-
1
-
-
0029020282
-
Protein kinases 6. the eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks, S. K. & Hunter, T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9, 576-596 (1995).
-
(1995)
FASEB J.
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
2
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning, G., Whyte, D. B., Martinez, R., Hunter, T. & Sudarsanam, S. The protein kinase complement of the human genome. Science 298, 1912-1934 (2002).
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
3
-
-
0026342401
-
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton, D. R. et al. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253, 407-414 (1991).
-
(1991)
Science
, vol.253
, pp. 407-414
-
-
Knighton, D.R.1
-
4
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
Johnson, L. N., Noble, M. E. & Owen, D. J. Active and inactive protein kinases: structural basis for regulation. Cell 85, 149-158 (1996).
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.2
Owen, D.J.3
-
5
-
-
0036295728
-
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
-
Yang, J. et al. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol. Cell 9, 1227-1240 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 1227-1240
-
-
Yang, J.1
-
6
-
-
21444441749
-
Role of T-loop phosphorylation in PDK1 activation, stability and substrate binding
-
Komander, D., Kular, G., Deak, M., Alessi, D. R. & van Aalten, D. M. Role of T-loop phosphorylation in PDK1 activation, stability and substrate binding. J. Biol. Chem. 280, 18797-18802 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18797-18802
-
-
Komander, D.1
Kular, G.2
Deak, M.3
Alessi, D.R.4
Van Aalten, D.M.5
-
7
-
-
0037102153
-
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
-
Biondi, R. M. et al. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J. 21, 4219-4228 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 4219-4228
-
-
Biondi, R.M.1
-
8
-
-
18744373865
-
Crystal structure of an activated Akt/ protein kinase B ternary complex with GSK3-peptide and AMP-PNP
-
Yang, J. et al. Crystal structure of an activated Akt/ protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nature Struct. Biol. 9, 940-944 (2002).
-
(2002)
Nature Struct. Biol.
, vol.9
, pp. 940-944
-
-
Yang, J.1
-
9
-
-
34247572532
-
Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation
-
Hauge, C. et al. Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation. EMBO J. 26, 2251-2261 (2007).
-
(2007)
EMBO J.
, vol.26
, pp. 2251-2261
-
-
Hauge, C.1
-
10
-
-
33751570046
-
Structure of the catalytic domain of human protein kinase C p. II complexed with a bisindolylmaleimide inhibitor
-
Grodsky, N. et al. Structure of the catalytic domain of human protein kinase C p II complexed with a bisindolylmaleimide inhibitor. Biochemistry 45, 13970-13981 (2006).
-
(2006)
Biochemistry
, vol.45
, pp. 13970-13981
-
-
Grodsky, N.1
-
11
-
-
57149120091
-
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
-
Komander, D., Garg, R., Wan, P. T., Ridley, A. J. & Barford, D. Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J. 27, 3175-3185 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 3175-3185
-
-
Komander, D.1
Garg, R.2
Wan, P.T.3
Ridley, A.J.4
Barford, D.5
-
12
-
-
2942617368
-
The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
-
Smith, K. J. et al. The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. Structure 12, 1067-1077 (2004).
-
(2004)
Structure
, vol.12
, pp. 1067-1077
-
-
Smith, K.J.1
-
13
-
-
77951184638
-
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation
-
28 Oct doi: 10.1074/jbc.M109.040667
-
Sunami, T. et al. Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J. Biol. Chem. 28 Oct 2009 (doi: 10.1074/jbc.M109.040667).
-
(2009)
J. Biol. Chem.
-
-
Sunami, T.1
-
14
-
-
28844463975
-
Snapshot of activated G proteins at the membrane: The Gaq-GRK2-G-3y complex
-
Tesmer, V. M., Kawano, T., Shankaranarayanan, A., Kozasa, T. & Tesmer, J. J. Snapshot of activated G proteins at the membrane: the Gaq-GRK2-G-3y complex. Science 310, 1686-1690 (2005).
-
(2005)
Science
, vol.310
, pp. 1686-1690
-
-
Tesmer, V.M.1
Kawano, T.2
Shankaranarayanan, A.3
Kozasa, T.4
Tesmer, J.J.5
-
15
-
-
0033084143
-
Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
-
Currie, R. A. et al. Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337, 575-583 (1999).
-
(1999)
Biochem. J.
, Issue.337
, pp. 575-583
-
-
Currie, R.A.1
-
16
-
-
34247391898
-
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
-
Calleja, V. et al. Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol. 5, e95 (2007).
-
(2007)
PLoS Biol.
, vol.5
-
-
Calleja, V.1
-
17
-
-
12644301164
-
3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
-
Alessi, D. R. et al. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7, 776-789 (1997).
-
(1997)
Curr. Biol.
, vol.7
, pp. 776-789
-
-
Alessi, D.R.1
-
18
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
19
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin, D. A. & Sabatini, D. M. Defining the role of mTOR in cancer. Cancer Cell 12, 9-22 (2007).
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
20
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
Ikenoue, T., Inoki, K., Yang, Q., Zhou, X. & Guan, K. L. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 27, 1919-1931 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
21
-
-
47949125486
-
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase, C
-
Facchinetti, V. et al. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase, C. EMBO J. 27, 1932-1943 (2008).
-
(2008)
EMBO J.
, Issue.27
, pp. 1932-1943
-
-
Facchinetti, V.1
-
22
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K. et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 11 0, 177-189 (2002).
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
-
23
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D. H. et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 11 0, 163-175 (2002).
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
-
24
-
-
58649092475
-
R. mTOR complex-2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum and glucocorticoid induced protein kinase-1 (SGK1)
-
Garcia-Martinez, J. M. & Alessi, D. R. mTOR complex-2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum and glucocorticoid induced protein kinase-1 (SGK1). Biochem. J. 416, 375-385 (2008).
-
(2008)
Biochem. J.
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.2
-
25
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
Nicklin, P. et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136, 521-534 (2009).
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
-
26
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak, Y. et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (2008).
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
-
27
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P. & Guan, K. L. Regulation of TORC1 by Rag GTPases in nutrient response. Nature Cell Biol. 10, 935-945 (2008).
-
(2008)
Nature Cell Biol.
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
28
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
Findlay, G. M., Yan, L., Procter, J., Mieulet, V. & Lamb, R. F. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem. J. 403, 13-20 (2007).
-
(2007)
Biochem. J.
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
29
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., Zhu, T. & Guan, K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 11 5, 577-590 (2003).
-
(2003)
Cell
, vol.11
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
30
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn, D. M. et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
-
31
-
-
0035882103
-
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
-
Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M. & Alessi, D. R. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20, 4380-4390 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 4380-4390
-
-
Biondi, R.M.1
Kieloch, A.2
Currie, R.A.3
Deak, M.4
Alessi, D.R.5
-
32
-
-
0042967831
-
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
-
Collins, B. J., Deak, M., Arthur, J. S., Armit, L. J. & Alessi, D. R. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J. 22, 4202-4211 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 4202-4211
-
-
Collins, B.J.1
Deak, M.2
Arthur, J.S.3
Armit, L.J.4
Alessi, D.R.5
-
33
-
-
33747649796
-
Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3
-
Tessier, M. & Woodgett, J. R. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. J. Biol. Chem. 281, 23978-23989 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 23978-23989
-
-
Tessier, M.1
Woodgett, J.R.2
-
34
-
-
33646060747
-
Sgk kinases and their role in epithelial transport
-
Loffing, J., Flores, S. Y. & Staub, O. Sgk kinases and their role in epithelial transport. Annu. Rev. Physiol. 68, 461-490 (2006).
-
(2006)
Annu. Rev. Physiol.
, vol.68
, pp. 461-490
-
-
Loffing, J.1
Flores, S.Y.2
Staub, O.3
-
35
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
Newton, A. C. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem. J. 370, 361-371 (2003).
-
(2003)
Biochem. J.
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
36
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good, J. A. et al. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281, 2042-2045 (1998).
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
-
37
-
-
0032585532
-
Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
-
Dutil, E. M., Toker, A. & Newton, A. C. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr. Biol. 8, 1366-1375 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 1366-1375
-
-
Dutil, E.M.1
Toker, A.2
Newton, A.C.3
-
38
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D. D. et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
-
39
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1
-
Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1. Dev. Cell 11, 859-871 (2006).
-
(2006)
Dev. Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
-
40
-
-
0023555557
-
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain
-
House, C. & Kemp, B. E. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238, 1726-1728 (1987).
-
(1987)
Science
, vol.238
, pp. 1726-1728
-
-
House, C.1
Kemp, B.E.2
-
41
-
-
0034617281
-
A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Cζ (PKCζ) and PKC- related kinase 2 by PDK1
-
DOI 10.1074/jbc.M000421200
-
Balendran, A. et al. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Cζ (PKCζ) and PKC-related kinase 2 by PDK1. J. Biol. Chem. 275, 20806-20813 (2000). (Pubitemid 30457673)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.27
, pp. 20806-20813
-
-
Balendran, A.1
Biondi, R.M.2
Cheung, P.C.F.3
Casamayor, A.4
Deak, M.5
Alessi, D.R.6
-
42
-
-
0034161251
-
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
-
Biondi, R. M. et al. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J. 19, 979-988 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 979-988
-
-
Biondi, R.M.1
-
43
-
-
0034646677
-
Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase
-
Flynn, P., Mellor, H., Casamassima, A. & Parker, P. J. Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase. J. Biol. Chem. 275, 11064-11070 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 11064-11070
-
-
Flynn, P.1
Mellor, H.2
Casamassima, A.3
Parker, P.J.4
-
44
-
-
0031952597
-
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
-
Dalby, K. N., Morrice, N., Caudwell, F. B., Avruch, J. & Cohen, P. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J. Biol. Chem. 273, 1496-1505 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1496-1505
-
-
Dalby, K.N.1
Morrice, N.2
Caudwell, F.B.3
Avruch, J.4
Cohen, P.5
-
45
-
-
0032479983
-
Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/ p38 and may mediate activation of CREB
-
Deak, M., Clifton, A. D., Lucocq, L. M. & Alessi, D. R. Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/ p38, and may mediate activation of CREB. EMBO J. 17, 4426-4441 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 4426-4441
-
-
Deak, M.1
Clifton, A.D.2
Lucocq, L.M.3
Alessi, D.R.4
-
46
-
-
52449095361
-
The RSK family of kinases: Emerging roles in cellular signalling
-
Anjum, R. & Blenis, J. The RSK family of kinases: emerging roles in cellular signalling. Nature Rev. Mol. Cell Biol. 9, 747-758 (2008).
-
(2008)
Nature Rev. Mol. Cell Biol.
, vol.9
, pp. 747-758
-
-
Anjum, R.1
Blenis, J.2
-
47
-
-
0242612949
-
A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1
-
Frodin, M., Jensen, C. J., Merienne, K. & Gammeltoft, S. A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J. 19, 2924-2934 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 2924-2934
-
-
Frodin, M.1
Jensen, C.J.2
Merienne, K.3
Gammeltoft, S.4
-
48
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams, M. R. et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10, 439-448 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
-
49
-
-
50049084144
-
MSK activation and physiological roles
-
Arthur, J. S. MSK activation and physiological roles. Front. Biosci. 13, 5866-5879 (2008).
-
(2008)
Front. Biosci.
, vol.13
, pp. 5866-5879
-
-
Arthur, J.S.1
-
50
-
-
35548930283
-
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
-
Zaru, R., Ronkina, N., Gaestel, M., Arthur, J. S. & Watts, C. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nature Immunol. 8, 1227-1235 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 1227-1235
-
-
Zaru, R.1
Ronkina, N.2
Gaestel, M.3
Arthur, J.S.4
Watts, C.5
-
51
-
-
50049086910
-
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
-
Ananieva, O. et al. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nature Immunol. 9, 1028-1036 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 1028-1036
-
-
Ananieva, O.1
-
52
-
-
43249093752
-
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
-
Bayascas, J. R. et al. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol. Cell. Biol 28, 3258-3272 (2008).
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 3258-3272
-
-
Bayascas, J.R.1
-
53
-
-
4444229881
-
The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1
-
King, C. C. & Newton, A. C. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J. Biol. Chem. 279, 37518-37527 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 37518-37527
-
-
King, C.C.1
Newton, A.C.2
-
54
-
-
52649111175
-
Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling
-
Nakamura, A., Naito, M., Tsuruo, T. & Fujita, N. Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol. Cell. Biol. 28, 5996-6009 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 5996-6009
-
-
Nakamura, A.1
Naito, M.2
Tsuruo, T.3
Fujita, N.4
-
55
-
-
69549116880
-
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
-
Yang, W. L. et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325, 1134-1138 (2009).
-
(2009)
Science
, vol.325
, pp. 1134-1138
-
-
Yang, W.L.1
-
56
-
-
0033199841
-
Phosphorylation of ser 241 is essential for the activity of PDK1; Identification of five sites of phosphorylation in vivo
-
Casamayor, A., Morrice, N. & Alessi, D. R. Phosphorylation of Ser 241 is essential for the activity of PDK1; identification of five sites of phosphorylation in vivo. Biochem. J. 342, 287-292 (1999).
-
(1999)
Biochem. J.
, vol.342
, pp. 287-292
-
-
Casamayor, A.1
Morrice, N.2
Alessi, D.R.3
-
57
-
-
8144228588
-
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates
-
Komander, D. et al. Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J. 23, 3918-3928 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 3918-3928
-
-
Komander, D.1
-
58
-
-
28444443387
-
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPα
-
Michel, J. J. et al. Spatial restriction of PDK1 activation cascades by anchoring to mAKAPα. Mol. Cell 20, 661-672 (2005).
-
(2005)
Mol. Cell
, vol.20
, pp. 661-672
-
-
Michel, J.J.1
-
59
-
-
0344270855
-
Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): A potential regulatory mechanism for PDK-1 function
-
Lim, M. A., Kikani, C. K., Wick, M. J. & Dong, L. Q. Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. Proc. Natl Acad. Sci USA 100, 14006-14011 (2003).
-
(2003)
Proc. Natl Acad. Sci USA
, vol.100
, pp. 14006-14011
-
-
Lim, M.A.1
Kikani, C.K.2
Wick, M.J.3
Dong, L.Q.4
-
60
-
-
14844357714
-
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation
-
Scheid, M. P., Parsons, M. & Woodgett, J. R. Phosphoinositide- dependent phosphorylation of PDK1 regulates nuclear translocation. Mol. Cell. Biol. 25, 2347-2363 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 2347-2363
-
-
Scheid, M.P.1
Parsons, M.2
Woodgett, J.R.3
-
61
-
-
0025330489
-
CAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes
-
Taylor, S. S., Buechler, J. A. & Yonemoto, W. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem. 59, 971-1005 (1990). (Pubitemid 120024460)
-
(1990)
Annual Review of Biochemistry
, vol.59
, Issue.1
, pp. 971-1005
-
-
Taylor, S.S.1
Buechler, J.A.2
Yonemoto, W.3
-
62
-
-
0030856102
-
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli
-
Yonemoto, W., McGlone, M. L., Grant, B. & Taylor, S. S. Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Eng. 10, 915-925 (1997).
-
(1997)
Protein Eng.
, vol.10
, pp. 915-925
-
-
Yonemoto, W.1
McGlone, M.L.2
Grant, B.3
Taylor, S.S.4
-
63
-
-
0032544011
-
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase
-
DOI 10.1073/pnas.95.17.9849
-
Cheng, X., Ma, Y., Moore, M., Hemmings, B. A. & Taylor, S. S. Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc. Natl Acad. Sci. USA 95, 9849-9854 (1998). (Pubitemid 28415258)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.17
, pp. 9849-9854
-
-
Cheng, X.1
Ma, Y.2
Moore, M.3
Hemmings, B.A.4
Taylor, S.S.5
-
64
-
-
33745821637
-
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4
-
Nirula, A., Ho, M., Phee, H., Roose, J. & Weiss, A. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J. Exp. Med. 203, 1733-1744 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1733-1744
-
-
Nirula, A.1
Ho, M.2
Phee, H.3
Roose, J.4
Weiss, A.5
-
65
-
-
0032852479
-
CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
-
Shaywitz, A. J. & Greenberg, M. E. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68, 821-861 (1999).
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 821-861
-
-
Shaywitz, A.J.1
Greenberg, M.E.2
-
66
-
-
0027203084
-
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
-
Frey, U., Huang, Y. Y. & Kandel, E. R. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260, 1661-1664 (1993).
-
(1993)
Science
, vol.260
, pp. 1661-1664
-
-
Frey, U.1
Huang, Y.Y.2
Kandel, E.R.3
-
67
-
-
10044253425
-
AKAP signalling complexes: Focal points in space and time
-
Wong, W. & Scott, J. D. AKAP signalling complexes: focal points in space and time. Nature Rev. Mol. Cell Biol. 5, 959-970 (2004).
-
(2004)
Nature Rev. Mol. Cell Biol.
, vol.5
, pp. 959-970
-
-
Wong, W.1
Scott, J.D.2
-
68
-
-
0033605139
-
PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type i
-
Zimmermann, B., Chiorini, J. A., Ma, Y., Kotin, R. M. & Herberg, F. W. PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. J. Biol. Chem. 274, 5370-5378 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5370-5378
-
-
Zimmermann, B.1
Chiorini, J.A.2
Ma, Y.3
Kotin, R.M.4
Herberg, F.W.5
-
69
-
-
0033832073
-
Guanylyl cyclases and signaling by cyclic GMP
-
Lucas, K. A. et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol. Rev. 52, 375-414 (2000).
-
(2000)
Pharmacol. Rev.
, vol.52
, pp. 375-414
-
-
Lucas, K.A.1
-
70
-
-
0034723192
-
Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase
-
Browning, D. D., McShane, M. P., Marty, C. & Ye, R. D. Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase. J. Biol. Chem. 275, 2811-2816 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2811-2816
-
-
Browning, D.D.1
McShane, M.P.2
Marty, C.3
Ye, R.D.4
-
71
-
-
0028275855
-
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
-
Zhuo, M., Hu, Y., Schultz, C., Kandel, E. R. & Hawkins, R. D. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368, 635-639 (1994).
-
(1994)
Nature
, vol.368
, pp. 635-639
-
-
Zhuo, M.1
Hu, Y.2
Schultz, C.3
Kandel, E.R.4
Hawkins, R.D.5
-
72
-
-
0031692337
-
G protein-coupled receptor kinases
-
Pitcher, J. A., Freedman, N. J. & Lefkowitz, R. J. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67, 653-692 (1998).
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 653-692
-
-
Pitcher, J.A.1
Freedman, N.J.2
Lefkowitz, R.J.3
-
73
-
-
0042029729
-
Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G β γ complex on membrane is required for GRK2 function in vivo
-
Li, J. et al. Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G β γ complex on membrane is required for GRK2 function in vivo. J. Biol. Chem. 278, 30219-30226 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30219-30226
-
-
Li, J.1
-
74
-
-
0035805528
-
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79
-
Cong, M. et al. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J. Biol. Chem. 276, 15192-15199 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 15192-15199
-
-
Cong, M.1
-
75
-
-
0033521109
-
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
-
Pitcher, J. A. et al. Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J. Biol. Chem. 274, 34531-34534 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34531-34534
-
-
Pitcher, J.A.1
-
76
-
-
0032553549
-
Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation
-
Pronin, A. N., Carman, C. V. & Benovic, J. L. Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. J. Biol. Chem. 273, 31510-31518 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31510-31518
-
-
Pronin, A.N.1
Carman, C.V.2
Benovic, J.L.3
-
77
-
-
38149140880
-
Mammalian NDR protein kinases: From regulation to a role in centrosome duplication
-
Hergovich, A., Cornils, H. & Hemmings, B. A. Mammalian NDR protein kinases: from regulation to a role in centrosome duplication. Biochim. Biophys. Acta 1784, 3-15 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, pp. 3-15
-
-
Hergovich, A.1
Cornils, H.2
Hemmings, B.A.3
-
78
-
-
57049097531
-
The Hippo-YAP pathway: New connections between regulation of organ size and cancer
-
Zhao, B., Lei, Q. Y. & Guan, K. L. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr. Opin. Cell Biol. 20, 638-646 (2008).
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 638-646
-
-
Zhao, B.1
Lei, Q.Y.2
Guan, K.L.3
-
79
-
-
2642546543
-
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases
-
Devroe, E., Erdjument-Bromage, H., Tempst, P. & Silver, P. A. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J. Biol. Chem. 279, 24444-24451 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24444-24451
-
-
Devroe, E.1
Erdjument-Bromage, H.2
Tempst, P.3
Silver, P.A.4
-
80
-
-
4143117852
-
Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein
-
Bichsel, S. J., Tamaskovic, R., Stegert, M. R. & Hemmings, B. A. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J. Biol. Chem. 279, 35228-35235 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35228-35235
-
-
Bichsel, S.J.1
Tamaskovic, R.2
Stegert, M.R.3
Hemmings, B.A.4
-
81
-
-
24344474135
-
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation
-
Hergovich, A., Bichsel, S. J. & Hemmings, B. A. Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation. Mol. Cell. Biol. 25, 8259-8272 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 8259-8272
-
-
Hergovich, A.1
Bichsel, S.J.2
Hemmings, B.A.3
-
82
-
-
0032531742
-
Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins
-
Millward, T. A., Heizmann, C. W., Schafer, B. W. & Hemmings, B. A. Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins. EMBO J. 17, 5913-5922 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 5913-5922
-
-
Millward, T.A.1
Heizmann, C.W.2
Schafer, B.W.3
Hemmings, B.A.4
-
83
-
-
16444373346
-
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
-
Chan, E. H. et al. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24, 2076-2086 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2076-2086
-
-
Chan, E.H.1
-
84
-
-
28544435761
-
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
-
Stegert, M. R., Hergovich, A., Tamaskovic, R., Bichsel, S. J. & Hemmings, B. A. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Mol. Cell. Biol. 25, 11019-11029 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 11019-11029
-
-
Stegert, M.R.1
Hergovich, A.2
Tamaskovic, R.3
Bichsel, S.J.4
Hemmings, B.A.5
-
85
-
-
66449103527
-
Rassf family of tumor suppressor polypeptides
-
Avruch, J. et al. Rassf family of tumor suppressor polypeptides. J Biol Chem 284, 11001-11005 (2009).
-
(2009)
J Biol Chem
, vol.284
, pp. 11001-11005
-
-
Avruch, J.1
-
86
-
-
0034715885
-
Regulation and functions of Rho-associated kinase
-
Amano, M., Fukata, Y. & Kaibuchi, K. Regulation and functions of Rho-associated kinase. Exp. Cell Res. 261, 44-51 (2000).
-
(2000)
Exp. Cell Res.
, vol.261
, pp. 44-51
-
-
Amano, M.1
Fukata, Y.2
Kaibuchi, K.3
-
87
-
-
0032491424
-
Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron
-
Di Cunto, F. et al. Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J. Biol. Chem. 273, 29706-29711 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29706-29711
-
-
Di Cunto, F.1
-
88
-
-
52149111161
-
Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1
-
Kaliman, P. & Llagostera, E. Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1. Cell Signal. 20, 1935-1941 (2008).
-
(2008)
Cell Signal.
, vol.20
, pp. 1935-1941
-
-
Kaliman, P.1
Llagostera, E.2
-
89
-
-
0033601250
-
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase
-
Feng, J. et al. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J. Biol. Chem. 274, 37385-37390 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37385-37390
-
-
Feng, J.1
-
90
-
-
14844293207
-
And other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation
-
Zhao, Z. S. & Manser, E. PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation. Biochem. J. 386, 201-214 (2005).
-
(2005)
Biochem. J.
, vol.386
, pp. 201-214
-
-
Zhao, Z.S.1
Pak, M.E.2
-
91
-
-
0033527745
-
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity
-
Amano, M. et al. The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J. Biol. Chem. 274, 32418-32424 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32418-32424
-
-
Amano, M.1
-
92
-
-
0034705685
-
Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase
-
Shimizu, M., Wang, W., Walch, E. T., Dunne, P. W. & Epstein, H. F. Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase. FEBS Lett. 475, 273-277 (2000).
-
(2000)
FEBS Lett.
, vol.475
, pp. 273-277
-
-
Shimizu, M.1
Wang, W.2
Walch, E.T.3
Dunne, P.W.4
Epstein, H.F.5
-
93
-
-
0035075597
-
Caspase-3-mediated cleavage of ROCK i induces MLC phosphorylation and apoptotic membrane blebbing
-
Sebbagh, M. et al. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nature Cell Biol. 3, 346-352 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 346-352
-
-
Sebbagh, M.1
-
94
-
-
0033525125
-
Rho-associated kinase of chicken gizzard smooth muscle
-
Feng, J. et al. Rho-associated kinase of chicken gizzard smooth muscle. J. Biol. Chem, 274, 3744-3752 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 3744-3752
-
-
Feng, J.1
-
95
-
-
62749110739
-
The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity
-
Couzens, A. L., Saridakis, V. & Scheid, M. P. The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity. Biochem. J. 419, 141-148 (2009).
-
(2009)
Biochem. J.
, vol.419
, pp. 141-148
-
-
Couzens, A.L.1
Saridakis, V.2
Scheid, M.P.3
-
96
-
-
38849185196
-
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
-
Pinner, S. & Sahai, E. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nature Cell Biol. 10, 127-137 (2008).
-
(2008)
Nature Cell Biol.
, vol.10
, pp. 127-137
-
-
Pinner, S.1
Sahai, E.2
-
97
-
-
23844473290
-
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/ threonine kinases
-
Valiente, M. et al. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/ threonine kinases. J. Biol. Chem. 280, 28936-28943 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 28936-28943
-
-
Valiente, M.1
-
98
-
-
33747886526
-
Emerging roles of pseudokinases
-
Boudeau, J., Miranda-Saavedra, D., Barton, G. J. & Alessi, D. R. Emerging roles of pseudokinases. Trends Cell Biol. 16, 443-452 (2006).
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 443-452
-
-
Boudeau, J.1
Miranda-Saavedra, D.2
Barton, G.J.3
Alessi, D.R.4
-
99
-
-
0037031948
-
Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein
-
Hayashi, S. et al. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J. Biol. Chem. 277, 33319-33324 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 33319-33324
-
-
Hayashi, S.1
-
100
-
-
22844431509
-
RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains
-
Liu, L. et al. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Mol. Cells 19, 39-45 (2005).
-
(2005)
Mol. Cells
, vol.19
, pp. 39-45
-
-
Liu, L.1
-
101
-
-
0026040191
-
Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
-
Kennelly, P. J. & Krebs, E. G. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266, 15555-15558 (1991).
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 15555-15558
-
-
Kennelly, P.J.1
Krebs, E.G.2
-
102
-
-
0030590875
-
Molecular basis for the substrate specificity of protein kinase B; Comparison with MAPKAP kinase-1 and p70 S6 kinase
-
Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A. & Cohen, P. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 399, 333-338 (1996).
-
(1996)
FEBS Lett.
, vol.399
, pp. 333-338
-
-
Alessi, D.R.1
Caudwell, F.B.2
Andjelkovic, M.3
Hemmings, B.A.4
Cohen, P.5
-
103
-
-
0035477020
-
GSK3 takes centre stage more than 20 years after its discovery
-
Frame, S. & Cohen, P. GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1-16 (2001).
-
(2001)
Biochem. J.
, vol.359
, pp. 1-16
-
-
Frame, S.1
Cohen, P.2
-
104
-
-
33750040886
-
S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
-
Zhang, H. H., Lipovsky, A. I., Dibble, C. C., Sahin, M. & Manning, B. D. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol. Cell 24, 185-197 (2006).
-
(2006)
Mol. Cell
, vol.24
, pp. 185-197
-
-
Zhang, H.H.1
Lipovsky, A.I.2
Dibble, C.C.3
Sahin, M.4
Manning, B.D.5
-
105
-
-
34347242470
-
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
-
Roux, P. P. et al. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J. Biol. Chem. 282, 14056-14064 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14056-14064
-
-
Roux, P.P.1
-
106
-
-
0035135841
-
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
-
Brunet, A. et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21, 952-965 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 952-965
-
-
Brunet, A.1
-
107
-
-
1342342993
-
PDK1 the master regulator of AGC kinase signal transduction
-
Mora, A., Komander, D., Van Aalten, D. M. & Alessi, D. R. PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell. Dev. Biol. 15, 161-170 (2004).
-
(2004)
Semin. Cell. Dev. Biol.
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
Van Aalten, D.M.3
Alessi, D.R.4
-
108
-
-
19944408613
-
Exploitation of KESTREL to identify N-myc downstream-regulated gene family members as physiological substrates for SGK1 and GSK3
-
Murray, J. T. et al. Exploitation of KESTREL to identify N-myc downstream-regulated gene family members as physiological substrates for SGK1 and GSK3. Biochem. J. 384, 477-488 (2004).
-
(2004)
Biochem. J.
, vol.384
, pp. 477-488
-
-
Murray, J.T.1
-
109
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten, J. D. et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448, 439-444 (2007).
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
-
110
-
-
68049117229
-
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma
-
Maurer, M. et al. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res. 69, 6299-6306 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 6299-6306
-
-
Maurer, M.1
-
111
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning, B. D. & Cantley, L. C. AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (2007).
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
112
-
-
0346455772
-
Posttranslational modification of MDM2
-
Meek, D. W. & Knippschild, U. Posttranslational modification of MDM2. Mol. Cancer Res. 1, 1017-1026 (2003).
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 1017-1026
-
-
Meek, D.W.1
Knippschild, U.2
-
113
-
-
64049087382
-
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
-
Lin, H. K. et al. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nature Cell Biol. 11, 420-432 (2009).
-
(2009)
Nature Cell Biol.
, vol.11
, pp. 420-432
-
-
Lin, H.K.1
-
114
-
-
43749083041
-
Brick by brick: Metabolism and tumor cell growth
-
Deberardinis, R. J., Sayed, N., Ditsworth, D. & Thompson, C. B. Brick by brick: metabolism and tumor cell growth. Curr. Opin. Genet. Dev. 18, 54-61 (2008).
-
(2008)
Curr. Opin. Genet. Dev.
, vol.18
, pp. 54-61
-
-
Deberardinis, R.J.1
Sayed, N.2
Ditsworth, D.3
Thompson, C.B.4
-
115
-
-
0035881470
-
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
-
Wang, X. et al. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 20, 4370-4379 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 4370-4379
-
-
Wang, X.1
-
116
-
-
2442574729
-
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
-
Raught, B. et al. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J. 23, 1761-1769 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 1761-1769
-
-
Raught, B.1
-
117
-
-
51049083138
-
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
-
Carriere, A. et al. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr. Biol. 18, 1269-1277 (2008).
-
(2008)
Curr. Biol.
, vol.18
, pp. 1269-1277
-
-
Carriere, A.1
-
118
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
Roux, P. P., Ballif, B. A., Anjum, R., Gygi, S. P. & Blenis, J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc. Natl Acad. Sci. USA 101, 13489-13494 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
119
-
-
11144356304
-
-/-mice exhibit perinatal lethality and rapamycin-sensitive 5́-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
-
-/-mice exhibit perinatal lethality and rapamycin-sensitive 5́-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24, 3112-3124 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3112-3124
-
-
Pende, M.1
-
120
-
-
33745570504
-
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
-
Shahbazian, D. et al. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25, 2781-2791 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 2781-2791
-
-
Shahbazian, D.1
-
121
-
-
44349134920
-
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
-
Zhu, J., Blenis, J. & Yuan, J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc. Natl Acad. Sci. USA 105, 6584-6589 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 6584-6589
-
-
Zhu, J.1
Blenis, J.2
Yuan, J.3
-
122
-
-
65949103405
-
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1
-
Jones, K. T., Greer, E. R., Pearce, D. & Ashrafi, K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 7, e60 (2009).
-
(2009)
PLoS Biol.
, vol.7
-
-
Jones, K.T.1
Greer, E.R.2
Pearce, D.3
Ashrafi, K.4
-
123
-
-
61449244533
-
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
-
Soukas, A. A., Kane, E. A., Carr, C. E., Melo, J. A. & Ruvkun, G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 23, 496-511 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 496-511
-
-
Soukas, A.A.1
Kane, E.A.2
Carr, C.E.3
Melo, J.A.4
Ruvkun, G.5
-
124
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
Vasudevan, K. M. et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16, 21-32 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
-
125
-
-
68249093818
-
Targeting the phosphoinositide 3-kinase pathway in cancer
-
Liu, P., Cheng, H., Roberts, T. M. & Zhao, J. J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nature Rev. Drug Discov. 8, 627-644 (2009).
-
(2009)
Nature Rev. Drug Discov.
, vol.8
, pp. 627-644
-
-
Liu, P.1
Cheng, H.2
Roberts, T.M.3
Zhao, J.J.4
-
127
-
-
67650337799
-
Inhibitor hijacking of Akt activation
-
Okuzumi, T. et al. Inhibitor hijacking of Akt activation. Nature Chem. Biol. 5, 484-493 (2009).
-
(2009)
Nature Chem. Biol.
, vol.5
, pp. 484-493
-
-
Okuzumi, T.1
-
128
-
-
0037677096
-
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
-
Sano, H. et al. Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J. Biol. Chem. 278, 14599-14602 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14599-14602
-
-
Sano, H.1
-
129
-
-
50349099779
-
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
-
Sakamoto, K. & Holman, G. D. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. Am. J. Physiol. Endocrinol. Metab. 295, E29-E37 (2008).
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.295
-
-
Sakamoto, K.1
Holman, G.D.2
-
130
-
-
18444399216
-
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
-
McManus, E. J. et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 24, 1571-1583 (2005).
-
(2005)
EMBO J.
, vol.24
, pp. 1571-1583
-
-
McManus, E.J.1
-
131
-
-
34250740323
-
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
-
Li, X., Monks, B., Ge, Q. & Birnbaum, M. J. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator. Nature 447, 1012-1016 (2007).
-
(2007)
Nature
, vol.447
, pp. 1012-1016
-
-
Li, X.1
Monks, B.2
Ge, Q.3
Birnbaum, M.J.4
-
132
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
-
Puigserver, P. et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature 423, 550-555 (2003).
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
-
133
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728-1731 (2001).
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
-
134
-
-
33750380920
-
Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
-
Dummler, B. et al. Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol. Cell. Biol. 26, 8042-8051 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8042-8051
-
-
Dummler, B.1
-
135
-
-
33845432866
-
Regulating insulin signaling and β-cell function through IRS proteins
-
White, M. F. Regulating insulin signaling and β-cell function through IRS proteins. Can. J. Physiol. Pharmacol. 84, 725-737 (2006).
-
(2006)
Can. J. Physiol. Pharmacol.
, vol.84
, pp. 725-737
-
-
White, M.F.1
-
136
-
-
4544220704
-
Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
-
Um, S. H. et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205 (2004).
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
-
137
-
-
41649093318
-
Inflammatory mechanisms in the regulation of insulin resistance
-
Tilg, H. & Moschen, A. R. Inflammatory mechanisms in the regulation of insulin resistance. Mol. Med. 14, 222-231 (2008).
-
(2008)
Mol. Med.
, vol.14
, pp. 222-231
-
-
Tilg, H.1
Moschen, A.R.2
-
138
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu, C. et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 50230-50236 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
-
139
-
-
8544244084
-
PKC-θ knockout mice are protected from fat-induced insulin resistance
-
Kim, J. K. et al. PKC-θ knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 11 4, 823-827 (2004).
-
(2004)
J. Clin. Invest.
, vol.11
, Issue.4
, pp. 823-827
-
-
Kim, J.K.1
-
140
-
-
33751583820
-
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
-
Engel, M. et al. Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. EMBO J. 25, 5469-5480 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 5469-5480
-
-
Engel, M.1
-
141
-
-
70349305603
-
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
-
Hindie, V. et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 5, 758-764 (2009).
-
(2009)
Nature Chem. Biol.
, vol.5
, pp. 758-764
-
-
Hindie, V.1
-
142
-
-
0031038950
-
Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness
-
Yamamoto, S., Sippel, K. C., Berson, E. L. & Dryja, T. P. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nature Genet. 15, 175-178 (1997).
-
(1997)
Nature Genet.
, vol.15
, pp. 175-178
-
-
Yamamoto, S.1
Sippel, K.C.2
Berson, E.L.3
Dryja, T.P.4
-
143
-
-
0031892644
-
Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man
-
Cideciyan, A. V. et al. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc. Natl Acad. Sci. USA 95, 328-333 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 328-333
-
-
Cideciyan, A.V.1
-
144
-
-
4043178555
-
Mutation in the catalytic domain of protein kinase C γ and extension of the phenotype associated with spinocerebellar ataxia type 14
-
Stevanin, G. et al. Mutation in the catalytic domain of protein kinase C γ and extension of the phenotype associated with spinocerebellar ataxia type 14. Arch. Neurol. 61, 1242-1248 (2004).
-
(2004)
Arch. Neurol.
, vol.61
, pp. 1242-1248
-
-
Stevanin, G.1
-
145
-
-
0346754906
-
Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C γ
-
Yabe, I. et al. Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C γ. Arch. Neurol. 60, 1749-1751 (2003).
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1749-1751
-
-
Yabe, I.1
-
146
-
-
0029832136
-
Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome
-
Trivier, E. et al. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384, 567-570 (1996).
-
(1996)
Nature
, vol.384
, pp. 567-570
-
-
Trivier, E.1
-
148
-
-
21444450805
-
And molecular aspects of the myotonic dystrophies: A review
-
Machuca-Tzili, L., Brook, D. & Hilton-Jones, D. Clinical and molecular aspects of the myotonic dystrophies: a review. Muscle Nerve 32, 1-18 (2005).
-
(2005)
Muscle Nerve
, vol.32
, pp. 1-18
-
-
MacHuca-Tzili, L.1
Brook, D.2
Clinical, H.D.3
-
149
-
-
33846318219
-
Myotonic dystrophy: Emerging mechanisms for DM1 and DM2
-
Cho, D. H. & Tapscott, S. J. Myotonic dystrophy: emerging mechanisms for DM1 and DM2. Biochim. Biophys. Acta 1772, 195-204 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1772
, pp. 195-204
-
-
Cho, D.H.1
Tapscott, S.J.2
-
150
-
-
67651177623
-
MAST3: A novel IBD risk factor that modulates TLR4 signaling
-
Labbe, C. et al. MAST3: a novel IBD risk factor that modulates TLR4 signaling. Genes Immun. 9, 602-612 (2008).
-
(2008)
Genes Immun.
, vol.9
, pp. 602-612
-
-
Labbe, C.1
-
151
-
-
0042173047
-
FLJ14813 missense mutation: A candidate for autosomal dominant thrombocytopenia on human chromosome 10
-
Gandhi, M. J., Cummings, C. L. & Drachman, J. G. FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. Hum. Hered. 55, 66-70 (2003).
-
(2003)
Hum. Hered.
, vol.55
, pp. 66-70
-
-
Gandhi, M.J.1
Cummings, C.L.2
Drachman, J.G.3
|