메뉴 건너뛰기




Volumn 27, Issue 5-6, 2006, Pages 455-470

The involvement of macroautophagy in aging and anti-aging interventions

Author keywords

Aging; Anti aging interventions; Anti lipolytic drug; Caloric restriction; IGF1; Insulin; Mitochondria; MTOR; Protein; Proteolysis

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANTIDIABETIC AGENT; ANTILIPOLYTIC DRUG; CARBOHYDRATE; DOLICHOL; FREE RADICAL; GLUCOSE; INSULIN; MITOCHONDRIAL DNA; OXYGEN; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 33749048512     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2006.08.003     Document Type: Review
Times cited : (40)

References (113)
  • 1
    • 33749078199 scopus 로고    scopus 로고
    • Abeliovich, H., 2003. Regulation of autophagy by the target of rapamycin (TOR) proteins. In: Autophagy, Landes Bioscience, Georgetown, TX, USA, pp. 60-69.
  • 2
    • 0032579227 scopus 로고    scopus 로고
    • Protein oxidation and enzyme activity decline in old brown norway rats are reduced by dietary restriction
    • Aksenova M.V., Aksenov M.Y., Carney J.M., and Butterfield D.A. Protein oxidation and enzyme activity decline in old brown norway rats are reduced by dietary restriction. Mech. Ageing Dev. 100 2 (1998) 157-168
    • (1998) Mech. Ageing Dev. , vol.100 , Issue.2 , pp. 157-168
    • Aksenova, M.V.1    Aksenov, M.Y.2    Carney, J.M.3    Butterfield, D.A.4
  • 4
    • 0036829433 scopus 로고    scopus 로고
    • Rate of generation of oxidative stress-related damage and animal longevity
    • Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic. Biol. Med. 33 9 (2002) 1167-1172
    • (2002) Free Radic. Biol. Med. , vol.33 , Issue.9 , pp. 1167-1172
    • Barja, G.1
  • 5
    • 0035430138 scopus 로고    scopus 로고
    • Mutations prolong life in flies; implications for aging in mammals
    • Bartke A. Mutations prolong life in flies; implications for aging in mammals. Trends Endocrinol. Metab. 12 6 (2001) 233-234
    • (2001) Trends Endocrinol. Metab. , vol.12 , Issue.6 , pp. 233-234
    • Bartke, A.1
  • 7
    • 0029595360 scopus 로고
    • Towards an understanding of the biological mechanism of dietary restriction: a signal transduction theory of aging
    • Bergamini E., and Gori Z. Towards an understanding of the biological mechanism of dietary restriction: a signal transduction theory of aging. Aging Clin. Exp. Res. 7 (1995) 473-475
    • (1995) Aging Clin. Exp. Res. , vol.7 , pp. 473-475
    • Bergamini, E.1    Gori, Z.2
  • 8
    • 0001381445 scopus 로고
    • Exploring the age-related changes in the hormone-regulated protein breakdown by the use of a physiologic model of stimulation of liver autophagy
    • Segal H.L., Rothstein M., and Bergamini E. (Eds), Wiley-Liss Inc.
    • Bergamini E., and Kovacs J. Exploring the age-related changes in the hormone-regulated protein breakdown by the use of a physiologic model of stimulation of liver autophagy. In: Segal H.L., Rothstein M., and Bergamini E. (Eds). Protein Metabolism in Aging (1990), Wiley-Liss Inc. 361-370
    • (1990) Protein Metabolism in Aging , pp. 361-370
    • Bergamini, E.1    Kovacs, J.2
  • 9
    • 0027170556 scopus 로고
    • A new method for the investigation of endocrine-regulated autophagy and protein degradation in rat liver
    • Bergamini E., Del Roso A., Fierabracci V., Gori Z., Masiello P., Masini M., and Pollera M. A new method for the investigation of endocrine-regulated autophagy and protein degradation in rat liver. Exp. Mol. Pathol. 59 1 (1993) 13-26
    • (1993) Exp. Mol. Pathol. , vol.59 , Issue.1 , pp. 13-26
    • Bergamini, E.1    Del Roso, A.2    Fierabracci, V.3    Gori, Z.4    Masiello, P.5    Masini, M.6    Pollera, M.7
  • 10
    • 4344660368 scopus 로고    scopus 로고
    • The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
    • Bergamini E., Cavallini G., Donati A., and Gori Z. The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int. J. Biochem. Cell Biol. 36 (2004) 2392-2404
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 2392-2404
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 12
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M., Kahn B.B., and Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 5606 (2003) 572-574
    • (2003) Science , vol.299 , Issue.5606 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 13
    • 33646731782 scopus 로고    scopus 로고
    • Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
    • Bonkowski M.S., Rocha J.S., Masternak M.M., Al Regaiey K.A., and Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. USA 103 20 (2006) 7901-7905
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.20 , pp. 7901-7905
    • Bonkowski, M.S.1    Rocha, J.S.2    Masternak, M.M.3    Al Regaiey, K.A.4    Bartke, A.5
  • 14
  • 16
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    • Brunk U.T., and Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur. J. Biochem. 269 8 (2002) 1996-2002
    • (2002) Eur. J. Biochem. , vol.269 , Issue.8 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2
  • 17
    • 0035098277 scopus 로고    scopus 로고
    • The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction
    • Cavallini G., Donati A., Gori Z., Pollera M., and Bergamini E. The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction. Exp. Gerontol. 36 (2001) 497-506
    • (2001) Exp. Gerontol. , vol.36 , pp. 497-506
    • Cavallini, G.1    Donati, A.2    Gori, Z.3    Pollera, M.4    Bergamini, E.5
  • 20
    • 0022339852 scopus 로고
    • Hypothesis. Glucose as a mediator of aging
    • Cerami A. Hypothesis. Glucose as a mediator of aging. J. Am. Geriatr. Soc. 33 9 (1985) 626-634
    • (1985) J. Am. Geriatr. Soc. , vol.33 , Issue.9 , pp. 626-634
    • Cerami, A.1
  • 21
    • 0033980885 scopus 로고    scopus 로고
    • Oxidative stress and glycemic regulation
    • Ceriello A. Oxidative stress and glycemic regulation. Metabolism 49 2 Suppl. 1 (2000) 27-29
    • (2000) Metabolism , vol.49 , Issue.2 SUPPL. 1 , pp. 27-29
    • Ceriello, A.1
  • 23
    • 0001944263 scopus 로고    scopus 로고
    • How do intracellular proteolytic systems change with age?
    • Cuervo A.M., and Dice J.F. How do intracellular proteolytic systems change with age?. Front. Biosci. 3 (1998) d25-d43
    • (1998) Front. Biosci. , vol.3
    • Cuervo, A.M.1    Dice, J.F.2
  • 26
    • 0037031843 scopus 로고    scopus 로고
    • The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana
    • Doelling J.H., Walker J.M., Friedman E.M., Thompson A.R., and Vierstra R.D. The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana. J. Biol. Chem. 277 36 (2002) 33105-33114
    • (2002) J. Biol. Chem. , vol.277 , Issue.36 , pp. 33105-33114
    • Doelling, J.H.1    Walker, J.M.2    Friedman, E.M.3    Thompson, A.R.4    Vierstra, R.D.5
  • 31
    • 33746704943 scopus 로고    scopus 로고
    • Donati, A., Taddei, M., Cavallini, G., Bergamini, E., 2006. Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda. Rejuvenation Res., in press.
  • 32
    • 0842270038 scopus 로고    scopus 로고
    • Oxidative stress and aging
    • Droge W. Oxidative stress and aging. Adv. Exp. Med. Biol. 543 (2003) 191-200
    • (2003) Adv. Exp. Med. Biol. , vol.543 , pp. 191-200
    • Droge, W.1
  • 33
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K., Papaconstantinou J., Miller R.A., and Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98 12 (2001) 6736-6741
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.12 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 34
    • 0035986633 scopus 로고    scopus 로고
    • Oxidative stress in mice is dependent on the free glucose content of the diet
    • Folmer V., Soares J.C., and Rocha J.B. Oxidative stress in mice is dependent on the free glucose content of the diet. Int. J. Biochem. Cell Biol. 34 10 (2002) 1279-1285
    • (2002) Int. J. Biochem. Cell Biol. , vol.34 , Issue.10 , pp. 1279-1285
    • Folmer, V.1    Soares, J.C.2    Rocha, J.B.3
  • 35
    • 0344874551 scopus 로고    scopus 로고
    • Emerging role for autophagy in the removal of aggresomes in Schwann cells
    • Fortun J., Dunn Jr. W.A., Joy S., Li J., and Notterpek L. Emerging role for autophagy in the removal of aggresomes in Schwann cells. J. Neurosci. 23 33 (2003) 10672-10680
    • (2003) J. Neurosci. , vol.23 , Issue.33 , pp. 10672-10680
    • Fortun, J.1    Dunn Jr., W.A.2    Joy, S.3    Li, J.4    Notterpek, L.5
  • 36
    • 0034571026 scopus 로고    scopus 로고
    • Oxidative stress, aging and the proteasomal system
    • Grune T. Oxidative stress, aging and the proteasomal system. Biogerontology 1 1 (2000) 31-40
    • (2000) Biogerontology , vol.1 , Issue.1 , pp. 31-40
    • Grune, T.1
  • 37
    • 8844239959 scopus 로고    scopus 로고
    • Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis
    • Gu Y., Wang C., and Cohen A. Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis. FEBS Lett. 577 3 (2004) 357-360
    • (2004) FEBS Lett. , vol.577 , Issue.3 , pp. 357-360
    • Gu, Y.1    Wang, C.2    Cohen, A.3
  • 38
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 3 (1956) 298-300
    • (1956) J. Gerontol. , vol.11 , Issue.3 , pp. 298-300
    • Harman, D.1
  • 42
    • 0036233808 scopus 로고    scopus 로고
    • Oxidative stress and life span determination in the nematode Caenorhabditis elegans
    • Honda Y., and Honda S. Oxidative stress and life span determination in the nematode Caenorhabditis elegans. Ann N.Y. Acad Sci. 959 (2002) 466-474
    • (2002) Ann N.Y. Acad Sci. , vol.959 , pp. 466-474
    • Honda, Y.1    Honda, S.2
  • 44
    • 33645905712 scopus 로고    scopus 로고
    • Autophagy, mitochondrial quality control, and oncogenesis
    • Jin S. Autophagy, mitochondrial quality control, and oncogenesis. Autophagy 2 2 (2006) 80-84
    • (2006) Autophagy , vol.2 , Issue.2 , pp. 80-84
    • Jin, S.1
  • 45
    • 0024401216 scopus 로고
    • Age-related changes in the lipid compositions of rat and human tissues
    • Kalen A., Appelkvist E.L., and Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 24 7 (1989) 579-584
    • (1989) Lipids , vol.24 , Issue.7 , pp. 579-584
    • Kalen, A.1    Appelkvist, E.L.2    Dallner, G.3
  • 46
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366 6454 (1993) 461-464
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 47
    • 0033791650 scopus 로고    scopus 로고
    • Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
    • Kim J., and Klionsky D.J. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 69 (2000) 303-342
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 303-342
    • Kim, J.1    Klionsky, D.J.2
  • 48
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky D.J., and Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science 290 (2000) 1717-1721
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 51
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee C.K., Klopp R.G., Weindruch R., and Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction. Science 285 5432 (1999) 1390-1393
    • (1999) Science , vol.285 , Issue.5432 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 52
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee C.K., Weindruch R., and Prolla T.A. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25 3 (2000) 294-297
    • (2000) Nat. Genet. , vol.25 , Issue.3 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 53
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters J.J. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 8 1 (2005) 3-5
    • (2005) Rejuvenation Res. , vol.8 , Issue.1 , pp. 3-5
    • Lemasters, J.J.1
  • 54
    • 1642282736 scopus 로고    scopus 로고
    • Cellular mechanisms of redox cell signaling: the role of cysteine modification in controlling antioxidant defenses in response to electrophylic lipid oxidation products
    • Levonen A.L., Landar A., Ramachandran A., Ceaser E.K., Dickinson D.A., Zanoni G., Morrow J.D., and Darley-Usmar V.M. Cellular mechanisms of redox cell signaling: the role of cysteine modification in controlling antioxidant defenses in response to electrophylic lipid oxidation products. Biochem. J. 378 (2004) 373-382
    • (2004) Biochem. J. , vol.378 , pp. 373-382
    • Levonen, A.L.1    Landar, A.2    Ramachandran, A.3    Ceaser, E.K.4    Dickinson, D.A.5    Zanoni, G.6    Morrow, J.D.7    Darley-Usmar, V.M.8
  • 55
    • 0021799460 scopus 로고
    • Effects of antilipolytic agents on rat liver peroxisomes and peroxisomal oxidative activities
    • Locci Cubeddu T., Masiello P., Pollera M., and Bergamini E. Effects of antilipolytic agents on rat liver peroxisomes and peroxisomal oxidative activities. Biochim. Biophys. Acta 839 1 (1985) 96-104
    • (1985) Biochim. Biophys. Acta , vol.839 , Issue.1 , pp. 96-104
    • Locci Cubeddu, T.1    Masiello, P.2    Pollera, M.3    Bergamini, E.4
  • 59
    • 0348154290 scopus 로고    scopus 로고
    • Caloric restriction: a key to understand and modulating aging
    • Vijg J. (Ed), Elsevier Science, Amsterdam
    • Masoro E.J. Caloric restriction: a key to understand and modulating aging. In: Vijg J. (Ed). Research Profiles in Aging (2002), Elsevier Science, Amsterdam
    • (2002) Research Profiles in Aging
    • Masoro, E.J.1
  • 60
    • 0026526384 scopus 로고
    • Dietary restriction alters characteristics of glucose fuel use
    • Masoro E.J., McCarter R.J., Katz M.S., and McMahan C.A. Dietary restriction alters characteristics of glucose fuel use. J. Gerontol. 47 6 (1992) B202-B208
    • (1992) J. Gerontol. , vol.47 , Issue.6
    • Masoro, E.J.1    McCarter, R.J.2    Katz, M.S.3    McMahan, C.A.4
  • 61
    • 0027263739 scopus 로고
    • Food restriction suppresses an age-dependent increase in the exhalation rate of pentane from rats: a longitudinal study
    • Matsuo M., Gomi F., Kuramoto K., and Sagai M. Food restriction suppresses an age-dependent increase in the exhalation rate of pentane from rats: a longitudinal study. J. Gerontol. 48 4 (1993) B133-B136
    • (1993) J. Gerontol. , vol.48 , Issue.4
    • Matsuo, M.1    Gomi, F.2    Kuramoto, K.3    Sagai, M.4
  • 62
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301 5638 (2003) 1387-1391
    • (2003) Science , vol.301 , Issue.5638 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 63
    • 33646748876 scopus 로고    scopus 로고
    • Restriction of amino acids extends lifespan in Drosophila melanogaster
    • Min K.J., and Tatar M. Restriction of amino acids extends lifespan in Drosophila melanogaster. Mech. Ageing Dev. 127 7 (2006) 643-646
    • (2006) Mech. Ageing Dev. , vol.127 , Issue.7 , pp. 643-646
    • Min, K.J.1    Tatar, M.2
  • 65
    • 27644493346 scopus 로고    scopus 로고
    • The pleiotropic role of autophagy: from protein metabolism to bactericide
    • Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell. Death Differ. 12 Suppl. 2 (2005) 1535-1541
    • (2005) Cell. Death Differ. , vol.12 , Issue.SUPPL. 2 , pp. 1535-1541
    • Mizushima, N.1
  • 66
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima N., Yamamoto A., Matsui M., Yoshimori T., and Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15 3 (2004) 1101-1111
    • (2004) Mol. Biol. Cell , vol.15 , Issue.3 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 67
    • 0023065242 scopus 로고
    • Intracellular protein catabolism and its control during nutrient deprivation and supply
    • Mortimore G.E., and Poso A.R. Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu. Rev. Nutr. 7 (1987) 539-564
    • (1987) Annu. Rev. Nutr. , vol.7 , pp. 539-564
    • Mortimore, G.E.1    Poso, A.R.2
  • 68
    • 0024498119 scopus 로고
    • Mechanism and regulation of protein degradation in liver
    • Mortimore G.E., Poso A.R., and Lardeux B.R. Mechanism and regulation of protein degradation in liver. Diabetes Metab. Rev. 5 1 (1989) 49-70
    • (1989) Diabetes Metab. Rev. , vol.5 , Issue.1 , pp. 49-70
    • Mortimore, G.E.1    Poso, A.R.2    Lardeux, B.R.3
  • 69
    • 14644440847 scopus 로고    scopus 로고
    • Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging
    • Parentini I., Cavallini G., Donati A., Gori Z., and Bergamini E. Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging. J. Gerontol. A Biol. Sci. Med. Sci. 60 1 (2005) 39-43
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , Issue.1 , pp. 39-43
    • Parentini, I.1    Cavallini, G.2    Donati, A.3    Gori, Z.4    Bergamini, E.5
  • 71
    • 0017816161 scopus 로고
    • Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy
    • Pfeifer U. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J. Cell Biol. 78 (1978) 152-167
    • (1978) J. Cell Biol. , vol.78 , pp. 152-167
    • Pfeifer, U.1
  • 73
    • 33746696116 scopus 로고
    • Changes in the temporal pattern of stimulation of liver autophagy in rats during growth and aging
    • Segal H.L., Rothstein M., and Bergamini E. (Eds), Wiley-Liss Inc.
    • Pollera M., Masini M., Del Roso A., and Bergamini E. Changes in the temporal pattern of stimulation of liver autophagy in rats during growth and aging. In: Segal H.L., Rothstein M., and Bergamini E. (Eds). Protein Metabolism in Aging (1990), Wiley-Liss Inc. 169-173
    • (1990) Protein Metabolism in Aging , pp. 169-173
    • Pollera, M.1    Masini, M.2    Del Roso, A.3    Bergamini, E.4
  • 74
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers R.W., Kaeberlein M., Caldwell S.D., Kennedy B.K., and Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20 2 (2006) 174-184
    • (2006) Genes Dev. , vol.20 , Issue.2 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 75
    • 0018789803 scopus 로고
    • Protein degradation in aged nematodes (Turbatrix aceti)
    • Prasanna H.R., and Lane R.S. Protein degradation in aged nematodes (Turbatrix aceti). Biochem. Biophys. Res. Commun. 86 3 (1979) 552-559
    • (1979) Biochem. Biophys. Res. Commun. , vol.86 , Issue.3 , pp. 552-559
    • Prasanna, H.R.1    Lane, R.S.2
  • 76
    • 0034603991 scopus 로고    scopus 로고
    • Caloric restriction prevents oxidative damage induced by the carcinogen clofibrate in mouse liver
    • Qu B., Halliwell B., Ong C.N., Lee B.L., and Li Q.T. Caloric restriction prevents oxidative damage induced by the carcinogen clofibrate in mouse liver. FEBS Lett. 473 1 (2000) 85-88
    • (2000) FEBS Lett. , vol.473 , Issue.1 , pp. 85-88
    • Qu, B.1    Halliwell, B.2    Ong, C.N.3    Lee, B.L.4    Li, Q.T.5
  • 77
    • 0029983808 scopus 로고    scopus 로고
    • Synthesis, modifications, and turnover of proteins during aging
    • Rattan S.I. Synthesis, modifications, and turnover of proteins during aging. Exp. Gerontol. 31 1-2 (1996) 33-47
    • (1996) Exp. Gerontol. , vol.31 , Issue.1-2 , pp. 33-47
    • Rattan, S.I.1
  • 78
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar B., Duden R., and Rubinsztein D.C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 11 9 (2002) 1107-1117
    • (2002) Hum. Mol. Genet. , vol.11 , Issue.9 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 80
    • 4344583901 scopus 로고    scopus 로고
    • Role of mitochondrial permeability transition pores in mitochondrial autophagy
    • Rodriguez-Enriquez S., He L., and Lemasters J.J. Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int. J. Biochem. Cell Biol. 36 12 (2004) 2463-2472
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , Issue.12 , pp. 2463-2472
    • Rodriguez-Enriquez, S.1    He, L.2    Lemasters, J.J.3
  • 81
    • 0025887533 scopus 로고
    • Senescence and the accumulation of abnormal proteins
    • Rosenberger R.F. Senescence and the accumulation of abnormal proteins. Mutat. Res. 256 2-6 (1991) 255-262
    • (1991) Mutat. Res. , vol.256 , Issue.2-6 , pp. 255-262
    • Rosenberger, R.F.1
  • 82
    • 0036132470 scopus 로고    scopus 로고
    • Protein turnover plays a key role in aging
    • Ryazanov A.G., and Nefsky B.S. Protein turnover plays a key role in aging. Mech. Ageing Dev. 123 2-3 (2002) 207-213
    • (2002) Mech. Ageing Dev. , vol.123 , Issue.2-3 , pp. 207-213
    • Ryazanov, A.G.1    Nefsky, B.S.2
  • 83
    • 20044370216 scopus 로고    scopus 로고
    • Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals
    • Sanz A., Gredilla R., Pamplona R., Portero-Otín M., Vara E., Tresguerres J.A.F., and Barja G. Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals. Biogerontology 6 (2005) 15-26
    • (2005) Biogerontology , vol.6 , pp. 15-26
    • Sanz, A.1    Gredilla, R.2    Pamplona, R.3    Portero-Otín, M.4    Vara, E.5    Tresguerres, J.A.F.6    Barja, G.7
  • 84
    • 0026584008 scopus 로고
    • Autophagy and other vacuolar protein degradation mechanisms
    • Seglen P.O., and Bohley P. Autophagy and other vacuolar protein degradation mechanisms. Experientia 48 2 (1992) 158-172
    • (1992) Experientia , vol.48 , Issue.2 , pp. 158-172
    • Seglen, P.O.1    Bohley, P.2
  • 85
    • 0018791237 scopus 로고
    • The effect of age on enolase turnover in the free-living nematode, Turbatrix aceti
    • Sharma H.K., Prasanna H.R., Lane R.S., and Rothstein M. The effect of age on enolase turnover in the free-living nematode, Turbatrix aceti. Arch. Biochem. Biophys. 194 1 (1979) 275-282
    • (1979) Arch. Biochem. Biophys. , vol.194 , Issue.1 , pp. 275-282
    • Sharma, H.K.1    Prasanna, H.R.2    Lane, R.S.3    Rothstein, M.4
  • 86
    • 0027949202 scopus 로고
    • Oxidative damage and mitochondrial decay in aging
    • Shigenaga M.K., Hagen T.M., and Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91 23 (1994) 10771-10778
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.23 , pp. 10771-10778
    • Shigenaga, M.K.1    Hagen, T.M.2    Ames, B.N.3
  • 87
    • 0036628724 scopus 로고    scopus 로고
    • Role of oxidative stress and protein oxidation in the aging process
    • Sohal R.S. Role of oxidative stress and protein oxidation in the aging process. Free Radic. Biol. Med. 33 1 (2002) 37-44
    • (2002) Free Radic. Biol. Med. , vol.33 , Issue.1 , pp. 37-44
    • Sohal, R.S.1
  • 88
    • 0028342438 scopus 로고
    • Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
    • Sohal R.S., Ku H.H., Agarwal S., Forster M.J., and Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev. 74 1-2 (1994) 121-133
    • (1994) Mech. Ageing Dev. , vol.74 , Issue.1-2 , pp. 121-133
    • Sohal, R.S.1    Ku, H.H.2    Agarwal, S.3    Forster, M.J.4    Lal, H.5
  • 89
    • 0026793913 scopus 로고
    • Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1
    • Sonntag W.E., Lenham J.E., and Ingram R.L. Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1. J. Gerontol. 47 5 (1992) B159-B163
    • (1992) J. Gerontol. , vol.47 , Issue.5
    • Sonntag, W.E.1    Lenham, J.E.2    Ingram, R.L.3
  • 90
    • 0036240259 scopus 로고    scopus 로고
    • Are changes of the cell membrane structure causally involved in the aging process?
    • Spiteller G. Are changes of the cell membrane structure causally involved in the aging process?. Ann. N.Y. Acad. Sci. 959 (2002) 30-44
    • (2002) Ann. N.Y. Acad. Sci. , vol.959 , pp. 30-44
    • Spiteller, G.1
  • 91
    • 0023787912 scopus 로고
    • Protein modification in aging
    • Stadtman E.R. Protein modification in aging. J. Gerontol. 43 5 (1988) B112-B120
    • (1988) J. Gerontol. , vol.43 , Issue.5
    • Stadtman, E.R.1
  • 92
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., and Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292 5514 (2001) 107-110
    • (2001) Science , vol.292 , Issue.5514 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 93
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • Terman A. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41 Suppl. 2 (1995) 319-326
    • (1995) Gerontology , vol.41 , Issue.SUPPL. 2 , pp. 319-326
    • Terman, A.1
  • 94
    • 4344598932 scopus 로고    scopus 로고
    • Aging as a catabolic malfunction
    • Terman A., and Brunk U.T. Aging as a catabolic malfunction. Int. J. Biochem. Cell Biol. 36 12 (2004) 2365-2375
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , Issue.12 , pp. 2365-2375
    • Terman, A.1    Brunk, U.T.2
  • 95
    • 0027424777 scopus 로고
    • Isolation and characterization of macroautophagy-defective mutants of Saccharomyces cerevisiae
    • Tsukada M., and Ohsumi Y. Isolation and characterization of macroautophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 333 1-2 (1993) 169-174
    • (1993) FEBS Lett. , vol.333 , Issue.1-2 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 97
    • 0020772844 scopus 로고
    • Degradation and turnover of peroxisomes in the yeast Hansenula polimorha induced by selective inactivation of peroxisomal enzymes
    • Veenhuis M., Douma A., Harder W., and Osumi M. Degradation and turnover of peroxisomes in the yeast Hansenula polimorha induced by selective inactivation of peroxisomal enzymes. Arch. Microbiol. 134 3 (1983) 193-203
    • (1983) Arch. Microbiol. , vol.134 , Issue.3 , pp. 193-203
    • Veenhuis, M.1    Douma, A.2    Harder, W.3    Osumi, M.4
  • 100
    • 0023695135 scopus 로고
    • Food restriction enhances the proteolytic capacity of the aging rat liver
    • Ward W.F. Food restriction enhances the proteolytic capacity of the aging rat liver. J. Gerontol. 43 (1988) B121-B124
    • (1988) J. Gerontol. , vol.43
    • Ward, W.F.1
  • 101
    • 0036359773 scopus 로고    scopus 로고
    • Protein degradation in the aging organism
    • Ward W.F. Protein degradation in the aging organism. Prog. Mol. Subcell. Biol. 29 (2002) 35-42
    • (2002) Prog. Mol. Subcell. Biol. , vol.29 , pp. 35-42
    • Ward, W.F.1
  • 102
    • 0036790385 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
    • Wei Y.H., and Lee H.C. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp. Biol. Med. (Maywood) 227 9 (2002) 671-682
    • (2002) Exp. Biol. Med. (Maywood) , vol.227 , Issue.9 , pp. 671-682
    • Wei, Y.H.1    Lee, H.C.2
  • 103
    • 0032436502 scopus 로고    scopus 로고
    • Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function
    • Wei Y.H., Lu C.Y., Lee H.C., Pang C.Y., and Ma Y.S. Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann. N.Y. Acad. Sci. 854 (1998) 155-170
    • (1998) Ann. N.Y. Acad. Sci. , vol.854 , pp. 155-170
    • Wei, Y.H.1    Lu, C.Y.2    Lee, H.C.3    Pang, C.Y.4    Ma, Y.S.5
  • 104
    • 0019186034 scopus 로고
    • Modification of mitochondrial respiration by aging and dietary restriction
    • Weindruch R.H., Cheung M.K., Verity M.A., and Walford R.L. Modification of mitochondrial respiration by aging and dietary restriction. Mech. Ageing Dev. 12 4 (1980) 375-392
    • (1980) Mech. Ageing Dev. , vol.12 , Issue.4 , pp. 375-392
    • Weindruch, R.H.1    Cheung, M.K.2    Verity, M.A.3    Walford, R.L.4
  • 105
    • 0022517746 scopus 로고
    • The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake
    • Weindruch R., Walford R.L., Fligiel S., and Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. 116 4 (1986) 641-654
    • (1986) J. Nutr. , vol.116 , Issue.4 , pp. 641-654
    • Weindruch, R.1    Walford, R.L.2    Fligiel, S.3    Guthrie, D.4
  • 107
    • 0036860195 scopus 로고    scopus 로고
    • Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: Emergence of the gate theory of aging
    • Yeo E.J., and Park S.C. Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: Emergence of the gate theory of aging. Mech. Ageing Dev. 123 (2002) 1563-1578
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1563-1578
    • Yeo, E.J.1    Park, S.C.2
  • 108
    • 0036860951 scopus 로고    scopus 로고
    • Dose effect of oxidative stress on signal transduction in aging
    • Yoon S.O., Yun C.H., and Chung A.S. Dose effect of oxidative stress on signal transduction in aging. Mech. Ageing Dev. 123 (2002) 1597-1604
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1597-1604
    • Yoon, S.O.1    Yun, C.H.2    Chung, A.S.3
  • 109
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: molecular machinery for self-eating
    • Yorimitsu T., and Klionsky D.J. Autophagy: molecular machinery for self-eating. Cell Death Differ. 12 Suppl. 2 (2005) 1542-1552
    • (2005) Cell Death Differ. , vol.12 , Issue.SUPPL. 2 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 110
    • 0347626252 scopus 로고    scopus 로고
    • Macroautophagy: a regulated bulk degradation process inside cells
    • Yoshimori T. Macroautophagy: a regulated bulk degradation process inside cells. Biochem. Biophys. Res. Commun. 313 2 (2004) 453-458
    • (2004) Biochem. Biophys. Res. Commun. , vol.313 , Issue.2 , pp. 453-458
    • Yoshimori, T.1
  • 111
    • 0026726186 scopus 로고
    • Protein oxidation associated with aging is reduced by dietary restriction of protein or calories
    • Youngman L.D., Park J.Y., and Ames B.N. Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc. Natl. Acad. Sci. USA 89 19 (1992) 9112-9116
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.19 , pp. 9112-9116
    • Youngman, L.D.1    Park, J.Y.2    Ames, B.N.3
  • 112
    • 0029759443 scopus 로고    scopus 로고
    • Aging and oxidative stress: modulation by dietary restriction
    • Yu B.P. Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med. 21 5 (1996) 651-668
    • (1996) Free Radic. Biol. Med. , vol.21 , Issue.5 , pp. 651-668
    • Yu, B.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.