The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

Journal of Biological Chemistry

Volumn 280, Issue 45, 2005, Pages 37393-37399

  Weigert, Cora ^a   Hennige, Anita M ^a   Brischmann, Tasja ^a   Beck, Alexander ^a   Moeschel, Klaus ^a   Schäuble, Myriam ^a   Brodbeck, Katrin ^a   Häring, Hans Ulrich ^a   Schleicher, Erwin D ^a   Lehmann, Rainer ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; CHEMICAL ACTIVATION; ENZYME INHIBITION; ENZYMES; GLUCOSE; INSULIN; MOLECULAR BIOLOGY; MUSCLE; PHYSIOLOGY;

INSULIN RECEPTOR SUBSTRATE 1 (IRS); MUSCLE CELLS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CELLS;

ADRENALIN; ALANINE; GLUCOSE; GLUTAMIC ACID; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCLONAL ANTIBODY; PROTEIN KINASE B; PROTEIN KINASE C ZETA; SERINE; THREONINE; TUMOR NECROSIS FACTOR ALPHA; DEOXYGLUCOSE; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; PHOSPHOPROTEIN; PHOSPHOSERINE; PROTEIN KINASE C;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA; RODENTIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; DEOXYGLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; INSULIN; MALE; MICE; MUSCLE FIBERS; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 27844547130     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506134200     Document Type: Article

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