Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 8460-8467

  Wick, KeriLyn R ^a   Werner, Eric D ^c   Langlais, Paul ^b   Ramos, Fresnida J ^a   Dong, Lily Q ^b   Shoelson, Steven E ^c   Liu, Feng ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; CHEMICAL ACTIVATION; INSULIN;

PHOSPHORYLATION;

ENZYMES;

BINDING PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; GRB10 PROTEIN, MOUSE; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; ONCOPROTEIN; PHOSPHOPROTEIN; PRIMER DNA; PROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ADIPOCYTE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; DOSE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; HAMSTER; HUMAN; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; DNA PRIMERS; GRB10 ADAPTOR PROTEIN; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 0037424346     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208518200     Document Type: Article

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