Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

Genes and Development

Volumn 15, Issue 15, 2001, Pages 1926-1934

  Fernandez A M ^a   Kim, J K ^a   Yakar, S ^a   Dupont, J ^a   Hernandez Sanchez, C ^a   Castle, A L ^a   Filmore, J ^a   Shulman, G I ^a   Le Roith, D ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Dominant negative; IGF I receptor; Insulin receptor; Skeletal muscle; Transgenic; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; TISSUE HOMOGENATE; TRANSGENIC MOUSE;

AGING; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; LIVER; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUTAGENESIS, SITE-DIRECTED; PREDIABETIC STATE; PROTEIN HYBRIDIZATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; TRIGLYCERIDES;

ANIMALIA; MUS MUSCULUS;

EID: 0035425234     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.908001     Document Type: Article

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