J. Neurochem. 97, 1571-1584 (2006).
-
(2006)
J. Neurochem
, vol.97
, pp. 1571-1584
-
-
Jacobs, W.B.1
Kaplan, D.R.2
Miller, F.D.3
-
72
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner, S. D. et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53 (2002).
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
-
73
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier, B. et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18, 306-319 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
-
74
-
-
12344273381
-
Variation in the human TP53 gene affects old age survival and cancer mortality
-
van Heemst, D. et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40, 11-15 (2005).
-
(2005)
Exp. Gerontol
, vol.40
, pp. 11-15
-
-
van Heemst, D.1
-
75
-
-
85047689866
-
Telomeres, stem cells, senescence, and cancer
-
Sharpless, N. E. & DePinho, R. A. Telomeres, stem cells, senescence, and cancer. J. Clin. Invest. 113, 160-168 (2004).
-
(2004)
J. Clin. Invest
, vol.113
, pp. 160-168
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
76
-
-
27844596799
-
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
-
Bauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M. & Helfand, S. L. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15, 2063-2068 (2005).
-
(2005)
Curr. Biol
, vol.15
, pp. 2063-2068
-
-
Bauer, J.H.1
Poon, P.C.2
Glatt-Deeley, H.3
Abrams, J.M.4
Helfand, S.L.5
-
77
-
-
33748328032
-
New tricks of an old molecule: Lifespan regulation by p53
-
Bauer, J. H. & Helfand, S. L. New tricks of an old molecule: lifespan regulation by p53. Aging Cell 5, 437-440 (2006).
-
(2006)
Aging Cell
, vol.5
, pp. 437-440
-
-
Bauer, J.H.1
Helfand, S.L.2
-
78
-
-
24344448786
-
p53 isoforms can regulate p53 transcriptional activity
-
Bourdon, J. C. et al. p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19, 2122-2137 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2122-2137
-
-
Bourdon, J.C.1
-
79
-
-
11244347171
-
Glycolytic enzymes can modulate cellular lifespan
-
Kondoh, H. et al. Glycolytic enzymes can modulate cellular lifespan. Cancer Res. 65, 177-185 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
-
80
-
-
0037112844
-
Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao, I. et al. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21, 6225-6235 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
-
81
-
-
29944447632
-
-
Mendrysa, S. M. et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev. 20, 16-21 (2006). References 80 and 81 show that increasing the copy number of p53 while maintaining normal control over expression does not result in enhanced ageing.
-
Mendrysa, S. M. et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev. 20, 16-21 (2006). References 80 and 81 show that increasing the copy number of p53 while maintaining normal control over expression does not result in enhanced ageing.
-
-
-
-
82
-
-
33645711615
-
Tumor suppression by p53 without acceletated aging: Just enough of a good thing?
-
Mendrysa, S. M. & Perry, M. E. Tumor suppression by p53 without acceletated aging: just enough of a good thing? Cell Cycle 5, 714-717 (2006).
-
(2006)
Cell Cycle
, vol.5
, pp. 714-717
-
-
Mendrysa, S.M.1
Perry, M.E.2
-
83
-
-
30944435091
-
Unleashing the power of p53: Lessons from mice and men
-
Poyurovsky, M. V. & Prives, C. Unleashing the power of p53: lessons from mice and men. Genes Dev. 20, 125-131 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 125-131
-
-
Poyurovsky, M.V.1
Prives, C.2
-
84
-
-
33747176844
-
Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity
-
Wells, B. S., Yoshida, E. & Johnston, L. A. Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16, 1606-1615 (2006).
-
(2006)
Curr. Biol
, vol.16
, pp. 1606-1615
-
-
Wells, B.S.1
Yoshida, E.2
Johnston, L.A.3
-
85
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden, K. H. & Lu, X. Live or let die: the cell's response to p53. Nature Rev. Cancer 2, 594-604 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
86
-
-
22844445705
-
Temporal diffection of p53 function in vitro and in vivo
-
Christophorou, M. A. et al. Temporal diffection of p53 function in vitro and in vivo. Nature Genet. 37, 718-726 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 718-726
-
-
Christophorou, M.A.1
-
87
-
-
18144367783
-
p53 mutation heterogeneity in cancer
-
Soussi, T. & Lozano, G. p53 mutation heterogeneity in cancer. Biochem. Biophys. Res. Com. 331, 834-842 (2005).
-
(2005)
Biochem. Biophys. Res. Com
, vol.331
, pp. 834-842
-
-
Soussi, T.1
Lozano, G.2
-
88
-
-
13644260907
-
Gain-of-function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang, G. A. et al. Gain-of-function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119, 861-872 (2004).
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
-
89
-
-
10944236962
-
-
Olive, K. P. et al. Mutant p53 gain-of-function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (2004). Two sophisticated studies showing the effects of expression of mutant p53 in mouse models.
-
Olive, K. P. et al. Mutant p53 gain-of-function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (2004). Two sophisticated studies showing the effects of expression of mutant p53 in mouse models.
-
-
-
-
90
-
-
4344639696
-
Family feud in chemosensitivity: P73 and mutant p53
-
Irwin, M. S. Family feud in chemosensitivity: p73 and mutant p53. Cell Cycle 3, 319-323 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 319-323
-
-
Irwin, M.S.1
-
91
-
-
0034671945
-
Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
-
Sigal, A. & Rotter, V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res. 60, 6788-6793 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 6788-6793
-
-
Sigal, A.1
Rotter, V.2
-
92
-
-
22744458985
-
Transcriptional activities of mutant p53: When mutations are more than a loss
-
Kim, E. & Deppert, W. Transcriptional activities of mutant p53: when mutations are more than a loss. J. Cell Biochem. 93, 878-886 (2004).
-
(2004)
J. Cell Biochem
, vol.93
, pp. 878-886
-
-
Kim, E.1
Deppert, W.2
-
93
-
-
8844278362
-
A single nucleotide polymorphism in the Mdm2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
-
Bond, G. L. et al. A single nucleotide polymorphism in the Mdm2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 119, 591-602 (2004).
-
(2004)
Cell
, vol.119
, pp. 591-602
-
-
Bond, G.L.1
-
94
-
-
10744221485
-
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecular antagonists of MDM2. Science 303, 844-848 (2004). One of a number of studies describing smallmolecule activators of p53.
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecular antagonists of MDM2. Science 303, 844-848 (2004). One of a number of studies describing smallmolecule activators of p53.
-
-
-
-
95
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva, N. et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nature Med. 10, 1321-1328 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
-
96
-
-
20444369867
-
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang, Y. et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7, 547-559 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
-
97
-
-
0033543728
-
-
Komarov, P. G. et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999). The description of a small-molecule inhibitor of p53
-
Komarov, P. G. et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999). The description of a small-molecule inhibitor of p53
-
-
-
-
98
-
-
0032544268
-
Apoptotic pathways: The roads to ruin
-
Green, D. R. Apoptotic pathways: the roads to ruin. Cell 94, 695-698 (1998).
-
(1998)
Cell
, vol.94
, pp. 695-698
-
-
Green, D.R.1
-
99
-
-
0842281645
-
-
Danial, N. N. & Korsmeyer, S. J. Cell death: critical control points. Cell 116, 205-219 (2004).
-
Danial, N. N. & Korsmeyer, S. J. Cell death: critical control points. Cell 116, 205-219 (2004).
-
-
-
-
100
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory, S. & Adams, J. M. The Bcl2 family: regulators of the cellular life-or-death switch. Nature Rev. Cancer 2, 647-656 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
101
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and-independent apoptotic pathways
-
Jeffers, J. R. et al. Puma is an essential mediator of p53-dependent and-independent apoptotic pathways. Cancer Cell 4, 321-328 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
-
102
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa
-
Villunger, A. et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa. Science 302, 1036-1038 (2003).
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
-
103
-
-
24644438102
-
p53 and PUMA: A deadly duo
-
Vousden, K. H. p53 and PUMA: a deadly duo. Science 309, 1685-1686 (2005).
-
(2005)
Science
, vol.309
, pp. 1685-1686
-
-
Vousden, K.H.1
-
104
-
-
33747126523
-
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design
-
Parks, D. J. et al. Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design. Bioog. Med. Chem. Lett. 16, 3310-3314 (2006).
-
(2006)
Bioog. Med. Chem. Lett
, vol.16
, pp. 3310-3314
-
-
Parks, D.J.1
-
105
-
-
22944473048
-
Structure-based design of potent non-peptide MDM2 inhibitors
-
Ding, K. et al. Structure-based design of potent non-peptide MDM2 inhibitors. J. Am. Chem. Soc. 127, 10130-10131 (2005).
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 10130-10131
-
-
Ding, K.1
-
106
-
-
18744406282
-
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
-
Lai, Z. et al. Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc. Natl Acad. Sci. USA 99, 14734-14739 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 14734-14739
-
-
Lai, Z.1
-
107
-
-
0033601370
-
Pharmacological rescue of mutant p53 conformation and function
-
Foster, B. A., Coffey, H. A., Morin, M. J. & Rastinejad, F. Pharmacological rescue of mutant p53 conformation and function. Science 286, 2507-2510 (1999).
-
(1999)
Science
, vol.286
, pp. 2507-2510
-
-
Foster, B.A.1
Coffey, H.A.2
Morin, M.J.3
Rastinejad, F.4
-
108
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov, V. J. N. et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nature Med. 8, 282-288 (2002).
-
(2002)
Nature Med
, vol.8
, pp. 282-288
-
-
Bykov, V.J.N.1
-
109
-
-
18144428775
-
Prospective therapeutic applications of p53 inhibitors
-
Gudkov, A. V. & Komarova, E. A. Prospective therapeutic applications of p53 inhibitors. Biochem. Biophys. Res. Com. 331, 726-736 (2005).
-
(2005)
Biochem. Biophys. Res. Com
, vol.331
, pp. 726-736
-
-
Gudkov, A.V.1
Komarova, E.A.2
|